@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HASP_HUMAN: (2019-04-29 )
MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQSDDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSPTPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
Atome Classification :
(17 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAASLPGP
G
S
R
L
F
R
TYGAADGRRQRRPGR
E
A
AQWFP
P
Q
D
R
R
R
F
FNSSGSSDASIGDPSQSDDPDDPDDPDFPG
S
P
V
R
R
R
RRRPGGRVPKDRPS
L
T
VT
P
K
R
W
K
L
RARPS
L
T
V
T
P
R
RLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPD
L
S
VCGQPRDGDELG
I
S
A
S
L
F
S
S
L
ASPCPGSPTPRDS
V
I
SIG
T
S
A
C
L
V
A
A
S
AVPSGLHLPEVSLDRASLPCSQEEATGGAK
D
T
R
M
V
H
Q
T
R
A
S
L
R
S
V
L
F
G
L
M
NSGTPE
D
S
E
FRAD
G
K
N
M
R
E
S
C
C
KR
K
L
V
VGNGPEGPGLSSTGKRRATG
Q
D
S
C
Q
E
R
G
L
Q
E
A
V
R
R
E
H
Q
EASVPKGRIVP
R
G
I
D
R
L
E
R
T
R
S
S
R
K
S
K
H
Q
E
A
T
E
T
S
L
L
H
S
H
R
F
K
K
G
QKLGKDSFPTQDL
T
P
L
Q
N
V
C
F
W
TKTRASFS
F
H
K
K
K
I
V
T
D
V
S
E
V
C
S
I
Y
T
T
A
T
SL
S
G
S
L
L
S
E
CSNRPVMNRTSGAPSSWHSS
S
M
Y
L
LSPL
N
T
L
SISNKKAS
D
A
E
K
V
Y
G
E
CSQKGPV
P
F
S
HCL
P
T
E
K
L
Q
R
C
E
K
IGE
G
V
F
G
E
V
F
Q
T
I
ADHT
P
V
A
I
K
I
I
A
IEGPDLVNG
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
SGEVCNRTEG
F
I
GL
N
S
V
H
CVQGSYP
P
L
L
L
K
A
WDHYNSTKGSANDRPDFFKDD
Q
L
F
I
V
L
E
F
EFGGI
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
EHRDLHWG
N
V
L
L
KKTS
L
K
K
L
H
Y
T
LNGKSSTIPSCG
L
Q
V
S
I
I
D
Y
T
L
S
R
LERD
G
I
V
V
F
C
DVSMDEDLFTGDGDY
Q
F
D
I
Y
R
L
M
K
KENNNRWGEYHPYS
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
TFKTKCN
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
LNFS
S
A
T
D
L
L
C
QHSLFK
13
PsiBlast_PDB
96.76
100%
-104
- C1 -
-
6G36
3
A:
[24-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
C
S
Q
K
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
8
PsiBlast_PDB
95.36
100%
-109
- C1 -
-
4QTC
4
A:
[28-357]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
12
PsiBlast_PDB
95.26
100%
-105
- C1 -
-
6G35
3
A:
[24-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
C
S
Q
K
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
2
PsiBlast_PDB
95.24
100%
-103
- C1 -
-
3DLZ
3
A:
[29-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
18
PsiBlast_PDB
94.09
97%
-105
- C1 -
-
2VUW
3
A:
[8-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
4
PsiBlast_PDB
93.98
100%
-102
- C1 -
-
3F2N
6
A:
[30-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
14
PsiBlast_PDB
93.95
100%
-107
- C1 -
-
6G37
1
A:
[31-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
10
PsiBlast_PDB
93.88
100%
-107
- C1 -
-
5HTB
4
A:
[30-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
11
PsiBlast_PDB
93.78
100%
-107
- C1 -
-
6G34
2
A:
[31-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
16
PsiBlast_PDB
93.60
99%
-105
* C1 *
-
6G39
3
A:
[30-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
Y
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
17
PsiBlast_PDB
93.45
99%
-105
- C1 -
-
6G3A
2
A:
[30-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
T
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
5
PsiBlast_PDB
93.43
100%
-105
- C1 -
-
3FMD
2
A:
[29-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
15
PsiBlast_PDB
92.94
100%
-104
- C1 -
-
6G38
3
A:
[31-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
9
PsiBlast_PDB
92.83
100%
-105
- C1 -
-
5HTC
4
A:
[30-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
7
PsiBlast_PDB
92.81
100%
-97
- C1 -
-
4OUC
7
A:
[29-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
3
PsiBlast_PDB
92.21
100%
-99
- C1 -
-
3E7V
8
A:
[30-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K
6
PsiBlast_PDB
92.05
100%
-102
- C1 -
-
3IQ7
3
A:
[30-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
V
P
F
S
H
C
L
P
T
E
K
L
Q
R
C
E
K
I
G
E
G
V
F
G
E
V
F
Q
T
I
A
D
H
T
P
V
A
I
K
I
I
A
I
E
G
P
D
L
V
N
G
S
H
Q
K
T
F
E
E
I
L
P
E
I
I
I
S
K
E
L
S
L
L
S
G
E
V
C
N
R
T
E
G
F
I
G
L
N
S
V
H
C
V
Q
G
S
Y
P
P
L
L
L
K
A
W
D
H
Y
N
S
T
K
G
S
A
N
D
R
P
D
F
F
K
D
D
Q
L
F
I
V
L
E
F
E
F
G
G
I
D
L
E
Q
M
R
T
K
L
S
S
L
A
T
A
K
S
I
L
H
Q
L
T
A
S
L
A
V
A
E
A
S
L
R
F
E
H
R
D
L
H
W
G
N
V
L
L
K
K
T
S
L
K
K
L
H
Y
T
L
N
G
K
S
S
T
I
P
S
C
G
L
Q
V
S
I
I
D
Y
T
L
S
R
L
E
R
D
G
I
V
V
F
C
D
V
S
M
D
E
D
L
F
T
G
D
G
D
Y
Q
F
D
I
Y
R
L
M
K
K
E
N
N
N
R
W
G
E
Y
H
P
Y
S
N
V
L
W
L
H
Y
L
T
D
K
M
L
K
Q
M
T
F
K
T
K
C
N
T
P
A
M
K
Q
I
K
R
K
I
Q
E
F
H
R
T
M
L
N
F
S
S
A
T
D
L
L
C
Q
H
S
L
F
K