@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BTK_HUMAN: (2019-05-18 )
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Atome Classification :
(75 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
M
A
A
V
I
L
E
S
I
F
L
K
R
S
QQKKKTSPL
N
F
K
K
R
L
F
L
L
T
V
H
K
L
S
Y
Y
E
Y
D
F
E
RGRRGSKKGS
I
D
V
E
K
I
T
C
V
E
TVVPEKNPPPERQIPRRGE
E
S
S
E
M
E
Q
I
S
I
I
E
RFPY
P
F
Q
V
V
YDEG
P
L
Y
V
FS
P
T
E
E
L
R
K
R
W
I
H
Q
L
K
N
V
I
RY
N
S
D
L
V
Q
KYHP
C
F
W
IDG
Q
Y
L
C
C
S
Q
TAKNAMG
C
Q
I
LENRNGSLKPGSSHRKTKKPLPPTPE
E
D
Q
I
LKKPLPPEPAAAPV
S
T
S
E
L
K
K
V
V
A
L
Y
DYMPMNAND
L
Q
LRKGD
E
Y
F
I
L
EESNLP
W
W
RARDKNGQEGYIPSNYVTEAED
S
I
E
M
Y
E
W
Y
S
K
HM
T
R
S
Q
A
E
Q
L
L
K
QEGKEG
G
F
I
V
RDSSKA
G
K
Y
T
V
S
V
F
AKSTG
D
P
Q
G
V
I
R
H
Y
V
V
CSTPQS
Q
Y
Y
L
A
E
K
H
L
F
S
T
I
P
E
L
I
N
Y
HQHN
S
A
G
L
I
S
R
LKYPVSQQNKNAPSTAGLGYGSWEI
D
P
K
D
L
T
F
L
K
E
LGTGQ
F
G
V
V
K
YGKWRG
Q
Y
D
V
A
I
K
M
IKEGSM
S
E
D
E
F
I
E
E
A
K
V
M
M
NL
S
H
E
K
L
V
Q
L
Y
G
V
CTKQR
P
I
F
I
I
T
E
Y
MAN
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
ARNCLVNDQ
G
V
V
K
V
SDFG
L
S
R
Y
V
LDDEY
T
S
SVGSKFPVRWSPP
E
V
L
M
Y
SKFSSKS
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
LGKM
P
Y
E
RFTN
S
E
T
A
E
H
I
A
Q
G
L
R
L
YRPHLAS
E
K
V
Y
T
I
M
Y
S
C
W
HEKADER
P
T
F
K
I
L
L
S
N
I
L
D
VMDEES
41
Blastp_CBE
74.70
100%
-147
- C3 -
-
6DI5
7.3
-
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
53
Blastp_CBE
73.82
97%
-143
- C3 -
-
4Y93
9.4
-
?
A:
[172-446]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
T
A
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
E
Y
T
S
S
T
G
S
K
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
39
Blastp_CBE
73.79
100%
-141
- C3 -
-
6N9P
6.9
-
?
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
45
Blastp_CBE
73.61
100%
-138
- C3 -
-
5VFI
10.7
-
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
46
Blastp_CBE
73.57
100%
-132
- C3 -
-
5U9D
10.3
-
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
44
Blastp_CBE
73.53
100%
-137
- C3 -
-
6DI0
4.2
-
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
38
Blastp_CBE
73.39
100%
-134
- C3 -
-
6NFH
7.2
-
?
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
23
Blastp_CBE
73.35
99%
-143
- C3 -
-
3GEN
8.7
-
A:
[16-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
37
Blastp_CBE
73.25
99%
-141
- C3 -
-
3PIX
6.0
-
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
18
PsiBlast_PDB
73.16
99%
-134
- C3 -
-
5P9K
6.6
-
A:
[9-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
51
Blastp_CBE
73.15
100%
-135
- C3 -
-
4ZLY
4.2
-
A:
[1-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
127
HHSearch
73.11
100%
-135
- C3 -
-
6E4F
9.0
-
A:
[21-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
68
Blastp_CBE
73.06
99%
-145
- C3 -
-
5BPY
7.3
-
BTK_HUMAN
A:
[3-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
31
Blastp_CBE
73.05
98%
-134
- C3 -
-
6E4F
9.0
-
A:
[20-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
16
PsiBlast_PDB
72.86
99%
-136
- C3 -
-
5P9I
9.1
-
A:
[9-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
43
Blastp_CBE
72.82
100%
-137
- C3 -
-
6DI1
3.8
-
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
20
PsiBlast_PDB
72.81
99%
-138
- C3 -
-
5P9M
7.5
-
A:
[9-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
28
Blastp_CBE
72.74
100%
-134
- C3 -
-
5J87
9.6
-
BTK_HUMAN
B:
[1-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
T
A
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
9
PsiBlast_PDB
72.55
98%
-142
- C3 -
-
6EP9
9.9
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
21
Blastp_CBE
72.50
100%
-131
- C3 -
-
4YHF
9.3
-
B:
[9-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
50
Blastp_CBE
72.45
100%
-135
- C3 -
-
4ZLZ
5.4
-
A:
[1-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
24
Blastp_CBE
72.44
99%
-133
- C3 -
-
4Z3V
6.7
-
A:
[13-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
7
PsiBlast_PDB
72.38
98%
-140
- C3 -
-
4RFZ
10.0
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
3
PsiBlast_PDB
72.26
98%
-142
- C3 -
-
4OT6
7.0
-
A:
[18-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
8
PsiBlast_PDB
72.25
98%
-141
- C3 -
-
4RG0
10.4
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
14
PsiBlast_PDB
71.98
99%
-140
- C3 -
-
5P9G
10.3
-
A:
[14-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
4
PsiBlast_PDB
71.97
98%
-140
- C3 -
-
4OTQ
9.6
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
124
HHSearch
71.94
99%
-139
* C3 *
-
6AUA
9.4
-
A:
[2-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
A
--
54
Blastp_CBE
71.94
100%
-138
- C3 -
-
5VGO
10.1
-
A:
[3-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
11
PsiBlast_PDB
71.82
98%
-138
- C3 -
-
6HRT
11.4
-
?
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
10
PsiBlast_PDB
71.69
98%
-138
- C3 -
-
6HRP
10.3
-
?
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
15
PsiBlast_PDB
71.60
99%
-146
- C3 -
-
5P9H
8.6
-
A:
[15-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
5
PsiBlast_PDB
71.58
98%
-141
- C3 -
-
4OTR
10.4
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
71
Blastp_CBE
71.56
99%
-139
- C3 -
-
6AUA
9.4
-
A:
[1-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
55
Blastp_CBE
71.56
100%
-136
- C3 -
-
5KUP
10.2
-
A:
[3-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
13
PsiBlast_PDB
71.55
99%
-136
- C3 -
-
5P9F
10.2
-
A:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
56
Blastp_CBE
71.54
100%
-140
- C3 -
-
4RX5
8.5
-
A:
[3-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
57
Blastp_CBE
71.52
100%
-138
- C3 -
-
3OCS
9.7
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
69
Blastp_CBE
71.50
100%
-138
- C3 -
-
6AUB
9.8
-
A:
[1-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
6
PsiBlast_PDB
71.41
98%
-142
- C3 -
-
4RFY
9.7
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
12
PsiBlast_PDB
71.39
100%
-133
- C3 -
-
4YHF
8.8
-
BTK_HUMAN
A:
[10-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
2
PsiBlast_PDB
71.38
98%
-140
- C3 -
-
4OT5
10.4
-
A:
[20-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
A
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
22
Blastp_CBE
71.19
99%
-144
- C3 -
-
5BQ0
7.3
-
A:
[13-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
64
Blastp_CBE
70.95
99%
-137
- C3 -
-
5T18
9.0
-
A:
[2-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
76
Blastp_CBE
70.84
99%
-135
- C3 -
-
6BIK
9.4
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
66
Blastp_CBE
70.73
99%
-143
- C3 -
-
5JRS
9.0
-
BTK_HUMAN
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
29
Blastp_CBE
70.72
100%
-136
- C3 -
-
5J87
9.4
-
BTK_HUMAN
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
26
Blastp_CBE
70.56
100%
-137
- C3 -
-
5J87
7.6
-
D:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
73
Blastp_CBE
70.53
99%
-133
- C3 -
-
6BKW
8.9
-
A:
[2-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
27
Blastp_CBE
70.52
100%
-135
- C3 -
-
5J87
9.2
-
BTK_HUMAN
C:
[12-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
72
Blastp_CBE
70.38
99%
-136
- C3 -
-
6BLN
8.6
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
75
Blastp_CBE
70.21
99%
-136
- C3 -
-
6BKE
9.3
-
A:
[4-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
36
Blastp_CBE
69.88
99%
-131
- C3 -
-
3PIY
7.8
-
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
------
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
74
Blastp_CBE
69.59
99%
-134
- C3 -
-
6BKH
9.0
-
A:
[5-266]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
48
Blastp_CBE
69.34
100%
-145
- C3 -
-
5FBN
11.3
-
D:
[6-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
----------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
121
HHSearch
69.10
100%
-142
- C3 -
-
5P9J
8.7
-
A:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
---
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
17
PsiBlast_PDB
68.92
99%
-142
- C3 -
-
5P9J
8.7
-
A:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
T
---
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
33
Blastp_CBE
67.90
99%
-154
- C3 -
-
3PJ2
7.7
-
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
42
Blastp_CBE
67.67
100%
-146
- C3 -
-
6DI3
7.5
-
A:
[5-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
---------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
47
Blastp_CBE
66.96
100%
-155
- C3 -
-
5FBO
10.7
-
A:
[4-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
--------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
49
Blastp_CBE
66.84
100%
-146
- C3 -
-
5FBN
11.3
-
BTK_HUMAN
C:
[7-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
--------
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
40
Blastp_CBE
66.71
100%
-152
- C3 -
-
6DI9
5.4
-
A:
[4-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
------
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
19
PsiBlast_PDB
66.40
99%
-152
- C3 -
-
5P9L
5.8
-
A:
[12-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
----
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
30
Blastp_CBE
66.28
99%
-154
- C3 -
-
6MNY
7.4
-
?
A:
[12-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
R
E
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
K
I
L
L
S
N
I
L
D
V
M
D
---
35
Blastp_CBE
66.20
99%
-148
- C3 -
-
3PIZ
7.0
-
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
-----
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
70
Blastp_CBE
66.09
99%
-156
- C3 -
-
3OCT
8.9
-
A:
[3-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
--
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
---
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
--------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
---
32
Blastp_CBE
65.72
99%
-151
- C3 -
-
3PJ3
10.8
-
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
-------
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
-------------------
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
34
Blastp_CBE
65.64
99%
-156
- C3 -
-
3PJ1
7.6
-
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
-----
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
--
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
67
Blastp_CBE
65.57
99%
-158
- C3 -
-
5BPY
7.6
-
B:
[3-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
-
G
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
--
81
Blastp_CBE
65.40
68%
-132
- C3 -
-
3SXS
7.3
-
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
G
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
--------
52
Blastp_CBE
65.05
100%
-154
- C3 -
-
6NFI
7.2
-
?
A:
[1-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
----
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
---
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
----------------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
S
25
Blastp_CBE
64.62
99%
-150
- C3 -
-
3K54
7.4
-
A:
[16-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
-------
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
D
E
E
-
82
Blastp_CBE
64.22
68%
-131
- C3 -
-
3SXR
8.0
-
B:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
E
L
------
V
V
K
L
G
K
W
K
G
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
--------
83
Blastp_CBE
63.91
68%
-127
- C3 -
-
3SXR
8.1
-
BMX_HUMAN
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
M
E
L
K
R
E
E
I
T
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
K
G
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
Y
P
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
S
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
Q
Y
V
S
S
V
G
T
K
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
--------
65
Blastp_CBE
63.77
99%
-154
- C3 -
-
5JRS
9.0
-
B:
[3-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
I
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
G
Q
Y
D
V
A
I
K
M
I
K
--
S
M
S
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
----
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
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L
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L
A
A
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N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-----------
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
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T
A
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H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
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I
M
Y
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C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
----