@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK1_HUMAN: (2019-05-25 )
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILPGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSNNGLDIQDKPPAPPMRNT
S
T
M
IGAGSKDAGTLNHGSKPLPPN
P
E
E
K
K
K
K
D
R
F
Y
R
S
ILPGDKTNK
K
K
EKERPEISLPSDFE
H
T
I
H
V
GFDAVTGEFTG
M
P
E
Q
W
A
R
L
L
Q
TSNIT
K
S
E
QKK
N
P
Q
A
V
L
D
V
L
E
F
YNSKKTSNSQ
K
Y
M
SFTDKSAEDYNSSN
A
L
N
V
K
AVSETPAVPPVSEDEDDDDDDATPPPVIAPRPE
H
T
K
S
V
Y
T
R
SVIEPLPVTPTRDVATSPISPTENNTTP
P
D
A
LTRN
T
E
K
Q
KKKPKM
S
D
E
E
I
L
E
K
L
R
S
I
V
SVGD
P
K
K
K
Y
T
R
F
E
K
IGQGASG
T
V
Y
T
A
M
DVATGQ
E
V
A
I
K
Q
MNLQQQ
P
K
K
E
L
I
I
N
E
I
L
V
M
RENKNP
N
I
V
N
Y
L
D
S
Y
LV
G
D
E
L
W
V
V
M
E
Y
LAGG
S
L
T
D
V
V
T
E
T
CMDE
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
HSN
Q
V
I
H
R
DIKSD
N
I
L
L
GMDG
S
V
K
L
TDF
G
F
C
AQITPEQSKRSTMVGTPYWM
A
P
E
V
V
TRKAYGPKV
D
I
W
S
L
G
I
M
A
I
E
MIEGEPPYLNENP
L
R
A
L
Y
L
I
ATNGTPELQ
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
KRG
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
ATKNNH
16
PsiBlast_PDB
95.31
99%
-120
- C1 -
-
5DEY
1
PAK1_HUMAN
A:
[2-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
-
17
PsiBlast_PDB
94.73
99%
-116
- C1 -
-
5DEW
1
PAK1_HUMAN
A:
[2-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
-
12
PsiBlast_PDB
94.49
99%
-111
- C1 -
-
3FXZ
1
?
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
40
Blastp_CBE
94.14
99%
-116
- C1 -
-
5KBQ
1
PAK1_HUMAN
A:
[1-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
19
PsiBlast_PDB
94.06
99%
-110
- C1 -
-
4O0R
1
PAK1_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
15
PsiBlast_PDB
94.01
99%
-108
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
30
Blastp_CBE
93.76
99%
-113
- C1 -
-
4ZY4
2
PAK1_HUMAN
B:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
9
PsiBlast_PDB
92.97
98%
-107
- C1 -
-
4EQC
1
PAK1_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
T
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
43
HHSearch
92.86
99%
-115
- C1 -
-
5KBQ
1
PAK1_HUMAN
A:
[3-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
20
PsiBlast_PDB
92.09
99%
-103
- C1 -
-
4O0T
1
PAK1_HUMAN
A:
[3-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
13
PsiBlast_PDB
91.86
99%
-107
- C1 -
-
3FY0
1
PAK1_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
29
Blastp_CBE
91.73
99%
-115
- C1 -
-
4ZY5
2
PAK1_HUMAN
B:
[8-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
41
Blastp_CBE
91.65
95%
-101
- C1 -
-
6FD3
3
PAK3_HUMAN
A:
[2-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
L
D
I
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
D
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
V
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
R
L
S
A
V
F
R
D
F
L
N
R
C
L
E
M
D
V
D
R
R
G
S
A
K
E
L
L
Q
H
P
F
L
K
L
D
K
P
L
S
S
L
T
P
L
I
I
A
A
K
E
A
I
K
N
--
18
PsiBlast_PDB
91.16
98%
-118
- C1 -
-
3Q4Z
1
PAK1_HUMAN
A:
[4-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
D
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
36
Blastp_CBE
91.00
99%
-120
- C1 -
-
5IME
1
PAK1_HUMAN
A:
[3-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
-------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
K
Q
M
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
44
HHSearch
90.75
95%
-102
- C1 -
-
6FD3
3
PAK3_HUMAN
A:
[2-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
L
D
I
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
D
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
V
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
R
L
S
A
V
F
R
D
F
L
N
R
C
L
E
M
D
V
D
R
R
G
S
A
K
E
L
L
Q
H
P
F
L
K
L
D
K
P
L
S
S
L
T
P
L
I
I
A
A
K
-------
27
Blastp_CBE
90.58
99%
-114
- C1 -
-
6B16
1
PAK1_HUMAN
B:
[8-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
33
Blastp_CBE
90.28
99%
-112
- C1 -
-
5DEW
1
PAK1_HUMAN
B:
[7-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-------
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
1
PsiBlast_PDB
89.76
100%
-121
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[8-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
8
PsiBlast_PDB
89.71
99%
-118
- C1 -
-
4ZLO
2
PAK1_HUMAN
A:
[2-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
---------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
--
32
Blastp_CBE
89.66
99%
-108
- C1 -
-
5DEY
1
PAK1_HUMAN
B:
[7-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-------
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
28
Blastp_CBE
89.43
99%
-113
- C1 -
-
4ZY6
1
PAK1_HUMAN
B:
[8-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
--------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
35
Blastp_CBE
89.07
99%
-106
- C1 -
-
5IME
1
?
B:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
----
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
--------
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
26
Blastp_CBE
89.04
100%
-123
- C1 -
-
4ZJI
1
PAK1_HUMAN
B:
[8-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-----
2
PsiBlast_PDB
88.89
100%
-121
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[3-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
------
23
Blastp_CBE
87.87
100%
-124
- C1 -
-
4ZJJ
1
PAK1_HUMAN
B:
[5-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
------
25
Blastp_CBE
85.40
100%
-108
- C1 -
-
4ZJI
1
?
C:
[4-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
-----
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
24
Blastp_CBE
85.06
100%
-107
- C1 -
-
4ZJI
1
?
D:
[7-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
37
Blastp_CBE
84.44
99%
-122
- C1 -
-
4P90
1
PAK1_HUMAN
B:
[9-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---------
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
-----------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
39
Blastp_CBE
84.14
99%
-119
- C1 -
-
5KBR
1
PAK1_HUMAN
A:
[2-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
-------
E
V
A
I
K
Q
---------
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
------
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-------
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
21
Blastp_CBE
83.49
100%
-123
- C1 -
-
4ZJJ
1
PAK1_HUMAN
D:
[6-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
K
L
R
S
I
V
S
V
---
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
N
L
---
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
--
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
----
38
Blastp_CBE
82.14
99%
-115
- C1 -
-
5KBR
1
PAK1_HUMAN
B:
[2-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
-----
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------------
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
-----------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---
22
Blastp_CBE
81.99
100%
-113
- C1 -
-
4ZJJ
1
PAK1_HUMAN
C:
[5-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
---
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
---