@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR2A1_HNF4a: (2019-04-24 )
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
Atome Classification :
(7 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRL
S
K
T
L
V
DMDM
A
D
Y
SAALDP
A
Y
T
T
L
E
FE
N
V
Q
V
L
T
MGNDTSPSEGTNLNAPNSL
G
V
S
A
L
C
A
I
CGDRATGKHYGASSC
D
G
C
K
G
F
F
R
R
S
V
R
KNH
M
Y
S
C
RFSRQCVVDKDKR
N
Q
C
R
Y
C
R
L
K
K
C
F
R
AGM
K
K
E
A
V
Q
N
E
R
D
R
I
S
T
RRSSYEDSSL
P
S
I
N
A
L
L
Q
A
E
V
L
S
R
Q
ITSPVSGING
D
I
R
A
K
K
I
A
S
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
CELPLD
D
Q
V
A
L
L
R
AHAGE
H
L
L
LGAT
K
R
S
M
V
F
K
D
V
L
L
LGNDYIVPRH
C
P
E
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
VL
P
F
Q
E
LQIDDN
E
Y
A
Y
L
K
A
I
I
F
FDPDAKGLSD
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
INDRQYDSRGRF
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
LLGGSPSDAPHAHHPL
H
P
H
L
M
Q
E
HMGT
N
V
I
V
ANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSE
P
Y
KL
L
P
G
A
V
A
T
I
V
K
P
L
S
AIPQPTITKQEVI
4
PsiBlast_PDB
74.04
99%
-156
- C1 -
-
1PZL
1
HNF4A_HUMAN
A:
[5-237]
-------------------------------------------------------------------------------------------------------------------------------------------------
L
A
S
L
P
S
I
N
A
L
L
Q
A
E
V
L
S
R
Q
I
T
------
N
G
D
I
R
A
K
K
I
A
S
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
S
------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.35
100%
-153
- C1 -
-
3FS1
1
HNF4A_HUMAN
A:
[1-230]
---------------------------------------------------------------------------------------------------------------------------------------------------
S
L
P
S
I
N
A
L
L
Q
A
E
V
L
S
R
Q
I
T
S
P
V
S
G
I
N
G
D
I
R
A
K
K
I
A
S
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
-------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.90
97%
-167
- C1 -
-
1M7W
1
HNF4A_RAT
A:
[10-235]
------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
N
A
L
L
Q
A
E
V
L
S
Q
Q
I
T
S
P
I
S
---
G
D
I
R
A
K
R
I
A
S
I
T
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
L
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
C
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
--------------------------------------------------------------------------------------------------
31
Blastp_CBE
68.80
97%
-165
- C1 -
-
1M7W
1
HNF4A_RAT
D:
[7-235]
---------------------------------------------------------------------------------------------------------------------------------------------------
S
L
P
S
I
N
A
L
L
Q
A
E
V
L
S
Q
Q
I
T
S
--------
I
R
A
K
R
I
A
S
I
T
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
L
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
C
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
--------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.27
81%
-148
- C1 -
-
1LV2
1
HNF4G_HUMAN
A:
[4-229]
------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
N
T
L
A
Q
A
E
V
R
S
R
Q
I
S
V
S
S
----
T
D
I
N
V
K
K
I
A
S
I
G
D
V
C
E
S
M
K
Q
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
M
Y
K
D
I
L
L
L
G
N
N
Y
V
I
H
R
N
S
C
E
V
-
E
I
S
R
V
A
N
R
V
L
D
E
L
V
R
P
F
Q
E
I
Q
I
D
D
N
E
Y
A
C
L
K
A
I
V
F
F
D
P
D
A
K
G
L
S
D
P
V
K
I
K
N
M
R
F
Q
V
Q
I
G
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
V
K
L
F
G
M
V
K
I
D
N
L
L
Q
E
M
L
L
G
G
-------------------------------------------------------------------------------------------------
33
Blastp_CBE
64.23
97%
-154
- C1 -
-
1M7W
1
HNF4A_RAT
B:
[8-235]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
P
S
I
N
A
L
L
Q
A
E
V
L
S
Q
Q
I
T
----------
R
A
K
R
I
A
S
I
T
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
L
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
C
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
--------------------------------------------------------------------------------------------------
32
Blastp_CBE
63.16
97%
-145
- C1 -
-
1M7W
1
HNF4A_RAT
C:
[8-235]
----------------------------------------------------------------------------------------------------------------------------------------------------
L
P
S
I
N
A
L
L
Q
A
E
V
L
S
Q
Q
I
T
S
--------
I
R
A
K
R
I
A
S
I
T
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
L
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
E
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
C
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
--------------------------------------------------------------------------------------------------