@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1B1_RARa: (2019-04-24 )
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MASNSSSCPTPGGGHLNGYPVP
P
Y
A
FFF
P
P
M
LGGLSPP
G
A
L
T
T
L
Q
HQLPVSGYSTPS
P
A
T
I
ETQSSSSEEIVPSPPSPPPLPRIYK
P
C
F
V
CQDKSSGYHYGV
S
A
C
E
G
C
K
G
F
F
R
R
S
I
QKN
M
V
Y
T
CHRDKNC
I
I
N
K
V
T
R
N
R
C
Q
Y
C
R
L
Q
K
C
F
E
VGM
S
K
E
S
V
RNDRN
K
K
KKEVPKPECSE
S
Y
TL
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
LGKYTTNNSSE
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
QLPG
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
CTRYTPEQD
T
M
TFSDG
L
T
L
N
R
T
QMHNAGF
G
P
L
T
D
L
V
F
A
F
A
N
QLLPLEMDDA
E
T
G
L
L
S
A
I
C
L
ICG
D
R
Q
DLEQP
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
KRRPSRP
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
SAKGA
E
R
V
I
T
L
K
M
EIPGSM
P
P
L
I
Q
E
M
L
ENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
1
PsiBlast_PDB
83.20
80%
-124
- C1 -
-
5UAN
1
RARB_HUMAN
B:
[29-357]
--------------------------------------------------------------------------------------
P
C
F
V
C
Q
D
K
S
S
G
Y
H
Y
G
V
S
A
C
E
G
C
K
G
F
F
R
R
S
I
Q
K
N
M
I
Y
T
C
H
R
D
K
N
C
V
I
N
K
V
T
R
N
R
C
Q
Y
C
R
L
Q
K
C
F
E
V
G
M
S
K
E
S
V
R
---------------------
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
8
PsiBlast_PDB
60.18
100%
-141
- C1 -
-
1DKF
1
RARA_HUMAN
B:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
---
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
3
PsiBlast_PDB
56.56
100%
-131
- C1 -
-
3A9E
1
RARA_HUMAN
B:
[25-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
T
L
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
23
Blastp_CBE
54.13
100%
-134
- C1 -
-
4DQM
1
RARA_HUMAN
C:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
-
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
9
PsiBlast_PDB
52.91
100%
-130
- C1 -
-
4DQM
1
RARA_HUMAN
A:
[1-234]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
6
PsiBlast_PDB
52.87
100%
-132
- C1 -
-
5K13
1
RARA_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
13
PsiBlast_PDB
47.45
85%
-140
- C1 -
-
4JYG
1
RARB_HUMAN
A:
[23-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-----------------------------------------------
4
PsiBlast_PDB
47.39
100%
-128
- C1 -
-
3KMR
1
RARA_HUMAN
A:
[27-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
27
Blastp_CBE
47.30
86%
-136
- C1 -
-
4JYH
1
RARB_HUMAN
B:
[23-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-----------------------------------------------
14
PsiBlast_PDB
47.05
85%
-138
- C1 -
-
4JYH
1
RARB_HUMAN
A:
[23-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-----------------------------------------------
26
Blastp_CBE
45.72
86%
-133
- C1 -
-
4JYI
1
RARB_HUMAN
B:
[23-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-----------------------------------------------
25
Blastp_CBE
45.61
86%
-130
- C1 -
-
4DM6
1
RARB_HUMAN
B:
[24-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
15
PsiBlast_PDB
44.66
85%
-134
- C1 -
-
4JYI
1
RARB_HUMAN
A:
[23-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-----------------------------------------------
30
Blastp_CBE
40.71
83%
-135
* C1 *
-
1FCY
2
RARG_HUMAN
A:
[2-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
32
Blastp_CBE
40.39
83%
-135
- C1 -
-
1FCZ
2
RARG_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
33
Blastp_CBE
40.09
83%
-135
- C1 -
-
1FCX
2
RARG_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
20
PsiBlast_PDB
40.02
82%
-131
- C1 -
-
1EXX
2
RARG_HUMAN
A:
[5-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
31
Blastp_CBE
38.93
83%
-134
- C1 -
-
1FD0
2
RARG_HUMAN
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
24
Blastp_CBE
38.78
86%
-127
- C1 -
-
4DM8
1
RARB_HUMAN
B:
[24-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
18
PsiBlast_PDB
38.03
81%
-128
- C1 -
-
4LBD
1
RARG_HUMAN
A:
[26-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
N
----------------------------------------------
28
Blastp_CBE
38.01
86%
-128
- C1 -
-
4JYG
2
RARB_HUMAN
B:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-----------------------------------------------
19
PsiBlast_PDB
37.25
82%
-130
- C1 -
-
1EXA
2
RARG_HUMAN
A:
[5-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
2
PsiBlast_PDB
37.07
72%
-134
- C1 -
-
6FX0
2
RARG_HUMAN
A:
[180-417]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
29
Blastp_CBE
36.33
82%
-131
- C1 -
-
5M24
2
RARG_HUMAN
A:
[9-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
E
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-----------------------------------------------
11
PsiBlast_PDB
35.31
86%
-128
- C1 -
-
4DM6
1
RARB_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
12
PsiBlast_PDB
32.60
86%
-127
- C1 -
-
4DM8
1
RARB_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
--
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-----------------------------------------------
22
Blastp_CBE
31.80
85%
-121
- C1 -
-
1XDK
1
RARB_MOUSE
F:
[30-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
P
L
T
P
S
------------------------------------
17
PsiBlast_PDB
31.33
81%
-122
- C1 -
-
3LBD
1
RARG_HUMAN
A:
[26-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
N
----------------------------------------------
7
PsiBlast_PDB
29.79
84%
-121
- C1 -
-
1XDK
1
RARB_MOUSE
B:
[30-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
P
L
T
P
S
------------------------------------
10
PsiBlast_PDB
29.77
86%
-130
- C1 -
-
1XAP
1
RARB_HUMAN
A:
[28-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
---
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
----------------------------------------------
5
PsiBlast_PDB
22.95
100%
-126
- C1 -
-
3KMZ
5
RARA_HUMAN
B:
[26-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
-------------------------------------------------------------
21
Blastp_CBE
20.73
100%
-126
- C1 -
-
3KMZ
6
RARA_HUMAN
A:
[26-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
-------------------------------------------------------------