@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CHK2_HUMAN: (2019-04-28 )
MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MSRE
S
D
V
E
A
Q
Q
SHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTL
S
S
L
E
TV
S
T
Q
E
L
YSIPEDQEPEDQEPEEPTP
A
P
W
A
R
L
W
A
L
QDGFAN
L
E
C
VNDNYWFGRDKS
C
E
Y
C
FD
E
P
L
L
K
R
T
D
K
YRT
Y
S
K
K
H
F
R
I
F
R
E
VGPKN
S
Y
I
A
Y
I
EDHSGN
G
T
F
V
N
T
E
L
VGKGKRRPLNNN
S
E
I
A
L
S
LSR
N
K
V
F
V
F
F
D
L
T
VDDQSV
Y
P
K
A
L
R
D
E
Y
I
M
S
KTLGSGACG
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
SKRKFAIGSAREADPALN
V
E
T
E
I
E
I
L
K
KLNH
P
C
I
I
K
I
K
NFFDAE
D
Y
Y
I
V
L
E
LMEG
G
E
L
F
D
K
V
VGN
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
ENG
I
I
HRDLKPE
N
V
L
LSSQEE
D
C
L
I
K
I
TDFGHSKIL
G
E
T
S
L
M
R
T
L
CGTPTYL
A
P
E
V
L
V
S
VGTAGYNR
A
V
D
C
W
S
L
G
V
I
L
F
I
CLSGYPPFSEH
R
T
Q
V
S
L
K
DQITSGKYN
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
VVDPKARF
T
T
E
E
A
LRHPWLQ
D
E
D
M
K
R
K
F
Q
D
L
L
SEENESTA
L
P
Q
V
LAQPSTSRKRPREGEAEGAETTKRPA
V
C
AAVL
28
Blastp_CBE
37.32
100%
-148
- C1 -
-
4BDD
4.6
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
24
Blastp_CBE
35.42
100%
-143
- C1 -
-
4BDH
3.7
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
25
Blastp_CBE
35.00
100%
-138
- C1 -
-
4BDG
3.8
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
7
PsiBlast_PDB
34.38
100%
-138
- C1 -
-
2YCQ
8.8
-
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
16
PsiBlast_PDB
34.32
100%
-137
- C1 -
-
4A9R
6.3
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
27
Blastp_CBE
33.98
100%
-143
- C1 -
-
4BDE
4.3
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
14
PsiBlast_PDB
33.13
100%
-138
- C1 -
-
2WTJ
5.1
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
6
PsiBlast_PDB
32.89
100%
-138
- C1 -
-
2YIT
8.1
-
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
30
Blastp_CBE
31.37
100%
-141
- C1 -
-
4BDB
4.2
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
26
Blastp_CBE
30.63
100%
-136
- C1 -
-
4BDF
4.8
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
20
PsiBlast_PDB
30.61
100%
-138
- C1 -
-
4BDA
4.7
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
13
PsiBlast_PDB
30.28
100%
-133
- C1 -
-
2WTI
6.9
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
29
Blastp_CBE
30.27
100%
-137
* C1 *
-
4BDC
5.5
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
4
PsiBlast_PDB
29.57
100%
-137
- C1 -
-
2YIQ
7.6
-
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
----------------
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
12
PsiBlast_PDB
29.13
100%
-135
- C1 -
-
2WTD
7.0
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
21
Blastp_CBE
28.52
100%
-135
- C1 -
-
4BDK
5.9
-
CHK2_HUMAN
A:
[9-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
22
Blastp_CBE
28.21
100%
-136
- C1 -
-
4BDJ
5.6
-
CHK2_HUMAN
A:
[9-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
------------------------------
19
PsiBlast_PDB
28.18
100%
-135
- C1 -
-
4A9U
6.5
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-----------
D
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
17
PsiBlast_PDB
27.61
100%
-134
- C1 -
-
4A9S
6.6
-
CHK2_HUMAN
A:
[9-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
31
Blastp_CBE
27.40
100%
-133
- C1 -
-
2YCF
8.3
-
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
23
Blastp_CBE
27.21
100%
-130
- C1 -
-
4BDI
4.7
-
CHK2_HUMAN
A:
[8-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
----------------------------
5
PsiBlast_PDB
26.67
100%
-134
- C1 -
-
2YIR
9.1
-
CHK2_HUMAN
A:
[2-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
----------------------------------
32
Blastp_CBE
26.24
99%
-136
- C1 -
-
2YCR
7.0
-
CHK2_HUMAN
A:
[3-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
---------------------------------
18
PsiBlast_PDB
26.11
100%
-130
- C1 -
-
4A9T
6.6
-
CHK2_HUMAN
A:
[8-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
15
PsiBlast_PDB
26.07
100%
-133
- C1 -
-
2XM9
7.9
-
CHK2_HUMAN
A:
[9-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
3
PsiBlast_PDB
25.74
100%
-136
- C1 -
-
2W0J
7.5
-
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-
T
A
L
P
Q
---------------------------------
9
PsiBlast_PDB
24.18
100%
-134
- C1 -
-
2CN5
6.2
-
CHK2_HUMAN
A:
[8-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
---------------------------------------
8
PsiBlast_PDB
22.56
100%
-134
- C1 -
-
2YCS
6.8
-
CHK2_HUMAN
A:
[2-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
---------------------------------
11
PsiBlast_PDB
22.54
100%
-131
- C1 -
-
2WTC
6.1
-
CHK2_HUMAN
A:
[9-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-------------------------------
10
PsiBlast_PDB
14.34
100%
-137
- C1 -
-
2CN8
5.2
-
CHK2_HUMAN
A:
[10-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
K
A
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
----------------------------------------