@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Screening
Virtual Screening Score
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TTK_HUMAN: (2019-05-05 )
MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK
Atome Classification :
(35 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(pKd)
(pKd)
(Uniprot)
MESEDLSGR
E
L
T
I
D
S
I
M
N
K
V
R
D
I
K
N
KFKNEDLTDELSLNKISADTTDNSGTV
N
Q
I
M
M
MANN
P
E
D
W
L
S
L
L
L
K
LEKNSVP
L
S
D
A
L
L
N
K
L
I
G
R
Y
S
Q
A
I
EALPPDKYGQNE
S
F
A
R
I
Q
V
R
F
A
E
L
K
AIQEPD
D
A
R
D
Y
F
Q
M
A
RANC
K
K
F
A
F
V
H
I
S
F
A
Q
F
ELSQG
N
V
K
K
S
K
Q
L
L
Q
K
A
V
E
RGAV
P
L
E
M
L
E
I
A
L
R
NLN
L
Q
K
K
Q
L
L
S
E
E
E
K
KNLSA
S
T
V
L
T
A
Q
E
SFSGSLGHLQNRNNSCDSRGQT
T
K
A
R
F
L
YGENMPPQDAEI
G
Y
R
N
S
LRQTNKTKQSCPFGRV
P
V
N
LLNSPDCDVKTDDS
V
V
P
C
F
M
K
RQT
S
R
S
E
C
R
DLVVPGSKPSGNDSC
E
L
R
N
L
K
S
V
Q
N
SHFKEPLVSDEKSS
E
L
I
I
TD
S
I
T
LKNK
T
E
S
S
L
L
A
K
L
E
E
T
KEYQEPEVPES
N
Q
K
Q
W
Q
S
K
R
K
S
E
CINQNPAASSNHWQ
I
P
E
L
A
R
KVNTEQKHTTFEQP
V
F
S
VSKQSPPISTSKWF
D
P
K
S
I
CKTPSSN
T
L
D
D
Y
M
S
C
F
RTPVVKNDFPPACQLSTPYGQ
P
A
C
F
Q
Q
Q
Q
H
Q
I
L
A
T
P
L
Q
N
L
Q
V
L
A
SSSAN
E
C
I
SV
K
G
R
I
Y
S
I
L
K
Q
IGSG
G
S
S
K
V
F
Q
V
L
NEK
K
Q
I
Y
A
I
K
Y
V
NLEEADN
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
HSD
K
I
I
R
L
Y
D
Y
EI
T
D
Q
Y
I
Y
M
V
M
ECGNI
D
L
N
S
W
L
K
KKKSI
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
QHGIVHSDLKPA
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
IANQMQPDT
T
S
VVKDSQV
G
T
V
NYM
P
P
E
A
I
K
D
M
S
SSRENGKSKSKISPKS
D
V
W
S
L
G
C
I
L
Y
Y
M
TYGK
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
IIDPNHEIEFPDI
P
E
K
D
L
Q
D
V
L
K
C
C
LKRD
P
K
QRIS
I
P
E
L
LAH
P
Y
V
Q
I
Q
THP
V
N
Q
M
AKG
T
T
E
E
M
K
Y
V
L
G
Q
L
VGLNS
P
N
S
I
L
K
A
A
K
T
L
Y
E
HYSGGESHNSSSSK
T
F
E
K
KRGKK
1
PsiBlast_PDB
91.40
99%
-117
- C1 -
-
6GVJ
2.3
-
?
A:
[136-416]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
T
T
S
V
V
K
D
S
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
S
---------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
--------------------------------------------------------------
10
PsiBlast_PDB
89.80
100%
-138
- C1 -
-
3HMN
4.3
-
A:
[49-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
------------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
12
PsiBlast_PDB
88.63
98%
-127
- C1 -
-
3CEK
4.0
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
--------------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
17
PsiBlast_PDB
88.50
98%
-143
- C1 -
-
5EHY
4.0
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
-------------
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
26
Blastp_CBE
87.87
99%
-131
- C1 -
-
5N87
8.7
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
------------
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
9
PsiBlast_PDB
87.71
100%
-129
- C1 -
-
3VQU
5.8
-
A:
[1-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
-
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-----------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
--------------------------------------------------------------
28
Blastp_CBE
87.44
99%
-138
- C1 -
-
4CV9
6.6
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
--------------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-----------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
13
PsiBlast_PDB
87.37
98%
-134
- C1 -
-
3GFW
8.0
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
----------------
G
T
V
N
Y
M
P
P
E
A
I
K
D
-----------
S
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
23
Blastp_CBE
87.13
99%
-131
- C1 -
-
5O91
8.1
-
A:
[21-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
W
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
T
T
------
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
-----------
S
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
H
-------------------------------------------------------------
6
PsiBlast_PDB
86.48
100%
-124
- C1 -
-
3WZK
7.9
-
A:
[2-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-----------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
37
Blastp_CBE
86.43
98%
-109
- C1 -
-
5NTT
9.4
-
A:
[6-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
Y
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
T
T
S
V
V
K
D
S
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
H
P
------------------------------------------------------------
36
Blastp_CBE
86.39
99%
-128
- C1 -
-
4O6L
8.1
-
B:
[1-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
-----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
----------------------------------------------------------------
11
PsiBlast_PDB
86.33
100%
-127
- C1 -
-
3HMO
7.7
-
A:
[47-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
------------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
7
PsiBlast_PDB
86.01
100%
-124
- C1 -
-
3WYX
7.6
-
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
-----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-----------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
--------------------------------------------------------------
34
Blastp_CBE
85.56
100%
-115
- C1 -
-
4ZEG
10.2
-
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
T
-----------
V
N
Y
M
P
P
E
A
I
K
D
M
S
S
---------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
--------------------------------------------------------------
25
Blastp_CBE
85.30
99%
-115
- C1 -
-
5AP6
9.7
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
W
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
------
D
S
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
38
Blastp_CBE
85.24
99%
-121
- C1 -
-
4JS8
8.0
-
A:
[1-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
-
T
-------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
----------------------------------------------------------------
4
PsiBlast_PDB
85.23
100%
-122
- C1 -
-
3W1F
8.4
-
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-----------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
--------------------------------------------------------------
21
Blastp_CBE
85.22
99%
-144
- C1 -
-
5AP5
9.2
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
G
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
----------------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
32
Blastp_CBE
85.09
99%
-145
- C1 -
-
4D2S
8.0
-
A:
[2-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
N
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
--
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
-----------------
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-------------
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
----------------------------------------------------------------
27
Blastp_CBE
84.97
99%
-131
- C1 -
-
4CVA
7.6
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
--------------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
22
Blastp_CBE
84.97
99%
-118
- C1 -
-
5LJJ
7.9
-
A:
[21-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
Y
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
T
-----
D
S
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
--------------------------------------------------------------
33
Blastp_CBE
84.75
98%
-122
- C1 -
-
6B4W
9.6
-
A:
[21-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
---------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
----------------------------------------------------------------
3
PsiBlast_PDB
84.58
100%
-136
- C1 -
-
2X9E
7.8
-
A:
[4-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
---------------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
5
PsiBlast_PDB
83.61
100%
-124
- C1 -
-
3WZJ
8.9
-
A:
[2-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
15
PsiBlast_PDB
83.58
98%
-130
- C1 -
-
5EHL
5.1
-
A:
[21-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
--------------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
H
-------------------------------------------------------------
30
Blastp_CBE
82.78
98%
-117
- C1 -
-
5N9S
11.6
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
-------
S
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
------------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
39
Blastp_CBE
82.61
91%
-126
- C1 -
-
5EH0
8.9
-
A:
[1-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
24
Blastp_CBE
82.61
99%
-120
- C1 -
-
5N84
6.8
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
------------
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
35
Blastp_CBE
81.94
99%
-125
* C1 *
-
6H3K
9.3
-
A:
[1-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
------------
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
16
PsiBlast_PDB
80.71
98%
-119
- C1 -
-
5EHO
8.5
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
---------
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
------------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
31
Blastp_CBE
80.51
98%
-121
- C1 -
-
5N7V
8.9
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
-------
S
Q
V
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
8
PsiBlast_PDB
79.58
100%
-119
- C1 -
-
3WYY
7.8
-
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
I
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
-----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-----------
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
-
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
T
--------------------------------------------------------------
14
PsiBlast_PDB
78.94
98%
-126
- C1 -
-
5AP2
9.9
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
----------
G
T
V
N
Y
M
P
P
E
A
I
K
D
M
S
-------------
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------
29
Blastp_CBE
47.79
98%
-67
- C1 -
-
5NAD
9.2
-
A:
[21-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
V
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
S
S
K
V
F
Q
V
L
N
E
K
K
Q
I
Y
A
I
K
Y
V
N
L
E
E
A
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
N
K
L
Q
Q
H
S
D
K
I
I
R
L
Y
D
Y
E
I
T
D
Q
Y
I
Y
M
V
M
E
C
G
N
I
D
L
N
S
W
L
K
K
K
K
S
I
D
P
W
E
R
K
S
Y
W
K
N
M
L
E
A
V
H
T
I
H
Q
H
G
I
V
H
S
D
L
K
P
A
N
F
L
I
V
D
G
M
L
K
L
I
D
F
G
I
A
N
Q
M
Q
P
D
T
-----------
V
N
Y
M
P
P
E
A
I
K
D
M
-----------
K
I
S
P
K
S
D
V
W
S
L
G
C
I
L
Y
Y
M
T
Y
G
K
T
P
F
Q
Q
I
I
N
Q
I
S
K
L
H
A
I
I
D
P
N
H
E
I
E
F
P
D
I
P
E
K
D
L
Q
D
V
L
K
C
C
L
K
R
D
P
K
Q
R
I
S
I
P
E
L
L
A
H
P
Y
V
Q
I
Q
---------------------------------------------------------------