@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAPK2_HUMAN: (2019-05-01 )
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPP
P
Q
Q
F
P
Q
F
H
V
KSG
L
Q
I
KKNAIID
D
Y
K
V
T
S
Q
V
LGLGIN
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
AR
R
E
V
E
L
H
W
RASQC
P
H
I
V
R
I
V
D
V
Y
E
N
L
YAG
R
K
C
L
L
I
V
M
E
CL
D
G
G
E
L
F
S
R
I
Q
DRGD
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
SINIAHRDVKPEN
L
L
Y
TSKRP
N
A
I
L
K
LTDFGFAKETTSHNSLTTPCYTPYYV
A
P
E
VL
G
P
E
K
YDKSCD
M
W
S
L
G
V
I
M
Y
I
L
LCGYPPFYSNH
G
L
A
ISPGMK
T
R
I
RMGQYEFPNP
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
LKTEPTQ
R
M
T
I
T
E
FMNHP
W
I
MQSTKVPQTPL
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
V
D
Y
E
Q
I
K
I
K
K
IEDASN
P
L
L
L
K
R
R
K
K
A
R
A
L
E
A
A
ALAH
69
Blastp_CBE
52.88
100%
-104
- C1 -
-
2PZY
1
MAPK2_HUMAN
C:
[2-319]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
-----------------------------------------
10
PsiBlast_PDB
51.45
100%
-119
- C1 -
-
2JBO
1
MAPK2_HUMAN
A:
[6-308]
-------------------------------------------
P
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
--------
C
Y
T
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
------------------------------------------------------
19
PsiBlast_PDB
43.62
99%
-130
- C1 -
-
3KA0
1
MAPK2_HUMAN
A:
[1-318]
----------------------------------------------
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
------------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
---------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
9
PsiBlast_PDB
42.32
97%
-113
- C1 -
-
1NXK
1
MAPK2_HUMAN
A:
[42-345]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
70
Blastp_CBE
40.05
100%
-117
- C1 -
-
2PZY
1
MAPK2_HUMAN
B:
[4-305]
-------------------------------------------
P
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
13
PsiBlast_PDB
39.86
100%
-113
- C1 -
-
2PZY
1
MAPK2_HUMAN
A:
[2-306]
-----------------------------------------
Q
F
P
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
---
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-----------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
------------------------------------------------------
3
PsiBlast_PDB
39.74
100%
-121
- C1 -
-
1NY3
1
MAPK2_HUMAN
A:
[46-345]
---------------------------------------------
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
H
---------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
--------
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------
74
Blastp_CBE
38.35
93%
-106
- C1 -
-
3KGA
1
MAPK2_HUMAN
A:
[3-299]
----------------------------------------------
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
G
---------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
72
Blastp_CBE
38.07
93%
-107
- C1 -
-
3M42
1
MAPK2_HUMAN
A:
[3-299]
----------------------------------------------
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
G
---------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
8
PsiBlast_PDB
36.65
100%
-115
- C1 -
-
3FYK
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
6
PsiBlast_PDB
36.37
100%
-113
- C1 -
-
2P3G
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
73
Blastp_CBE
34.41
93%
-100
- C1 -
-
3M2W
1
MAPK2_HUMAN
A:
[3-299]
----------------------------------------------
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
G
---------------------
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
-------
P
G
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
7
PsiBlast_PDB
28.01
100%
-105
- C1 -
-
3FYJ
1
MAPK2_HUMAN
X:
[1-320]
--------------------------------------------
Q
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
G
D
Q
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
S
----------------------
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
----------------
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
K
E
R
W
E
D
V
K
E
E
M
T
S
A
L
A
T
M
R
------------------------------------
18
PsiBlast_PDB
25.76
100%
-124
- C1 -
-
3R2Y
1
MAPK2_HUMAN
A:
[1-300]
---------------------------------------------
F
H
V
K
S
G
L
Q
I
K
K
N
A
I
I
D
D
Y
K
V
T
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
P
K
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
L
Y
A
G
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
------
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
P
N
A
I
L
K
L
T
D
F
G
F
A
K
E
T
T
-------------------------
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
----------
M
K
T
R
I
R
M
G
Q
Y
E
F
P
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------