@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3C4_ANDR: (2019-08-20 )
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
Atome Classification :
(101 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
V
QLGLGRVYPRPP
S
K
T
Y
R
G
A
F
Q
N
L
F
Q
S
V
R
E
V
I
QNPGPRHPEAASAAPPG
A
S
L
L
L
L
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
QETS
P
R
Q
Q
Q
Q
QQGEDGSP
Q
A
HRRGP
T
G
Y
L
V
LDEEQQPSQP
Q
S
A
L
ECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPS
T
L
S
LLGPTFP
G
L
S
S
C
S
A
D
L
K
D
I
L
S
E
A
S
T
M
Q
L
L
Q
Q
Q
Q
Q
E
A
V
SEGSSSGRAREASGAPTSSKDNYLGGTSTISD
N
A
K
E
L
C
K
A
V
S
V
SMG
L
G
V
E
A
L
E
HLS
P
G
E
Q
LRGD
C
M
YAPLLGVPPAVRPTPCA
P
L
A
E
CKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSG
T
L
ELP
S
T
L
S
L
Y
KSGAL
D
E
A
A
A
YQSRDYYNF
P
L
ALAGPPPPPPPPHP
H
A
R
I
K
LENPLDYG
S
A
W
A
A
A
A
A
QCRYGD
L
A
S
LHGAGAAGPGSGSPSAAASSS
W
H
T
L
F
TAEE
G
Q
L
YGPCGGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSP
T
C
V
K
SEMGPWMDSYSGPYGD
M
R
L
ETARD
H
V
L
P
I
D
Y
YFPPQ
K
T
C
L
I
CGDEASG
C
H
Y
G
A
LTCG
S
C
K
V
F
F
K
R
AAEGKQ
K
Y
L
CASRNDC
T
I
D
K
F
R
RKNC
P
S
C
R
L
R
K
C
Y
E
AGM
T
L
G
A
R
K
L
K
K
LGN
L
K
L
QEEGEASSTTSP
T
E
E
T
T
Q
K
L
T
V
S
HIEGYEC
Q
P
I
F
L
N
V
L
E
AIEP
G
V
V
C
AGHDNNQ
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
ALPGFRNLHVDD
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
FTNVNS
R
M
L
Y
FA
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
EF
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
IIPVDGLKN
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
CKRKNP
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
HMVSVD
F
P
E
M
M
A
E
I
I
S
VQ
V
P
K
I
LSGK
V
K
P
I
Y
F
HTQ
9
PsiBlast_PDB
92.57
100%
-162
- C2 -
-
1XJ7
1
A:
[1-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
E
G
Y
E
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
33
Blastp_CBE
92.24
100%
-163
- C2 -
-
2QPY
2
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
7
PsiBlast_PDB
91.52
100%
-162
- C2 -
-
1E3G
1
A:
[13-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
35
Blastp_CBE
90.65
100%
-163
- C2 -
-
2PIX
2
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
53
Blastp_CBE
90.21
100%
-161
- C2 -
-
1T63
1
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
55
Blastp_CBE
89.49
100%
-159
- C2 -
-
2HVC
1
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
29
Blastp_CBE
89.15
99%
-166
- C2 -
-
2AX8
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
17
PsiBlast_PDB
88.50
99%
-160
- C2 -
-
3G0W
1
A:
[11-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
15
PsiBlast_PDB
88.43
99%
-161
- C2 -
-
2IHQ
1
A:
[12-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
70
Blastp_CBE
88.36
100%
-162
- C2 -
-
1XQ3
1
?
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
71
Blastp_CBE
88.30
100%
-163
- C2 -
-
1XOW
1
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
41
Blastp_CBE
88.21
100%
-157
- C2 -
-
2PIQ
2
?
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
45
Blastp_CBE
88.19
100%
-157
- C2 -
-
1T7R
1
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
85
Blastp_CBE
88.04
99%
-164
- C2 -
-
4OH6
1
A:
[2-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
26
Blastp_CBE
88.02
99%
-163
- C2 -
-
2AX6
1
A:
[8-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-----
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
20
PsiBlast_PDB
87.98
100%
-157
- C2 -
-
2YLO
2
?
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
91
Blastp_CBE
87.92
99%
-164
- C2 -
-
4OKX
1
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
87
Blastp_CBE
87.90
99%
-162
- C2 -
-
4OGH
1
A:
[2-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
93
Blastp_CBE
87.83
99%
-160
- C2 -
-
4OKT
1
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
54
Blastp_CBE
87.68
100%
-156
- C2 -
-
1T5Z
1
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
22
Blastp_CBE
87.58
100%
-157
- C2 -
-
3ZQT
2
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
28
Blastp_CBE
87.54
99%
-159
- C2 -
-
1I38
1
A:
[13-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
19
PsiBlast_PDB
87.42
100%
-166
- C2 -
-
2AXA
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
90
Blastp_CBE
87.40
99%
-165
- C2 -
-
4OLM
1
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
58
Blastp_CBE
87.33
97%
-159
- C2 -
-
5T8E
3
A:
[10-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
65
Blastp_CBE
87.20
100%
-155
- C2 -
-
3B66
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
69
Blastp_CBE
87.18
100%
-161
- C2 -
-
2AO6
1
A:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
36
Blastp_CBE
87.10
100%
-157
- C2 -
-
2PIW
3
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
84
Blastp_CBE
86.89
99%
-162
- C2 -
-
4OHA
1
A:
[2-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
40
Blastp_CBE
86.87
100%
-157
- C2 -
-
2PIR
2
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
99
Blastp_CBE
86.84
99%
-164
* C2 *
-
1Z95
1
A:
[1-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
56
Blastp_CBE
86.80
100%
-160
- C2 -
-
5VO4
1
A:
[1-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-----
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
1
PsiBlast_PDB
86.77
100%
-160
- C2 -
-
5CJ6
1
A:
[33-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
----
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
79
Blastp_CBE
86.65
100%
-157
- C2 -
-
2Z4J
1
A:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
67
Blastp_CBE
86.48
100%
-156
- C2 -
-
3B5R
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
97
Blastp_CBE
86.41
99%
-163
- C2 -
-
3RLL
1
A:
[2-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
94
Blastp_CBE
86.21
99%
-164
- C2 -
-
4OKB
1
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
24
Blastp_CBE
86.18
100%
-154
- C2 -
-
2YLP
3
A:
[8-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
8
PsiBlast_PDB
86.16
100%
-160
- C2 -
-
4QL8
1
A:
[11-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
-------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
44
Blastp_CBE
86.10
100%
-155
- C2 -
-
1T7T
1
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
63
Blastp_CBE
85.86
100%
-154
- C2 -
-
3B68
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
49
Blastp_CBE
85.85
100%
-156
- C2 -
-
1T76
2
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
5
PsiBlast_PDB
85.83
100%
-159
- C2 -
-
2PNU
3
A:
[17-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
-----
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
81
Blastp_CBE
85.79
99%
-157
- C2 -
-
4OJ9
2
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
14
PsiBlast_PDB
85.77
99%
-156
- C2 -
-
1I37
1
A:
[13-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
2
PsiBlast_PDB
85.70
100%
-154
- C2 -
-
2AM9
3
A:
[17-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
86
Blastp_CBE
85.69
99%
-161
- C2 -
-
4OH5
1
A:
[2-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
78
Blastp_CBE
85.68
99%
-155
- C2 -
-
5V8Q
4
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
A
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
25
Blastp_CBE
85.66
99%
-163
- C2 -
-
2AX7
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
6
PsiBlast_PDB
85.65
100%
-157
- C2 -
-
3V49
1
A:
[18-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
-----
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
66
Blastp_CBE
85.56
100%
-154
- C2 -
-
3B65
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
23
Blastp_CBE
85.52
100%
-153
- C2 -
-
2YLQ
2
A:
[8-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
75
Blastp_CBE
85.48
99%
-159
- C2 -
-
4OEY
1
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
57
Blastp_CBE
85.41
97%
-155
- C2 -
-
5T8J
2
A:
[10-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
51
Blastp_CBE
85.41
100%
-153
- C2 -
-
1T73
1
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
98
Blastp_CBE
85.33
99%
-158
- C2 -
-
1GS4
1
A:
[1-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
H
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
----
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
3
PsiBlast_PDB
85.32
100%
-158
- C2 -
-
2AMA
1
A:
[18-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
18
PsiBlast_PDB
85.18
100%
-162
- C2 -
-
2AX9
1
A:
[9-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
46
Blastp_CBE
85.17
100%
-154
- C2 -
-
1T7M
3
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
68
Blastp_CBE
85.16
100%
-154
- C2 -
-
2YHD
2
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
80
Blastp_CBE
85.13
99%
-156
- C2 -
-
2OZ7
1
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
39
Blastp_CBE
85.07
100%
-153
- C2 -
-
2PIT
2
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
83
Blastp_CBE
85.05
99%
-159
- C2 -
-
4OIL
1
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
92
Blastp_CBE
85.03
99%
-161
- C2 -
-
4OKW
1
A:
[2-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
95
Blastp_CBE
84.89
99%
-153
- C2 -
-
4OK1
1
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
47
Blastp_CBE
84.82
100%
-153
- C2 -
-
1T7F
1
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
77
Blastp_CBE
84.76
99%
-159
- C2 -
-
4OEA
1
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
89
Blastp_CBE
84.52
100%
-152
- C2 -
-
3RLJ
1
?
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
73
Blastp_CBE
84.45
99%
-158
- C2 -
-
4OFR
1
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-----
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
82
Blastp_CBE
84.41
99%
-159
- C2 -
-
4OIU
1
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
A
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
13
PsiBlast_PDB
84.40
99%
-153
- C2 -
-
2Q7L
2
A:
[9-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
Y
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
48
Blastp_CBE
84.38
100%
-151
- C2 -
-
1T79
1
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
52
Blastp_CBE
84.36
100%
-153
- C2 -
-
1T65
1
A:
[1-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
31
Blastp_CBE
84.35
100%
-151
- C2 -
-
5JJM
2
?
C:
[1-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
37
Blastp_CBE
84.30
100%
-153
- C2 -
-
2PIV
2
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
16
PsiBlast_PDB
84.12
99%
-155
- C2 -
-
2NW4
1
A:
[12-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
96
Blastp_CBE
83.97
99%
-159
- C2 -
-
4OJB
1
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--------
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
21
Blastp_CBE
83.95
100%
-156
- C2 -
-
4HLW
3
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
------
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
76
Blastp_CBE
83.90
99%
-156
- C2 -
-
4OED
1
?
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
64
Blastp_CBE
83.88
100%
-152
- C2 -
-
3B67
1
A:
[1-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
61
Blastp_CBE
83.26
100%
-153
- C2 -
-
3L3Z
1
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
-
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
72
Blastp_CBE
83.05
99%
-157
- C2 -
-
4OFU
1
A:
[2-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
10
PsiBlast_PDB
82.94
100%
-156
- C2 -
-
2Q7I
2
A:
[9-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
--------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
32
Blastp_CBE
82.87
100%
-148
- C2 -
-
5JJM
3
A:
[1-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
62
Blastp_CBE
82.69
100%
-150
- C2 -
-
3L3X
1
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
38
Blastp_CBE
82.54
100%
-152
- C2 -
-
2PIU
3
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
42
Blastp_CBE
82.27
100%
-151
- C2 -
-
2PIP
3
?
L:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
50
Blastp_CBE
82.26
100%
-150
- C2 -
-
1T74
2
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
11
PsiBlast_PDB
82.26
100%
-149
- C2 -
-
2Q7J
2
A:
[9-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
--
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
12
PsiBlast_PDB
82.04
99%
-155
- C2 -
-
2Q7K
2
?
A:
[9-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
Y
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
4
PsiBlast_PDB
81.91
100%
-152
- C2 -
-
2AMB
4
A:
[18-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
---
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
74
Blastp_CBE
81.82
99%
-153
- C2 -
-
4OEZ
1
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
60
Blastp_CBE
81.55
100%
-151
- C2 -
-
3V4A
1
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
-----
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
43
Blastp_CBE
80.21
100%
-146
- C2 -
-
2PIO
3
A:
[3-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
34
Blastp_CBE
79.76
100%
-145
- C2 -
-
2PKL
2
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
59
Blastp_CBE
77.49
99%
-143
- C2 -
-
5JJM
4
?
B:
[2-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
-
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
88
Blastp_CBE
77.32
99%
-149
- C2 -
-
4K7A
2
?
A:
[1-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
I
F
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
A
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
-------
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
103
Blastp_CBE
73.97
62%
-152
- C2 -
-
4LTW
4
?
A:
[4-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
101
Blastp_CBE
72.28
62%
-152
- C2 -
-
4FN9
3
?
B:
[6-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
--
102
Blastp_CBE
70.36
62%
-149
- C2 -
-
4FN9
6
?
A:
[6-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
100
Blastp_CBE
69.76
62%
-152
- C2 -
-
4FNE
5
?
A:
[6-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
-
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
---