@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDK13_HUMAN: (2019-04-27 )
MPSSSDTALGGGGGLSWAEKKLEERRKRRRFLSPQQPPLLLPLLQPQLLQPPPPPPPLLFLAAPGTAAAAAAAAAASSSCFSPGPPLEVKRLARGKRRAGGRQKRRRGPRAGQEAEKRRVFSLPQPQQDGGGGASSGGGVTPLVEYEDVSSQSEQGLLLGGASAATAATAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLSRSRSRHSSISPSTLTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTETSASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAVIVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEADSLRGNISVKAVKKEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTDDVSTIKAPRKDLSLGLDDSRTNTPQGVLPSSQLKSQGSSNVAPVKTGPGQHLNHSELAILLNLLQSKTSVNMADFVQVLNIKVNSETQQQLNKINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVETDAAQAAVQSAFAVLLTQLIKAQQSKQKDVLLEERENGSGHEASLQLRPPPEPSTPVSGQDDLIQHQDMRILELTPEPDRPRILPPDQRPPEPPEPPPVTEEDLDYRTENQHVPTTSSSLTDPHAGVKAALLQLLAQHQPQDDPKREGGIDYQAGDTYVSTSDYKDNFGSSSFSSAPYVSNDGLGSSSAPPLERRSFIGNSDIQSLDNYSTASSHSGGPPQPSAFSESFPSSVAGYGDIYLNAGPMLFSGDKDHRFEYSHGPIAVLANSSDPSTGPESTHPLPAKMHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY
Atome Classification :
(9 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MPSSSDTALGGGGG
L
S
W
A
E
K
K
L
E
E
R
R
K
R
R
RFLSPQQP
P
L
L
L
PLL
Q
P
Q
LLQPPPPPP
P
L
L
F
L
AAPG
T
A
A
A
A
A
A
A
AAASSSCFSPGP
P
L
E
V
K
R
L
ARGKRRAGG
R
Q
K
RRRGPRAG
Q
E
A
E
K
RRVFSLPQPQQDGGGGASSGGGV
T
P
L
V
E
YEDVSSQSEQ
G
L
L
LGGASAA
T
A
A
TAAGGTGGSGGSPASSSGTQRRGEGSERRPRRDRRSSSGR
S
K
E
R
H
R
E
H
R
RRDGQRGGS
E
A
S
KSRSRHSHS
G
E
E
R
A
E
V
A
KSGSSSSSGGRRKSASATSSSSSSRKDR
D
S
K
A
H
RSRTKSSKEP
P
S
AYKEP
P
K
A
Y
REDKTE
P
K
A
Y
R
R
RRSLSPLGGRDDSP
V
S
H
R
A
S
Q
S
L
R
SRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPY
S
P
V
L
R
RSGKSRSRSPYS
S
R
H
S
R
S
R
S
R
H
R
L
S
R
SRSRHSSISPS
T
L
T
L
K
S
S
L
A
A
E
LNKNK
K
A
R
A
A
E
A
A
R
A
A
E
A
A
K
A
A
E
A
T
K
A
A
E
A
A
A
K
AAKASNTSTPTKGNTETSASASQTN
H
V
K
D
V
K
K
I
K
I
E
HAPSPSSGGTLKNDKAKTKPP
L
Q
V
T
KVEN
N
L
I
V
DKAT
K
K
A
V
I
V
GKESKSAATKEESVSLKEKTKPLTPSIGAK
E
K
E
Q
H
V
A
L
VTSTLPPLPLPPMLPEDKE
A
D
SLRGNI
S
V
K
A
V
K
K
E
V
E
K
K
L
R
C
L
L
ADLPLPPELPGGDDLSKS
P
E
E
K
K
T
A
T
Q
L
HSKRRPKICGPRYGETKE
K
D
I
D
W
G
K
R
C
V
D
KF
D
I
I
G
I
IGEGTYG
Q
V
Y
KARDKDTG
E
M
V
A
L
K
K
V
RLDNEKEGFP
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
IVTD
K
E
D
ALDFKKDK
G
A
F
Y
L
V
F
E
YM
D
H
D
L
M
G
L
L
E
S
G
L
V
HF
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
KKNFLHRDIKCS
N
I
L
LNNRG
Q
I
K
L
A
D
F
G
L
A
R
L
YSSEESRPYTN
K
V
I
T
L
W
YR
P
P
E
L
LLGEERYT
P
A
IDV
W
S
C
G
C
I
L
G
E
L
FTKKP
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
CGSPCPAV
W
P
D
V
IKLPYFNTM
K
P
K
K
Q
Y
R
R
K
L
R
EE
F
V
FI
P
A
A
A
L
D
L
F
D
Y
M
L
ALDPSKRC
T
A
E
Q
A
L
Q
C
E
F
L
RDVEPSKMPPPDL
P
L
W
Q
D
C
H
E
L
W
S
K
K
R
R
R
Q
K
QMGMTDD
V
S
T
IKAPR
K
D
LSLGLDDSRTNTPQGVL
P
S
S
Q
L
KSQGSSNVAPVKTGPGQHL
N
H
S
E
L
A
I
L
L
N
L
L
Q
S
KTSV
N
M
A
D
F
V
Q
V
L
N
I
K
VN
S
E
T
Q
Q
Q
L
N
KINLPAGILATGEKQTDPSTPQQESSKPLGGIQPSSQTIQPKVE
T
D
A
A
Q
A
A
V
Q
S
A
F
A
V
L
L
T
Q
L
I
K
A
Q
QSKQKD
V
L
L
E
ERENGSGHE
A
S
L
Q
LRPPPEPSTPVSG
Q
D
D
L
I
Q
HQD
M
R
I
L
E
LTPEPDRPRILPPDQRPPEPPEPPPV
T
E
E
DLDYRTENQHVPTTSSSLTDPH
A
G
V
K
A
A
L
L
Q
L
L
A
QHQPQDDPKREGGIDYQAGD
T
Y
V
STSDYKDNFGSSSFSSAPYVSNDGLGSSSAPP
L
E
R
R
SFIGN
S
D
I
Q
S
LDNYSTASSHSGGPPQP
S
A
F
S
E
SFPSSVAGY
G
D
I
Y
LNAG
P
M
L
FSGDKD
H
R
F
EYSHG
P
I
A
V
L
ANSSDPSTGPESTHPLP
A
K
MHNYNYGGNLQENPSGPSLMHGQTWTSPAQGPGYSQGYRGHISTSTGRGRGRGLPY
21
Blastp_CBE
89.58
99%
-113
- C1 -
-
5EFQ
6.5
-
C:
[5-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
T
D
K
E
---------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
K
L
R
E
E
F
V
F
I
P
A
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
V
E
P
S
K
M
P
P
P
D
L
P
L
W
Q
D
C
H
E
L
W
S
K
K
R
R
R
Q
K
Q
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.71
91%
-113
* C1 *
-
4CXA
6.5
-
CDK12_HUMAN
A:
[6-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
--
L
D
F
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
-
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
R
R
R
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.24
99%
-116
- C1 -
-
5EFQ
6.4
-
CDK13_HUMAN
A:
[3-333]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
T
D
K
E
---------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
N
E
N
H
I
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
R
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
Q
E
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
K
L
R
E
E
F
V
F
I
P
A
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
R
C
T
A
E
Q
A
L
Q
C
E
F
L
R
D
V
E
P
S
K
M
P
P
P
D
L
P
L
W
Q
D
C
H
E
L
W
S
K
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.97
91%
-118
- C1 -
-
5ACB
8.2
-
CDK12_HUMAN
C:
[6-328]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
D
A
L
D
F
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
80.78
91%
-119
- C1 -
-
5ACB
6.8
-
D:
[6-332]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
----
F
K
K
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
---
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.94
90%
-112
- C1 -
-
4NST
6.2
-
CDK12_HUMAN
A:
[6-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
D
K
Q
D
--------
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
Q
D
C
H
E
L
W
S
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.23
90%
-119
- C1 -
-
6B3E
8.6
-
CDK12_HUMAN
A:
[2-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
----------
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
75.98
91%
-124
- C1 -
-
6B3E
9.1
-
C:
[3-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
----------
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
L
S
K
M
A
P
P
D
L
P
H
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.05
90%
-135
- C1 -
-
6CKX
7.8
-
CDK12_HUMAN
A:
[10-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T
----------
D
K
G
A
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
L
V
H
F
S
E
D
H
I
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
S
G
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
R
P
Y
T
N
K
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
K
P
I
F
Q
A
N
L
E
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
P
Y
F
N
T
M
K
P
K
K
Q
Y
R
R
R
L
R
E
E
F
S
F
I
P
S
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
R
C
T
A
E
Q
T
L
Q
S
D
F
L
K
D
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------