@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BMX_HUMAN: (2019-05-18 )
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
Atome Classification :
(79 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
M
D
T
K
S
I
L
E
E
L
L
L
K
R
S
Q
Q
KKKMSPNNY
K
E
R
L
F
V
L
TKTNL
S
Y
Y
E
Y
D
K
MKRGSRKG
S
I
E
I
K
K
I
R
C
V
E
KVNLEEQTPVERQY
P
F
Q
I
V
YKD
G
L
L
Y
V
Y
ASN
E
E
S
R
S
Q
W
L
K
A
L
Q
K
E
IRGNP
H
L
L
V
K
YHS
G
F
F
VDG
K
F
L
C
C
Q
Q
SCKAAPG
C
T
L
W
E
A
Y
A
N
L
H
T
AVNEEKHRVPTF
P
D
R
V
LKIPRAV
P
V
L
K
MDAPSSS
T
T
L
A
QYDNESKKNYGSQPPSSSTS
L
A
QYDSNS
K
K
I
YGSQPNF
N
M
Q
YIPREDFP
D
W
W
Q
V
R
K
LKSSSSSEDVASSNQKERNVNHTTS
K
I
S
W
EFPESSSSEEEENLDDYDWFAGNIS
R
S
Q
S
E
Q
L
L
R
QKGKE
G
A
F
M
V
RNSSQV
G
M
Y
T
V
S
L
F
S
K
A
VNDKKG
T
V
K
H
Y
H
V
HTNAE
N
K
L
Y
L
AEN
Y
C
F
D
S
I
P
K
L
I
H
Y
HQHNSAG
M
I
T
R
LRHPVSTKANKVPDSVSLGN
G
I
W
E
L
K
R
E
E
I
T
L
L
K
E
LGSG
Q
F
G
V
V
Q
LGKWKGQ
Y
D
V
A
V
K
M
I
KEGSM
S
E
D
E
F
F
Q
E
A
Q
T
M
M
KLSH
P
K
L
V
K
F
Y
G
VCSKEY
P
I
Y
I
V
T
E
Y
ISN
G
C
L
L
N
Y
L
R
SHGKGL
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
RNCLVDRD
L
C
V
K
VSDFG
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
VGTKFPVKWSAPE
V
F
H
Y
F
KYSSKS
D
V
W
A
F
G
I
L
M
W
E
V
F
S
LGKQPYDLYDN
S
Q
V
V
L
K
VSQG
H
R
LYRPHLAS
D
T
I
Y
Q
I
M
Y
S
C
W
H
ELPEKR
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
EKDKH
2
PsiBlast_PDB
84.42
97%
-134
- C1 -
-
3SXS
7.3
-
A:
[1-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
G
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
21
Blastp_CBE
82.46
98%
-133
- C1 -
-
3SXR
8.0
-
B:
[1-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
E
L
------
V
V
K
L
G
K
W
K
G
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
1
PsiBlast_PDB
82.35
97%
-129
- C1 -
-
3SXR
8.2
-
BMX_HUMAN
A:
[1-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
K
G
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
R
E
----
43
Blastp_CBE
75.58
66%
-150
- C1 -
-
6DI5
7.2
-
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
98
HHSearch
75.18
65%
-144
* C1 *
-
5P9J
8.8
-
A:
[14-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
---
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
47
Blastp_CBE
74.67
66%
-143
- C1 -
-
5VFI
10.9
-
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
46
Blastp_CBE
74.67
66%
-140
- C1 -
-
6DI0
4.2
-
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
95
HHSearch
74.63
65%
-141
- C1 -
-
6AUA
9.5
-
A:
[2-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
A
---
52
Blastp_CBE
74.59
66%
-138
- C1 -
-
6E4F
8.9
-
A:
[20-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
101
HHSearch
74.55
64%
-136
- C1 -
-
6E4F
8.9
-
A:
[23-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
--
15
PsiBlast_PDB
74.47
64%
-145
- C1 -
-
5BQ0
7.3
-
A:
[13-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
66
Blastp_CBE
74.38
65%
-142
- C1 -
-
4Y93
9.4
-
?
A:
[172-439]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
T
A
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
E
Y
T
S
S
T
G
S
K
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
56
Blastp_CBE
74.29
66%
-143
- C1 -
-
5KUP
10.2
-
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
40
Blastp_CBE
74.29
66%
-137
- C1 -
-
6NFH
7.2
-
?
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
22
Blastp_CBE
74.28
65%
-133
- C1 -
-
4YHF
6.7
-
B:
[9-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
25
Blastp_CBE
74.23
65%
-136
- C1 -
-
5P9K
6.6
-
A:
[9-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
78
Blastp_CBE
74.19
66%
-145
- C1 -
-
5BPY
7.6
-
BTK_HUMAN
A:
[3-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
41
Blastp_CBE
74.17
66%
-143
- C1 -
-
6N9P
6.7
-
?
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
57
Blastp_CBE
74.14
66%
-144
- C1 -
-
4RX5
8.5
-
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
26
Blastp_CBE
74.01
65%
-146
- C1 -
-
5P9J
8.8
-
A:
[14-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
---
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
54
Blastp_CBE
73.97
66%
-136
- C1 -
-
4ZLY
4.2
-
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
29
Blastp_CBE
73.96
66%
-133
- C1 -
-
5J87
9.6
-
BTK_HUMAN
B:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
A
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
55
Blastp_CBE
73.81
66%
-143
- C1 -
-
5VGO
10.0
-
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
48
Blastp_CBE
73.80
66%
-137
- C1 -
-
5U9D
10.2
-
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
31
Blastp_CBE
73.60
65%
-138
- C1 -
-
4Z3V
6.8
-
A:
[13-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
73
Blastp_CBE
73.49
66%
-142
- C1 -
-
6AUA
9.5
-
A:
[2-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
45
Blastp_CBE
73.39
66%
-139
- C1 -
-
6DI1
3.9
-
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
14
PsiBlast_PDB
73.39
64%
-146
- C1 -
-
3GEN
8.7
-
A:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
38
Blastp_CBE
73.27
66%
-138
- C1 -
-
3PIX
5.7
-
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
76
Blastp_CBE
73.21
66%
-144
- C1 -
-
5JRS
9.2
-
BTK_HUMAN
A:
[3-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
80
Blastp_CBE
73.20
66%
-140
- C1 -
-
6BKW
8.9
-
A:
[2-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
74
Blastp_CBE
73.15
66%
-141
- C1 -
-
5T18
9.1
-
A:
[2-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
16
PsiBlast_PDB
73.07
65%
-138
- C1 -
-
4YHF
7.3
-
BTK_HUMAN
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
65
Blastp_CBE
73.05
66%
-142
- C1 -
-
3OCS
9.8
-
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
17
PsiBlast_PDB
73.01
64%
-142
- C1 -
-
5P9F
10.2
-
A:
[14-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
23
Blastp_CBE
72.96
65%
-140
- C1 -
-
5P9M
7.3
-
A:
[9-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
5
PsiBlast_PDB
72.96
64%
-145
- C1 -
-
4OT6
7.0
-
A:
[18-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
67
Blastp_CBE
72.90
67%
-142
- C1 -
-
6AUB
9.8
-
A:
[1-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
18
PsiBlast_PDB
72.88
64%
-144
- C1 -
-
5P9G
10.3
-
A:
[14-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
4
PsiBlast_PDB
72.80
64%
-142
- C1 -
-
4OT5
10.3
-
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
20
PsiBlast_PDB
72.79
64%
-140
- C1 -
-
5P9I
9.1
-
A:
[9-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
19
PsiBlast_PDB
72.74
64%
-149
- C1 -
-
5P9H
8.8
-
A:
[15-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
53
Blastp_CBE
72.69
66%
-138
- C1 -
-
4ZLZ
5.4
-
A:
[1-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
44
Blastp_CBE
72.59
66%
-150
- C1 -
-
6DI3
7.0
-
A:
[5-263]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
---------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
28
Blastp_CBE
72.59
66%
-139
- C1 -
-
5J87
9.3
-
BTK_HUMAN
C:
[12-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
9
PsiBlast_PDB
72.56
64%
-142
- C1 -
-
4RFZ
10.0
-
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
12
PsiBlast_PDB
72.51
64%
-140
- C1 -
-
6HRP
10.3
-
?
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
6
PsiBlast_PDB
72.49
64%
-142
- C1 -
-
4OTQ
9.7
-
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
8
PsiBlast_PDB
72.46
64%
-146
- C1 -
-
4RFY
9.6
-
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
79
Blastp_CBE
72.41
66%
-139
- C1 -
-
6BLN
8.5
-
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
13
PsiBlast_PDB
72.33
64%
-140
- C1 -
-
6HRT
11.4
-
?
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
49
Blastp_CBE
72.31
66%
-156
- C1 -
-
5FBO
10.5
-
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
--------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
11
PsiBlast_PDB
72.31
64%
-144
- C1 -
-
6EP9
9.9
-
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
82
Blastp_CBE
72.25
66%
-139
- C1 -
-
6BKE
9.3
-
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
10
PsiBlast_PDB
72.23
64%
-143
- C1 -
-
4RG0
10.6
-
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
30
Blastp_CBE
72.15
66%
-142
- C1 -
-
5J87
9.6
-
BTK_HUMAN
A:
[12-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
7
PsiBlast_PDB
72.13
64%
-142
- C1 -
-
4OTR
10.3
-
A:
[20-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
83
Blastp_CBE
72.07
66%
-138
- C1 -
-
6BIK
9.4
-
A:
[4-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
27
Blastp_CBE
71.76
66%
-140
- C1 -
-
5J87
8.2
-
D:
[12-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
72
Blastp_CBE
71.60
66%
-160
- C1 -
-
3OCT
8.7
-
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
---
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
--------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
81
Blastp_CBE
71.52
66%
-137
- C1 -
-
6BKH
9.0
-
A:
[5-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
34
Blastp_CBE
71.47
66%
-157
- C1 -
-
3PJ2
7.8
-
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
51
Blastp_CBE
71.29
66%
-150
- C1 -
-
5FBN
7.7
-
BTK_HUMAN
C:
[7-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
50
Blastp_CBE
71.29
66%
-149
- C1 -
-
5FBN
11.1
-
D:
[6-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
----------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
32
Blastp_CBE
71.27
65%
-153
- C1 -
-
6MNY
7.6
-
?
A:
[12-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
R
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
---------
37
Blastp_CBE
71.13
66%
-135
- C1 -
-
3PIY
7.5
-
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
------
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
42
Blastp_CBE
70.98
66%
-155
- C1 -
-
6DI9
5.5
-
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
------
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
24
Blastp_CBE
70.77
65%
-152
- C1 -
-
5P9L
5.7
-
A:
[12-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
----
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
77
Blastp_CBE
70.72
66%
-156
- C1 -
-
5BPY
7.6
-
B:
[3-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
-
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
75
Blastp_CBE
70.59
66%
-156
- C1 -
-
5JRS
9.0
-
B:
[3-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
--
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
87
Blastp_CBE
69.91
61%
-152
- C1 -
-
3QGW
6.2
-
ITK_HUMAN
A:
[28-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-----------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
35
Blastp_CBE
69.87
66%
-159
- C1 -
-
3PJ1
7.6
-
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
-----
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
--
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
36
Blastp_CBE
69.74
66%
-153
- C1 -
-
3PIZ
7.0
-
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
-----
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
58
Blastp_CBE
69.72
66%
-156
- C1 -
-
6NFI
7.1
-
?
A:
[2-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
----
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
---
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
----------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
33
Blastp_CBE
69.58
66%
-155
- C1 -
-
3PJ3
10.8
-
A:
[6-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
-------
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
-------------------
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------
85
Blastp_CBE
69.34
61%
-149
- C1 -
-
3QGY
6.8
-
ITK_HUMAN
A:
[28-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
----
84
Blastp_CBE
67.96
61%
-137
- C1 -
-
3QGY
5.3
-
B:
[28-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----
86
Blastp_CBE
66.79
61%
-148
- C1 -
-
3QGW
5.0
-
B:
[28-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
N
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
-----
39
Blastp_CBE
66.71
64%
-148
- C1 -
-
3K54
7.4
-
A:
[16-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
-------
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
---------