@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3C1_GCR: (2019-04-25 )
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Atome Classification :
(54 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740-.......750.......760.......770.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDSKESLTPGREE
N
P
S
S
V
L
A
Q
ERG
D
V
M
D
F
Y
K
T
LRGG
A
T
V
K
V
SASSP
S
L
A
V
ASQSDSKQ
R
R
L
L
V
DFPKGSVSNAQQP
D
L
S
K
A
V
S
LS
M
G
L
Y
MGETE
T
K
VMGNDLGFPQQG
Q
I
S
LSSGE
T
D
L
K
L
L
E
E
S
I
A
NLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDV
S
S
E
Q
Q
H
LKGQTGTNGG
N
V
K
L
Y
TTDQ
S
T
F
D
I
L
Q
D
LEFSSGSPGKETNESPWRSD
L
L
IDENCLLSPLAGEDD
S
F
L
L
EGNSNEDCK
P
L
ILPDTKPKIKDNG
D
L
V
LSSPSNVTLPQVKT
E
K
E
D
F
I
E
LCTPGV
I
K
QEKL
G
T
V
Y
C
Q
ASFPGANIIGNK
M
S
A
I
S
V
H
G
V
STSG
G
Q
M
Y
H
Y
DMNTASLSQQQDQKP
I
F
NVIPPIPVGSENWNRCQGSGDDNL
T
S
L
GTLNFPG
R
T
V
FSNGYSSPSMRPDVSSPPSSSSTATTGPPP
K
L
C
L
V
CSDEASG
C
H
Y
G
V
L
TCG
S
C
K
V
F
F
K
R
A
VEGQH
N
Y
L
CAGRN
D
C
I
I
D
K
I
RRKNC
P
A
C
R
Y
R
K
C
L
Q
AGMNL
E
A
R
K
T
K
K
K
I
K
G
I
Q
Q
A
TTGVSQETSENPGN
K
T
I
V
PATLPQL
T
P
T
L
V
S
L
L
E
VIEP
E
V
L
Y
AGYDSSVPDS
T
W
R
I
M
T
T
L
N
MLG
G
R
Q
V
I
A
A
V
K
W
A
K
AIPGFRNLHLD
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
A
F
A
L
G
W
R
S
Y
R
QSSA
N
L
L
C
FAPD
L
I
INEQRMTL
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
SE
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
SSVPKDGL
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
KREGNS
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
TMSIE
F
P
E
M
L
A
E
I
I
T
N
QIPKYSNGN
I
K
K
L
L
FHQK
37
Blastp_CBE
95.06
97%
-170
- C1 -
-
4P6W
1
A:
[1-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
A
A
I
V
A
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
39
Blastp_CBE
94.49
94%
-168
- C1 -
-
3MNP
3
A:
[4-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
38
Blastp_CBE
92.73
94%
-172
- C1 -
-
3MNO
3
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
---
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
13
PsiBlast_PDB
92.52
99%
-164
* C1 *
-
1M2Z
4
GCR_HUMAN
A:
[3-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
16
PsiBlast_PDB
91.18
99%
-163
- C1 -
-
3K22
2
GCR_HUMAN
A:
[8-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
-
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
17
PsiBlast_PDB
90.74
99%
-168
- C1 -
-
3E7C
2
GCR_HUMAN
A:
[6-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
28
Blastp_CBE
90.16
99%
-165
- C1 -
-
3E7C
3
B:
[5-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
-----
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
21
Blastp_CBE
89.98
99%
-164
- C1 -
-
1P93
1
D:
[30-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
22
Blastp_CBE
89.97
99%
-165
- C1 -
-
1P93
1
GCR_HUMAN
C:
[30-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
24
Blastp_CBE
89.65
99%
-160
- C1 -
-
1M2Z
1
D:
[5-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
36
Blastp_CBE
89.54
95%
-164
- C1 -
-
3MNE
3
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
-----
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
3
PsiBlast_PDB
89.27
98%
-161
- C1 -
-
4UDC
2
A:
[32-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
8
PsiBlast_PDB
88.63
98%
-161
- C1 -
-
5NFP
4
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
5
PsiBlast_PDB
88.60
98%
-160
- C1 -
-
4UDD
5
A:
[32-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
20
PsiBlast_PDB
88.54
98%
-160
- C1 -
-
3BQD
1
A:
[3-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
18
PsiBlast_PDB
88.44
98%
-173
- C1 -
-
4LSJ
2
A:
[7-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
--------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
26
Blastp_CBE
88.11
99%
-161
- C1 -
-
3K23
1
GCR_HUMAN
B:
[9-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
---
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
14
PsiBlast_PDB
87.60
99%
-163
- C1 -
-
3CLD
1
GCR_HUMAN
A:
[8-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
27
Blastp_CBE
87.33
99%
-165
- C1 -
-
3CLD
1
B:
[10-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
6
PsiBlast_PDB
86.89
98%
-156
- C1 -
-
5G3J
3
A:
[32-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
4
PsiBlast_PDB
86.35
98%
-157
- C1 -
-
4CSJ
2
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
9
PsiBlast_PDB
85.86
98%
-155
- C1 -
-
6EL6
2
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
7
PsiBlast_PDB
85.86
98%
-155
- C1 -
-
5G5W
2
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
12
PsiBlast_PDB
84.21
97%
-155
- C1 -
-
6EL9
2
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
23
Blastp_CBE
84.01
99%
-157
- C1 -
-
1P93
1
GCR_HUMAN
B:
[32-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
2
PsiBlast_PDB
83.58
98%
-157
- C1 -
-
1P93
1
GCR_HUMAN
A:
[30-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
11
PsiBlast_PDB
83.10
97%
-153
- C1 -
-
6EL7
2
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
25
Blastp_CBE
83.04
99%
-154
- C1 -
-
3K23
1
C:
[7-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
-
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
-
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
---
N
I
K
K
L
L
F
H
--
43
Blastp_CBE
82.51
98%
-173
- C1 -
-
3H52
1
D:
[7-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
----------
E
M
L
A
E
I
I
T
N
Q
I
----
N
G
N
I
K
K
L
L
F
H
Q
-
10
PsiBlast_PDB
82.03
97%
-151
- C1 -
-
5NFT
4
A:
[32-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
15
PsiBlast_PDB
80.64
99%
-152
- C1 -
-
3K23
1
GCR_HUMAN
A:
[7-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
-
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
-----
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
52
Blastp_CBE
80.30
78%
-156
- C1 -
-
5UFS
1
?
A:
[1-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
45
Blastp_CBE
80.08
98%
-154
- C1 -
-
3H52
2
GCR_HUMAN
B:
[5-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
19
PsiBlast_PDB
79.49
99%
-161
- C1 -
-
5UC3
9
GCR_HUMAN
A:
[6-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
K
P
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
-------------------
G
N
I
K
K
L
L
F
H
Q
-
51
Blastp_CBE
79.21
78%
-155
- C1 -
-
5UFS
1
?
B:
[1-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
44
Blastp_CBE
79.11
98%
-170
- C1 -
-
3H52
1
GCR_HUMAN
C:
[5-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
--------------
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
50
Blastp_CBE
78.40
78%
-157
- C1 -
-
4E2J
2
?
A:
[4-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
-
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
29
Blastp_CBE
77.70
99%
-162
- C1 -
-
5UC3
3
B:
[6-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
K
P
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
-------------------
G
N
I
K
K
L
L
F
H
Q
-
49
Blastp_CBE
77.68
78%
-153
- C1 -
-
4E2J
3
?
B:
[4-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
48
Blastp_CBE
77.41
78%
-154
- C1 -
-
3GN8
1
?
A:
[1-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
47
Blastp_CBE
76.70
78%
-152
- C1 -
-
3GN8
1
?
B:
[1-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
42
Blastp_CBE
75.19
96%
-154
- C1 -
-
4MDD
1
GCR_HUMAN
A:
[11-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
A
L
E
T
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
41
Blastp_CBE
73.90
96%
-143
- C1 -
-
6DXK
1
GCR_HUMAN
A:
[11-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
A
L
E
T
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
40
Blastp_CBE
73.86
96%
-145
- C1 -
-
6DXK
1
B:
[11-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
A
L
E
T
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
46
Blastp_CBE
73.67
98%
-146
- C1 -
-
3H52
1
GCR_HUMAN
A:
[5-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
----
G
N
I
K
K
L
L
F
H
Q
-
1
PsiBlast_PDB
73.27
98%
-152
- C1 -
-
1NHZ
4
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
--------
N
I
K
K
L
L
F
H
Q
-
53
Blastp_CBE
67.94
92%
-164
- C1 -
-
5UC1
10
?
B:
[4-210]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
G
T
V
P
D
T
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
G
N
V
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
G
L
P
Y
M
Y
D
Q
C
K
Q
M
L
F
V
S
S
E
L
K
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
F
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
N
V
T
------------------------------------------------
55
Blastp_CBE
67.49
72%
-138
- C1 -
-
3RY9
3
?
B:
[1-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
--
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
-
58
Blastp_CBE
66.88
66%
-145
- C1 -
-
2Q1H
3
?
A:
[4-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
S
I
L
E
A
I
E
P
E
V
V
Y
A
G
Y
D
N
S
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
G
K
Q
M
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
R
Q
I
S
Q
E
F
V
R
L
Q
V
T
Y
E
E
F
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
R
R
A
I
A
---
N
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
D
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
K
-
56
Blastp_CBE
65.92
72%
-135
- C1 -
-
3RY9
2
?
A:
[2-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
S
T
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
K
59
Blastp_CBE
64.08
63%
-136
- C1 -
-
4FN9
3
?
B:
[5-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
--
54
Blastp_CBE
63.84
92%
-157
- C1 -
-
5UC1
9
?
A:
[4-210]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
G
T
V
P
D
T
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
G
N
V
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
G
L
P
Y
M
Y
D
Q
C
K
Q
M
L
F
V
S
S
E
L
K
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
F
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
N
V
T
------------------------------------------------
61
Blastp_CBE
63.74
63%
-134
- C1 -
-
4LTW
4
?
A:
[3-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
60
Blastp_CBE
63.21
63%
-132
- C1 -
-
4FN9
6
?
A:
[5-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-