@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MKNK2_HUMAN: (2019-05-02 )
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
Atome Classification :
(9 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVQKK
P
A
E
L
Q
G
F
H
R
SFKGQN
P
F
E
L
A
F
SLDQPDHGDSDF
G
L
QCSARPDMPASQPIDIP
D
A
K
K
RGKKKKRGRATDSFS
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
LGEG
A
H
A
R
V
Q
T
C
I
N
L
ITS
Q
E
Y
A
V
K
I
I
EKQP
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
QCQG
H
R
N
V
L
E
L
I
E
F
F
EEED
R
F
Y
L
V
F
EKMRG
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
HNKGIAHRDLKPE
N
I
LCEHPNQVS
P
V
K
I
C
D
FDLGS
G
I
K
LNGDCSPISTPELLTPCGSAEYM
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
KRC
D
L
W
S
L
G
V
I
L
Y
I
L
LSGYP
P
F
VGRCGSDCGWDRGEA
C
P
A
C
Q
N
M
L
F
E
S
I
Q
EGKYEFPDKDW
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
QHPWVQGCAPENTLPTP
M
V
L
QR
N
S
C
A
K
D
L
T
S
F
A
A
E
A
I
A
M
N
R
Q
L
A
Q
H
D
E
D
L
A
E
E
EAAGQGQ
P
V
L
V
RATSR
C
L
QLSPP
S
Q
S
K
L
A
Q
R
R
Q
RASLSSA
P
V
V
L
VGDHA
4
PsiBlast_PDB
96.34
99%
-143
- C1 -
-
6CJ5
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
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G
A
H
A
R
V
Q
T
C
I
N
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I
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E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
10
PsiBlast_PDB
95.47
99%
-131
- C1 -
-
6CK6
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
6
PsiBlast_PDB
95.34
99%
-144
- C1 -
-
6CJH
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.68
99%
-137
- C1 -
-
2HW7
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
9
PsiBlast_PDB
94.60
99%
-136
- C1 -
-
6CK3
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
7
PsiBlast_PDB
94.58
99%
-137
* C1 *
-
6CJW
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
11
PsiBlast_PDB
93.37
99%
-136
- C1 -
-
6CKI
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.29
99%
-134
- C1 -
-
6CJE
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
---------------------
P
C
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
92.99
99%
-141
- C1 -
-
6CJY
1
MKNK2_HUMAN
A:
[2-302]
----------------------------------------------------------------------
S
T
D
S
F
S
G
R
F
E
D
V
Y
Q
L
Q
E
D
V
L
G
E
G
A
H
A
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
K
Q
P
G
H
I
R
S
R
V
F
R
E
V
E
M
L
Y
Q
C
Q
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
H
I
H
K
R
R
H
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
L
C
E
H
P
N
Q
V
S
P
V
K
I
C
D
F
G
-----------------------
G
S
A
E
Y
M
A
P
E
V
V
E
A
F
S
E
E
A
S
I
Y
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
V
G
R
C
---
C
G
-----
A
C
P
A
C
Q
N
M
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
P
W
V
Q
G
C
----------------------------------------------------------------------------------------------