@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MELK_HUMAN: (2019-05-01 )
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Atome Classification :
(19 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
IGTG
G
F
A
K
V
K
L
A
C
H
I
LTG
E
M
V
A
I
K
I
M
DKNTLGSD
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
TAN
K
I
F
M
V
L
E
YCPG
G
E
L
F
D
Y
I
I
S
Q
D
RL
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
HSQGYAHRDLKPEN
L
L
F
D
EYH
K
L
K
L
I
D
F
GLCAKPKGNKDY
H
L
Q
T
C
C
G
S
L
A
Y
A
A
P
E
L
IQGKSYLGSEA
D
V
W
S
M
G
I
L
L
Y
V
L
M
CGFLPFDDD
N
V
M
A
L
Y
K
K
I
MRGKYDVPKWLS
P
S
S
I
L
L
L
Q
Q
M
L
QVD
P
K
K
R
I
S
M
K
N
LLNHP
W
I
MQDYNYP
V
E
WQSKNP
F
I
H
LDD
D
C
V
T
E
L
S
V
HHRNN
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
KARGK
P
V
R
L
R
L
SSFSCGQASATPFTDIKSNNWSLEDVTASDKN
Y
V
A
G
LIDYDWCE
D
D
L
STGAATPRT
S
Q
F
T
K
YWTESNGVESKSL
T
P
A
L
C
RT
P
A
N
KLKNKENVYTPKSAVKNE
E
Y
F
MFPEPKTPVNK
N
Q
H
K
R
E
ILTTPNRYTT
P
S
K
A
R
N
Q
C
L
KETP
I
K
I
PVNSTG
T
D
K
L
M
T
G
VI
S
P
E
R
RC
R
S
V
E
LDL
N
Q
A
H
M
E
ETPKR
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
V
I
T
V
L
T
RSKRKGSARDG
P
R
R
L
K
L
H
Y
NV
T
T
T
RLV
N
P
D
Q
L
L
N
E
I
M
S
IL
P
K
K
H
V
D
F
V
QKG
Y
T
L
K
C
Q
TQSDF
G
K
V
T
M
Q
F
E
L
E
V
C
QLQKPD
V
V
G
I
R
R
Q
RLKG
D
A
W
V
Y
K
R
L
V
E
D
I
L
S
SCKV
13
PsiBlast_PDB
84.72
100%
-144
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
-------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.44
99%
-146
- C1 -
-
5M5A
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.19
99%
-147
- C1 -
-
4BKY
1
MELK_HUMAN
A:
[4-334]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.81
99%
-143
- C1 -
-
5MAH
2
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
80.66
100%
-148
- C1 -
-
5TWZ
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
-----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.10
99%
-148
- C1 -
-
4BKZ
1
MELK_HUMAN
A:
[3-335]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
79.48
99%
-147
- C1 -
-
5MAI
2
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
--
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
78.03
99%
-143
- C1 -
-
5MAG
3
MELK_HUMAN
A:
[4-336]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.15
99%
-152
- C1 -
-
5IHC
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
75.79
99%
-150
- C1 -
-
5IHA
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-----
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
75.33
100%
-150
- C1 -
-
5TX3
2
MELK_HUMAN
A:
[5-337]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
--------
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.63
99%
-141
- C1 -
-
4BL1
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
---
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.83
99%
-139
- C1 -
-
5MAF
2
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.42
99%
-141
- C1 -
-
5K00
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
P
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
73.22
100%
-145
- C1 -
-
5TWY
1
MELK_HUMAN
B:
[3-333]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
----
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
-----------------
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.14
99%
-142
- C1 -
-
5IH9
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
----
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
--------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
69.80
100%
-149
- C1 -
-
5TX3
2
MELK_HUMAN
B:
[5-338]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
----------
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
-------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
60.65
92%
-144
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[2-312]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
L
G
S
D
L
P
R
V
K
T
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
N
H
K
L
K
L
I
D
F
G
L
C
A
K
------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
M
Q
D
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
59.88
92%
-142
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[2-312]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
N
A
L
G
S
D
L
P
R
V
K
T
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
N
H
K
L
K
L
I
D
F
G
L
C
A
K
------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
N
L
L
N
H
P
W
V
M
Q
D
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------