@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : DYRK2_HUMAN: (2019-05-19 )
MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNAAAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
Atome Classification :
(11 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLTRKPSAAAPAAYPTGRG
G
D
S
A
V
R
Q
L
QASPGLGAGATRSGVGTGPPSPIALPPLRASNAAA
A
A
HTIGGSKHTMNDHLHVGSHAH
G
Q
I
Q
V
Q
Q
L
F
EDNSN
K
R
T
V
L
TTQPNG
L
T
TVGKTGLPVV
P
E
R
Q
L
D
S
I
H
R
RQGSSTS
L
K
S
M
EGMGKVKATPM
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
HHEIFSYP
E
I
Y
F
L
GLNAKKRQGMTGGPNNGGYDDDQG
S
Y
V
QVP
H
D
H
V
A
Y
R
Y
E
V
L
K
V
IGKGS
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
KQDKDN
T
M
N
V
I
H
M
L
E
NFTFRN
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
KNKFQGFS
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
HKN
R
I
I
H
C
DLKPE
N
I
L
L
KQQGRSG
I
K
V
I
DFGS
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
FYRA
P
E
V
I
L
GARYGMP
I
D
M
W
S
L
G
C
I
L
A
E
L
LTGYPLLPGEDEG
D
Q
L
A
C
M
I
E
L
LGM
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
SSKGYP
R
Y
C
T
V
T
TLSD
G
S
V
V
L
NGGRSRRGKLRGPPE
S
R
E
W
G
N
ALKGCD
D
P
L
F
L
D
F
L
K
Q
C
LEWDPAVRMTP
G
Q
A
L
R
H
P
W
L
R
RRLPKPPTGEK
T
S
V
K
R
I
T
ESTGAITSISKLPPPSS
S
A
S
K
L
R
T
N
L
A
Q
MTDANGNI
Q
Q
RTVL
P
K
LVS
5
PsiBlast_PDB
97.08
98%
-109
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[20-413]
----------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
2
PsiBlast_PDB
96.50
99%
-106
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[9-394]
--------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
23
HHSearch
96.15
100%
-106
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[9-394]
--------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
21
Blastp_CBE
96.00
99%
-106
- C1 -
-
5LXD
6
DYRK2_HUMAN
B:
[9-394]
--------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
4
PsiBlast_PDB
95.98
98%
-109
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[20-413]
----------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
22
Blastp_CBE
95.81
99%
-106
- C1 -
-
5LXC
5
DYRK2_HUMAN
B:
[9-394]
--------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
R
R
---------------------------------------------------------------
1
PsiBlast_PDB
95.29
99%
-107
- C1 -
-
5LXC
10
DYRK2_HUMAN
A:
[9-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
G
S
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
24
HHSearch
95.07
100%
-109
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[29-413]
-------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
T
L
S
D
--
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
3
PsiBlast_PDB
95.04
98%
-106
- C1 -
-
5ZTN
1
DYRK2_HUMAN
A:
[20-413]
----------------------------------------------------------------------------------------------------------------------------------------------
F
Q
S
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
H
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
V
S
S
K
G
Y
P
R
Y
C
T
V
T
-------
V
L
N
G
G
R
S
R
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
K
G
C
D
D
P
L
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------
25
HHSearch
90.69
75%
-101
- C1 -
-
5Y86
10
DYRK3_HUMAN
A:
[138-527]
------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
P
L
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
I
N
Y
P
E
I
Y
F
V
G
P
N
A
K
K
R
H
G
V
I
G
G
P
N
N
G
G
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
K
L
R
Q
Y
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
I
H
M
L
E
S
F
T
F
R
N
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
L
K
H
H
G
R
S
S
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
L
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
I
P
R
Y
C
S
V
T
T
Q
A
D
G
R
V
V
L
V
G
G
R
S
R
R
G
K
K
R
G
P
P
G
S
K
D
W
G
T
A
L
K
G
C
D
D
Y
L
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
V
P
-------------------------------------------------------------
6
PsiBlast_PDB
88.89
61%
-101
- C1 -
-
5Y86
10
DYRK3_HUMAN
A:
[138-532]
------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
P
L
T
P
E
Q
A
L
K
Q
Y
K
H
H
L
T
A
Y
E
K
L
E
I
I
N
Y
P
E
I
Y
F
V
G
P
N
A
K
K
R
H
G
V
I
G
G
P
N
N
G
G
Y
D
D
A
D
G
A
Y
I
H
V
P
R
D
H
L
A
Y
R
Y
E
V
L
K
I
I
G
K
G
S
F
G
Q
V
A
R
V
Y
D
H
K
L
R
Q
Y
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
K
K
Q
D
K
T
G
S
M
N
V
I
H
M
L
E
S
F
T
F
R
N
H
V
C
M
A
F
E
L
L
S
I
D
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
V
Q
L
V
R
K
F
A
Q
S
I
L
Q
S
L
D
A
L
H
K
N
K
I
I
H
C
D
L
K
P
E
N
I
L
L
K
H
H
G
R
S
S
T
K
V
I
D
F
G
S
S
C
F
E
Y
Q
K
L
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
G
S
R
Y
S
T
P
I
D
I
W
S
F
G
C
I
L
A
E
L
L
T
G
Q
P
L
F
P
G
E
D
E
G
D
Q
L
A
C
M
M
E
L
L
G
M
P
P
P
K
L
L
E
Q
S
K
R
A
K
Y
F
I
N
S
K
G
I
P
R
Y
C
S
V
T
T
Q
A
D
G
R
V
V
L
V
G
G
R
S
R
R
G
K
K
R
G
P
P
G
S
K
D
W
G
T
A
L
K
G
C
D
D
Y
L
F
I
E
F
L
K
R
C
L
H
W
D
P
S
A
R
L
T
P
A
Q
A
L
R
H
P
W
I
S
K
S
V
P
R
P
L
T
T
--------------------------------------------------------