@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TYK2_HUMAN: (2019-05-05 )
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPLRHWGMARGSKPVGDGA
Q
P
M
A
A
MGG
L
K
V
L
L
H
WAGPGGGEP
W
V
T
FSESSL
T
A
E
E
V
C
I
H
I
A
H
KVGIT
P
P
C
F
N
L
F
A
L
FDAQ
A
Q
V
WLP
P
N
H
I
LEIPRDA
S
L
M
L
Y
F
R
I
R
F
Y
F
RNWHGMNPREP
A
V
Y
RCGPPGTEASSDQTAQGMQLLDP
A
S
F
E
Y
L
F
E
QG
K
H
E
F
V
N
D
V
A
S
L
WELS
T
E
E
E
I
H
H
FKNE
S
L
G
M
A
F
L
H
L
C
H
L
A
L
RHGI
P
L
E
E
V
A
K
KT
S
F
K
D
C
I
P
R
S
F
R
R
H
I
R
Q
H
S
A
L
T
R
L
R
L
R
N
V
F
R
R
F
L
R
DFQPG
R
L
S
Q
Q
M
V
M
V
K
Y
L
A
T
L
E
R
L
A
P
RFGTERV
P
V
C
H
L
R
L
L
A
QAEGE
P
C
Y
I
RDSGVAPTDPGPESAAGPPT
H
E
V
L
V
TGTGG
I
Q
WWPV
E
E
EVNKEEGSSGSSGRNP
Q
A
S
L
FGK
K
A
K
A
H
KAVGQPADRPRE
P
L
W
A
Y
F
CD
F
R
D
I
T
H
V
V
L
K
E
H
C
V
S
I
HRQDN
K
C
L
E
LSLP
S
R
A
A
A
L
S
F
V
S
L
VDG
Y
F
R
LTADSSH
Y
L
C
HEVAP
P
R
L
V
M
S
I
RDGIHG
P
L
L
E
P
F
V
Q
AKLRPED
G
L
Y
L
I
H
WSTSH
P
Y
R
L
I
L
T
V
A
Q
RSQAP
D
G
M
Q
S
L
RLRKFPIEQQDG
A
F
V
L
E
GWGRSF
P
S
V
R
E
L
G
A
A
L
Q
G
C
L
L
RAG
D
D
C
F
S
L
R
R
CCLPQPGETS
N
L
I
I
M
RGARASPRTL
N
L
S
Q
L
S
FHRV
D
Q
K
E
I
T
Q
L
S
HLGQGTRTNVYE
G
R
L
R
VEGSGDPEEGKMDDEDPLVPGRDR
G
Q
E
L
R
V
V
L
K
VLDPSHHD
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
VSH
T
H
L
A
F
V
H
G
V
CVRGPE
N
I
M
V
T
E
Y
VEHGP
L
D
V
W
L
RRERGHV
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
LENKNLVHGNVCG
R
N
I
L
L
A
RLGLAEGTS
P
F
I
K
LSDPGVGLGAL
S
R
E
E
R
V
E
RIPWLAPECLPGGA
N
S
L
S
T
A
M
D
KWG
F
G
A
T
L
L
E
I
CFDGEAPLQSRSP
S
E
K
E
H
F
Y
Q
R
Q
HRLPEPSC
P
Q
L
A
T
L
T
S
Q
CLTYEPTQRP
S
F
R
T
I
L
R
D
L
T
RLQPHNLA
D
V
L
T
VNPDSPASD
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
LGEGHF
G
K
V
S
L
Y
C
YDPTNDGTG
E
M
V
A
V
K
A
L
KADCGPQHRS
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
YKGCCEDQ
G
E
K
S
L
Q
L
V
M
E
YVPL
G
S
L
R
D
Y
L
PRHSI
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
AR
N
V
LLDND
R
L
V
K
IGDF
G
L
A
KAVPEGH
E
Y
Y
R
V
REDGDS
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
HCDSSQS
P
P
T
K
F
L
E
L
I
GIAQG
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
ERLPRPDKC
P
C
E
V
Y
H
L
M
K
N
C
W
ETEASFR
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
YQGQAPSVFSVC
1
PsiBlast_PDB
84.24
98%
-109
- C2 -
-
4OLI
2
TYK2_HUMAN
A:
[37-635]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
V
-------------------------
E
L
R
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
G
L
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P
G
----
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
S
C
P
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
Q
P
-----------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-------
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
--
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
-----
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
----------
6
PsiBlast_PDB
32.04
99%
-136
* C2 *
-
3NZ0
1
A:
[7-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
C
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
------
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
14
PsiBlast_PDB
31.93
97%
-139
- C2 -
-
3LXP
1
A:
[24-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
--
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
---
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
8
PsiBlast_PDB
31.25
98%
-148
- C2 -
-
4GFO
4
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-----------
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
------
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
28
Blastp_CBE
30.88
91%
-138
- C2 -
-
4E1Z
1
A:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
E
G
C
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
---
K
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
C
V
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
P
H
T
K
F
T
E
L
I
G
H
T
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
Q
T
A
Q
E
K
Y
Q
----------
7
PsiBlast_PDB
30.58
98%
-142
- C2 -
-
3NYX
3
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
--
G
E
M
V
A
V
K
A
L
K
A
D
C
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
-
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
26
Blastp_CBE
30.39
98%
-130
- C2 -
-
4GJ2
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
25
Blastp_CBE
30.31
98%
-131
- C2 -
-
4GJ3
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
13
PsiBlast_PDB
30.13
97%
-136
- C2 -
-
3LXN
1
A:
[24-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
---
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
29
Blastp_CBE
30.08
91%
-146
- C2 -
-
4E20
1
A:
[1-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
E
G
C
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
----
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
C
V
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
P
H
T
K
F
T
E
L
I
G
----
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
Q
T
A
Q
E
K
Y
Q
----------
27
Blastp_CBE
30.04
98%
-130
- C2 -
-
4GIH
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
20
PsiBlast_PDB
29.39
97%
-131
- C2 -
-
4GII
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
9
PsiBlast_PDB
29.39
99%
-133
- C2 -
-
5F1Z
1
A:
[5-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
--------
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
---
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
-----------
24
Blastp_CBE
29.16
98%
-130
- C2 -
-
5WAL
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
--
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
19
PsiBlast_PDB
28.42
97%
-129
- C2 -
-
4GVJ
1
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
16
PsiBlast_PDB
27.52
97%
-125
- C2 -
-
4PY1
1
A:
[25-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
17
PsiBlast_PDB
27.28
97%
-125
- C2 -
-
6DBK
1
A:
[25-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
15
PsiBlast_PDB
27.03
97%
-136
- C2 -
-
6AAM
1
A:
[4-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
----
G
K
V
S
L
Y
C
Y
D
P
T
N
--
T
G
E
M
V
A
V
K
A
L
--
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
--------------
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
L
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
10
PsiBlast_PDB
26.12
99%
-137
- C2 -
-
5F20
1
A:
[7-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
---------
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
----
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
--
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
-----------
18
PsiBlast_PDB
25.65
97%
-130
- C2 -
-
6DBM
1
A:
[25-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
--------
E
M
V
A
V
K
A
L
K
-----
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
R
H
S
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
---
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
21
Blastp_CBE
13.80
100%
-100
- C2 -
-
5C03
6
B:
[51-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
--------------------------
E
L
R
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
G
L
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P
-----
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
S
C
P
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------