@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1C3_PPARg: (2019-08-19 )
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Atome Classification :
(345 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGETLGDSPIDPESDSFT
D
T
L
SANISQ
E
M
T
M
VDTEMPFWPTNFGISSV
D
L
S
V
MEDHSHSFDI
K
P
F
T
T
V
DFSSISTPHYEDIPFTRTDP
V
V
AD
Y
K
YDL
K
L
Q
E
Y
Q
S
A
IKVEPASPPYY
S
E
K
T
Q
LYNKPHEEPSN
S
L
M
A
I
E
C
R
VCGDKASGF
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
DRCD
L
N
C
R
I
HKKSRN
K
C
Q
Y
C
R
F
Q
K
C
L
A
VGMSHNAIRFGRMP
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
QLNPE
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
SFPLT
K
A
K
A
R
A
I
L
TGKTTDKS
P
F
V
I
Y
D
M
N
S
LMMGED
K
I
K
F
KHIT
P
L
Q
E
Q
S
K
E
V
A
I
R
I
FQGCQFR
S
V
E
A
V
Q
E
I
T
E
Y
A
K
SIP
G
F
V
N
LDLND
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
MNKD
G
V
L
ISEGQ
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
FMEP
K
F
E
F
A
V
K
F
N
A
L
ELDDS
D
L
A
I
F
I
A
V
I
I
LSGDRPGLLNVK
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
LNHP
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
KTETDM
S
L
H
P
L
L
Q
E
I
Y
K
DLY
3
PsiBlast_PDB
87.20
100%
-144
- C1 -
-
3E00
1
PPARG_HUMAN
D:
[49-419]
--------------------------------------------------------------------------------------------------------------------------------------
M
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
--------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
1
PsiBlast_PDB
83.52
100%
-143
- C1 -
-
3DZU
1
PPARG_HUMAN
D:
[50-419]
---------------------------------------------------------------------------------------------------------------------------------------
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
26
Blastp_CBE
66.34
99%
-159
- C1 -
-
5DVC
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
117
Blastp_CBE
64.26
99%
-145
- C1 -
-
6FZG
1
?
A:
[2-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
M
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
201
Blastp_CBE
64.25
99%
-158
- C1 -
-
6IZN
1
?
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
89
Blastp_CBE
64.14
100%
-159
- C1 -
-
3OSW
2
PPARG_HUMAN
A:
[14-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
8
PsiBlast_PDB
63.98
99%
-145
- C1 -
-
3ADW
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
223
Blastp_CBE
63.60
100%
-144
- C1 -
-
5UGM
3
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
202
Blastp_CBE
63.38
99%
-152
- C1 -
-
6IZM
1
?
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
27
Blastp_CBE
63.22
99%
-149
- C1 -
-
5DV8
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
---
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
67
Blastp_CBE
62.97
99%
-143
- C1 -
-
2ZK6
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
157
Blastp_CBE
62.94
100%
-142
- C1 -
-
2OM9
3
PPARG_HUMAN
A:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
25
Blastp_CBE
62.91
99%
-149
- C1 -
-
5DWL
1
PPARG_HUMAN
A:
[15-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
--
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
124
Blastp_CBE
62.88
99%
-139
- C1 -
-
6FZF
1
?
B:
[5-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
M
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
69
Blastp_CBE
62.87
99%
-143
- C1 -
-
2ZK5
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
151
Blastp_CBE
62.86
100%
-156
- C1 -
-
2VST
1
PPARG_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
155
Blastp_CBE
62.58
100%
-141
- C1 -
-
2OM9
2
PPARG_HUMAN
C:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
92
Blastp_CBE
62.52
99%
-143
- C1 -
-
2ZVT
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
S
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
9
PsiBlast_PDB
62.52
99%
-143
- C1 -
-
3ADX
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
60
Blastp_CBE
62.23
99%
-145
- C1 -
-
3CDP
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
274
Blastp_CBE
62.20
99%
-156
- C1 -
-
3ET0
1
PPARG_HUMAN
A:
[22-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
11
PsiBlast_PDB
62.16
99%
-151
- C1 -
-
2YFE
1
PPARG_HUMAN
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
235
Blastp_CBE
62.13
100%
-155
- C1 -
-
3FEJ
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
85
Blastp_CBE
62.13
100%
-152
- C1 -
-
3PBA
1
PPARG_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
234
Blastp_CBE
62.12
100%
-155
- C1 -
-
3G9E
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
246
Blastp_CBE
62.11
100%
-154
- C1 -
-
2FVJ
2
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
207
Blastp_CBE
62.05
99%
-156
- C1 -
-
3V9V
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
42
Blastp_CBE
62.05
100%
-150
- C1 -
-
5YCN
1
PPARG_HUMAN
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
236
Blastp_CBE
62.01
100%
-152
- C1 -
-
3ET3
1
PPARG_HUMAN
A:
[22-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
74
Blastp_CBE
61.99
99%
-140
- C1 -
-
2ZK2
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
81
Blastp_CBE
61.77
100%
-153
- C1 -
-
6AN1
1
PPARG_HUMAN
A:
[13-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
125
Blastp_CBE
61.74
99%
-142
- C1 -
-
6FZF
1
?
A:
[9-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
M
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
12
PsiBlast_PDB
61.71
99%
-150
- C1 -
-
4A4V
1
PPARG_HUMAN
A:
[13-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
56
Blastp_CBE
61.70
99%
-145
- C1 -
-
3HOD
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
242
Blastp_CBE
61.69
100%
-153
- C1 -
-
2GTK
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
54
Blastp_CBE
61.66
99%
-152
- C1 -
-
3VJI
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
245
Blastp_CBE
61.65
100%
-143
- C1 -
-
2G0G
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
45
Blastp_CBE
61.55
100%
-148
- C1 -
-
5GTO
3
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
87
Blastp_CBE
61.54
100%
-158
- C1 -
-
1I7I
1
PPARG_HUMAN
A:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
13
PsiBlast_PDB
61.54
99%
-149
- C1 -
-
4A4W
1
PPARG_HUMAN
A:
[13-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
160
Blastp_CBE
61.44
100%
-150
- C1 -
-
3B0R
1
PPARG_HUMAN
A:
[1-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
156
Blastp_CBE
61.34
100%
-154
- C1 -
-
2OM9
3
PPARG_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
213
Blastp_CBE
61.33
99%
-152
- C1 -
-
3B1M
1
PPARG_HUMAN
A:
[12-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
183
Blastp_CBE
61.31
100%
-139
- C1 -
-
5TWO
1
PPARG_HUMAN
A:
[2-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
240
Blastp_CBE
61.24
100%
-156
- C1 -
-
2HWR
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
79
Blastp_CBE
61.24
99%
-144
- C1 -
-
2I4J
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
208
Blastp_CBE
61.18
99%
-153
- C1 -
-
3V9T
1
PPARG_HUMAN
A:
[12-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
43
Blastp_CBE
61.18
99%
-157
- C1 -
-
5LSG
1
PPARG_HUMAN
A:
[34-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
83
Blastp_CBE
61.12
100%
-152
- C1 -
-
3PO9
1
PPARG_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
29
Blastp_CBE
61.12
99%
-151
- C1 -
-
5DV3
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
58
Blastp_CBE
61.09
99%
-145
- C1 -
-
3D6D
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
10
PsiBlast_PDB
61.04
99%
-144
- C1 -
-
3R8I
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
230
Blastp_CBE
61.01
100%
-139
- C1 -
-
3NOA
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
90
Blastp_CBE
61.00
100%
-152
- C1 -
-
3OSI
1
PPARG_HUMAN
A:
[14-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
224
Blastp_CBE
60.97
100%
-140
- C1 -
-
5UGM
3
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
154
Blastp_CBE
60.96
100%
-154
- C1 -
-
2OM9
2
PPARG_HUMAN
D:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
165
Blastp_CBE
60.95
99%
-152
- C1 -
-
4R6S
1
PPARG_HUMAN
A:
[1-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
F
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
134
Blastp_CBE
60.91
100%
-147
- C1 -
-
4XUH
2
PPARG_HUMAN
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
103
Blastp_CBE
60.89
100%
-155
- C1 -
-
6FZP
1
?
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
--
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
4
PsiBlast_PDB
60.89
99%
-152
- C1 -
-
3ADS
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
140
Blastp_CBE
60.85
100%
-155
- C1 -
-
3X1H
1
PPARG_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
53
Blastp_CBE
60.81
99%
-148
- C1 -
-
3VSO
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
77
Blastp_CBE
60.80
99%
-142
- C1 -
-
2I4Z
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
249
Blastp_CBE
60.77
100%
-139
- C1 -
-
2ATH
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
59
Blastp_CBE
60.68
99%
-144
- C1 -
-
3CDS
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
107
Blastp_CBE
60.66
100%
-155
- C1 -
-
6AVI
2
PPARG_HUMAN
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
78
Blastp_CBE
60.65
99%
-141
- C1 -
-
2I4P
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
191
Blastp_CBE
60.63
100%
-157
- C1 -
-
3FUR
1
PPARG_HUMAN
A:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
153
Blastp_CBE
60.58
100%
-152
- C1 -
-
2VSR
2
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
71
Blastp_CBE
60.45
99%
-139
- C1 -
-
2ZK4
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
185
Blastp_CBE
60.42
100%
-149
- C1 -
-
4CI5
1
PPARG_HUMAN
A:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
166
Blastp_CBE
60.36
100%
-153
- C1 -
-
5U5L
1
PPARG_HUMAN
A:
[1-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
7
PsiBlast_PDB
60.33
99%
-151
- C1 -
-
3ADV
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
76
Blastp_CBE
60.31
99%
-138
- C1 -
-
2ZK1
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
132
Blastp_CBE
60.29
100%
-149
- C1 -
-
4XUM
2
PPARG_HUMAN
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
120
Blastp_CBE
60.29
100%
-153
- C1 -
-
3R5N
2
PPARG_HUMAN
A:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
88
Blastp_CBE
60.24
100%
-150
- C1 -
-
3VN2
1
PPARG_HUMAN
A:
[15-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
62
Blastp_CBE
60.09
99%
-149
- C1 -
-
3AN4
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
251
Blastp_CBE
60.06
100%
-163
- C1 -
-
4HEE
1
PPARG_HUMAN
X:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
243
Blastp_CBE
60.03
100%
-138
- C1 -
-
2G0H
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
55
Blastp_CBE
60.03
99%
-150
- C1 -
-
3VJH
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
206
Blastp_CBE
59.96
99%
-152
- C1 -
-
3V9Y
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
52
Blastp_CBE
59.93
99%
-146
- C1 -
-
3VSP
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
187
Blastp_CBE
59.87
100%
-152
- C1 -
-
3KMG
1
PPARG_HUMAN
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
168
Blastp_CBE
59.84
100%
-150
- C1 -
-
5TTO
1
PPARG_HUMAN
A:
[2-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
118
Blastp_CBE
59.76
99%
-144
- C1 -
-
6FZJ
1
?
B:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
I
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
---
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
130
Blastp_CBE
59.71
100%
-149
- C1 -
-
5AZV
1
PPARG_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
46
Blastp_CBE
59.69
100%
-140
- C1 -
-
5GTN
1
PPARG_HUMAN
A:
[8-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-----
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
244
Blastp_CBE
59.62
100%
-137
- C1 -
-
2G0H
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
94
Blastp_CBE
59.63
100%
-151
- C1 -
-
6MD4
1
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
203
Blastp_CBE
59.62
99%
-146
- C1 -
-
5Z6S
1
PPARG_HUMAN
A:
[12-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
216
Blastp_CBE
59.59
99%
-148
- C1 -
-
5Y2O
1
PPARG_HUMAN
A:
[24-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
40
Blastp_CBE
59.54
99%
-151
- C1 -
-
6F2L
1
PPARG_HUMAN
A:
[34-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
205
Blastp_CBE
59.51
99%
-150
- C1 -
-
4F9M
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
57
Blastp_CBE
59.52
99%
-142
- C1 -
-
3HO0
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
6
PsiBlast_PDB
59.51
99%
-156
- C1 -
-
3ADU
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
174
Blastp_CBE
59.46
100%
-151
- C1 -
-
2Q61
1
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
142
Blastp_CBE
59.46
100%
-149
- C1 -
-
3SZ1
2
PPARG_HUMAN
A:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
258
Blastp_CBE
59.43
99%
-152
- C1 -
-
6E5A
1
?
A:
[1-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
222
Blastp_CBE
59.41
100%
-158
- C1 -
-
6DHA
3
?
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
247
Blastp_CBE
59.39
100%
-135
- C1 -
-
2F4B
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
233
Blastp_CBE
59.35
100%
-137
- C1 -
-
3GBK
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
143
Blastp_CBE
59.29
100%
-159
- C1 -
-
2VV4
1
PPARG_HUMAN
A:
[4-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
63
Blastp_CBE
59.15
99%
-147
- C1 -
-
3AN3
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
96
Blastp_CBE
59.12
100%
-152
- C1 -
-
6MD2
2
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
28
Blastp_CBE
59.11
99%
-146
- C1 -
-
5DV6
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
199
Blastp_CBE
59.05
99%
-135
- C1 -
-
2HFP
2
PPARG_HUMAN
A:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
100
Blastp_CBE
59.04
100%
-154
- C1 -
-
6MD0
1
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
113
Blastp_CBE
58.98
100%
-149
- C1 -
-
3BC5
1
PPARG_HUMAN
A:
[22-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
---
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
--
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
211
Blastp_CBE
58.89
100%
-156
- C1 -
-
3S9S
1
PPARG_HUMAN
A:
[15-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
176
Blastp_CBE
58.86
100%
-151
- C1 -
-
2Q5S
1
PPARG_HUMAN
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
267
Blastp_CBE
58.85
99%
-154
- C1 -
-
2Q59
1
PPARG_HUMAN
A:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
102
Blastp_CBE
58.83
100%
-151
- C1 -
-
6MCZ
1
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
106
Blastp_CBE
58.78
100%
-152
- C1 -
-
6AVI
3
PPARG_HUMAN
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
184
Blastp_CBE
58.73
100%
-155
- C1 -
-
4CI5
1
PPARG_HUMAN
B:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
146
Blastp_CBE
58.66
100%
-151
- C1 -
-
2VV2
1
PPARG_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
15
PsiBlast_PDB
58.60
99%
-142
- C1 -
-
4E4Q
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
212
Blastp_CBE
58.58
99%
-142
- C1 -
-
3LMP
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
119
Blastp_CBE
58.55
99%
-143
- C1 -
-
6FZJ
1
?
A:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
I
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
--
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
109
Blastp_CBE
58.55
100%
-151
- C1 -
-
6AUG
2
PPARG_HUMAN
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
30
Blastp_CBE
58.54
99%
-153
- C1 -
-
5DSH
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
204
Blastp_CBE
58.48
99%
-145
- C1 -
-
5Z5S
1
PPARG_HUMAN
A:
[12-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
241
Blastp_CBE
58.47
100%
-149
- C1 -
-
2HWQ
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
138
Blastp_CBE
58.36
100%
-151
- C1 -
-
3X1I
1
PPARG_HUMAN
A:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
61
Blastp_CBE
58.36
99%
-139
- C1 -
-
3B3K
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
262
Blastp_CBE
58.34
100%
-140
- C1 -
-
4PRG
1
PPARG_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
221
Blastp_CBE
58.33
100%
-151
- C1 -
-
6DHA
1
?
B:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
73
Blastp_CBE
58.30
99%
-133
- C1 -
-
2ZK3
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
158
Blastp_CBE
58.25
99%
-139
- C1 -
-
1WM0
1
PPARG_HUMAN
X:
[18-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
147
Blastp_CBE
58.21
100%
-150
- C1 -
-
2VV1
1
PPARG_HUMAN
A:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
65
Blastp_CBE
58.20
99%
-145
- C1 -
-
2ZNO
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
--------
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
269
Blastp_CBE
58.11
100%
-146
- C1 -
-
4Y29
1
PPARG_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
231
Blastp_CBE
58.05
100%
-154
- C1 -
-
3IA6
1
PPARG_HUMAN
B:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
---
51
Blastp_CBE
57.98
99%
-147
- C1 -
-
3WMH
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
144
Blastp_CBE
57.95
100%
-148
- C1 -
-
2VV3
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
14
PsiBlast_PDB
57.89
99%
-138
- C1 -
-
4E4K
2
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
215
Blastp_CBE
57.88
99%
-145
- C1 -
-
5Y2T
1
PPARG_HUMAN
A:
[24-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
268
Blastp_CBE
57.83
100%
-148
- C1 -
-
6D3E
1
?
A:
[11-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
98
Blastp_CBE
57.82
100%
-147
- C1 -
-
6MD1
1
?
A:
[5-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
44
Blastp_CBE
57.79
100%
-148
- C1 -
-
5GTP
2
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
126
Blastp_CBE
57.75
100%
-147
- C1 -
-
5WR1
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
23
Blastp_CBE
57.73
99%
-161
- C1 -
-
5HZC
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
193
Blastp_CBE
57.68
100%
-149
- C1 -
-
2POB
1
PPARG_HUMAN
A:
[2-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
218
Blastp_CBE
57.67
99%
-149
- C1 -
-
3WJ5
1
PPARG_HUMAN
A:
[4-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
163
Blastp_CBE
57.54
100%
-142
- C1 -
-
6C1I
2
PPARG_HUMAN
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
178
Blastp_CBE
57.51
100%
-150
- C1 -
-
2Q5P
1
PPARG_HUMAN
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
149
Blastp_CBE
57.42
100%
-150
- C1 -
-
2VV0
1
PPARG_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
116
Blastp_CBE
57.33
100%
-143
- C1 -
-
1ZEO
1
PPARG_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
21
Blastp_CBE
57.33
99%
-148
- C1 -
-
6AD9
1
PPARG_HUMAN
A:
[18-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
5
PsiBlast_PDB
57.32
99%
-151
- C1 -
-
3ADT
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
80
Blastp_CBE
57.26
100%
-152
- C1 -
-
6ENQ
1
PPARG_HUMAN
A:
[9-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
229
Blastp_CBE
57.18
100%
-134
- C1 -
-
3NOA
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
128
Blastp_CBE
57.12
100%
-145
- C1 -
-
5WQX
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
162
Blastp_CBE
57.06
100%
-150
- C1 -
-
6C1I
2
PPARG_HUMAN
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
L
-
72
Blastp_CBE
57.04
99%
-142
- C1 -
-
2ZK3
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
237
Blastp_CBE
57.02
100%
-154
- C1 -
-
2Q8S
1
PPARG_HUMAN
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
186
Blastp_CBE
56.87
100%
-147
- C1 -
-
3KMG
1
PPARG_HUMAN
D:
[3-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
108
Blastp_CBE
56.81
100%
-147
- C1 -
-
6AUG
1
PPARG_HUMAN
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
227
Blastp_CBE
56.70
100%
-142
- C1 -
-
4EM9
4
PPARG_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
32
Blastp_CBE
56.67
99%
-145
- C1 -
-
4A4W
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
272
Blastp_CBE
56.64
99%
-145
- C1 -
-
6C5Q
2
PPARG_HUMAN
A:
[11-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
33
Blastp_CBE
56.44
99%
-144
- C1 -
-
4A4V
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
127
Blastp_CBE
56.40
100%
-143
- C1 -
-
5WR0
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
266
Blastp_CBE
56.39
100%
-139
- C1 -
-
4FGY
1
PPARG_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-----
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
189
Blastp_CBE
56.37
100%
-148
- C1 -
-
3K8S
1
PPARG_HUMAN
A:
[2-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
----
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
----
L
H
P
L
L
Q
E
I
Y
K
D
L
-
169
Blastp_CBE
56.28
100%
-153
- C1 -
-
4R06
1
PPARG_HUMAN
A:
[2-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
--
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
105
Blastp_CBE
56.20
100%
-142
- C1 -
-
4R2U
1
PPARG_HUMAN
A:
[3-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
248
Blastp_CBE
56.15
100%
-129
- C1 -
-
2ATH
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
256
Blastp_CBE
56.16
100%
-142
- C1 -
-
3CWD
1
PPARG_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
-------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
219
Blastp_CBE
56.15
99%
-153
- C1 -
-
3WJ4
1
PPARG_HUMAN
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
---
H
P
L
L
Q
E
I
Y
K
D
--
95
Blastp_CBE
56.11
100%
-153
- C1 -
-
6MD2
2
?
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
188
Blastp_CBE
56.05
100%
-143
- C1 -
-
3K8S
2
PPARG_HUMAN
B:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
220
Blastp_CBE
56.04
99%
-146
- C1 -
-
3WJ4
1
PPARG_HUMAN
A:
[4-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
75
Blastp_CBE
55.92
99%
-140
- C1 -
-
2ZK1
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
232
Blastp_CBE
55.90
100%
-148
- C1 -
-
3IA6
1
PPARG_HUMAN
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
190
Blastp_CBE
55.72
100%
-133
- C1 -
-
3H0A
1
PPARG_HUMAN
D:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-------
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
97
Blastp_CBE
55.71
100%
-147
- C1 -
-
6MD1
2
?
B:
[5-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
--
68
Blastp_CBE
55.69
99%
-139
- C1 -
-
2ZK5
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
179
Blastp_CBE
55.68
100%
-152
- C1 -
-
2Q59
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
---------
H
P
L
L
Q
E
I
Y
K
D
--
170
Blastp_CBE
55.65
100%
-155
- C1 -
-
2Q6S
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
---------
H
P
L
L
Q
E
I
Y
K
D
--
17
PsiBlast_PDB
55.55
99%
-133
- C1 -
-
4JL4
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
133
Blastp_CBE
55.48
100%
-149
- C1 -
-
4XUH
2
PPARG_HUMAN
B:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
Y
91
Blastp_CBE
55.32
99%
-138
- C1 -
-
2ZVT
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
S
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
16
PsiBlast_PDB
55.31
99%
-132
- C1 -
-
4JAZ
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
255
Blastp_CBE
55.30
100%
-140
- C1 -
-
3CWD
1
PPARG_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
19
PsiBlast_PDB
55.24
99%
-148
- C1 -
-
4PWL
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
257
Blastp_CBE
55.11
99%
-153
- C1 -
-
6E5A
1
?
B:
[3-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
D
L
-
175
Blastp_CBE
55.01
100%
-149
- C1 -
-
2Q5S
1
PPARG_HUMAN
B:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
D
L
-
101
Blastp_CBE
54.97
100%
-151
- C1 -
-
6MCZ
1
?
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
214
Blastp_CBE
54.90
99%
-148
- C1 -
-
5Y2T
1
PPARG_HUMAN
B:
[21-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
99
Blastp_CBE
54.87
100%
-150
- C1 -
-
6MD0
1
?
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
47
Blastp_CBE
54.85
99%
-151
- C1 -
-
4YT1
1
PPARG_HUMAN
B:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
131
Blastp_CBE
54.81
100%
-147
- C1 -
-
4XUM
1
PPARG_HUMAN
B:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
159
Blastp_CBE
54.80
100%
-158
- C1 -
-
3B0R
1
PPARG_HUMAN
B:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-------
H
P
L
L
Q
E
I
Y
----
39
Blastp_CBE
54.64
99%
-142
- C1 -
-
2YFE
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
----
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
---
327
Blastp_CBE
54.51
63%
-161
- C1 -
-
3SP9
1
PPARD_HUMAN
A:
[13-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
141
Blastp_CBE
54.46
100%
-147
- C1 -
-
3SZ1
2
PPARG_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
--
L
H
P
L
L
Q
E
I
Y
K
D
L
-
148
Blastp_CBE
54.23
100%
-151
- C1 -
-
2VV0
1
PPARG_HUMAN
B:
[7-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
93
Blastp_CBE
54.22
100%
-144
- C1 -
-
1NYX
1
PPARG_HUMAN
A:
[1-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
---------------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
35
Blastp_CBE
54.21
99%
-144
- C1 -
-
3ADW
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
273
Blastp_CBE
54.14
99%
-146
- C1 -
-
3ET0
1
PPARG_HUMAN
B:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
152
Blastp_CBE
53.99
100%
-148
- C1 -
-
2VSR
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
104
Blastp_CBE
53.96
100%
-146
- C1 -
-
4R2U
1
PPARG_HUMAN
D:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
150
Blastp_CBE
53.86
100%
-155
- C1 -
-
2VST
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
----
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
260
Blastp_CBE
53.85
100%
-131
- C1 -
-
4PRG
1
PPARG_HUMAN
C:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
164
Blastp_CBE
53.80
99%
-149
- C1 -
-
4R6S
1
PPARG_HUMAN
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
F
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
---
173
Blastp_CBE
53.68
100%
-142
- C1 -
-
2Q61
1
PPARG_HUMAN
B:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
--
H
P
L
L
Q
E
I
Y
K
D
L
-
228
Blastp_CBE
53.60
100%
-131
- C1 -
-
3QT0
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
182
Blastp_CBE
53.57
99%
-157
- C1 -
-
2VV4
1
PPARG_HUMAN
B:
[5-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
Q
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
K
---
70
Blastp_CBE
53.57
99%
-134
- C1 -
-
2ZK4
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
38
Blastp_CBE
53.56
99%
-151
- C1 -
-
3ADS
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
136
Blastp_CBE
53.51
100%
-156
- C1 -
-
4XTA
1
PPARG_HUMAN
A:
[9-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
--
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
--
L
H
P
L
L
Q
E
I
Y
----
135
Blastp_CBE
53.51
100%
-163
- C1 -
-
4XTA
1
PPARG_HUMAN
B:
[9-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
--------------------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
---
H
P
L
L
Q
E
I
Y
K
D
--
319
Blastp_CBE
53.45
63%
-155
- C1 -
-
5U3R
12
PPARD_HUMAN
A:
[1-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
338
Blastp_CBE
53.43
62%
-161
- C1 -
-
3TKM
2
PPARD_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
167
Blastp_CBE
53.41
100%
-146
- C1 -
-
5TTO
1
PPARG_HUMAN
B:
[3-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
344
Blastp_CBE
53.28
63%
-152
- C1 -
-
5U3T
10
PPARD_HUMAN
A:
[1-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
261
Blastp_CBE
53.21
100%
-133
- C1 -
-
4PRG
1
PPARG_HUMAN
B:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
145
Blastp_CBE
53.16
100%
-146
- C1 -
-
2VV2
2
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
181
Blastp_CBE
52.60
99%
-163
- C1 -
-
2VV1
1
PPARG_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
----
36
Blastp_CBE
52.60
99%
-147
- C1 -
-
3ADV
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
---
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
50
Blastp_CBE
52.59
99%
-149
- C1 -
-
3WMH
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
303
Blastp_CBE
52.56
63%
-150
- C1 -
-
5U42
8
PPARD_HUMAN
A:
[1-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
331
Blastp_CBE
52.54
62%
-154
- C1 -
-
3GWX
1
PPARD_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
180
Blastp_CBE
52.47
99%
-141
- C1 -
-
4OJ4
1
PPARG_HUMAN
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
---------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
M
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
24
Blastp_CBE
52.36
99%
-156
- C1 -
-
5F9B
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
139
Blastp_CBE
52.35
100%
-146
- C1 -
-
3X1H
1
PPARG_HUMAN
B:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
226
Blastp_CBE
52.27
100%
-164
- C1 -
-
4EM9
4
PPARG_HUMAN
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---
F
K
H
I
--------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
---------
L
H
P
L
L
Q
E
I
Y
K
---
171
Blastp_CBE
52.24
100%
-145
- C1 -
-
2Q6R
1
PPARG_HUMAN
B:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
82
Blastp_CBE
52.24
100%
-153
- C1 -
-
3PO9
5
PPARG_HUMAN
B:
[16-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
L
Y
359
Blastp_CBE
52.20
62%
-168
- C1 -
-
3KDT
1
PPARA_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
-------
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
86
Blastp_CBE
52.07
100%
-144
- C1 -
-
1I7I
1
PPARG_HUMAN
B:
[22-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
31
Blastp_CBE
52.04
99%
-149
- C1 -
-
4PVU
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
--------------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
271
Blastp_CBE
52.00
99%
-140
- C1 -
-
6C5T
1
PPARG_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-----
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
-
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
326
Blastp_CBE
51.97
63%
-156
- C1 -
-
3SP9
1
PPARD_HUMAN
B:
[13-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
--
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
311
Blastp_CBE
51.90
63%
-159
- C1 -
-
5U3Y
8
PPARD_HUMAN
A:
[2-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
129
Blastp_CBE
51.86
100%
-152
- C1 -
-
5AZV
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
K
---
287
Blastp_CBE
51.75
63%
-156
- C1 -
-
3ET2
4
PPARD_HUMAN
A:
[18-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
---
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
321
Blastp_CBE
51.64
63%
-157
- C1 -
-
5U3Q
11
PPARD_HUMAN
A:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
----
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
317
Blastp_CBE
51.64
63%
-149
- C1 -
-
5U3S
7
PPARD_HUMAN
A:
[1-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
309
Blastp_CBE
51.41
63%
-152
- C1 -
-
5U3Z
11
PPARD_HUMAN
A:
[3-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
217
Blastp_CBE
51.40
99%
-146
- C1 -
-
3WJ5
1
PPARG_HUMAN
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
289
Blastp_CBE
51.17
63%
-158
- C1 -
-
2B50
3
PPARD_HUMAN
A:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
-----
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
192
Blastp_CBE
51.16
100%
-158
- C1 -
-
2POB
1
PPARG_HUMAN
B:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
--------------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
---
L
H
P
L
L
Q
E
I
Y
K
---
333
Blastp_CBE
51.14
62%
-167
- C1 -
-
3DY6
1
PPARD_HUMAN
A:
[2-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
294
Blastp_CBE
51.12
63%
-156
- C1 -
-
5U46
4
PPARD_HUMAN
B:
[1-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
253
Blastp_CBE
51.07
100%
-140
- C1 -
-
3R8A
1
PPARG_HUMAN
A:
[12-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
-------
288
Blastp_CBE
51.05
63%
-157
- C1 -
-
2B50
3
PPARD_HUMAN
B:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
---
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
-----
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
115
Blastp_CBE
50.92
100%
-149
- C1 -
-
2P4Y
2
PPARG_HUMAN
A:
[5-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
------------------------
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
330
Blastp_CBE
50.78
62%
-148
- C1 -
-
3GWX
1
PPARD_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
295
Blastp_CBE
50.72
63%
-155
- C1 -
-
5U46
6
PPARD_HUMAN
A:
[1-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
64
Blastp_CBE
50.72
99%
-144
- C1 -
-
2ZNO
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
66
Blastp_CBE
50.65
99%
-138
- C1 -
-
2ZK6
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
263
Blastp_CBE
50.63
99%
-142
- C1 -
-
4L98
2
PPARG_HUMAN
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
34
Blastp_CBE
50.60
99%
-143
- C1 -
-
3ADX
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
286
Blastp_CBE
50.59
63%
-156
- C1 -
-
3ET2
3
PPARD_HUMAN
B:
[19-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
--
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
343
Blastp_CBE
50.58
63%
-154
- C1 -
-
5U3T
13
PPARD_HUMAN
B:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
---
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
339
Blastp_CBE
50.53
63%
-160
- C1 -
-
5U3W
4
PPARD_HUMAN
B:
[5-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
299
Blastp_CBE
50.42
63%
-161
- C1 -
-
5U44
5
PPARD_HUMAN
A:
[5-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
--------
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
360
Blastp_CBE
50.38
62%
-171
- C1 -
-
2REW
2
PPARA_HUMAN
A:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
----------
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
37
Blastp_CBE
50.37
99%
-137
- C1 -
-
3ADU
3
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
22
Blastp_CBE
50.29
99%
-152
- C1 -
-
5HZC
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
316
Blastp_CBE
50.23
63%
-158
- C1 -
-
5U3S
7
PPARD_HUMAN
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
340
Blastp_CBE
50.20
63%
-152
* C1 *
-
5U3W
7
PPARD_HUMAN
A:
[1-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
356
Blastp_CBE
50.15
62%
-157
- C1 -
-
3KDU
1
PPARA_HUMAN
B:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
341
Blastp_CBE
50.15
63%
-155
- C1 -
-
5U3V
8
PPARD_HUMAN
B:
[1-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
---
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
320
Blastp_CBE
50.12
63%
-151
- C1 -
-
5U3Q
10
PPARD_HUMAN
B:
[1-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
-
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
357
Blastp_CBE
49.88
62%
-159
- C1 -
-
3KDU
1
PPARA_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
-------
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
324
Blastp_CBE
49.88
63%
-168
- C1 -
-
2AWH
3
PPARD_HUMAN
B:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----------
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
349
Blastp_CBE
49.84
62%
-158
- C1 -
-
5Y7X
3
PPARD_HUMAN
B:
[24-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
--
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
296
Blastp_CBE
49.82
63%
-153
- C1 -
-
5U45
8
PPARD_HUMAN
B:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
--
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
310
Blastp_CBE
49.78
63%
-162
- C1 -
-
5U3Y
8
PPARD_HUMAN
B:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
278
Blastp_CBE
49.76
63%
-157
- C1 -
-
2XYW
2
PPARD_HUMAN
A:
[21-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
347
Blastp_CBE
49.73
63%
-174
- C1 -
-
2BAW
3
PPARD_HUMAN
B:
[1-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
-------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
------------
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
302
Blastp_CBE
49.70
63%
-156
- C1 -
-
5U42
8
PPARD_HUMAN
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
259
Blastp_CBE
49.59
100%
-124
- C1 -
-
4PRG
1
PPARG_HUMAN
D:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
358
Blastp_CBE
49.57
62%
-157
- C1 -
-
3KDT
1
PPARA_HUMAN
B:
[6-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
293
Blastp_CBE
49.56
63%
-158
- C1 -
-
2ZNP
3
PPARD_HUMAN
A:
[10-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
-------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
265
Blastp_CBE
49.55
99%
-138
- C1 -
-
4L96
1
PPARG_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
298
Blastp_CBE
49.49
63%
-155
- C1 -
-
5U44
4
PPARD_HUMAN
B:
[3-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
-------
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
276
Blastp_CBE
49.49
63%
-158
- C1 -
-
2XYX
2
PPARD_HUMAN
A:
[23-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
301
Blastp_CBE
49.47
63%
-149
- C1 -
-
5U43
7
PPARD_HUMAN
A:
[1-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
177
Blastp_CBE
49.44
100%
-153
- C1 -
-
2Q5P
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
----
F
K
H
I
T
--------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
--------
L
H
P
L
L
Q
E
I
Y
K
D
--
283
Blastp_CBE
49.38
63%
-164
- C1 -
-
3OZ0
1
PPARD_HUMAN
A:
[19-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
332
Blastp_CBE
49.29
62%
-166
- C1 -
-
3DY6
1
PPARD_HUMAN
B:
[4-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
277
Blastp_CBE
49.28
63%
-156
- C1 -
-
2XYW
2
PPARD_HUMAN
B:
[21-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
337
Blastp_CBE
49.25
62%
-162
- C1 -
-
5XMX
1
PPARD_HUMAN
A:
[6-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
313
Blastp_CBE
49.23
63%
-157
- C1 -
-
5U3X
6
PPARD_HUMAN
A:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
137
Blastp_CBE
49.16
100%
-159
- C1 -
-
3X1I
1
PPARG_HUMAN
B:
[9-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
--------
P
L
L
Q
E
I
Y
----
325
Blastp_CBE
49.08
63%
-164
- C1 -
-
2AWH
3
PPARD_HUMAN
A:
[1-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
----
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
----------
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
300
Blastp_CBE
49.04
63%
-158
- C1 -
-
5U43
7
PPARD_HUMAN
B:
[5-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
323
Blastp_CBE
49.03
63%
-158
- C1 -
-
1Y0S
2
PPARD_HUMAN
A:
[1-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
328
Blastp_CBE
49.02
62%
-164
- C1 -
-
3PEQ
2
PPARD_HUMAN
B:
[3-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
279
Blastp_CBE
49.00
63%
-159
- C1 -
-
2XYJ
4
PPARD_HUMAN
B:
[20-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
----
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
329
Blastp_CBE
48.95
62%
-162
- C1 -
-
3PEQ
3
PPARD_HUMAN
A:
[3-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
342
Blastp_CBE
48.82
63%
-155
- C1 -
-
5U3V
7
PPARD_HUMAN
A:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
348
Blastp_CBE
48.81
63%
-165
- C1 -
-
2BAW
3
PPARD_HUMAN
A:
[1-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
-----
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
----------
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
367
Blastp_CBE
48.61
62%
-154
- C1 -
-
3ET1
1
PPARA_HUMAN
B:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
275
Blastp_CBE
48.51
63%
-153
- C1 -
-
2XYX
2
PPARD_HUMAN
B:
[21-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
315
Blastp_CBE
48.42
63%
-161
- C1 -
-
5U3U
5
PPARD_HUMAN
A:
[3-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
--
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
305
Blastp_CBE
48.37
63%
-155
- C1 -
-
5U41
10
PPARD_HUMAN
A:
[5-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
345
Blastp_CBE
48.26
63%
-163
- C1 -
-
3D5F
1
PPARD_HUMAN
B:
[1-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
-------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
318
Blastp_CBE
48.25
63%
-159
- C1 -
-
5U3R
11
PPARD_HUMAN
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
--
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
355
Blastp_CBE
48.18
62%
-161
- C1 -
-
1I7G
2
PPARA_HUMAN
A:
[18-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
----------
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
304
Blastp_CBE
48.17
63%
-153
- C1 -
-
5U41
5
PPARD_HUMAN
B:
[4-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
297
Blastp_CBE
48.02
63%
-155
- C1 -
-
5U45
6
PPARD_HUMAN
A:
[5-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
314
Blastp_CBE
47.92
63%
-166
- C1 -
-
5U3U
2
PPARD_HUMAN
B:
[5-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
--------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
----
292
Blastp_CBE
47.87
63%
-154
- C1 -
-
2ZNP
3
PPARD_HUMAN
B:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
---
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
350
Blastp_CBE
47.69
62%
-158
- C1 -
-
5Y7X
4
PPARD_HUMAN
A:
[24-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
---
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
290
Blastp_CBE
47.67
63%
-155
- C1 -
-
2ZNQ
3
PPARD_HUMAN
B:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
307
Blastp_CBE
47.61
63%
-161
- C1 -
-
5U40
8
PPARD_HUMAN
A:
[5-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
--
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
308
Blastp_CBE
47.58
63%
-154
- C1 -
-
5U3Z
9
PPARD_HUMAN
B:
[5-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
291
Blastp_CBE
47.42
63%
-154
- C1 -
-
2ZNQ
3
PPARD_HUMAN
A:
[9-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
379
Blastp_CBE
47.37
62%
-157
- C1 -
-
2P54
1
PPARA_HUMAN
A:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
252
Blastp_CBE
47.19
100%
-155
- C1 -
-
3R8A
1
PPARG_HUMAN
B:
[12-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
------------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
----------
H
P
L
L
Q
E
I
Y
K
D
--
362
Blastp_CBE
47.18
62%
-153
- C1 -
-
3SP6
1
PPARA_HUMAN
A:
[14-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
----
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
381
Blastp_CBE
46.90
61%
-159
- C1 -
-
5AZT
1
PPARA_HUMAN
A:
[5-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
----
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
L
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
312
Blastp_CBE
46.71
63%
-161
- C1 -
-
5U3X
8
PPARD_HUMAN
B:
[5-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
--------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
352
Blastp_CBE
46.64
62%
-169
- C1 -
-
4CI4
1
PPARA_HUMAN
A:
[10-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
-----------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
280
Blastp_CBE
46.39
63%
-145
- C1 -
-
2XYJ
4
PPARD_HUMAN
A:
[20-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
--
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
---
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
377
Blastp_CBE
46.26
62%
-160
- C1 -
-
5HYK
1
PPARA_HUMAN
A:
[6-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
------
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
346
Blastp_CBE
46.23
63%
-158
- C1 -
-
3D5F
1
PPARD_HUMAN
A:
[1-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
361
Blastp_CBE
46.15
62%
-165
- C1 -
-
3G8I
1
PPARA_HUMAN
A:
[4-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
--------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
353
Blastp_CBE
46.07
62%
-157
- C1 -
-
4BCR
3
PPARA_HUMAN
B:
[3-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
322
Blastp_CBE
46.04
63%
-158
- C1 -
-
1Y0S
2
PPARD_HUMAN
B:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
380
Blastp_CBE
45.78
61%
-159
- C1 -
-
5AZT
1
PPARA_HUMAN
B:
[5-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
-
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
------------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
L
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
368
Blastp_CBE
45.64
62%
-154
- C1 -
-
3ET1
1
PPARA_HUMAN
A:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
--------
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
306
Blastp_CBE
45.60
63%
-152
- C1 -
-
5U40
7
PPARD_HUMAN
B:
[5-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
285
Blastp_CBE
45.57
63%
-158
- C1 -
-
2J14
1
PPARD_HUMAN
A:
[18-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
---
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
----------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
336
Blastp_CBE
45.46
62%
-164
- C1 -
-
5XMX
1
PPARD_HUMAN
B:
[10-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
-----------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
----
369
Blastp_CBE
45.28
62%
-155
- C1 -
-
3VI8
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
--
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
378
Blastp_CBE
44.60
62%
-166
- C1 -
-
3FEI
1
PPARA_HUMAN
A:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
---------------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
284
Blastp_CBE
43.56
63%
-154
- C1 -
-
2J14
1
PPARD_HUMAN
B:
[19-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
-----
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
--------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
370
Blastp_CBE
43.42
62%
-154
- C1 -
-
2ZNN
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
--
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
354
Blastp_CBE
42.95
62%
-151
- C1 -
-
4BCR
3
PPARA_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
114
Blastp_CBE
42.51
100%
-161
- C1 -
-
2P4Y
1
PPARG_HUMAN
B:
[9-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
-------
S
P
F
V
I
Y
D
M
N
S
-----------------------
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
------------
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
264
Blastp_CBE
41.90
99%
-140
- C1 -
-
4L98
2
PPARG_HUMAN
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
--------------------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
375
Blastp_CBE
40.60
62%
-155
- C1 -
-
1KKQ
1
PPARA_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
281
Blastp_CBE
39.14
63%
-168
- C1 -
-
2Q5G
1
PPARD_HUMAN
B:
[15-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----------
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
------------------
374
Blastp_CBE
39.05
62%
-155
- C1 -
-
1KKQ
1
PPARA_HUMAN
C:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
172
Blastp_CBE
38.92
100%
-146
- C1 -
-
2Q6R
1
PPARG_HUMAN
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
----
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
-----------------
H
P
L
L
Q
E
I
Y
K
D
L
-
376
Blastp_CBE
37.46
62%
-151
- C1 -
-
1KKQ
1
PPARA_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
373
Blastp_CBE
36.63
62%
-145
- C1 -
-
1KKQ
1
PPARA_HUMAN
D:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
-
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
282
Blastp_CBE
32.99
63%
-147
- C1 -
-
2Q5G
1
PPARD_HUMAN
A:
[16-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
--
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----------
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
--------
P
L
L
Q
E
I
Y
K
---
270
Blastp_CBE
30.37
100%
-
- C1 -
-
3U9Q
1
PPARG_HUMAN
A:
[208-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-