@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1I1_VDR: (2019-04-24 )
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
Atome Classification :
(102 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEAMAASTSLPDPGDFDRNV
P
R
I
C
GVCGDRAT
G
F
H
FNAM
T
C
E
G
C
K
G
F
F
R
R
S
MKR
K
A
L
F
TCPFNGD
C
R
ITKDN
R
R
H
C
Q
A
C
R
L
K
R
C
V
D
I
G
M
M
K
E
F
ILT
D
E
E
V
Q
R
K
R
E
M
I
L
K
R
K
E
E
E
A
L
K
D
SLRPKL
S
E
E
Q
Q
R
I
I
A
I
LLDAHHKTYDP
T
Y
S
D
F
CQFRP
P
V
R
VNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCIT
S
S
DMMDSSSFSNLDLSEEDSDDP
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
MIPGFRDLTSED
Q
I
V
L
L
KSS
A
I
E
V
I
M
LRSNESFTMDD
M
S
W
TCGNQD
Y
K
Y
R
V
S
D
V
TKAGH
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
KLNLHEEE
H
V
L
L
M
A
I
C
I
VSPDRPGV
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
RCRHPPPGS
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
SK
Q
Y
R
CLSFQPECSM
K
L
T
P
L
V
L
E
V
FGNEIS
25
Blastp_CBE
79.90
84%
-129
- C1 -
-
3X31
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
----------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
7
PsiBlast_PDB
78.79
83%
-123
- C1 -
-
4G2I
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
18
PsiBlast_PDB
78.45
83%
-118
- C1 -
-
3A3Z
1
VDR_HUMAN
X:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
35
Blastp_CBE
78.07
83%
-122
- C1 -
-
5GT4
1
VDR_HUMAN
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
9
PsiBlast_PDB
77.81
83%
-124
- C1 -
-
1S19
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
30
Blastp_CBE
76.20
84%
-123
- C1 -
-
3AUQ
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
10
PsiBlast_PDB
76.01
83%
-122
- C1 -
-
1TXI
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
37
Blastp_CBE
75.87
83%
-122
- C1 -
-
3B0T
1
VDR_HUMAN
A:
[1-254]
----------------------------------------------------------------------------------------------------------------------
A
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
5
PsiBlast_PDB
75.86
83%
-121
- C1 -
-
3KPZ
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
15
PsiBlast_PDB
75.46
83%
-118
- C1 -
-
2HB8
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
20
PsiBlast_PDB
75.44
83%
-117
- C1 -
-
3A78
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
26
Blastp_CBE
75.28
84%
-123
- C1 -
-
3WWR
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
----------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
32
Blastp_CBE
75.16
83%
-123
- C1 -
-
3A2J
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
F
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
8
PsiBlast_PDB
75.03
83%
-121
- C1 -
-
1S0Z
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
21
Blastp_CBE
74.89
84%
-116
- C1 -
-
3P8X
1
VDR_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
19
PsiBlast_PDB
74.82
83%
-117
- C1 -
-
3A40
1
VDR_HUMAN
X:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
23
Blastp_CBE
74.65
84%
-127
- C1 -
-
4ITE
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
45
Blastp_CBE
74.62
83%
-118
- C1 -
-
3M7R
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
Q
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
31
Blastp_CBE
74.48
83%
-123
- C1 -
-
3A2I
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
6
PsiBlast_PDB
74.21
83%
-117
- C1 -
-
3TKC
1
?
A:
[2-255]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
17
PsiBlast_PDB
73.92
83%
-115
- C1 -
-
3CS6
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
4
PsiBlast_PDB
73.69
83%
-116
- C1 -
-
3OGT
1
VDR_HUMAN
A:
[2-255]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
14
PsiBlast_PDB
73.44
83%
-117
- C1 -
-
2HB7
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
3
PsiBlast_PDB
73.09
83%
-115
- C1 -
-
1IE9
1
VDR_HUMAN
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
24
Blastp_CBE
72.79
84%
-120
- C1 -
-
3X36
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
----------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
28
Blastp_CBE
71.39
84%
-121
- C1 -
-
3AX8
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
34
Blastp_CBE
71.17
83%
-118
- C1 -
-
5YSY
1
VDR_HUMAN
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
22
Blastp_CBE
71.03
84%
-120
- C1 -
-
4ITF
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
36
Blastp_CBE
70.98
83%
-119
- C1 -
-
5V39
1
VDR_HUMAN
A:
[4-254]
-------------------------------------------------------------------------------------------------------------------------
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
L
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
29
Blastp_CBE
70.94
84%
-121
- C1 -
-
3AUR
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
33
Blastp_CBE
70.92
83%
-119
- C1 -
-
5YT2
1
VDR_HUMAN
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
16
PsiBlast_PDB
70.69
83%
-115
- C1 -
-
3CS4
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
39
Blastp_CBE
69.76
83%
-125
- C1 -
-
3W0Y
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
43
Blastp_CBE
69.14
83%
-126
- C1 -
-
3AZ2
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
41
Blastp_CBE
68.76
83%
-126
- C1 -
-
3W0A
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
40
Blastp_CBE
68.65
83%
-126
- C1 -
-
3W0C
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
27
Blastp_CBE
68.39
84%
-114
- C1 -
-
3VHW
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
----------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
1
PsiBlast_PDB
67.96
83%
-124
- C1 -
-
1DB1
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
42
Blastp_CBE
67.67
83%
-124
- C1 -
-
3AZ3
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
12
PsiBlast_PDB
66.93
83%
-122
- C1 -
-
2HAR
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
--
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
44
Blastp_CBE
66.74
83%
-123
- C1 -
-
3AZ1
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
13
PsiBlast_PDB
65.74
83%
-119
- C1 -
-
2HAS
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
-
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
38
Blastp_CBE
65.17
83%
-121
- C1 -
-
3WGP
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
11
PsiBlast_PDB
64.90
83%
-118
- C1 -
-
2HAM
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
-
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
2
PsiBlast_PDB
62.66
83%
-119
- C1 -
-
1IE8
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
59
Blastp_CBE
52.47
76%
-135
- C1 -
-
3VRW
1
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
65
Blastp_CBE
52.22
76%
-130
- C1 -
-
2ZL9
1
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
48
Blastp_CBE
51.53
76%
-129
- C1 -
-
1RK3
1
VDR_RAT
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
53
Blastp_CBE
51.35
76%
-125
- C1 -
-
5XZH
1
VDR_RAT
A:
[16-267]
------------------------------------------------------------------------------------------------------------------------
R
P
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
51
Blastp_CBE
49.69
76%
-134
- C1 -
-
5ZWH
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
57
Blastp_CBE
49.15
76%
-124
- C1 -
-
5B41
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
60
Blastp_CBE
48.27
76%
-132
- C1 -
-
3VRV
1
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
47
Blastp_CBE
48.05
76%
-123
- C1 -
-
2O4J
1
VDR_RAT
A:
[8-259]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
62
Blastp_CBE
46.94
76%
-126
- C1 -
-
3VJT
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
69
Blastp_CBE
46.76
75%
-131
- C1 -
-
5GID
1
VDR_RAT
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
54
Blastp_CBE
46.61
76%
-125
- C1 -
-
5XZF
2
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
46
Blastp_CBE
45.60
76%
-120
- C1 -
-
2O4R
1
VDR_RAT
A:
[8-259]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
50
Blastp_CBE
45.08
76%
-119
- C1 -
-
3A2H
1
VDR_RAT
A:
[12-263]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
56
Blastp_CBE
44.75
76%
-124
- C1 -
-
5XPM
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
---------------------------------------------------------------
S
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
67
Blastp_CBE
44.36
76%
-130
- C1 -
-
5GIE
1
VDR_RAT
A:
[1-256]
--------------------------------------------------------------------------------------------------------------------
K
D
S
L
R
P
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
D
G
S
-----------------------------------------------------
S
V
T
L
D
L
S
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
---
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
64
Blastp_CBE
44.16
76%
-123
- C1 -
-
2ZLA
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
61
Blastp_CBE
43.91
76%
-127
- C1 -
-
3VRU
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
68
Blastp_CBE
43.73
75%
-131
- C1 -
-
5GIC
1
VDR_RAT
A:
[1-250]
---------------------------------------------------------------------------------------------------------------------------
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
49
Blastp_CBE
43.36
76%
-120
- C1 -
-
1RJK
1
VDR_RAT
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
52
Blastp_CBE
43.32
76%
-123
- C1 -
-
5ZWF
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
-----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
63
Blastp_CBE
42.96
76%
-120
- C1 -
-
3VJS
1
VDR_RAT
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
58
Blastp_CBE
42.52
76%
-115
- C1 -
-
4YNK
1
VDR_RAT
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
86
Blastp_CBE
31.43
69%
-139
- C1 -
-
5LGA
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
-----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
101
Blastp_CBE
30.66
68%
-135
- C1 -
-
4RUO
1
VDRA_DANRE
X:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
H
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
72
Blastp_CBE
30.55
69%
-129
- C1 -
-
5OW7
1
VDRA_DANRE
A:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
85
Blastp_CBE
30.26
69%
-137
- C1 -
-
6FO7
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
70
Blastp_CBE
29.94
69%
-131
- C1 -
-
5OWD
1
VDRA_DANRE
A:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
-----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
55
Blastp_CBE
29.66
76%
-126
- C1 -
-
5XUQ
1
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
---------------------------------------------------------------
S
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
-------
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
77
Blastp_CBE
29.35
69%
-135
- C1 -
-
3O1D
1
VDRA_DANRE
A:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
71
Blastp_CBE
29.33
69%
-131
* C1 *
-
5OW9
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
82
Blastp_CBE
29.26
69%
-135
- C1 -
-
6FOD
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
83
Blastp_CBE
28.80
69%
-136
- C1 -
-
6FOB
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
66
Blastp_CBE
28.52
76%
-142
- C1 -
-
5GIE
1
VDR_RAT
D:
[8-256]
---------------------------------------------------------------------------------------------------------------------------
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
------------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
----
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
73
Blastp_CBE
28.43
69%
-134
- C1 -
-
5NMA
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
74
Blastp_CBE
28.18
69%
-135
- C1 -
-
5NKY
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
87
Blastp_CBE
28.05
69%
-135
- C1 -
-
5E7V
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
100
Blastp_CBE
27.77
68%
-134
- C1 -
-
4RUP
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
H
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
88
Blastp_CBE
27.58
69%
-136
- C1 -
-
4IA7
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
89
Blastp_CBE
27.56
69%
-134
- C1 -
-
4IA3
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
96
Blastp_CBE
27.39
69%
-132
- C1 -
-
4G1Y
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
102
Blastp_CBE
26.94
68%
-130
- C1 -
-
4RUJ
1
VDRA_DANRE
A:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
H
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
80
Blastp_CBE
26.50
69%
-134
- C1 -
-
2HC4
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
90
Blastp_CBE
26.35
69%
-131
- C1 -
-
4IA2
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
99
Blastp_CBE
25.91
69%
-132
- C1 -
-
4FHH
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
75
Blastp_CBE
25.69
69%
-130
- C1 -
-
4Q0A
2
VDRA_DANRE
C:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
98
Blastp_CBE
25.65
69%
-132
- C1 -
-
4FHI
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
93
Blastp_CBE
25.23
69%
-135
- C1 -
-
4G21
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
84
Blastp_CBE
25.15
69%
-133
- C1 -
-
6FO9
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
91
Blastp_CBE
25.11
69%
-132
- C1 -
-
4IA1
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
79
Blastp_CBE
25.10
69%
-133
- C1 -
-
2HCD
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
76
Blastp_CBE
24.61
69%
-131
- C1 -
-
3O1E
1
VDRA_DANRE
A:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
-----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
95
Blastp_CBE
24.18
69%
-132
- C1 -
-
4G1Z
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
97
Blastp_CBE
24.01
69%
-133
- C1 -
-
4G1D
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
94
Blastp_CBE
23.64
69%
-131
- C1 -
-
4G20
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
92
Blastp_CBE
22.96
69%
-132
- C1 -
-
4G2H
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
81
Blastp_CBE
21.34
69%
-128
- C1 -
-
2HBH
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
78
Blastp_CBE
20.90
69%
-128
- C1 -
-
3DR1
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-