@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : WNK3_HUMAN: (2020-09-25 )
MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
Atome Classification :
(102 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150--.......160.......170-....-....180.......190........200.......210.......220.......230.......240--...----......250.......260.......270.......280..-.....--------290.......300......-----.-310.......-320..----.....330.......340.....-.--.350.......360.......370...---....380.......390.------......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MATDSGDPASTEDSEKPDGISFENRVP
Q
V
A
A
T
L
T
V
E
A
R
LKEKNSTFSASG
E
T
V
E
R
K
R
F
F
R
K
SVEMTEDDKVAESSP
K
D
E
R
I
K
A
A
MNIP
R
V
D
KL
P
S
N
V
LRGGQE
V
K
Y
E
Q
CSK
S
T
S
E
I
S
K
D
C
F
K
EK
N
E
K
E
M
E
E
E
A
E
M
K
A
V
ATSPSG
R
F
L
K
F
D
I
E--LGR
G
A
F
K
T
V
Y
KGLDTE
T
W
-
V
-
E
V
A
W
-
C
ELQDRKL
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
GLQHP
N
I
V
R
F
Y
D
S
W
E
S
I
LKGK
K
C
I
V
L
V
T
E
L
MTS
G
T
L
K
T
Y
L
K
----
R
FK----VM
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
HTRTP
P
I
I
H
RDLKCD
N
I
F
I
T-GPTG
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----V-IGTPEFM
A
P
E
-
M
Y
E
E
H
----YDES
V
D
V
Y
A
F
G
M
C
M
L
E
MATSEY
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
TSGIKPASFNKVT
D
---
P
E
V
K
E
I
I
E
G
C
I
RQNKSE
R
------
L
S
I
R
D
L
L
N
H
A
FFAEDTG
L
R
V
E
LAEEDDCSNS
S
L
A
L
R
L
W
VE
D
P
K
K
LKGKHKDN
E
A
I
E
F
S
F
NLETD
T
P
E
E
V
A
Y
E
M
V
K
SGFFHES
D
S
K
A
V
A
K
S
I
R
D
RVT
P
I
K
K
TREKKPA
G
C
L
E
E
R
R
D
S
Q
C
K
S
M
G
NVFPQPQNTTLPLAPAQQTGAE
C
E
E
T
E
V
D
Q
H
V
R
Q
Q
L
L
Q
R
K
P
Q
Q
H
C
S
SVTGDNLSEAGA
A
S
V
I
HSDTSSQP
S
V
A
YSSNQ
T
M
G
S
Q
M
V
S
NIPQAEVNVPGQIY
S
S
Q
Q
L
V
G
H
Y
Q
Q
V
S
G
L
Q
K
HSKLTQP
Q
I
L
P
L
VQGQ
S
T
V
L
P
V
H
VLGPTVVSQPQVSPL
T
V
QKVPQIKPVSQPVG
A
E
Q
Q
A
A
LL
K
P
D
L
V
R
S
L
N
Q
D
V
ATTKENVSSPDNPSGN
G
K
Q
D
R
I
K
Q
R
R
ASCPRPEKG
T
K
F
Q
L
T
V
L
Q
V
STSGD
N
M
V
E
C
Q
L
ETHN
N
K
M
V
T
F
K
F
DVDGD
A
P
E
D
I
A
D
Y
M
VED
N
F
V
L
E
S
E
K
E
K
F
V
E
E
L
R
A
I
V
G
Q
A
Q
E
I
L
H
V
H
FATERATGV
D
S
I
T
VDSNSSQTGSS
E
Q
V
Q
I
NSTSTQTSNESAPQSSPV
G
R
W
R
F
C
I
N
Q
T
IRNRETQSP
P
S
L
Q
H
S
M
S
AVPGRHPLPSPKNTSNKEISR
D
T
L
L
T
IENNPC
H
R
A
LFTSKSEHKDVVDG
K
I
S
E
CASVETKQ
P
A
I
L
Y
Q
VEDN
R
Q
I
M
A
PVTNSSSYST
T
S
V
R
AV
P
A
ECEGLTKQ
A
S
I
F
I
P
VYPCHQ
T
A
S
Q
A
D
A
L
M
SHPGESTQTSGN
S
L
T
T
L
A
FDQKPQT
L
S
VQQPAM
D
A
E
F
I
SQEGE
T
T
VNTEASSP
K
T
V
I
PTQTPGLEPTTLQP
T
T
VLESDGERPPKLEFAD
N
R
I
K
T
L
D
E
K
L
R
N
L
L
Y
Q
EH
S
I
S
SIYPESQKD
T
Q
SIDSPFSSSAEDTLSCPV
T
E
V
I
A
I
SHCGIKDSPVQSP
N
F
Q
Q
T
G
S
K
L
L
S
N
V
AASQPA
N
I
S
V
F
K
R
D
L
N
V
I
T
SV
P
S
E
L
C
L
H
E
MSSDASLPGDPEAYPAAVSSG
G
A
I
H
L
QTGG
G
Y
F
G
L
S
F
TCPSLKNPI
S
K
K
S
W
T
R
K
L
K
S
W
A
Y
R
L
R
Q
S
T
S
F
F
K
R
S
KVRQV
E
T
E
E
M
R
S
AIAPDPIPLTRESTA
D
T
R
A
L
N
R
C
K
AMSGSFQRG
R
F
Q
V
I
T
IPQQQSAKMTSFGI
E
H
I
S
V
FSETNHS
S
E
E
A
F
I
K
T
A
KS
Q
L
V
E
IEPATQNPKTSF
S
Y
E
K
L
Q
A
L
Q
E
T
C
K
ENKGVPKQGDN
F
L
S
FSAACETDVSSVT
P
E
K
E
F
E
E
TSATGSSMQS
G
S
E
L
L
L
K
E
R
E
I
LTAGKQPSSD
S
E
F
S
A
S
LAGSGK
S
V
AKTGPESNQCLPH
H
E
E
Q
A
Y
A
Q
T
Q
S
S
L
F
YSPSSPMSSDDESEIE
D
E
D
L
K
V
E
L
Q
R
L
R
E
K
H
I
Q
E
V
V
N
L
QTQQ
N
K
E
L
Q
E
L
Y
E
R
L
R
S
I
KDSKTQSTEIPLPPASPRR
P
R
S
F
K
S
K
L
R
SRP
Q
S
L
T
HVDN
G
I
VATG
K
S
C
L
I
N
ELEN
P
L
C
VESN
A
A
SCQQSPASKKGM
F
T
D
D
L
H
K
L
V
D
D
W
T
K
E
A
VGNSLIK
P
S
L
N
Q
L
K
Q
S
Q
HKLETENWNKVSENTPSTMG
Y
T
S
T
W
I
S
S
L
S
Q
I
RGAVPTSLPQGLSLPSFPGP
L
S
SYGMP
H
V
C
Q
YNAVAGAGY
P
V
Q
W
V
GISGTTQ
Q
S
V
V
I
PAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
222
HHSearch
95.36
100%
-103
- C4 -
-
5O2C
5
WNK3_HUMAN
A:
[12-376]
-----------------------------------------------------------------------------------------------------------------------------------
E
A
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
E
L
A
E
E
D
D
C
S
N
S
S
L
A
L
R
L
W
V
E
D
P
K
K
L
K
G
K
H
K
D
N
E
A
I
E
F
S
F
N
L
E
T
D
T
P
E
E
V
A
Y
E
M
V
K
S
G
F
F
H
E
S
D
S
K
A
V
A
K
S
I
R
D
R
V
T
P
I
K
K
T
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.56
100%
-104
- C4 -
-
5O2C
5
WNK3_HUMAN
A:
[18-376]
-----------------------------------------------------------------------------------------------------------------------------------------
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
E
L
A
E
E
D
D
C
S
N
S
S
L
A
L
R
L
W
V
E
D
P
K
K
L
K
G
K
H
K
D
N
E
A
I
E
F
S
F
N
L
E
T
D
T
P
E
E
V
A
Y
E
M
V
K
S
G
F
F
H
E
S
D
S
K
A
V
A
K
S
I
R
D
R
V
T
P
I
K
K
T
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.04
99%
-127
- C4 -
-
5O1V
10
WNK3_HUMAN
A:
[5-283]
-------------------------------------------------------------------------------------------------------------------------------------
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.97
100%
-127
- C4 -
-
5O2B
1
WNK3_HUMAN
A:
[3-285]
-----------------------------------------------------------------------------------------------------------------------------------
E
A
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
---
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
----
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
--------------
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
HHSearch
76.39
100%
-127
- C4 -
-
5O1V
10
WNK3_HUMAN
A:
[6-281]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
75.93
99%
-112
- C4 -
-
5O21
9
WNK3_HUMAN
B:
[6-279]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
75.66
100%
-131
- C4 -
-
5O2B
1
WNK3_HUMAN
B:
[6-277]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
---
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
----------------
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
--
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
75.14
99%
-110
- C4 -
-
5O26
1
WNK3_HUMAN
B:
[6-284]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
------
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
-----
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.01
99%
-109
- C4 -
-
5O21
8
WNK3_HUMAN
A:
[6-278]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
74.92
90%
-110
- C4 -
-
5W7T
1
WNK1_RAT
B:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.87
99%
-111
- C4 -
-
5O23
13
WNK3_HUMAN
A:
[7-276]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
74.85
99%
-106
- C4 -
-
5O23
13
WNK3_HUMAN
B:
[3-279]
-----------------------------------------------------------------------------------------------------------------------------------
E
A
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
74.81
99%
-120
- C4 -
-
5O1V
6
WNK3_HUMAN
B:
[5-281]
-------------------------------------------------------------------------------------------------------------------------------------
E
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
L
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
-
F
-----------
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.53
99%
-108
- C4 -
-
5O26
2
WNK3_HUMAN
A:
[5-285]
--------------------------------------------------------------------------------------------------------------------------------------
M
K
A
V
A
T
S
P
S
G
R
F
L
K
F
D
I
E
--
L
G
R
G
A
F
K
T
V
Y
K
G
L
D
T
E
T
W
-
V
-
E
V
A
W
-
C
E
L
Q
D
---
T
K
A
E
Q
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
I
----
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
M
R
T
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
H
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
T
S
G
I
K
P
A
S
F
N
K
V
T
D
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
S
E
R
------
L
S
I
R
D
L
L
N
H
A
F
F
A
E
D
T
G
L
R
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.32
90%
-104
- C4 -
-
5W7T
1
WNK1_RAT
A:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.76
87%
-119
- C4 -
-
5DRB
1
WNK1_RAT
A:
[17-289]
--------------------------------------------------------------------------------------------------------------------------------------
T
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
A
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.68
85%
-119
- C4 -
-
6CN9
4
WNK1_RAT
A:
[17-287]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
72.56
89%
-133
- C4 -
-
5TF9
2
WNK1_HUMAN
B:
[2-276]
-----------------------------------------------------------------------------------------------------------------------------------
E
L
E
T
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
---------------
G
T
P
E
F
M
A
P
E
-
M
Y
A
A
A
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
HHSearch
72.44
91%
-105
- C4 -
-
5W7T
1
WNK1_RAT
A:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.92
88%
-116
- C4 -
-
4Q2A
-
WNK1_RAT
A:
[17-286]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
A
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
71.66
89%
-123
- C4 -
-
5WE8
3
WNK1_HUMAN
B:
[3-276]
------------------------------------------------------------------------------------------------------------------------------------
L
E
T
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
--
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
D
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
A
A
A
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
HHSearch
71.57
91%
-119
- C4 -
-
5DRB
1
WNK1_RAT
A:
[23-289]
--------------------------------------------------------------------------------------------------------------------------------------------
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
A
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.46
89%
-125
- C4 -
-
5WE8
3
WNK1_HUMAN
A:
[5-279]
--------------------------------------------------------------------------------------------------------------------------------------
T
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
-----
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
D
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
A
A
A
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.19
89%
-129
- C4 -
-
5WDY
2
WNK1_HUMAN
A:
[4-277]
-------------------------------------------------------------------------------------------------------------------------------------
E
T
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
-----
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
---------------
P
E
F
M
A
P
E
-
M
Y
A
A
A
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.74
89%
-123
- C4 -
-
5TF9
2
WNK1_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
---
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
---------------
G
T
P
E
F
M
A
P
E
-
M
Y
A
A
A
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
E
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
69.60
85%
-110
- C4 -
-
6CN9
5
WNK1_RAT
B:
[17-288]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
A
S
F
A
K
S
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
L
L
E
E
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
69.28
89%
-129
- C4 -
-
5WDY
2
WNK1_HUMAN
B:
[2-276]
-----------------------------------------------------------------------------------------------------------------------------------
E
L
E
T
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
-
V
-
E
V
A
W
-
C
E
L
Q
---
L
T
K
S
E
R
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
--------
V
K
I
G
D
L
G
L
A
T
L
K
R
---------------
T
P
E
F
M
A
P
E
-
M
Y
A
A
A
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
--
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
----
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
I
K
D
L
L
N
H
A
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
45.11
32%
-37
- C4 -
-
3Q96
1
B:
[17-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
-----------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
44.64
32%
-30
- C4 -
-
3OMV
1
RAF1_HUMAN
A:
[44-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
-
H
G
D
V
A
V
-
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
-
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
VQET
K
F
Q
----
M
F
Q
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
----------
V
K
I
G
D
F
G
L
A
T
V
--------------P
T
G
S
V
L
W
M
A
P
E
-
V
I
R
M
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
-
Y
--
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
NCP
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
PLFPQI
L
S
S
I
E
L
L
Q
H
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
44.32
32%
-33
- C4 -
-
4DBN
1
B:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
-----------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
43.58
32%
-24
- C4 -
-
4EHE
1
BRAF_HUMAN
A:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
-----------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
43.54
32%
-31
- C4 -
-
5VAM
1
BRAF_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
--FEQ--
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
43.33
32%
-33
- C4 -
-
4FC0
1
B:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
-----------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
43.26
32%
-28
- C4 -
-
6N0P
1
B:
[14-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
-----------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-KNP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
43.26
32%
-24
- C4 -
-
4E4X
1
BRAF_HUMAN
A:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
43.20
32%
-22
- C4 -
-
6N0Q
1
?
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
-------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-KNP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
43.12
32%
-10
- C4 -
-
4MBJ
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
S
HQFEQ
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
42.99
32%
-29
- C4 -
-
5CT7
1
BRAF_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
42.94
32%
-10
- C4 -
-
4EHE
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
S
HQFEQ
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
42.89
32%
-42
- C4 -
-
1UWH
1
BRAF_HUMAN
A:
[15-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
42.88
32%
-39
- C4 -
-
4G9C
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
42.69
32%
-24
- C4 -
-
3IDP
1
BRAF_HUMAN
A:
[35-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
-----------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
42.57
32%
-33
- C4 -
-
3IDP
1
B:
[35-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
42.51
32%
-21
- C4 -
-
5VAL
1
B:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
42.42
32%
-33
- C4 -
-
4G9C
1
BRAF_HUMAN
A:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
-----------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
42.35
32%
-28
- C4 -
-
4KSQ
1
B:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
42.32
32%
-40
- C4 -
-
1UWH
1
B:
[15-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
42.29
32%
-36
- C4 -
-
3PRI
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
42.29
32%
-37
- C4 -
-
4KSQ
1
BRAF_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
42.21
32%
-22
- C4 -
-
6N0Q
1
?
B:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
42.15
32%
-15
- C4 -
-
6B8U
1
BRAF_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
42.04
32%
-27
- C4 -
-
4PP7
1
BRAF_HUMAN
A:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
41.97
32%
-29
- C4 -
-
1UWJ
1
B:
[15-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
--------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
41.97
32%
-25
- C4 -
-
3II5
1
B:
[42-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
41.94
32%
-17
- C4 -
-
4RZW
1
B:
[21-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
---------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
41.85
32%
-23
- C4 -
-
4KSP
1
BRAF_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
41.77
32%
-30
- C4 -
-
4KSP
1
B:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
41.74
32%
-13
- C4 -
-
4PP7
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
S
HQFEQ
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
41.61
32%
-7
- C4 -
-
3SKC
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
S
HQFEQ
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
41.50
32%
-10
- C4 -
-
4R5Y
1
B:
[32-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
----------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-P---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
41.40
32%
-24
- C4 -
-
4JVG
1
BRAF_HUMAN
C:
[24-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
-------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
41.35
32%
-9
- C4 -
-
3C4C
1
BRAF_HUMAN
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
-------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
41.34
32%
-22
- C4 -
-
5VAL
1
BRAF_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
---------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-KNP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
41.33
32%
-17
- C4 -
-
4R5Y
1
BRAF_HUMAN
A:
[32-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
---------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
41.30
32%
-18
- C4 -
-
4XV9
1
A:
[32-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
41.26
32%
-7
- C4 -
-
4E4X
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
S
HQFEQ
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
41.20
32%
-3
- C4 -
-
4WO5
1
BRAF_HUMAN
A:
[40-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASE-
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
--FEQ--
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
41.08
32%
-12
- C4 -
-
6N0P
1
BRAF_HUMAN
A:
[14-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
--EQ---
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
40.92
32%
-18
- C4 -
-
4WO5
1
B:
[40-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
-----------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
40.86
32%
-13
- C4 -
-
5CSX
2
A:
[22-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
-----------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
40.77
32%
-20
- C4 -
-
3Q96
1
BRAF_HUMAN
A:
[17-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
40.55
32%
-10
- C4 -
-
5JSM
6
BRAF_HUMAN
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
-------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
40.53
32%
-28
- C4 -
-
1UWJ
1
BRAF_HUMAN
A:
[15-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
-------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
40.52
32%
-20
- C4 -
-
5C9C
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
40.46
32%
-5
- C4 -
-
5JRQ
3
BRAF_HUMAN
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
S
R
-------------
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
40.45
32%
-11
- C4 -
-
4FC0
1
BRAF_HUMAN
A:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
40.40
32%
-27
- C4 -
-
4G9R
1
B:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
--------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
40.29
32%
-18
- C4 -
-
4JVG
1
BRAF_HUMAN
B:
[24-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
40.21
32%
-13
- C4 -
-
5JSM
3
D:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
S
------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
---
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
40.12
32%
-21
- C4 -
-
5ITA
1
BRAF_HUMAN
A:
[37-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
39.82
32%
-6
- C4 -
-
5JSM
5
BRAF_HUMAN
B:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
S
R
-------------
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
39.82
32%
-13
- C4 -
-
6B8U
1
B:
[20-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
----
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
---------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
39.80
32%
-7
- C4 -
-
5CSW
1
B:
[22-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
--P---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
39.79
32%
-27
- C4 -
-
4G9R
1
BRAF_HUMAN
A:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
-
E
K
-------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
39.78
32%
-21
- C4 -
-
4JVG
1
BRAF_HUMAN
A:
[24-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
--------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
39.67
32%
-6
- C4 -
-
4CQE
1
BRAF_HUMAN
A:
[18-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
--
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
39.51
32%
-27
- C4 -
-
5C9C
1
BRAF_HUMAN
A:
[43-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
--------
V
K
I
G
D
F
G
L
A
T
------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
39.42
32%
-10
- C4 -
-
4RZW
1
BRAF_HUMAN
A:
[21-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
39.06
32%
-15
- C4 -
-
3OG7
1
BRAF_HUMAN
A:
[32-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
AS---
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
38.99
32%
-26
- C4 -
-
2WQN
1
NEK7_HUMAN
A:
[34-282]
----------------------------------------------------------------------------------------------------------------------------------------------------
F
R
I
E
KK
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
-
V
-
P
V
A
L
-
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
Y
Y
A
S
F
--
I
E
D
N
E
L
N
I
V
L
--
E
L
A
D
A
G
D
L
S
R
M
I
K
----
H
F
K
KQKR
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
--
V
M
H
R
D
I
K
P
A
N
V
F
I
T
-
A
-
T
G
V
--------
V
K
L
G
D
L
----------------------
T
P
Y
Y
M
S
P
E
R
I
H
E
N
G
----
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
-----
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
Y
P
P
L
P
S
D
H
Y
S
---
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
38.66
32%
-5
- C4 -
-
6NSQ
1
B:
[24-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
--P---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
38.59
32%
-15
- C4 -
-
4JVG
1
D:
[24-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
--------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
38.26
32%
-4
- C4 -
-
6CAD
1
BRAF_HUMAN
A:
[24-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
-
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
-------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-P---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
-
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
38.07
32%
-4
- C4 -
-
4FK3
1
BRAF_HUMAN
A:
[32-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
-------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
37.68
32%
4
- C4 -
-
4XV2
1
BRAF_HUMAN
A:
[32-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
--P---
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
36.40
31%
-3
- C4 -
-
5HI2
1
A:
[28-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
-----------
K
W
H
G
D
V
A
V
K
M
L
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
36.02
32%
10
- C4 -
-
4XV2
1
B:
[32-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
-
D
V
A
V
-
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASE--
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
F
P
R
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
35.85
32%
-42
- C4 -
-
4WNP
1
ULK1_HUMAN
C:
[26-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
V
A
V
-
K
C
I
N
K
K
N
L
A
K
S
-
Q
T
L
-
L
G
K
E
I
K
I
L
K
E
L
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
----
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
H
----
A
M
R
----
T
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
--
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
-
N
P
A
G
R
RANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
Q
S
N
M
M
A
A
-----
L
-
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
Q
H
----
Y
D
G
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
QA
S
S
P
Q
D
L
R
L
F
Y
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
35.02
31%
7
- C4 -
-
5HID
3
BRAF_HUMAN
A:
[28-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
-----------
K
W
H
G
D
V
A
V
K
M
L
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
----------EQ---
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
34.73
31%
7
- C4 -
-
5HID
3
B:
[28-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
-----------
K
W
H
G
D
V
A
V
K
M
L
T
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
--------
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
S
HQFEQ
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
--
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
21.49
32%
-6
- C4 -
-
6QAS
7
ULK1_HUMAN
B:
[26-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
V
A
V
-
K
C
I
N
K
K
N
L
A
K
S
-
Q
T
L
-
L
G
K
E
I
K
I
L
K
E
L
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
-----
A
N
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
H
----
A
M
R
----
T
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
--
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
-
N
P
A
G
R
RANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
Q
S
N
M
M
A
A
-----
L
-
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
Q
H
----
Y
D
G
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
QA
S
S
P
Q
D
L
R
L
F
Y
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
21.35
32%
-3
- C4 -
-
6QAS
14
ULK1_HUMAN
A:
[26-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
-
E
V
A
V
-
K
C
I
N
K
K
N
L
A
K
S
-
Q
T
L
-
L
G
K
E
I
K
I
L
K
E
L
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
-----
A
N
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
H
----
A
M
R
----
T
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
--
I
I
H
R
D
L
K
P
Q
N
I
L
L
S
-
N
P
A
G
R
RANPNSIR
V
K
I
A
D
F
G
F
A
R
Y
L
Q
S
N
M
M
A
A
-----
L
-
C
G
S
P
M
Y
M
A
P
E
V
I
M
S
Q
H
----
Y
D
G
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
-
F
QA
S
S
P
Q
D
L
R
L
F
Y
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------