@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CHK1_HUMAN: (2019-04-28 )
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Atome Classification :
(103 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MAVPFVE
D
W
D
L
V
Q
T
L
GEGAY
G
E
V
Q
L
A
V
N
R
VTEE
A
V
A
V
K
I
V
D
M
K
R
AVDC
P
E
N
I
K
K
E
I
C
I
N
K
ML
N
H
E
N
V
V
K
F
YGHRREG
N
I
Q
Y
L
F
L
E
YCSGG
E
L
F
D
RIEPDIGMPEP
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
HGIGITHRDIKPENLLLDERDN
L
K
ISDF
G
L
A
T
V
F
RYN
N
R
E
R
L
L
N
K
M
CGTL
P
Y
V
A
P
E
L
L
K
R
R
EFHAEP
V
D
V
W
S
C
G
I
V
L
T
A
M
L
AGELPWDQPS
D
S
C
Q
E
Y
S
D
W
K
E
K
K
TYL
N
P
W
K
KIDS
A
P
L
A
L
L
H
K
I
L
VENPS
A
R
I
TIPDIKKDRWYNK
P
L
KKGAKRPRVTSGGVSESP
S
G
F
S
K
H
I
Q
SNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDT
S
P
S
Y
I
D
K
L
V
QGISFSQPTCPDH
M
L
LNSQLLGTPGSSQ
N
P
W
Q
R
L
V
K
R
M
T
R
F
F
T
KLDAD
K
S
Y
Q
C
L
K
E
T
C
E
K
L
G
Y
Q
W
K
K
S
CMN
Q
V
T
I
S
TTDRRN
N
K
L
I
F
K
V
N
L
LEMD
D
K
I
L
V
D
F
R
LSKGD
G
L
E
F
K
R
H
F
L
K
IK
G
K
L
I
D
I
VSS
Q
K
I
WLPAT
58
Blastp_CBE
90.30
97%
-114
- C2 -
-
5OQ5
5.7
-
CHK1_HUMAN
A:
[3-270]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.68
100%
-99
- C2 -
-
3TKI
7.5
-
CHK1_HUMAN
A:
[2-280]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
84.83
100%
-101
- C2 -
-
4FSR
8.1
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
84.05
100%
-103
- C2 -
-
2AYP
7.3
-
CHK1_HUMAN
A:
[2-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
83.73
97%
-107
- C2 -
-
5OP7
5.0
-
CHK1_HUMAN
A:
[4-270]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
83.07
100%
-102
- C2 -
-
6FC8
6.6
-
CHK1_HUMAN
A:
[2-270]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
82.89
100%
-104
- C2 -
-
2E9V
7.4
-
CHK1_HUMAN
B:
[1-268]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
82.87
97%
-108
- C2 -
-
5OOT
4.9
-
CHK1_HUMAN
A:
[4-270]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
82.80
100%
-100
- C2 -
-
6FCK
6.9
-
CHK1_HUMAN
A:
[2-270]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
82.76
96%
-110
- C2 -
-
5OQ6
5.0
-
CHK1_HUMAN
A:
[5-270]
----
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
S
F
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
82.67
97%
-106
- C2 -
-
5OPV
6.8
-
CHK1_HUMAN
A:
[3-270]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.21
100%
-98
- C2 -
-
2QHN
5.0
-
CHK1_HUMAN
A:
[2-280]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
82.06
99%
-96
- C2 -
-
4QYE
7.0
-
CHK1_HUMAN
A:
[3-280]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
81.83
100%
-104
- C2 -
-
4FTL
9.7
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.82
100%
-99
- C2 -
-
3TKH
5.9
-
CHK1_HUMAN
A:
[2-280]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
81.66
100%
-93
- C2 -
-
2X8D
4.9
-
CHK1_HUMAN
A:
[2-280]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.08
100%
-95
- C2 -
-
2HY0
8.5
-
CHK1_HUMAN
A:
[1-279]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
81.01
100%
-100
- C2 -
-
4FTJ
6.7
-
CHK1_HUMAN
A:
[2-278]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
80.93
100%
-102
- C2 -
-
4FTM
8.3
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
80.80
100%
-104
- C2 -
-
2X8E
5.9
-
CHK1_HUMAN
A:
[9-270]
--------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
80.78
100%
-102
- C2 -
-
2E9V
6.9
-
CHK1_HUMAN
A:
[1-268]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
80.77
97%
-105
- C2 -
-
5OP4
4.3
-
CHK1_HUMAN
A:
[3-270]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
80.73
100%
-105
- C2 -
-
2XEY
6.2
-
CHK1_HUMAN
A:
[6-269]
-----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
80.59
97%
-105
- C2 -
-
5OPS
5.0
-
CHK1_HUMAN
A:
[3-270]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.53
100%
-96
- C2 -
-
2HXL
6.6
-
CHK1_HUMAN
A:
[1-275]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
80.45
96%
-106
- C2 -
-
5OQ8
4.7
-
CHK1_HUMAN
A:
[4-270]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
S
F
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
80.44
97%
-105
- C2 -
-
5OP2
4.7
-
CHK1_HUMAN
A:
[4-271]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
C
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.40
98%
-97
- C2 -
-
2BRO
6.7
-
CHK1_HUMAN
A:
[2-276]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
80.22
99%
-100
- C2 -
-
4RVM
7.4
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
80.04
100%
-97
- C2 -
-
4FTI
8.4
-
CHK1_HUMAN
A:
[2-278]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
80.03
99%
-96
- C2 -
-
4QYF
5.9
-
CHK1_HUMAN
A:
[3-280]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
--
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
79.73
100%
-102
- C2 -
-
4FTK
8.5
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
79.64
100%
-99
- C2 -
-
4FSQ
9.2
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.58
100%
-94
- C2 -
-
2R0U
7.6
-
CHK1_HUMAN
A:
[2-280]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
79.56
100%
-96
- C2 -
-
2E9U
6.8
-
CHK1_HUMAN
A:
[1-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
79.52
98%
-95
- C2 -
-
2BRB
6.6
-
CHK1_HUMAN
A:
[2-276]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.34
100%
-95
- C2 -
-
2QHM
5.2
-
CHK1_HUMAN
A:
[2-280]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
79.31
97%
-102
- C2 -
-
5OOP
4.3
-
CHK1_HUMAN
A:
[5-271]
----
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
------
D
C
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
79.24
100%
-97
- C2 -
-
1NVQ
9.2
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
79.12
99%
-93
- C2 -
-
4FSN
8.1
-
CHK1_HUMAN
A:
[1-278]
--
A
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
79.12
100%
-91
- C2 -
-
2YDI
4.9
-
CHK1_HUMAN
A:
[2-280]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
79.00
99%
-97
- C2 -
-
4FSY
7.3
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
78.96
100%
-97
- C2 -
-
4FT0
7.6
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
----
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
78.90
100%
-97
- C2 -
-
4FSM
7.4
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
78.89
100%
-96
- C2 -
-
4FT9
5.9
-
CHK1_HUMAN
A:
[1-279]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
78.85
99%
-99
- C2 -
-
4RVK
7.3
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
78.67
97%
-105
- C2 -
-
5OPR
6.3
-
CHK1_HUMAN
A:
[4-270]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.36
100%
-94
- C2 -
-
2HOG
7.9
-
CHK1_HUMAN
A:
[1-279]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
78.35
100%
-99
- C2 -
-
3OT3
7.7
-
CHK1_HUMAN
A:
[4-270]
----
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
78.35
100%
-96
- C2 -
-
4FTT
7.1
-
CHK1_HUMAN
A:
[2-279]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
77.96
99%
-96
- C2 -
-
4QYG
7.0
-
CHK1_HUMAN
B:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
77.79
99%
-90
- C2 -
-
1ZLT
5.7
-
CHK1_HUMAN
A:
[2-276]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
77.74
100%
-97
- C2 -
-
2E9N
8.2
-
CHK1_HUMAN
A:
[1-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
77.69
100%
-110
- C2 -
-
2WMU
4.3
-
CHK1_HUMAN
A:
[9-270]
--------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
77.63
100%
-102
* C2 *
-
5F4N
6.6
-
CHK1_HUMAN
A:
[5-271]
----
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
77.56
98%
-100
- C2 -
-
2C3L
4.7
-
CHK1_HUMAN
A:
[2-273]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
77.55
97%
-104
- C2 -
-
5OQ7
4.6
-
CHK1_HUMAN
B:
[8-270]
-------
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
C
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.54
98%
-97
- C2 -
-
2BRN
6.2
-
CHK1_HUMAN
A:
[6-276]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.38
98%
-95
- C2 -
-
2BR1
6.7
-
CHK1_HUMAN
A:
[2-276]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
77.19
99%
-98
- C2 -
-
2CGU
5.6
-
CHK1_HUMAN
A:
[6-271]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
76.78
99%
-101
- C2 -
-
4RVL
6.7
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
76.67
97%
-102
- C2 -
-
5OQ7
4.2
-
CHK1_HUMAN
A:
[8-271]
-------
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
C
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
76.57
99%
-95
- C2 -
-
4QYH
6.9
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
75.86
98%
-100
- C2 -
-
2C3J
4.9
-
CHK1_HUMAN
A:
[6-270]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-----
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
75.82
99%
-96
- C2 -
-
4FSU
8.3
-
CHK1_HUMAN
A:
[3-270]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
A
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
75.74
97%
-100
- C2 -
-
5OPB
5.7
-
CHK1_HUMAN
A:
[5-271]
----
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
C
P
E
N
I
K
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
D
E
R
D
N
L
K
I
A
D
Y
S
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
75.67
99%
-91
- C2 -
-
1ZYS
7.8
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
A
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
75.43
100%
-95
- C2 -
-
2GHG
8.1
-
CHK1_HUMAN
A:
[1-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.39
100%
-89
- C2 -
-
2HXQ
6.7
-
CHK1_HUMAN
A:
[1-275]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
75.13
100%
-93
- C2 -
-
2YWP
5.7
-
CHK1_HUMAN
A:
[1-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
74.83
99%
-95
- C2 -
-
4QYH
6.8
-
CHK1_HUMAN
B:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
74.66
100%
-93
- C2 -
-
1NVR
8.9
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
74.53
100%
-94
- C2 -
-
4HYH
8.3
-
CHK1_HUMAN
A:
[4-272]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
74.52
99%
-93
- C2 -
-
4QYG
7.1
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
74.43
99%
-97
- C2 -
-
3NLB
6.9
-
CHK1_HUMAN
A:
[6-271]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-----
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
74.38
100%
-93
- C2 -
-
1NVS
7.1
-
CHK1_HUMAN
A:
[3-273]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
74.16
100%
-90
- C2 -
-
2YER
6.3
-
CHK1_HUMAN
A:
[2-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
74.00
100%
-96
- C2 -
-
2X8I
6.2
-
CHK1_HUMAN
A:
[2-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
73.93
100%
-107
- C2 -
-
2WMS
4.1
-
CHK1_HUMAN
A:
[7-270]
------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
-----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.78
98%
-96
- C2 -
-
2BRH
5.9
-
CHK1_HUMAN
A:
[6-271]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
73.76
99%
-95
- C2 -
-
2CGX
3.8
-
CHK1_HUMAN
A:
[6-273]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.53
98%
-95
- C2 -
-
2C3K
8.6
-
CHK1_HUMAN
A:
[6-270]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
73.47
99%
-92
- C2 -
-
2GDO
7.5
-
CHK1_HUMAN
A:
[1-273]
M
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
----
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
73.26
100%
-100
- C2 -
-
4FTO
6.8
-
CHK1_HUMAN
A:
[2-270]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
73.26
100%
-88
- C2 -
-
4HYI
8.0
-
CHK1_HUMAN
A:
[3-274]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
----
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
72.67
100%
-97
- C2 -
-
4FTR
8.0
-
CHK1_HUMAN
A:
[2-270]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
72.67
100%
-103
- C2 -
-
2YM8
7.3
-
CHK1_HUMAN
A:
[8-270]
-------
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.64
98%
-95
- C2 -
-
2BRG
5.4
-
CHK1_HUMAN
A:
[7-269]
------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
72.58
100%
-102
- C2 -
-
2YM6
5.1
-
CHK1_HUMAN
A:
[7-270]
------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
72.51
100%
-89
- C2 -
-
2YEX
6.3
-
CHK1_HUMAN
A:
[2-270]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
72.43
100%
-98
- C2 -
-
4JIK
7.3
-
CHK1_HUMAN
A:
[3-271]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
71.98
99%
-94
- C2 -
-
2CGW
4.6
-
CHK1_HUMAN
A:
[6-271]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
----
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
71.90
100%
-91
- C2 -
-
2E9P
6.1
-
CHK1_HUMAN
A:
[1-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
71.77
100%
-103
- C2 -
-
2YM7
5.3
-
CHK1_HUMAN
A:
[7-271]
------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
71.61
99%
-93
- C2 -
-
2CGV
5.1
-
CHK1_HUMAN
A:
[6-272]
-----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
71.36
100%
-100
- C2 -
-
2YM4
5.1
-
CHK1_HUMAN
A:
[4-270]
---
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
71.27
100%
-89
- C2 -
-
2E9O
7.5
-
CHK1_HUMAN
A:
[1-269]
-
A
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
D
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
70.81
100%
-101
- C2 -
-
2XF0
6.0
-
CHK1_HUMAN
A:
[4-270]
---
P
F
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
70.79
100%
-100
- C2 -
-
2YM3
4.7
-
CHK1_HUMAN
A:
[8-270]
-------
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
69.92
100%
-87
- C2 -
-
2YDK
5.8
-
CHK1_HUMAN
A:
[3-270]
--
V
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-----
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
69.04
100%
-102
- C2 -
-
2WMQ
3.8
-
CHK1_HUMAN
A:
[7-269]
------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
--------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.02
98%
-91
- C2 -
-
2BRM
6.2
-
CHK1_HUMAN
A:
[7-274]
------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
C
P
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
68.07
100%
-91
- C2 -
-
3U9N
7.6
-
CHK1_HUMAN
A:
[6-270]
------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------
E
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------