@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ARAF_HUMAN: (2019-05-18 )
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
Atome Classification :
(98 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MEPPRGPPANGAEPSR
A
V
G
T
V
K
V
Y
LPNK
Q
R
T
V
V
T
VRD
G
M
S
V
Y
D
S
L
D
K
A
L
K
VRGL
N
Q
D
C
C
V
V
Y
R
L
IKGR
K
T
V
T
AWDTAIAPLD
G
E
E
L
I
V
E
V
L
E
DV
P
L
T
M
H
N
F
V
R
K
T
F
F
S
L
A
F
C
D
F
C
L
K
F
L
FHG
F
R
CQTCG
Y
K
F
H
Q
H
CSSKV
P
T
V
C
V
DMST
N
R
Q
Q
F
Y
H
S
V
Q
DLSGGSRQHEAPSNRP
L
N
E
LLTPQGPSPRTQHCDPEHFPFPAPAN
A
P
L
Q
R
I
RSTSTP
N
V
H
M
V
S
TTAPMDS
N
L
I
Q
LTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKS
P
A
E
Q
R
E
R
K
S
LAD
D
K
K
K
V
K
NLGYRDS
G
Y
Y
W
EV
P
P
S
E
V
Q
L
L
K
R
IGTGSFG
T
V
F
RGRWHG
D
V
A
V
K
V
L
KVSQP
T
A
E
Q
A
Q
A
F
K
N
E
M
Q
V
L
R
KTRH
V
N
I
L
L
F
MGFMTRP
G
F
A
I
I
T
Q
WCEGS
S
L
Y
H
H
L
H
VAD
T
R
F
D
M
V
Q
L
I
D
V
A
R
Q
T
AQG
M
D
Y
L
H
A
K
N
I
I
H
R
DLKSN
N
I
F
L
HE
G
L
T
V
K
IGDF
G
L
A
T
V
K
TRWSGAQPLEQPSG
S
V
L
W
M
A
A
E
V
I
RMQDPNPYS
F
Q
S
D
V
Y
A
Y
G
V
V
L
Y
E
L
M
TGSLPYSHIGCR
D
Q
I
I
F
M
VGRGYLSP
D
L
S
K
I
SSN
C
P
K
A
M
R
R
L
L
S
D
C
L
K
F
Q
REERP
L
F
P
Q
I
L
A
T
I
E
L
L
Q
R
S
L
P
K
I
E
RSASEPSLHR
T
Q
A
D
E
L
P
A
C
L
L
S
A
ARLVP
25
Blastp_CBE
91.36
74%
-131
- C2 -
-
4EHE
8.0
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
51
Blastp_CBE
90.79
74%
-145
- C2 -
-
4MBJ
5.1
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
28
Blastp_CBE
90.57
74%
-134
- C2 -
-
3TV6
8.4
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
58
Blastp_CBE
90.17
76%
-125
- C2 -
-
5VAM
11.5
-
BRAF_HUMAN
A:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
----
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
14
PsiBlast_PDB
90.06
74%
-132
- C2 -
-
4E26
5.1
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
------
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
50
Blastp_CBE
89.97
74%
-135
- C2 -
-
4MBJ
7.0
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
61
Blastp_CBE
89.93
76%
-142
- C2 -
-
5CT7
11.6
-
BRAF_HUMAN
A:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
29
Blastp_CBE
89.78
74%
-133
- C2 -
-
3TV4
7.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
15
PsiBlast_PDB
89.55
74%
-144
- C2 -
-
4E4X
9.6
-
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
56
Blastp_CBE
89.53
76%
-140
- C2 -
-
4KSP
9.8
-
BRAF_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------
22
Blastp_CBE
89.49
77%
-142
- C2 -
-
3OMV
6.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
Q
E
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
------------------------------
64
Blastp_CBE
89.42
77%
-142
- C2 -
-
4H58
7.5
-
BRAF_HUMAN
A:
[3-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------
69
Blastp_CBE
89.38
73%
-135
- C2 -
-
4XV9
10.0
-
A:
[17-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
--------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
9
PsiBlast_PDB
89.23
74%
-138
- C2 -
-
3Q4C
7.9
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
23
Blastp_CBE
89.12
74%
-132
- C2 -
-
4PP7
9.0
-
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
30
Blastp_CBE
89.10
74%
-126
- C2 -
-
3SKC
9.2
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
2
PsiBlast_PDB
89.07
76%
-140
- C2 -
-
3OMV
4.4
-
RAF1_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
Q
E
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
------------------------------
18
PsiBlast_PDB
89.06
74%
-136
- C2 -
-
4PP7
9.0
-
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
57
Blastp_CBE
88.99
76%
-140
- C2 -
-
5VAM
11.4
-
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
----
R
W
S
G
---------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
13
PsiBlast_PDB
88.96
74%
-138
- C2 -
-
3TV6
8.3
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
--------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
26
Blastp_CBE
88.84
74%
-133
- C2 -
-
4E4X
9.3
-
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
16
PsiBlast_PDB
88.82
74%
-137
- C2 -
-
4G9C
9.5
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
-----------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
59
Blastp_CBE
88.79
76%
-133
- C2 -
-
5VAL
10.6
-
BRAF_HUMAN
A:
[4-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
--
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
60
Blastp_CBE
88.72
76%
-141
- C2 -
-
5CT7
11.5
-
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
88
Blastp_CBE
88.65
72%
-129
- C2 -
-
4RZV
11.0
-
B:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
12
PsiBlast_PDB
88.59
74%
-138
- C2 -
-
3TV4
7.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
37
Blastp_CBE
88.22
74%
-134
- C2 -
-
3D4Q
6.6
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
100
Blastp_CBE
88.12
72%
-130
- C2 -
-
5HID
10.7
-
B:
[14-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
6
PsiBlast_PDB
88.10
74%
-141
- C2 -
-
3PPK
9.0
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
17
PsiBlast_PDB
88.04
74%
-137
- C2 -
-
4EHE
7.7
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
7
PsiBlast_PDB
88.04
74%
-142
- C2 -
-
3PRF
8.3
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
27
Blastp_CBE
88.01
74%
-138
- C2 -
-
4E26
3.7
-
B:
[29-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
-----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------
89
Blastp_CBE
87.89
72%
-143
- C2 -
-
4RZV
11.1
-
BRAF_HUMAN
A:
[7-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
42
Blastp_CBE
87.83
74%
-135
- C2 -
-
5FD2
8.7
-
BRAF_HUMAN
A:
[22-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
---------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
52
Blastp_CBE
87.79
74%
-145
- C2 -
-
5HIE
11.2
-
D:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------
24
Blastp_CBE
87.66
74%
-138
- C2 -
-
4G9C
9.9
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
54
Blastp_CBE
87.62
74%
-149
- C2 -
-
5HIE
11.2
-
BRAF_HUMAN
B:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------
4
PsiBlast_PDB
87.56
74%
-135
- C2 -
-
3PSB
7.5
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
91
Blastp_CBE
87.50
73%
-150
- C2 -
-
5ITA
9.6
-
B:
[24-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
-
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
3
PsiBlast_PDB
87.50
74%
-134
- C2 -
-
3D4Q
7.2
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
21
Blastp_CBE
87.36
73%
-140
- C2 -
-
4MNF
7.7
-
B:
[42-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
---------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
19
PsiBlast_PDB
87.29
74%
-134
- C2 -
-
3II5
10.4
-
BRAF_HUMAN
A:
[28-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
-----------
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
11
PsiBlast_PDB
87.17
74%
-138
- C2 -
-
3SKC
8.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
35
Blastp_CBE
87.15
74%
-134
- C2 -
-
3PPK
8.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
48
Blastp_CBE
87.08
74%
-140
- C2 -
-
4EHG
8.2
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
43
Blastp_CBE
87.06
74%
-137
- C2 -
-
3IDP
10.7
-
B:
[22-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
70
Blastp_CBE
87.05
73%
-131
- C2 -
-
5CSX
10.4
-
A:
[7-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
38
Blastp_CBE
87.04
74%
-140
- C2 -
-
3II5
10.1
-
B:
[29-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
36
Blastp_CBE
87.03
74%
-134
- C2 -
-
3PPJ
7.5
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
63
Blastp_CBE
86.97
77%
-137
- C2 -
-
1UWH
9.1
-
BRAF_HUMAN
A:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
55
Blastp_CBE
86.92
74%
-144
- C2 -
-
5HIE
11.2
-
BRAF_HUMAN
A:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------
34
Blastp_CBE
86.92
74%
-137
- C2 -
-
3PRF
7.4
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
67
Blastp_CBE
86.80
76%
-136
- C2 -
-
4YHT
8.1
-
B:
[2-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
T
N
E
T
K
F
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
S
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
T
L
A
R
S
---------------------------------
1
PsiBlast_PDB
86.78
73%
-136
- C2 -
-
4MNF
7.2
-
BRAF_HUMAN
A:
[42-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
---------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
10
PsiBlast_PDB
86.74
74%
-137
- C2 -
-
3PSD
8.3
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
31
Blastp_CBE
86.67
74%
-133
- C2 -
-
3PSD
8.1
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
68
Blastp_CBE
86.65
76%
-133
- C2 -
-
4YHT
7.6
-
BRAF_HUMAN
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
T
N
E
T
K
F
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
K
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
T
L
A
R
----------------------------------
44
Blastp_CBE
86.64
74%
-138
- C2 -
-
3IDP
10.9
-
BRAF_HUMAN
A:
[22-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
97
Blastp_CBE
86.58
73%
-131
- C2 -
-
5JSM
9.5
-
BRAF_HUMAN
A:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
E
K
S
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
84
Blastp_CBE
86.58
72%
-139
- C2 -
-
4XV2
10.9
-
B:
[17-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
87
Blastp_CBE
86.47
72%
-136
- C2 -
-
4RZW
9.0
-
BRAF_HUMAN
A:
[6-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
78
Blastp_CBE
86.38
73%
-136
- C2 -
-
4JVG
9.1
-
BRAF_HUMAN
B:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
----------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
32
Blastp_CBE
86.38
74%
-132
- C2 -
-
3PSB
7.7
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
49
Blastp_CBE
86.37
74%
-135
- C2 -
-
4EHG
7.5
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
76
Blastp_CBE
86.32
73%
-130
- C2 -
-
4JVG
8.6
-
D:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
-------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
53
Blastp_CBE
86.32
74%
-141
- C2 -
-
5HIE
11.0
-
BRAF_HUMAN
C:
[30-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------
5
PsiBlast_PDB
86.32
74%
-133
- C2 -
-
3PPJ
7.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
82
Blastp_CBE
86.28
73%
-132
- C2 -
-
4WO5
2.6
-
B:
[27-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
---------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
71
Blastp_CBE
86.24
73%
-134
- C2 -
-
5CSW
10.8
-
BRAF_HUMAN
A:
[8-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
45
Blastp_CBE
86.16
74%
-141
- C2 -
-
5C9C
9.9
-
BRAF_HUMAN
A:
[30-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
----------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
46
Blastp_CBE
86.09
74%
-127
- C2 -
-
4G9R
10.9
-
B:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
79
Blastp_CBE
85.99
73%
-132
- C2 -
-
4JVG
8.3
-
BRAF_HUMAN
A:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
-------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
96
Blastp_CBE
85.89
73%
-138
- C2 -
-
5JSM
9.4
-
BRAF_HUMAN
C:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
E
---------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
-
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
62
Blastp_CBE
85.88
77%
-138
- C2 -
-
1UWH
9.1
-
B:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
74
Blastp_CBE
85.75
73%
-145
- C2 -
-
6CAD
10.4
-
B:
[10-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
--
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
33
Blastp_CBE
85.63
74%
-130
- C2 -
-
3PRI
7.7
-
B:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
72
Blastp_CBE
85.60
73%
-137
- C2 -
-
3C4C
6.0
-
B:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
99
Blastp_CBE
85.53
73%
-134
- C2 -
-
4CQE
11.2
-
BRAF_HUMAN
A:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
65
Blastp_CBE
85.45
76%
-126
- C2 -
-
1UWJ
8.8
-
B:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
101
Blastp_CBE
85.24
72%
-135
- C2 -
-
5HID
10.8
-
BRAF_HUMAN
A:
[14-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
------------
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
8
PsiBlast_PDB
85.17
74%
-130
- C2 -
-
3PRI
7.6
-
BRAF_HUMAN
A:
[29-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
80
Blastp_CBE
85.07
72%
-137
- C2 -
-
4R5Y
10.8
-
B:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
98
Blastp_CBE
84.96
73%
-139
* C2 *
-
4CQE
11.1
-
B:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
77
Blastp_CBE
84.95
73%
-130
- C2 -
-
4JVG
8.4
-
BRAF_HUMAN
C:
[9-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-----------------
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
66
Blastp_CBE
84.93
76%
-126
- C2 -
-
1UWJ
9.5
-
BRAF_HUMAN
A:
[3-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
S
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------
85
Blastp_CBE
84.71
72%
-133
- C2 -
-
4XV2
10.9
-
BRAF_HUMAN
A:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
------------------
G
S
I
L
W
M
A
P
E
V
I
R
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
94
Blastp_CBE
84.70
73%
-136
- C2 -
-
5JT2
9.2
-
BRAF_HUMAN
B:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
----------------
S
I
L
W
M
A
P
E
V
I
R
M
--
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
----------------------------------
47
Blastp_CBE
84.50
74%
-129
- C2 -
-
4G9R
10.8
-
BRAF_HUMAN
A:
[29-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
T
E
K
S
------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------
75
Blastp_CBE
84.36
73%
-139
- C2 -
-
6CAD
10.3
-
BRAF_HUMAN
A:
[10-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
-
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
-
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
86
Blastp_CBE
84.04
72%
-142
- C2 -
-
4XV1
9.2
-
BRAF_HUMAN
A:
[18-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
-
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
--
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
----
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
-------------------------------------
83
Blastp_CBE
83.95
72%
-140
- C2 -
-
4XV3
8.5
-
BRAF_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
---
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
----
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
------------------------------------
81
Blastp_CBE
83.92
72%
-134
- C2 -
-
4R5Y
10.6
-
BRAF_HUMAN
A:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------
95
Blastp_CBE
83.57
73%
-138
- C2 -
-
5JT2
8.6
-
BRAF_HUMAN
A:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
E
K
S
R
W
S
-----------
I
L
W
M
A
P
E
V
I
------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
--
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
----------------------------------
90
Blastp_CBE
83.51
72%
-143
- C2 -
-
3OG7
9.6
-
BRAF_HUMAN
A:
[18-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
---
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
------------------
G
S
I
L
W
M
A
P
E
V
I
R
----
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
----------------------------------
73
Blastp_CBE
83.26
73%
-123
- C2 -
-
3C4C
8.1
-
BRAF_HUMAN
A:
[5-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------
93
Blastp_CBE
82.88
73%
-140
- C2 -
-
5JT2
9.1
-
BRAF_HUMAN
C:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
E
K
S
R
------------
S
I
L
W
M
A
P
E
V
I
R
-----
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
-
I
N
N
---
I
I
E
M
V
G
R
G
--
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
----------------------------------
41
Blastp_CBE
81.45
74%
-145
- C2 -
-
5FD2
7.5
-
B:
[23-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
----------
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----------
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------
92
Blastp_CBE
78.02
73%
-129
- C2 -
-
5JT2
8.6
-
D:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
E
---------------
S
I
L
W
M
A
P
E
V
I
R
----
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
-----------------
S
P
D
L
S
K
V
R
-
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
-----------------------------------