@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : YES_HUMAN: (2020-09-25 )
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
Atome Classification :
(454 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120-..-.....130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250......-.260---.--.-------.---------------.-.--..270.......280--------........290....-..---.-300---........310-.--...---.--...-320.......330.......340-.-.-......350.......360.......370.......380.......390.......400.......410.......420...---....-430--.-......440.......450.......460.......470.......480.......490.......500.......510.......520......-----.530.......540.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGCIKSKENKS
P
A
I
K
YRPENTPEPV
S
T
S
V
S
HYGAEPTTVSPCPSSSAKG
T
A
V
N
F
SS
L
S
MTPFGGSSGVTPFGGASS
S
F
S
VVPSSYPAGLTG
G
V
T
I
F
V
A
L
Y
DYEARTTEDLSFKKG
E
R
F
Q
I
I
N-NT-EGD
W
W
E
A
RSIATGKNGYIPSNYVAPADSIQAE
E
W
Y
FGKMGR
K
D
A
E
R
LLLNPGNQR
G
I
F
L
V
RESETTK
G
A
Y
S
L
SIR
D
W
D
E
IRGDNV
K
H
Y
K
I
R
K
LDNG
G
Y
Y
I
T
T
R
A
Q
F
D
T
L
Q
K
L
V
K
H
Y
T
E
H
AD
G
L
C
H
K
L
T
T
VCPTV-KPQT---Q--G-------
L
---------------
A
-
K
--
D
A
W
EI
P
R
E
S
L
R
L
E
V
---------
K
LGQGCFG
E
V
W
M
GTW-NG---
T
-
T
K
----
V
A
I
K
TLKPGT--M--M
P
E
---
A
--
F
L
Q
-
E
A
Q
I
M
K
K
LRHDKL
V
P
L
Y
A
VVS-E-E-
P
-
I
Y
I
V
T
E
F
MSK
G
S
L
L
D
F
L
K
EGDG
K
Y
L
K
L
P
Q
L
V
D
M
A
A
Q
I
A
D
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
A
A
N
I
LVGEN
L
V
C
K
I
A
D
F
G
L
A
R
L
IEDNE---YTAR-QGA--K-F
P
I
K
WTAPEA
A
L
Y
G
R
F
T
IKSD
V
W
S
FG
I
L
Q
T
ELVTKGRVPYPGMV
N
R
E
V
L
E
Q
V
E
RGYRMPCPQG
C
P
E
S
L
H
E
L
M
N
L
CWKKDPDER
P
T
F
E
Y
I
Q
S
F
L
E
D
-----
Y
F
TATEPQYQPGENL
5
PsiBlast_PDB
95.41
84%
-102
- C2 -
-
2SRC
1
SRC_HUMAN
A:
[3-452]
---------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
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S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
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D
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G
G
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S
R
T
Q
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N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
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T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
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L
Y
G
R
F
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G
I
L
L
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L
T
T
K
G
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Y
P
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G
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P
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P
P
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C
P
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S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
8
PsiBlast_PDB
94.11
83%
-97
- C2 -
-
4K11
1
SRC_HUMAN
A:
[1-448]
---------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
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N
P
R
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T
F
L
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R
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S
E
T
T
K
G
A
Y
C
L
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D
F
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N
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K
G
L
N
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K
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K
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---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
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G
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W
M
G
T
W
-
N
G
---
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-
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----
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---
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M
A
Y
V
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N
Y
V
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L
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C
K
V
A
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G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
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K
W
T
A
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A
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P
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P
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P
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L
H
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L
M
C
Q
C
W
R
K
E
P
E
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P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
--
526
HHSearch
93.99
84%
-102
- C2 -
-
2H8H
1
SRC_HUMAN
A:
[87-531]
----------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
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D
W
W
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N
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V
K
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Y
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G
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F
N
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L
Q
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Y
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K
H
A
D
G
L
C
H
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L
T
T
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C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
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W
M
G
T
W
-
N
G
---
T
-
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----
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--
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--
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---
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-
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L
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L
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A
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A
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G
M
A
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N
Y
V
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R
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L
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A
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L
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G
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N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
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A
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P
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M
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R
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G
Y
R
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P
C
P
P
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C
P
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L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
----
1
PsiBlast_PDB
93.50
82%
-102
- C2 -
-
2H8H
1
SRC_HUMAN
A:
[87-531]
----------------------------------------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
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T
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Q
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Y
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Y
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A
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C
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L
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K
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Y
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G
F
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Q
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V
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Y
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K
H
A
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L
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L
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T
V
C
P
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K
P
Q
T
---
Q
--
G
-------
L
---------------
A
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K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
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K
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L
K
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M
--
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A
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F
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Q
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A
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-
E
-
E
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P
-
I
Y
I
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T
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Y
M
S
K
G
S
L
L
D
F
L
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T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
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E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
----
7
PsiBlast_PDB
93.12
83%
-97
- C2 -
-
1KSW
1
SRC_HUMAN
A:
[3-452]
---------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
6
PsiBlast_PDB
92.31
83%
-97
- C2 -
-
6F3F
1
SRC_MOUSE
A:
[5-451]
--------------------------------------------------------------------------------------------
V
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
----
2
PsiBlast_PDB
91.87
84%
-107
- C2 -
-
1Y57
1
SRC_HUMAN
A:
[2-452]
--------------------------------------------------------------------------------------------
V
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
528
HHSearch
91.76
84%
-107
- C2 -
-
1Y57
1
SRC_HUMAN
A:
[3-452]
---------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
4
PsiBlast_PDB
85.32
84%
-102
- C2 -
-
1FMK
-
SRC_HUMAN
A:
[83-533]
--------------------------------------------------------------------------------------------
V
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
527
HHSearch
85.14
84%
-101
- C2 -
-
1FMK
-
SRC_HUMAN
A:
[84-533]
---------------------------------------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
530
HHSearch
84.99
67%
-102
- C2 -
-
5H0B
1
HCK_HUMAN
A:
[8-452]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
K
------
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
Y
E
E
----
9
PsiBlast_PDB
84.74
66%
-96
- C2 -
-
1QCF
1
HCK_HUMAN
A:
[5-451]
-----------------------------------------------------------------------------------------
S
G
I
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
Y
E
-----
24
Blastp_CBE
84.53
66%
-104
- C2 -
-
5H0B
1
HCK_HUMAN
A:
[8-449]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
-------
22
Blastp_CBE
84.48
66%
-100
- C2 -
-
5H0G
1
HCK_HUMAN
A:
[8-449]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
-------
25
Blastp_CBE
84.43
66%
-101
- C2 -
-
5H09
1
HCK_HUMAN
A:
[8-449]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
-------
21
Blastp_CBE
84.40
66%
-101
- C2 -
-
5H0H
1
HCK_HUMAN
A:
[8-449]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
-------
23
Blastp_CBE
83.70
66%
-101
- C2 -
-
5H0E
1
HCK_HUMAN
A:
[8-449]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
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F
M
A
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S
L
L
D
F
L
K
S
D
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G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
-------
3
PsiBlast_PDB
82.23
83%
-110
- C2 -
-
2PTK
-
SRC_CHICK
A:
[83-528]
--------------------------------------------------------------------------------------------
V
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
-
E
G
D
W
W
L
A
H
S
L
T
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
P
E
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P
R
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T
F
L
V
R
E
S
E
T
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K
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
S
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
N
V
C
P
T
S
-
K
P
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
--------
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
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-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
-----
35
Blastp_CBE
80.47
66%
-105
- C2 -
-
3VS4
1
HCK_HUMAN
B:
[8-449]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
-------
41
Blastp_CBE
80.29
66%
-107
- C2 -
-
3VRY
1
HCK_HUMAN
B:
[8-449]
--------------------------------------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
-
E
S
--
G
E
W
W
K
A
R
S
L
A
T
R
K
E
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D
Y
D
P
R
Q
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
-
K
P
Q
----
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-------------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
-------
529
HHSearch
79.59
66%
-104
- C2 -
-
2HCK
1
HCK_HUMAN
B:
[2-437]
--------------------------------------------------------------------------------------------
D
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
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-
E
S
--
G
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W
W
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A
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A
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K
E
G
Y
I
P
S
N
Y
V
A
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L
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E
E
W
F
F
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G
I
S
R
K
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Q
L
L
A
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N
M
L
G
S
F
M
I
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T
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Y
S
L
S
V
R
D
Y
D
P
R
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D
N
G
G
F
Y
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H
Y
K
K
G
N
D
G
L
C
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L
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P
C
M
S
S
-
K
P
Q
K
------
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
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A
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F
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W
M
A
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Y
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N
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---
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----
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A
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--
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---
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L
A
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A
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L
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L
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A
Q
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A
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M
A
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N
Y
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L
R
A
A
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L
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A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
G
A
K
-----------------
F
P
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K
W
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A
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A
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N
F
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F
T
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I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
S
Q
Y
Q
Q
Q
---
232
Blastp_CBE
68.15
44%
4
- C2 -
-
2FO0
4
ABL1_HUMAN
A:
[41-474]
---------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
---
Y
--
G
-------
V
---------------
S
-
P
NY
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
182
Blastp_CBE
67.89
90%
-129
- C2 -
-
3U4W
4
SRC_CHICK
A:
[1-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
534
HHSearch
67.51
44%
7
- C2 -
-
2FO0
4
ABL1_HUMAN
A:
[37-477]
-----------------------------------------------------------------------------------------
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
-
N
K
P
T
V--
Y
GV
S
-------
P
---------------
N
-
Y
--
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
Q
E
S
----------
536
HHSearch
67.35
44%
-11
- C2 -
-
1OPK
3
ABL1_MOUSE
A:
[44-479]
---------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
-
H
N
G
E
W
C
E
A
Q
T
-
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
-
N
K
P
T
IYG
V
--
S
-------
P
---------------
N
-
Y
--
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
Q
E
-----------
164
Blastp_CBE
67.27
90%
-135
- C2 -
-
3DQW
1
SRC_CHICK
A:
[8-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
163
Blastp_CBE
67.10
90%
-131
- C2 -
-
3DQW
1
SRC_CHICK
B:
[8-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
161
Blastp_CBE
67.02
90%
-128
- C2 -
-
3DQW
1
SRC_CHICK
D:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
231
Blastp_CBE
66.95
44%
5
- C2 -
-
1OPK
3
ABL1_MOUSE
A:
[44-477]
---------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
I
---
Y
--
G
-------
V
---------------
S
-
P
NY
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
162
Blastp_CBE
66.53
90%
-127
- C2 -
-
3DQW
1
SRC_CHICK
C:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
234
Blastp_CBE
66.34
44%
6
- C2 -
-
1OPL
2
ABL1_HUMAN
A:
[83-516]
---------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
---
Y
--
G
-------
V
---------------
S
-
P
NY
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
95
Blastp_CBE
64.05
90%
-131
- C2 -
-
4MXO
1
SRC_HUMAN
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
185
Blastp_CBE
63.96
87%
-129
- C2 -
-
2DQ7
1
FYN_HUMAN
X:
[1-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
V
W
E
I
P
R
E
S
L
Q
L
I
K
---------
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
-
N
G
---
N
-
T
K
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
S
--
F
L
E
-
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
G
E
G
R
A
L
K
L
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
D
-----
Y
--------------
141
Blastp_CBE
63.92
90%
-137
- C2 -
-
6HVE
1
?
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
112
Blastp_CBE
63.74
90%
-132
- C2 -
-
4MXX
1
SRC_HUMAN
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
94
Blastp_CBE
63.63
90%
-130
- C2 -
-
4MXO
1
SRC_HUMAN
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
187
Blastp_CBE
63.61
71%
-125
- C2 -
-
5ZJ6
1
HCK_HUMAN
A:
[14-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
----------
121
Blastp_CBE
63.61
90%
-123
- C2 -
-
3GEQ
1
SRC_CHICK
B:
[4-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
78
Blastp_CBE
63.60
90%
-129
- C2 -
-
3F6X
1
SRC_CHICK
B:
[8-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
122
Blastp_CBE
63.56
90%
-121
- C2 -
-
3GEQ
1
SRC_CHICK
A:
[4-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
---
Q
--
G
-------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
84
Blastp_CBE
63.56
90%
-129
- C2 -
-
3EN4
1
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
88
Blastp_CBE
63.55
90%
-127
- C2 -
-
3DQX
1
SRC_CHICK
B:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
Q
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
166
Blastp_CBE
63.54
90%
-127
- C2 -
-
2BDF
1
SRC_HUMAN
B:
[1-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-------------
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
-----
186
Blastp_CBE
63.53
71%
-128
- C2 -
-
5ZJ6
1
HCK_HUMAN
B:
[15-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
---------------
E
-
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
Y
T
A
T
----------
150
Blastp_CBE
63.48
89%
-133
- C2 -
-
4MXY
1
SRC_HUMAN
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
148
Blastp_CBE
63.48
89%
-133
- C2 -
-
4MXZ
1
SRC_HUMAN
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
76
Blastp_CBE
63.38
90%
-124
- C2 -
-
3F6X
1
SRC_CHICK
D:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
120
Blastp_CBE
63.33
90%
-128
- C2 -
-
3SVV
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
167
Blastp_CBE
63.31
90%
-131
- C2 -
-
2BDF
1
SRC_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
-----
92
Blastp_CBE
63.19
90%
-124
- C2 -
-
2OIQ
3
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
215
Blastp_CBE
63.14
69%
-133
- C2 -
-
1QPC
2
?
A:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
90
Blastp_CBE
63.11
90%
-128
- C2 -
-
3D7T
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
73
Blastp_CBE
63.04
90%
-131
- C2 -
-
3UQF
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
204
Blastp_CBE
63.02
68%
-135
- C2 -
-
3AC3
1
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
230
Blastp_CBE
62.99
69%
-136
- C2 -
-
2OFU
1
LCK_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
169
Blastp_CBE
62.99
90%
-123
- C2 -
-
4MCV
1
SRC_CHICK
A:
[1-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
214
Blastp_CBE
62.97
69%
-134
- C2 -
-
1QPE
1
LCK_HUMAN
A:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
89
Blastp_CBE
62.94
90%
-131
- C2 -
-
3DQX
1
SRC_CHICK
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
195
Blastp_CBE
62.89
68%
-134
- C2 -
-
6PDJ
2
?
A:
[1-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
K
P
Q
----
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
-----------
82
Blastp_CBE
62.87
90%
-133
- C2 -
-
3EN5
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
109
Blastp_CBE
62.78
90%
-125
- C2 -
-
5SWH
1
SRC_CHICK
B:
[8-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
206
Blastp_CBE
62.76
68%
-135
- C2 -
-
3AC1
3
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
151
Blastp_CBE
62.74
89%
-131
- C2 -
-
4MXY
1
SRC_HUMAN
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
149
Blastp_CBE
62.74
89%
-131
- C2 -
-
4MXZ
1
SRC_HUMAN
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
75
Blastp_CBE
62.74
90%
-124
- C2 -
-
3G6G
3
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
224
Blastp_CBE
62.68
68%
-134
- C2 -
-
1QPD
1
?
A:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
A
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
A
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
A
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
202
Blastp_CBE
62.67
68%
-132
- C2 -
-
3AC5
2
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
123
Blastp_CBE
62.68
90%
-138
- C2 -
-
3G5D
2
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
---
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
-----
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
79
Blastp_CBE
62.67
90%
-133
- C2 -
-
3F6X
1
SRC_CHICK
A:
[8-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
---------
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
228
Blastp_CBE
62.66
69%
-133
- C2 -
-
3BYO
1
?
A:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
229
Blastp_CBE
62.65
69%
-130
- C2 -
-
3BYM
1
LCK_HUMAN
A:
[6-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
200
Blastp_CBE
62.64
68%
-135
- C2 -
-
3ACJ
2
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
219
Blastp_CBE
62.63
69%
-134
- C2 -
-
2OF4
1
LCK_HUMAN
A:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
213
Blastp_CBE
62.62
69%
-136
- C2 -
-
1QPJ
1
LCK_HUMAN
A:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
209
Blastp_CBE
62.61
68%
-133
- C2 -
-
2ZM1
2
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
205
Blastp_CBE
62.59
68%
-132
- C2 -
-
3AC2
3
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
198
Blastp_CBE
62.59
68%
-136
- C2 -
-
3AD4
3
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
220
Blastp_CBE
62.55
69%
-133
- C2 -
-
2OF2
1
LCK_HUMAN
A:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
208
Blastp_CBE
62.54
68%
-128
- C2 -
-
2ZM4
2
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
168
Blastp_CBE
62.54
90%
-127
- C2 -
-
4MCV
1
SRC_CHICK
B:
[2-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
-
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
189
Blastp_CBE
62.55
72%
-136
- C2 -
-
2HK5
1
HCK_HUMAN
A:
[7-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
K
L
E
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
-
N
K
---
H
-
T
K
----
V
A
V
K
T
M
K
P
G
S
--
M
--
S
V
E
---
A
--
F
L
A
-
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
-----
F
--------------
74
Blastp_CBE
62.54
90%
-128
- C2 -
-
3G6G
2
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
199
Blastp_CBE
62.42
68%
-130
- C2 -
-
3ACK
2
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
96
Blastp_CBE
62.42
90%
-132
- C2 -
-
3QLG
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
-----
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
154
Blastp_CBE
62.37
90%
-131
- C2 -
-
3F3W
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
101
Blastp_CBE
62.31
90%
-125
- C2 -
-
3OEZ
2
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
197
Blastp_CBE
62.29
68%
-130
- C2 -
-
3AD5
3
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
221
Blastp_CBE
62.26
68%
-131
- C2 -
-
3KMM
1
LCK_HUMAN
A:
[14-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
71
Blastp_CBE
62.28
90%
-126
- C2 -
-
3UQG
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
119
Blastp_CBE
62.26
90%
-133
- C2 -
-
3SVV
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
---
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
-
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
201
Blastp_CBE
62.24
68%
-129
- C2 -
-
3AC8
1
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
110
Blastp_CBE
62.23
90%
-128
- C2 -
-
5SWH
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
115
Blastp_CBE
62.21
90%
-125
- C2 -
-
3TZ8
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
---------------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
85
Blastp_CBE
62.18
90%
-128
- C2 -
-
3EN4
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
----
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
143
Blastp_CBE
62.13
90%
-139
- C2 -
-
5D12
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
---------
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
116
Blastp_CBE
62.13
90%
-130
- C2 -
-
3TZ8
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
111
Blastp_CBE
62.13
90%
-127
- C2 -
-
4MXX
1
SRC_HUMAN
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
97
Blastp_CBE
62.11
90%
-126
- C2 -
-
3QLG
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
196
Blastp_CBE
62.10
68%
-125
- C2 -
-
3AD6
2
LCK_HUMAN
A:
[6-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
E
---------
68
Blastp_CBE
62.09
90%
-125
- C2 -
-
4AGW
3
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
203
Blastp_CBE
62.04
68%
-123
- C2 -
-
3AC4
2
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
100
Blastp_CBE
62.05
90%
-125
- C2 -
-
3OEZ
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
155
Blastp_CBE
62.04
90%
-131
- C2 -
-
3F3W
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
124
Blastp_CBE
61.94
90%
-138
- C2 -
-
3G5D
2
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
---
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
---------
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
118
Blastp_CBE
61.91
90%
-126
- C2 -
-
3TZ7
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
103
Blastp_CBE
61.91
90%
-129
- C2 -
-
5T0P
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
69
Blastp_CBE
61.89
90%
-125
- C2 -
-
4AGW
3
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
207
Blastp_CBE
61.87
68%
-131
- C2 -
-
2ZYB
1
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
144
Blastp_CBE
61.85
90%
-140
- C2 -
-
5D11
2
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
------------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
117
Blastp_CBE
61.84
90%
-132
- C2 -
-
3TZ7
1
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
114
Blastp_CBE
61.75
90%
-133
- C2 -
-
3TZ9
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
159
Blastp_CBE
61.70
89%
-127
- C2 -
-
1YOM
1
SRC_HUMAN
B:
[5-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
235
Blastp_CBE
61.66
44%
5
- C2 -
-
5MO4
2
ABL1_HUMAN
A:
[44-477]
---------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
-
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
N
K
P
T
V
---
Y
--
G
-------
V
---------------
S
-
P
NY
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
126
Blastp_CBE
61.64
90%
-125
- C2 -
-
3F3V
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
188
Blastp_CBE
61.63
68%
-124
- C2 -
-
2PL0
1
LCK_HUMAN
A:
[11-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
-------------
128
Blastp_CBE
61.62
90%
-122
- C2 -
-
3F3U
2
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
77
Blastp_CBE
61.62
90%
-121
- C2 -
-
3F6X
1
SRC_CHICK
C:
[8-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
--------
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
98
Blastp_CBE
61.59
90%
-128
- C2 -
-
3QLF
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
----
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
--------------------
A
--
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
129
Blastp_CBE
61.58
90%
-130
- C2 -
-
3F3T
2
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
165
Blastp_CBE
61.53
90%
-130
- C2 -
-
2BDJ
1
SRC_HUMAN
A:
[3-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
------------
104
Blastp_CBE
61.51
90%
-122
- C2 -
-
3G6H
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
137
Blastp_CBE
61.42
89%
-123
- C2 -
-
1YOL
1
SRC_HUMAN
A:
[6-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
136
Blastp_CBE
61.42
89%
-124
- C2 -
-
1YOL
2
SRC_HUMAN
B:
[9-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
533
HHSearch
61.39
44%
9
- C2 -
-
5MO4
2
ABL1_HUMAN
A:
[44-480]
---------------------------------------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
-
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
R
-
N
K
P
T
VYG
V
--
S
-------
P
---------------
N
-
Y
--
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
Q
E
S
----------
180
Blastp_CBE
61.33
90%
-125
- C2 -
-
3U51
1
SRC_CHICK
B:
[3-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
70
Blastp_CBE
61.33
90%
-129
- C2 -
-
3UQG
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
----
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
--------
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
102
Blastp_CBE
61.29
90%
-126
- C2 -
-
5T0P
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
181
Blastp_CBE
61.28
90%
-125
- C2 -
-
3U51
2
SRC_CHICK
A:
[3-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
145
Blastp_CBE
61.22
90%
-138
- C2 -
-
5D11
2
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
107
Blastp_CBE
61.19
90%
-125
- C2 -
-
5SYS
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
86
Blastp_CBE
61.19
90%
-125
- C2 -
-
3EL8
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
125
Blastp_CBE
61.18
90%
-128
- C2 -
-
3F3V
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
194
Blastp_CBE
61.10
68%
-128
- C2 -
-
3KXZ
1
LCK_HUMAN
A:
[16-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
72
Blastp_CBE
61.09
90%
-129
- C2 -
-
3UQF
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
-----------
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
233
Blastp_CBE
61.04
44%
-27
- C2 -
-
1OPL
1
ABL1_HUMAN
B:
[140-516]
---------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
106
Blastp_CBE
61.04
90%
-126
- C2 -
-
5TEH
1
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
135
Blastp_CBE
61.00
90%
-141
- C2 -
-
2HWO
2
SRC_CHICK
A:
[8-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
----------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-----
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
108
Blastp_CBE
60.93
90%
-126
- C2 -
-
5SYS
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
157
Blastp_CBE
60.87
90%
-136
- C2 -
-
2QQ7
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
--------------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
93
Blastp_CBE
60.74
90%
-127
- C2 -
-
6ATE
1
SRC_HUMAN
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
----------
P
E
---
A
--
F
---
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
113
Blastp_CBE
60.54
90%
-123
- C2 -
-
3TZ9
1
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
131
Blastp_CBE
60.53
90%
-144
- C2 -
-
2QLQ
2
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
-----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
160
Blastp_CBE
60.52
89%
-119
- C2 -
-
1YOM
1
SRC_HUMAN
A:
[5-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
127
Blastp_CBE
60.51
90%
-123
- C2 -
-
3F3U
1
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
------
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
147
Blastp_CBE
60.40
90%
-130
- C2 -
-
5D10
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
----
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
-------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
133
Blastp_CBE
60.39
90%
-142
- C2 -
-
2HWP
1
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
--
V
---------
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
-------------------
F
L
Q
--
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
87
Blastp_CBE
60.37
90%
-123
- C2 -
-
3EL7
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
-
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-----
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
153
Blastp_CBE
60.34
90%
-139
- C2 -
-
3LOK
1
SRC_CHICK
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
---
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
----------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
146
Blastp_CBE
60.18
90%
-141
- C2 -
-
5D10
1
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
-----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
139
Blastp_CBE
60.18
90%
-135
- C2 -
-
6HVF
3
?
A:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
-------------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
130
Blastp_CBE
60.07
90%
-132
- C2 -
-
2QLQ
1
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
105
Blastp_CBE
59.98
90%
-122
- C2 -
-
5TEH
1
SRC_CHICK
B:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
156
Blastp_CBE
59.91
90%
-138
- C2 -
-
2QQ7
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
191
Blastp_CBE
59.67
68%
-138
- C2 -
-
3B2W
1
LCK_HUMAN
A:
[13-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
---
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
-----------
179
Blastp_CBE
59.66
90%
-132
- C2 -
-
4LGH
1
SRC_CHICK
A:
[1-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
-----
T
R
----
V
A
I
K
T
L
----------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
152
Blastp_CBE
59.61
90%
-137
- C2 -
-
3LOK
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
-------------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
99
Blastp_CBE
59.56
90%
-132
- C2 -
-
3QLF
1
SRC_CHICK
A:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
------------------
L
Q
-
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
184
Blastp_CBE
59.54
90%
-129
- C2 -
-
4LGG
1
SRC_CHICK
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
----------------
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
---
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
140
Blastp_CBE
59.30
90%
-138
- C2 -
-
6HVE
1
?
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
---------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
80
Blastp_CBE
59.27
90%
-135
- C2 -
-
3EN7
1
SRC_CHICK
A:
[9-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
---
G
E
V
W
M
G
T
W
-
N
------
T
R
----
V
A
I
K
T
L
K
P
----------------
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
134
Blastp_CBE
59.20
90%
-129
- C2 -
-
2HWO
2
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
138
Blastp_CBE
59.19
90%
-127
- C2 -
-
6HVF
2
?
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
-------------------
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
178
Blastp_CBE
59.10
90%
-123
- C2 -
-
4LGH
1
SRC_CHICK
B:
[3-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
--------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
183
Blastp_CBE
59.01
90%
-125
- C2 -
-
4LGG
1
SRC_CHICK
B:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
R
L
E
V
---------
K
L
G
----
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
K
P
G
T
--
M
--
S
P
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
132
Blastp_CBE
58.99
90%
-139
- C2 -
-
2HWP
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
---
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
---------------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
83
Blastp_CBE
58.78
90%
-135
- C2 -
-
3EN5
1
SRC_CHICK
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
------------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
----------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
81
Blastp_CBE
58.68
90%
-142
- C2 -
-
3EN6
1
SRC_CHICK
B:
[10-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
-----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
217
Blastp_CBE
58.01
68%
-134
- C2 -
-
3BYU
1
LCK_HUMAN
A:
[7-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
---------------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
142
Blastp_CBE
58.01
90%
-125
- C2 -
-
5D12
1
SRC_CHICK
B:
[11-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
R
L
E
V
---------
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
-
N
G
---
T
-
T
R
----
V
A
I
K
T
L
-----------
E
---
A
--
F
L
Q
-
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-
E
-
P
-
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
-----
Y
F
T
S
T
E
P
Q
Y
Q
P
G
E
N
L
226
Blastp_CBE
57.87
69%
-127
- C2 -
-
3MPM
2
LCK_HUMAN
A:
[4-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
--------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
-------------
225
Blastp_CBE
57.67
69%
-129
- C2 -
-
4C3F
1
LCK_HUMAN
A:
[4-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
E
---
Y
T
A
R
--------
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
-------------
223
Blastp_CBE
57.62
69%
-141
- C2 -
-
2OG8
1
LCK_HUMAN
A:
[2-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
------------
537
HHSearch
57.57
46%
-32
- C2 -
-
4XEY
1
ABL1_HUMAN
B:
[7-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
-----
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
--------------------------------------
Y
--
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
------
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-
P
-
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
Q
E
S
S
---------
238
Blastp_CBE
57.32
45%
-40
- C2 -
-
4XEY
1
ABL1_HUMAN
B:
[7-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
---------------------------------------Y-
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
------
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
218
Blastp_CBE
57.21
68%
-134
- C2 -
-
3BYS
1
LCK_HUMAN
A:
[6-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
----
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
T
----------
222
Blastp_CBE
56.66
69%
-134
- C2 -
-
2OG8
1
?
B:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
S
--
M
--
S
P
D
---
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-----------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
A
-----------
539
HHSearch
56.58
39%
-31
- C2 -
-
6JMF
1
A:
[6-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
W
D
-----
G
L
P
R
H
F
I
I
Q
S
L
-
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
----------
R
--
A
-------
V
---------------
P
-
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
E
T
L
PP
D
--
L
K
A
---
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
---
Y
A
A
S
G
G
L
R
--
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
-----
I
R
K
------------
423
Blastp_CBE
56.33
39%
-38
- C2 -
-
6JMF
1
A:
[8-368]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
----
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
-
W
D
G
L
----
P
R
H
F
I
I
Q
S
L
D
N
--
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
-
V
P
----------------------------------
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
E
-
T
--
L
--
P
P
D
LKA
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
---
Y
A
A
S
-
G
G
L
--
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
---------------------
538
HHSearch
56.15
39%
-32
- C2 -
-
3BKB
9
A:
[8-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
W
D
-----
G
L
P
R
H
F
I
I
Q
S
L
-
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
----------
R
--
A
-------
V
---------------
P
-
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
E
T
L
PP
D
--
L
K
A
---
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
---
Y
A
A
S
G
G
L
R
--
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
-----
I
R
K
------------
430
Blastp_CBE
55.48
39%
-33
* C2 *
-
3BKB
9
A:
[10-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
----
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
-
W
D
G
L
P
----
R
H
F
I
I
Q
S
L
D
N
--
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
-
V
P
----------------------------------
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
E
-
T
--
L
--
P
P
D
LKA
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
---
Y
A
A
S
-
G
G
L
--
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
---------------------
193
Blastp_CBE
55.41
68%
-134
- C2 -
-
2OFV
1
LCK_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
----------------
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
------------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
-------------
192
Blastp_CBE
55.10
68%
-130
- C2 -
-
2OFV
1
?
B:
[7-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-------
W
---------------
W
-
E
--
D
E
W
E
V
P
R
E
T
L
K
L
V
E
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
G
---
H
-
T
K
----
V
A
V
K
S
L
K
Q
G
------------
A
--
F
L
A
-
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
-
Q
-
E
-
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
-------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
-----
F
F
T
------------
540
HHSearch
55.03
34%
-35
- C2 -
-
4K2R
1
ZAP70_HUMAN
A:
[156-606]
--------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
K
-
E
Q
G
T
Y
A
L
S
L
I
Y
G
-----
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
S
------------DKPRPMP
M
DTSVYESPYSDPEEL
K
D
K
--
K
L
F
L
K
R
D
N
L
L
I
A
D
I
---------
E
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
-
R
M
RKK
Q
-
I
D
----
V
A
I
K
V
L
K
Q
G
T
--
E
KA
D
T
E
---
E
--
M
M
R
-
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
Q
-
A
-
E
-
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
K
-
R
E
E
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
----------------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
-----
C
Y
Y
S
L
A
S
K
V
E
G
----
364
Blastp_CBE
54.52
41%
-137
- C2 -
-
6NZM
1
BTK_HUMAN
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
541
HHSearch
53.71
39%
-34
- C2 -
-
3CBL
3
A:
[8-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
----
H
S
G
D
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
----------
P
R
H
F
I
I
-----
N
L
Y
R
L
-----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
V
L
-------
H
---
R
--
A
-------
V
---------------
P
-
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
E
T
L
PP
D
--
L
K
A
---
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
---
Y
A
A
S
G
G
L
R
--
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
-----
I
R
K
------------
429
Blastp_CBE
53.34
39%
-43
- C2 -
-
3CBL
3
A:
[10-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
----
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
------
P
----
R
H
F
I
I
----
N
--
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
V
L
H
R
A
-
V
P
----------------------------------
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
E
-
T
--
L
--
P
P
D
LKA
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
---
Y
A
A
S
-
G
G
L
--
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
---------------------
428
Blastp_CBE
53.22
39%
-37
- C2 -
-
4E93
1
A:
[10-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
----
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
L
-
W
D
G
L
P
----
R
H
F
I
I
Q
S
L
D
N
--
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
L
H
R
A
-
V
P
----------------------------------
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
E
-
T
--
L
--
P
P
D
LKA
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
--------------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
---------------------
424
Blastp_CBE
51.62
41%
-151
- C2 -
-
6NFI
1
A:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
----
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
---
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
----------------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
496
Blastp_CBE
51.58
41%
-153
- C2 -
-
5BPY
1
B:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
-
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
210
Blastp_CBE
50.62
67%
-41
- C2 -
-
2ZVA
1
LYN_MOUSE
A:
[5-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
W
E
I
P
R
E
S
I
K
L
V
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
N
---
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
--
M
--
S
V
Q
---
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
-------
T
A
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
-----
F
Y
T
------------
546
Fugue
50.52
38%
-40
- C2 -
-
3CD3
3
A:
[1-376]
-------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
----
D
F
L
V
R
E
S
Q
E
----
Y
V
L
S
V
P
R
-----
H
F
I
I
N
L
Y
R
L
---------------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
--------------------------------------
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
---
D
N
T
L
----
V
A
V
K
S
C
R
P
D
L
--
K
--
A
K
-------
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
---
A
A
S
G
-
G
L
R
--
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
-----
I
R
K
R
H
----------
212
Blastp_CBE
50.52
67%
-44
- C2 -
-
2ZV8
1
LYN_MOUSE
A:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
W
E
I
P
R
E
S
I
K
L
V
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
N
---
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
--
M
--
S
V
Q
---
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
----------
R
-
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
-----
F
Y
-------------
494
Blastp_CBE
50.51
41%
-151
- C2 -
-
5JRS
1
B:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
--
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
211
Blastp_CBE
49.96
67%
-44
- C2 -
-
2ZV9
1
LYN_MOUSE
A:
[5-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
W
E
I
P
R
E
S
I
K
L
V
K
---------
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
N
---
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
--
M
--
S
V
Q
---
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
------------
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
-----
F
Y
-------------
216
Blastp_CBE
49.79
67%
-42
- C2 -
-
5XY1
1
LYN_HUMAN
A:
[5-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
W
E
I
P
R
E
S
I
K
L
V
K
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
N
---
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
--
M
--
S
V
Q
---
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
-
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
------------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
-----
F
Y
T
------------
400
Blastp_CBE
49.57
41%
-152
- C2 -
-
3PJ1
2
A:
[6-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
---
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
---------
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
---
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
--
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
190
Blastp_CBE
49.45
68%
-46
- C2 -
-
3A4O
1
LYN_HUMAN
X:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
I
K
L
V
K
---------
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
-
N
N
---
S
-
T
K
----
V
A
V
K
T
L
K
P
G
T
--
M
--
S
V
Q
---
A
--
F
L
E
-
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-
E
-
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
-------------
E
G
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
-----
F
Y
T
A
T
E
---------
303
Blastp_CBE
48.45
50%
-9
- C2 -
-
1M52
1
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
337
Blastp_CBE
48.41
49%
-11
- C2 -
-
3IK3
1
ABL1_MOUSE
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
271
Blastp_CBE
48.41
50%
3
- C2 -
-
2G1T
1
ABL1_HUMAN
B:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
304
Blastp_CBE
48.01
50%
-6
- C2 -
-
1IEP
1
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
272
Blastp_CBE
47.99
50%
1
- C2 -
-
2G1T
1
ABL1_HUMAN
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
330
Blastp_CBE
47.96
50%
-7
- C2 -
-
2G2H
1
ABL1_HUMAN
B:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
P
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
335
Blastp_CBE
47.89
49%
-10
- C2 -
-
4TWP
1
ABL1_HUMAN
B:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
420
Blastp_CBE
47.88
41%
-51
- C2 -
-
4ZLY
5
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
396
Blastp_CBE
47.86
41%
-49
- C2 -
-
4Y93
1
?
A:
[173-441]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
---
A
--
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
E
---
Y
T
S
S
-
T
G
S
--
K
-
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
253
Blastp_CBE
47.85
50%
-10
- C2 -
-
4WA9
1
ABL1_HUMAN
B:
[7-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
331
Blastp_CBE
47.84
50%
-3
- C2 -
-
2G2H
1
ABL1_HUMAN
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
P
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
425
Blastp_CBE
47.77
41%
-54
- C2 -
-
6J6M
2
?
A:
[4-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
414
Blastp_CBE
47.80
41%
-54
- C2 -
-
5VFI
9
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
308
Blastp_CBE
47.78
50%
-42
- C2 -
-
3CS9
1
ABL1_HUMAN
D:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
---------
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
408
Blastp_CBE
47.77
41%
-51
- C2 -
-
6N9P
1
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
302
Blastp_CBE
47.70
50%
-9
- C2 -
-
1M52
3
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
394
Blastp_CBE
47.66
40%
-55
- C2 -
-
4OT6
1
A:
[18-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
305
Blastp_CBE
47.61
50%
-5
- C2 -
-
1IEP
1
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
433
Blastp_CBE
47.59
41%
-58
- C2 -
-
6S90
1
BTK_HUMAN
A:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
367
Blastp_CBE
47.53
41%
-50
- C2 -
-
5P9M
2
A:
[9-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
264
Blastp_CBE
47.54
50%
-12
- C2 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
286
Blastp_CBE
47.53
50%
-9
- C2 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
377
Blastp_CBE
47.51
41%
-46
- C2 -
-
5J87
1
BTK_HUMAN
B:
[1-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
---
A
--
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
313
Blastp_CBE
47.47
50%
-6
- C2 -
-
2HZI
1
ABL1_HUMAN
A:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
268
Blastp_CBE
47.46
50%
-7
- C2 -
-
3UE4
1
ABL1_HUMAN
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
369
Blastp_CBE
47.44
41%
-45
- C2 -
-
5P9K
1
A:
[9-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
270
Blastp_CBE
47.42
50%
3
- C2 -
-
2G1T
1
ABL1_HUMAN
C:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
492
Blastp_CBE
47.39
38%
-36
- C2 -
-
3CD3
3
A:
[10-370]
----------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
----
F
L
V
R
E
S
----
Q
E
Y
V
L
S
V
------
P
----
R
H
F
I
I
----
N
--
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
---
S
G
V
V
L
H
R
A
-
V
P
----------------------------------
K
--
D
K
W
V
L
N
H
E
D
L
V
L
G
E
---------
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
-
R
A
D--
N
-
T
L
----
V
A
V
K
S
C
R
---------
P
D
LKA
K
--
F
L
Q
-
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
-
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
--
E
E
A
D
---
G
V
A
A
-
S
G
G
LR
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
---------------------
269
Blastp_CBE
47.38
50%
6
- C2 -
-
2G1T
1
ABL1_HUMAN
D:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
469
Blastp_CBE
47.29
40%
-52
- C2 -
-
6AUA
2
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
-----
V
M
D
A
N
----------
334
Blastp_CBE
47.32
50%
-8
- C2 -
-
2F4J
1
ABL1_HUMAN
A:
[7-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
P
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
497
Blastp_CBE
47.30
41%
-53
- C2 -
-
5BPY
1
BTK_HUMAN
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
381
Blastp_CBE
47.29
41%
-48
- C2 -
-
4Z3V
5
A:
[13-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
406
Blastp_CBE
47.26
41%
-50
- C2 -
-
6OMU
1
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
342
Blastp_CBE
47.24
49%
-9
- C2 -
-
3OY3
1
ABL1_MOUSE
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
413
Blastp_CBE
47.18
41%
-48
- C2 -
-
6DI0
1
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
281
Blastp_CBE
47.21
50%
-4
- C2 -
-
3QRI
1
ABL1_HUMAN
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
340
Blastp_CBE
47.20
49%
-4
- C2 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
412
Blastp_CBE
47.19
41%
-52
- C2 -
-
6DI1
1
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
300
Blastp_CBE
47.18
50%
-6
- C2 -
-
1OPJ
2
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
415
Blastp_CBE
47.17
41%
-45
- C2 -
-
5U9D
6
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
371
Blastp_CBE
47.10
41%
-48
- C2 -
-
5P9I
3
A:
[9-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
273
Blastp_CBE
47.11
50%
-5
- C2 -
-
3KFA
1
ABL1_MOUSE
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
343
Blastp_CBE
47.10
49%
-5
- C2 -
-
3OY3
1
ABL1_MOUSE
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
346
Blastp_CBE
47.06
50%
-4
- C2 -
-
3HMI
1
ABL2_HUMAN
A:
[25-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
-
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
-----
M
F
-------------
372
Blastp_CBE
47.05
41%
-53
- C2 -
-
5P9H
1
A:
[15-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
373
Blastp_CBE
46.99
41%
-52
- C2 -
-
5P9G
1
A:
[14-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
365
Blastp_CBE
46.95
41%
-48
- C2 -
-
4YHF
2
B:
[9-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
404
Blastp_CBE
46.97
41%
-44
- C2 -
-
6E4F
5
A:
[20-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
301
Blastp_CBE
46.95
50%
-2
- C2 -
-
1OPJ
2
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
461
Blastp_CBE
46.94
43%
-62
- C2 -
-
4HCV
1
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
274
Blastp_CBE
46.93
50%
-2
- C2 -
-
3KFA
1
ABL1_MOUSE
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
374
Blastp_CBE
46.92
41%
-54
- C2 -
-
5P9F
6
A:
[14-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
432
Blastp_CBE
46.88
41%
-51
- C2 -
-
6S90
1
B:
[3-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
419
Blastp_CBE
46.87
41%
-48
- C2 -
-
4ZLZ
5
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
386
Blastp_CBE
46.85
40%
-55
- C2 -
-
6HRT
1
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
463
Blastp_CBE
46.84
43%
-66
- C2 -
-
4HCT
1
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
388
Blastp_CBE
46.80
40%
-53
- C2 -
-
6EP9
1
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
410
Blastp_CBE
46.82
41%
-46
- C2 -
-
6DI5
2
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
407
Blastp_CBE
46.81
41%
-47
- C2 -
-
6NFH
7
A:
[1-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
379
Blastp_CBE
46.80
41%
-52
- C2 -
-
5BQ0
4
A:
[13-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
L
---------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
---------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
436
Blastp_CBE
46.78
41%
-52
- C2 -
-
5VGO
5
A:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
307
Blastp_CBE
46.77
50%
1
- C2 -
-
1FPU
1
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
421
Blastp_CBE
46.74
44%
-64
- C2 -
-
3T9T
3
A:
[3-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
393
Blastp_CBE
46.70
40%
-52
- C2 -
-
4OTQ
3
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
380
Blastp_CBE
46.64
41%
-52
- C2 -
-
3GEN
1
A:
[16-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
---
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
499
Blastp_CBE
46.62
40%
-50
- C2 -
-
6BKW
4
A:
[3-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
VMDEN---------------
457
Blastp_CBE
46.57
43%
-60
- C2 -
-
4M13
1
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
333
Blastp_CBE
46.61
50%
0
- C2 -
-
2G2F
1
ABL1_HUMAN
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
P
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
387
Blastp_CBE
46.57
40%
-53
- C2 -
-
6HRP
1
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
360
Blastp_CBE
46.60
44%
-48
- C2 -
-
3SXS
1
A:
[4-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
---------
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
-
K
G
---
Q
-
Y
D
----
V
A
V
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
-
K
-
E
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
---
Y
V
S
S
-
V
G
T
--
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
---------------------
498
Blastp_CBE
46.58
40%
-51
- C2 -
-
6BLN
2
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
VMDEN---------------
363
Blastp_CBE
46.57
41%
-48
- C2 -
-
6NZM
2
D:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
493
Blastp_CBE
46.48
41%
-56
- C2 -
-
5T18
1
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
279
Blastp_CBE
46.49
50%
-2
- C2 -
-
3QRK
1
ABL1_HUMAN
A:
[11-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
--------------
462
Blastp_CBE
46.48
43%
-66
- C2 -
-
4HCU
1
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
392
Blastp_CBE
46.47
40%
-55
- C2 -
-
4OTR
3
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
501
Blastp_CBE
46.44
40%
-52
- C2 -
-
6BKE
1
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
VMDEN---------------
411
Blastp_CBE
46.38
41%
-59
- C2 -
-
6DI3
1
A:
[5-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-------------
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
284
Blastp_CBE
46.41
50%
1
- C2 -
-
2HIW
1
ABL1_HUMAN
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
438
Blastp_CBE
46.40
41%
-51
- C2 -
-
4RX5
4
A:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
252
Blastp_CBE
46.38
52%
-15
- C2 -
-
6CZ3
1
PTK6_HUMAN
A:
[3-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
A
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
----------------------
366
Blastp_CBE
46.37
41%
-46
- C2 -
-
4YHF
3
BTK_HUMAN
A:
[10-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
395
Blastp_CBE
46.34
40%
-52
- C2 -
-
4OT5
3
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
391
Blastp_CBE
46.31
40%
-51
- C2 -
-
4RFY
3
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
325
Blastp_CBE
46.30
49%
2
- C2 -
-
6BL8
1
ABL1_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
F
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
390
Blastp_CBE
46.26
40%
-50
- C2 -
-
4RFZ
3
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
460
Blastp_CBE
46.22
43%
-64
- C2 -
-
4M0Y
2
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
495
Blastp_CBE
46.21
41%
-53
- C2 -
-
5JRS
2
BTK_HUMAN
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
370
Blastp_CBE
46.20
41%
-55
- C2 -
-
5P9J
1
A:
[14-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
----
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
376
Blastp_CBE
46.19
41%
-44
- C2 -
-
5J87
1
BTK_HUMAN
C:
[12-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
378
Blastp_CBE
46.18
41%
-47
- C2 -
-
5J87
1
BTK_HUMAN
A:
[12-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
446
Blastp_CBE
46.09
41%
-52
- C2 -
-
6AUB
1
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
445
Blastp_CBE
46.13
41%
-52
- C2 -
-
3OCS
2
A:
[4-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
246
Blastp_CBE
46.11
52%
-10
- C2 -
-
5D7V
3
PTK6_HUMAN
D:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
437
Blastp_CBE
46.09
41%
-50
- C2 -
-
5KUP
4
A:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
458
Blastp_CBE
46.04
43%
-58
- C2 -
-
4M12
1
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
502
Blastp_CBE
45.95
40%
-51
- C2 -
-
6BIK
2
A:
[4-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
VMDEN---------------
456
Blastp_CBE
45.99
43%
-56
- C2 -
-
4M14
2
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
455
Blastp_CBE
45.95
43%
-58
- C2 -
-
4M15
2
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
389
Blastp_CBE
45.86
40%
-52
- C2 -
-
4RG0
1
A:
[20-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
243
Blastp_CBE
45.86
52%
-14
- C2 -
-
5H2U
4
PTK6_HUMAN
B:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
459
Blastp_CBE
45.77
43%
-57
- C2 -
-
4M0Z
2
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
I
D
P
S
E
L
T
F
V
Q
---------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-----------------------------
500
Blastp_CBE
45.75
40%
-48
- C2 -
-
6BKH
1
A:
[5-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
VMDEN---------------
251
Blastp_CBE
45.71
52%
-21
- C2 -
-
6CZ4
1
PTK6_HUMAN
A:
[4-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
-------
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
C
F
K
A
L
R
E
R
L
----------------------
362
Blastp_CBE
45.69
44%
-46
- C2 -
-
3SXR
1
BMX_HUMAN
A:
[4-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
---------
E
L
G
S
----
V
V
K
L
G
K
W
-
K
G
---
Q
-
Y
D
----
V
A
V
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
F
Q
-
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
-
K
-
E
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
-
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
---
Y
V
S
S
-
V
G
T
--
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
---------------------
283
Blastp_CBE
45.66
50%
3
- C2 -
-
2HIW
1
ABL1_HUMAN
B:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
418
Blastp_CBE
45.56
41%
-56
- C2 -
-
5FBN
3
BTK_HUMAN
C:
[7-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
------------
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
417
Blastp_CBE
45.59
41%
-54
- C2 -
-
5FBN
5
D:
[6-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
339
Blastp_CBE
45.58
49%
-15
- C2 -
-
2Z60
1
ABL1_MOUSE
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
-------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
247
Blastp_CBE
45.56
52%
-8
- C2 -
-
5D7V
3
PTK6_HUMAN
C:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
248
Blastp_CBE
45.53
52%
-5
- C2 -
-
5D7V
3
PTK6_HUMAN
B:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
348
Blastp_CBE
45.29
50%
-13
- C2 -
-
2XYN
4
ABL2_HUMAN
C:
[27-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
--
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
-
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
-----
M
F
-------------
236
Blastp_CBE
45.22
65%
-7
- C2 -
-
4UEU
1
?
A:
[4-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
I
P
R
S
E
I
T
L
E
R
---------
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
---
N
-
I
E
----
V
A
V
K
T
L
K
E
G
T
--
M
--
S
V
E
---
E
--
F
L
Q
-
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
H
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
--------------
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
-----
M
F
-------------
244
Blastp_CBE
45.20
52%
-12
- C2 -
-
5H2U
4
PTK6_HUMAN
A:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
321
Blastp_CBE
45.17
50%
-6
- C2 -
-
6NPE
2
ABL1_HUMAN
A:
[19-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
---------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
275
Blastp_CBE
45.16
50%
-13
- C2 -
-
3KF4
1
ABL1_MOUSE
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
317
Blastp_CBE
45.14
50%
-7
- C2 -
-
6NPV
2
ABL1_HUMAN
A:
[19-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
---------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
375
Blastp_CBE
45.12
41%
-40
- C2 -
-
5J87
1
D:
[12-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
242
Blastp_CBE
45.07
52%
-12
- C2 -
-
5H2U
4
PTK6_HUMAN
C:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
267
Blastp_CBE
45.00
50%
-7
- C2 -
-
3UE4
1
ABL1_HUMAN
B:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
249
Blastp_CBE
44.88
52%
-7
- C2 -
-
5D7V
3
PTK6_HUMAN
A:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
245
Blastp_CBE
44.87
52%
-7
- C2 -
-
5DA3
3
PTK6_HUMAN
A:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
----
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
278
Blastp_CBE
44.86
50%
-10
- C2 -
-
2QOH
1
ABL1_MOUSE
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
-------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
328
Blastp_CBE
44.84
50%
-7
- C2 -
-
2G2I
1
ABL1_HUMAN
B:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
----
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
P
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
368
Blastp_CBE
44.83
41%
-54
- C2 -
-
5P9L
1
A:
[12-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
----
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
261
Blastp_CBE
44.78
50%
-5
- C2 -
-
2HYY
1
ABL1_HUMAN
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
-
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
338
Blastp_CBE
44.77
49%
-5
- C2 -
-
3IK3
1
ABL1_MOUSE
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
241
Blastp_CBE
44.72
52%
-13
- C2 -
-
5H2U
4
PTK6_HUMAN
D:
[2-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
---------
K
L
G
S
G
Y
F
G
E
V
F
E
G
L
W
-
K
D
---
R
-
V
Q
----
V
A
I
K
V
I
S
R
D
N
--
L
--
L
H
Q
---
Q
--
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
-
V
G
D
-
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
-
S
D
E
K
V
L
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
Q
N
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
K
E
D
V
---
Y
L
S
--
H
D
H
--
N
-
I
P
Y
K
W
T
A
P
E
A
L
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
R
V
D
A
G
Y
R
M
P
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
R
E
R
L
S
S
-----
F
--------------
327
Blastp_CBE
44.70
49%
-9
- C2 -
-
3DK3
1
ABL1_MOUSE
A:
[4-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
--------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
F
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
323
Blastp_CBE
44.66
50%
-5
- C2 -
-
3PYY
1
ABL1_HUMAN
A:
[19-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
--------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
349
Blastp_CBE
44.65
50%
-12
- C2 -
-
2XYN
4
ABL2_HUMAN
B:
[26-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
--
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
-
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
-----
M
F
-------------
397
Blastp_CBE
44.64
40%
-56
- C2 -
-
6MNY
1
?
A:
[12-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
R
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
--------------------
326
Blastp_CBE
44.60
49%
-14
- C2 -
-
3DK3
1
ABL1_MOUSE
B:
[4-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
------
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
F
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
288
Blastp_CBE
44.60
50%
-5
- C2 -
-
6HD6
2
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
----
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
289
Blastp_CBE
44.51
50%
-6
- C2 -
-
6HD4
2
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
-----
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
350
Blastp_CBE
44.50
50%
-13
- C2 -
-
2XYN
2
ABL2_HUMAN
A:
[26-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
--
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
-
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
-----
M
F
-------------
295
Blastp_CBE
44.49
50%
-5
- C2 -
-
3MS9
2
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
319
Blastp_CBE
44.44
50%
-6
- C2 -
-
6NPU
2
ABL1_HUMAN
A:
[19-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
---------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
285
Blastp_CBE
44.42
50%
-8
- C2 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
---
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
416
Blastp_CBE
44.41
41%
-56
- C2 -
-
5FBO
2
A:
[4-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
------------------
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
332
Blastp_CBE
44.38
50%
-2
- C2 -
-
2G2F
1
ABL1_HUMAN
B:
[9-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
-----
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
P
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
402
Blastp_CBE
44.28
41%
-47
- C2 -
-
3PIY
1
A:
[6-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
----------
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
---
Y
T
S
S
-
V
G
S
--
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
257
Blastp_CBE
44.27
50%
-5
- C2 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
-----
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
347
Blastp_CBE
44.24
50%
-1
- C2 -
-
3GVU
2
ABL2_HUMAN
A:
[25-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
-
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
---
G
D
T
---
Y
T
-----
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
-----
M
F
-------------
312
Blastp_CBE
44.23
50%
-14
- C2 -
-
2HZI
1
ABL1_HUMAN
B:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
------
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
276
Blastp_CBE
44.22
50%
-11
- C2 -
-
3KF4
1
ABL1_MOUSE
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
---------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
298
Blastp_CBE
44.20
50%
-1
- C2 -
-
3K5V
2
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
---
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
329
Blastp_CBE
44.15
50%
-3
- C2 -
-
2G2I
1
ABL1_HUMAN
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
---
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
P
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
315
Blastp_CBE
44.14
50%
-6
- C2 -
-
2E2B
1
ABL1_HUMAN
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
------
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
----
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
277
Blastp_CBE
44.15
50%
-6
- C2 -
-
2QOH
1
ABL1_MOUSE
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
-----
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
297
Blastp_CBE
44.14
50%
-6
- C2 -
-
3K5V
2
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
-----
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
259
Blastp_CBE
44.13
50%
0
- C2 -
-
2HYY
1
ABL1_HUMAN
D:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
----
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
290
Blastp_CBE
44.08
50%
-0
- C2 -
-
6HD4
3
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
---
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
287
Blastp_CBE
44.06
50%
-7
- C2 -
-
6HD6
1
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
-----
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
239
Blastp_CBE
44.01
45%
-4
- C2 -
-
4XEY
1
ABL1_HUMAN
A:
[116-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NY
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
----
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
341
Blastp_CBE
43.97
49%
-11
- C2 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
--------------
311
Blastp_CBE
43.96
50%
1
- C2 -
-
3CS9
1
ABL1_HUMAN
A:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
--------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
422
Blastp_CBE
43.93
41%
-61
- C2 -
-
3OCT
1
A:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
-----
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
262
Blastp_CBE
43.91
50%
-3
- C2 -
-
2HYY
1
ABL1_HUMAN
A:
[8-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
-
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
336
Blastp_CBE
43.87
49%
-8
- C2 -
-
4TWP
1
ABL1_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
324
Blastp_CBE
43.86
49%
-5
- C2 -
-
6BL8
1
ABL1_HUMAN
B:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
---
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
F
T
A
H
--
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
293
Blastp_CBE
43.82
50%
-7
- C2 -
-
3MSS
2
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
260
Blastp_CBE
43.80
50%
-6
- C2 -
-
2HYY
1
ABL1_HUMAN
C:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
-
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
---
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
265
Blastp_CBE
43.76
50%
-0
- C2 -
-
4YC8
3
ABL1_HUMAN
B:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
------
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
399
Blastp_CBE
43.68
41%
-57
- C2 -
-
3PJ2
1
A:
[6-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
---
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
E
G
S
--
M
--
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
-------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
345
Blastp_CBE
43.67
50%
-3
- C2 -
-
4XLI
1
ABL2_MOUSE
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
--------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
-
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
-----
M
F
-------------
306
Blastp_CBE
43.66
50%
1
- C2 -
-
1FPU
1
ABL1_MOUSE
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-----
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
280
Blastp_CBE
43.64
50%
-2
- C2 -
-
3QRI
1
ABL1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
344
Blastp_CBE
43.63
50%
1
- C2 -
-
4XLI
1
B:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
----
G
E
V
Y
V
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-
P
-
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
-----
M
F
-------------
237
Blastp_CBE
43.60
65%
4
- C2 -
-
4CSV
1
?
A:
[5-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
---------
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
---
N
-
I
E
----
V
A
V
K
T
L
K
E
G
T
--
M
--
S
V
E
---
E
--
F
L
Q
-
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
-----
M
F
-------------
255
Blastp_CBE
43.48
50%
-4
- C2 -
-
5HU9
13
ABL1_HUMAN
A:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
357
Blastp_CBE
43.37
49%
-30
- C2 -
-
2V7A
1
ABL1_HUMAN
B:
[8-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
282
Blastp_CBE
43.34
50%
-8
- C2 -
-
3OXZ
1
ABL1_MOUSE
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-------------
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
291
Blastp_CBE
43.32
50%
-6
- C2 -
-
3MSS
2
ABL1_MOUSE
D:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
292
Blastp_CBE
43.20
50%
-5
- C2 -
-
3MSS
2
ABL1_MOUSE
C:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
299
Blastp_CBE
43.12
50%
-3
- C2 -
-
2HZN
1
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
---
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
--
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
294
Blastp_CBE
43.09
50%
-5
- C2 -
-
3MSS
2
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
314
Blastp_CBE
43.06
50%
-4
- C2 -
-
2E2B
1
ABL1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
296
Blastp_CBE
43.04
50%
-3
- C2 -
-
3MS9
2
ABL1_MOUSE
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
451
Blastp_CBE
43.00
45%
-53
- C2 -
-
3MJ2
1
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
Q
---
Y
T
S
S
-
T
G
T
--
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
354
Blastp_CBE
42.77
49%
-25
- C2 -
-
2GQG
2
ABL1_HUMAN
A:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
266
Blastp_CBE
42.71
50%
-4
- C2 -
-
4YC8
3
ABL1_HUMAN
A:
[8-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
------
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
------
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
405
Blastp_CBE
42.62
40%
-52
- C2 -
-
3K54
1
A:
[16-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
--------------
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
353
Blastp_CBE
42.52
49%
-23
- C2 -
-
2GQG
2
ABL1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
358
Blastp_CBE
42.19
49%
-24
- C2 -
-
2V7A
1
ABL1_HUMAN
A:
[7-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
E
D
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
505
Blastp_CBE
42.03
45%
-16
- C2 -
-
2XYU
7
A:
[2-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
A
S
C
I
K
I
E
K
---------
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
-
K
V
---
P
-
G
K
REIC
V
A
I
K
T
L
K
A
G
Y
--
T
--
D
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
-
K
C
K
-
P
-
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
R
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
---------------------
427
Blastp_CBE
42.00
45%
-21
- C2 -
-
1JPA
1
EPHB2_MOUSE
A:
[15-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
-
E
D
P
N
---
E
--
A
-------
V
---------------
R
-
E
--
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
---------
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
-
K
L
-------REIF
V
A
I
K
T
L
K
S
G
Y
--
T
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
T
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
---------------------
490
Blastp_CBE
41.97
45%
-20
- C2 -
-
2Y6O
1
A:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---------------
R
-
E
--
F
A
K
E
I
D
A
S
C
I
K
I
E
K
---------
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
-
K
V
---
P
-
G
K
REIC
V
A
I
K
T
L
K
A
G
Y
--
T
--
D
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
-
K
C
K
-
P
-
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
R
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
---------------------
401
Blastp_CBE
41.81
41%
-51
- C2 -
-
3PIZ
1
A:
[6-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
---
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
---------
S
E
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
525
Blastp_CBE
41.68
45%
-12
- C2 -
-
2QOC
2
A:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
L
D
A
T
N
I
S
I
D
K
---------
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
-
K
L
---
P
-
S
K
KEIS
V
A
I
K
T
L
K
V
G
Y
--
T
--
E
K
Q
---
R
RD
F
L
G
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
-
K
S
K
-
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
H
D
A
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
---------------
K
-
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
---------------------
434
Blastp_CBE
41.68
41%
-63
- C2 -
-
5XYZ
1
B:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
-------
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
-----
M
--
S
E
D
---
E
---
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
----
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
398
Blastp_CBE
41.68
41%
-51
- C2 -
-
3PJ3
1
A:
[6-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
Y
--
G
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
G
T
---
G
V
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
-----------
D
---
E
--
F
I
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
--------------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
426
Blastp_CBE
41.67
45%
-18
- C2 -
-
1JPA
1
B:
[15-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
F
-
E
D
P
N
---
E
--
A
-------
V
---------------
R
-
E
--
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
---------
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
---------
K
REIF
V
A
I
K
T
L
K
S
G
Y
--
T
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
-
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
---------------------
472
Blastp_CBE
41.60
46%
-21
- C2 -
-
2HEN
1
EPHB2_MOUSE
B:
[3-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
I
S
C
V
K
I
E
Q
---------
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
-
K
L
---
P
-
G
K
REIF
V
A
I
K
T
L
K
S
G
Y
--
T
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
T
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
---------------------
355
Blastp_CBE
41.59
49%
-31
- C2 -
-
3DK7
1
ABL1_MOUSE
B:
[4-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
------
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
318
Blastp_CBE
41.57
50%
-5
- C2 -
-
6NPU
5
ABL1_HUMAN
B:
[19-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
254
Blastp_CBE
41.46
50%
-13
- C2 -
-
4WA9
1
ABL1_HUMAN
A:
[10-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
------------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
---
Y
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
356
Blastp_CBE
41.45
49%
-27
- C2 -
-
3DK7
1
ABL1_MOUSE
A:
[4-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
K
--------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
470
Blastp_CBE
41.26
46%
-15
- C2 -
-
2HEN
1
D:
[3-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
I
S
C
V
K
I
E
Q
---------
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
-
K
L
---
P
-
G
K
REIF
V
A
I
K
T
L
K
S
G
Y
--
T
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
T
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
---------------------
471
Blastp_CBE
41.24
46%
-16
- C2 -
-
2HEN
1
EPHB2_MOUSE
C:
[3-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
I
S
C
V
K
I
E
Q
---------
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
-
K
L
---
P
-
G
K
REIF
V
A
I
K
T
L
K
S
G
Y
--
T
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
T
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
---------------------
491
Blastp_CBE
41.22
45%
-12
- C2 -
-
2Y6M
3
A:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---------------
R
-
E
--
F
A
K
E
I
D
A
S
C
I
K
I
E
K
---------
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
-
K
V
---
P
-
G
K
REIC
V
A
I
K
T
L
K
A
G
Y
--
T
--
D
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
-
K
C
K
-
P
-
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
N
D
G
R
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
--------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
---------------------
316
Blastp_CBE
41.08
50%
-2
- C2 -
-
6NPV
5
ABL1_HUMAN
B:
[19-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
447
Blastp_CBE
41.01
45%
-64
- C2 -
-
4RFM
1
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
473
Blastp_CBE
40.86
46%
-14
- C2 -
-
2HEN
1
EPHB2_MOUSE
A:
[3-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
I
S
C
V
K
I
E
Q
---------
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
-
K
L
---
P
-
G
K
REIF
V
A
I
K
T
L
K
S
G
Y
--
T
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
-
K
-
S
T
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
---------------------
310
Blastp_CBE
40.90
50%
2
- C2 -
-
3CS9
1
ABL1_HUMAN
B:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---
T
--
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
435
Blastp_CBE
40.86
41%
-62
- C2 -
-
5XYZ
1
BTK_HUMAN
A:
[3-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
---------
E
L
-------
V
K
Y
G
K
W
-
R
G
---
Q
-
Y
D
----
V
A
I
K
M
I
K
-----
M
--
S
E
D
--------
E
-
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
-
K
-
Q
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
---
R
F
-
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
--------------------
519
Blastp_CBE
40.70
44%
-62
- C2 -
-
4L7S
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
484
Blastp_CBE
40.43
45%
-55
- C2 -
-
1SNU
1
B:
[12-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
322
Blastp_CBE
40.40
50%
-1
- C2 -
-
3PYY
3
ABL1_HUMAN
B:
[19-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
----------
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-------------------
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
486
Blastp_CBE
40.34
45%
-58
- C2 -
-
1SM2
1
B:
[12-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
309
Blastp_CBE
40.30
50%
2
- C2 -
-
3CS9
1
ABL1_HUMAN
C:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
514
Blastp_CBE
40.24
44%
-59
- C2 -
-
4PP9
1
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
518
Blastp_CBE
40.15
44%
-55
- C2 -
-
4L7S
1
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
475
Blastp_CBE
40.02
45%
-57
- C2 -
-
3V8W
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
-
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
485
Blastp_CBE
40.05
45%
-56
- C2 -
-
1SNU
1
ITK_HUMAN
A:
[12-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
263
Blastp_CBE
40.02
50%
-5
- C2 -
-
2HZ0
1
ABL1_HUMAN
B:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
------
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
------
M
--
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
515
Blastp_CBE
39.85
44%
-56
- C2 -
-
4PP9
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
521
Blastp_CBE
39.72
44%
-53
- C2 -
-
4KIO
3
ITK_HUMAN
C:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
352
Blastp_CBE
39.72
49%
-27
- C2 -
-
3DK6
1
ABL1_MOUSE
A:
[4-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
474
Blastp_CBE
39.70
45%
-51
- C2 -
-
3V8W
1
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
-----
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
479
Blastp_CBE
39.69
45%
-53
- C2 -
-
3V5L
1
ITK_HUMAN
C:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
---
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
351
Blastp_CBE
39.64
49%
-24
- C2 -
-
3DK6
1
ABL1_MOUSE
B:
[5-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
H
---------
K
-------
E
V
Y
E
G
V
W
-
K
K
Y--
S
-
L
T
----
V
A
V
K
T
L
---------
E
V
E
---
E
--
F
L
K
-
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
-
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
T
G
D
---
T
T
A
H
-
A
G
A
--
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
-----
M
F
-------------
482
Blastp_CBE
39.61
45%
-60
- C2 -
-
3V5J
1
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
------
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
483
Blastp_CBE
39.56
45%
-56
- C2 -
-
3V5J
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
------
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
487
Blastp_CBE
39.55
45%
-51
- C2 -
-
1SM2
1
ITK_HUMAN
A:
[12-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
478
Blastp_CBE
39.51
45%
-57
- C2 -
-
3V5L
1
D:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
--
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
476
Blastp_CBE
39.47
45%
-58
- C2 -
-
3V8T
1
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
---
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
522
Blastp_CBE
39.41
44%
-61
- C2 -
-
4KIO
2
ITK_HUMAN
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
---
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
-----------
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
449
Blastp_CBE
39.34
45%
-50
- C2 -
-
4MF1
1
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
---
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
---------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
448
Blastp_CBE
39.12
45%
-58
- C2 -
-
4PQN
2
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
450
Blastp_CBE
39.04
45%
-54
- C2 -
-
4MF1
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
---
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
523
Blastp_CBE
38.91
44%
-59
- C2 -
-
4KIO
2
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
---
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
----------
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
481
Blastp_CBE
38.91
45%
-53
- C2 -
-
3V5L
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
------
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
480
Blastp_CBE
38.88
45%
-54
- C2 -
-
3V5L
1
ITK_HUMAN
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
----
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
--------
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
453
Blastp_CBE
38.27
45%
-48
- C2 -
-
3MIY
1
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
---------
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
454
Blastp_CBE
38.12
45%
-48
- C2 -
-
3MIY
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
---------
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
520
Blastp_CBE
38.11
44%
-51
- C2 -
-
4KIO
3
D:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
---------
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
477
Blastp_CBE
38.09
45%
-54
- C2 -
-
3V8T
1
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
---
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
R
E
G
A
--
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
452
Blastp_CBE
37.98
45%
-49
- C2 -
-
3MJ1
1
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
--------------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
506
Blastp_CBE
37.64
44%
-61
- C2 -
-
4QD6
2
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
----------
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
507
Blastp_CBE
37.04
44%
-56
- C2 -
-
4QD6
2
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
---------
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
513
Blastp_CBE
37.01
44%
-49
- C2 -
-
4PPA
2
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
-----------
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
466
Blastp_CBE
36.30
43%
0
- C2 -
-
3QGY
1
ITK_HUMAN
A:
[21-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
I
DPSELTFVQ
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
--
M
--
S
E
D
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
509
Blastp_CBE
36.26
44%
-49
- C2 -
-
4PPC
2
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
-------------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
517
Blastp_CBE
36.07
44%
-52
- C2 -
-
4MF0
2
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
---
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
------
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
465
Blastp_CBE
35.98
43%
3
- C2 -
-
3QGY
1
B:
[22-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
I
DPSELTFVQ
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
--
M
--
S
E
D
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
512
Blastp_CBE
35.91
44%
-49
- C2 -
-
4PPA
2
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
-----------
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
467
Blastp_CBE
35.79
43%
2
- C2 -
-
3QGW
1
B:
[24-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
DPSELTFVQ
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
--
M
--
S
E
D
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
510
Blastp_CBE
35.52
44%
-45
- C2 -
-
4PPB
2
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
-----------
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
508
Blastp_CBE
35.51
44%
-51
- C2 -
-
4PPC
2
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
-------------------
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
----A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
516
Blastp_CBE
35.46
44%
-48
- C2 -
-
4MF0
2
B:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
---
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
------
M
--
S
E
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
511
Blastp_CBE
35.35
44%
-46
- C2 -
-
4PPB
2
ITK_HUMAN
A:
[14-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
-----------
E
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
488
Blastp_CBE
34.29
45%
-17
- C2 -
-
5MJA
1
B:
[20-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
F
V
K
I
E
E
---------
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
-
K
L
---
P
-
G
K
REI-
V
A
I
K
T
L
K
A
G
Y
--
S
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
T
-
K
S
R
-
P
-
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
Q
------
T
T
S
S
-
L
G
G
--
K
-
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
---------------------
468
Blastp_CBE
34.29
43%
12
- C2 -
-
3QGW
1
ITK_HUMAN
A:
[24-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
DPSELTFVQ
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
-
L
N
---
K
-
D
K
----
V
A
I
K
T
I
K
E
G
S
--
M
--
S
E
D
---
D
--
F
I
E
-
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
-
Q
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
-
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
------------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-----------------------------
489
Blastp_CBE
33.25
45%
-6
- C2 -
-
5MJA
1
EPHB1_HUMAN
A:
[20-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
I
D
V
S
F
V
K
I
E
E
---------
V
I
G
A
G
E
F
G
E
V
Y
K
G
R
L
-
K
L
---
P
-
G
K
REI-
V
A
I
K
T
L
K
A
G
Y
--
S
--
E
K
Q
---
R
RD
F
L
S
-
E
A
S
I
M
G
Q
F
D
H
R
N
I
I
R
L
E
G
V
V
T
-
K
S
R
-
P
-
V
M
I
I
T
E
F
M
E
N
G
A
L
D
S
F
L
R
Q
N
D
G
Q
F
T
V
I
-
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
Y
L
Q
D
D
T
SDP--------------
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
N
T
L
D
---------------------
-
* C *
-
-
:
------------------------------------------------------------------------------