@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1H3_LXRa: (2021-05-27 )
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Atome Classification :
(76 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.........140.......150.......160.......170.......180.......190..-----------------------.....200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSLWLGAPVPDIPPDS
A
V
E
LWKPGAQDASSQAQGGS
S
C
I
L
R
E
EARMPHSAGGTAGVGLEAAEP
T
A
L
L
TRAEPPSEPTEIR
P
Q
KRKKGPA
P
K
M
L
G
N
E
L
C
S
VCGDKASG
F
H
Y
N
V
LSCE
G
C
K
G
F
F
R
R
S
V
I
KGA--
H
Y
I
CHSGGHC
P
M
D
T
Y
M
R
R
K
C
Q
E
C
R
L
R
K
C
R
Q
AGM
R
E
E
CVL
S
E
E
Q
I
R
L
K
K
L
K
R
Q
E
E
E
QAHATSLPP-----------------------RASSPPQILPQL
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
CNRRSFSDRLRVTPWPMAPDPH
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
QL
P
G
F
L
QLSRED
Q
I
A
L
L
KTS
A
I
E
V
M
L
LETSRRYNPGSE
S
I
T
F
L
K
DFSY
N
R
E
D
F
A
KAG
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
LQLNDA
E
F
A
L
L
I
A
I
S
I
FSADRP
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
SIHHPHDR
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
HSE
Q
V
F
A
L
R
LQDKKL
P
P
L
L
S
E
I
WDVHE
25
Blastp_CBE
81.95
69%
-3
- C1 -
-
4NQA
1
NR1H2_HUMAN
I:
[5-389]
-------------------------------------------------------------------------------------
K
G
P
A
P
K
M
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
AR
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
VGPQGSSSSASGPGASPGGSEAG
S
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
7
PsiBlast_PDB
73.15
68%
23
- C1 -
-
4NQA
1
NR1H2_HUMAN (first)
B:
[4-388]
------------------------------------------------------------------------------------
K
K
G
P
A
P
K
M
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
AR
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
VGPQGSS----------------
S
Q
G
S
G
E
G
E
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
27
Blastp_CBE
59.61
96%
-131
- C1 -
-
3FAL
1
NR1H3_MOUSE
D:
[23-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
26
Blastp_CBE
59.24
96%
-129
- C1 -
-
3FC6
1
NR1H3_MOUSE
D:
[24-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
3
PsiBlast_PDB
57.72
100%
-133
- C1 -
-
3IPU
1
NR1H3_HUMAN
A:
[40-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
----
P
H
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
9
PsiBlast_PDB
57.54
95%
-137
- C1 -
-
3FC6
1
NR1H3_MOUSE
B:
[24-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
10
PsiBlast_PDB
57.48
95%
-132
- C1 -
-
3FAL
1
NR1H3_MOUSE
B:
[23-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
----
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
23
Blastp_CBE
56.56
100%
-134
- C1 -
-
3IPU
1
NR1H3_HUMAN
B:
[41-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
22
Blastp_CBE
56.31
100%
-145
- C1 -
-
5AVI
1
NR1H3_HUMAN
C:
[40-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-----------
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
11
PsiBlast_PDB
56.13
98%
-118
- C1 -
-
2ACL
-
NR1H3_MOUSE
B:
[2-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
6
PsiBlast_PDB
55.95
100%
-152
- C1 -
-
5HJS
1
NR1H3_HUMAN
A:
[41-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
----------
L
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
4
PsiBlast_PDB
55.92
100%
-145
- C1 -
-
5AVI
1
NR1H3_HUMAN
A:
[40-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-----------
R
V
T
P
W
P
----
P
H
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
21
Blastp_CBE
55.05
100%
-151
- C1 -
-
5HJS
1
NR1H3_HUMAN
B:
[41-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
----------
L
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
24
Blastp_CBE
54.35
100%
-148
- C1 -
-
3IPS
1
NR1H3_HUMAN
B:
[41-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
----------
L
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
5
PsiBlast_PDB
51.06
100%
-150
- C1 -
-
5AVL
1
NR1H3_HUMAN
A:
[40-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
V
T
P
W
--------
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
2
PsiBlast_PDB
49.91
100%
-148
- C1 -
-
3IPS
1
NR1H3_HUMAN
A:
[41-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
31
Blastp_CBE
49.87
77%
-123
- C1 -
-
1P8D
1
NR1H2_HUMAN
B:
[8-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
---
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
61
Blastp_CBE
49.86
76%
-129
- C1 -
-
5I4V
1
NCOA2_HUMAN (first)
A:
[9-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
A
S
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
76
Blastp_CBE
48.99
76%
-126
- C1 -
-
5KYA
1
NR1H2_HUMAN
E:
[26-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
A
S
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
18
PsiBlast_PDB
48.92
76%
-134
- C1 -
-
6S4T
2
NR1H2_HUMAN
A:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
---
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
1
PsiBlast_PDB
47.98
100%
-146
- C1 -
-
3IPQ
1
NR1H3_HUMAN
A:
[41-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-------------
T
P
W
P
--------
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
57
Blastp_CBE
47.65
76%
-133
- C1 -
-
3L0E
1
NR1H2_HUMAN
A:
[11-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
S
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
S
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
S
S
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
A
D
A
A
L
P
P
L
L
S
E
I
W
D
V
H
E
71
Blastp_CBE
47.63
76%
-118
- C1 -
-
6K9G
1
NR1H2_HUMAN
A:
[14-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
A
S
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
75
Blastp_CBE
47.36
76%
-122
- C1 -
-
5KYJ
1
NR1H2_HUMAN
A:
[26-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
A
S
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
50
Blastp_CBE
47.24
77%
-130
- C1 -
-
1PQ6
2
NR1H2_HUMAN
B:
[12-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
59
Blastp_CBE
46.79
76%
-140
- C1 -
-
5HJP
2
NR1H2_HUMAN
B:
[3-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--
A
D
P
A
S
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
33
Blastp_CBE
46.73
77%
-141
- C1 -
-
6S4U
1
NR1H2_HUMAN
C:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
---
P
K
V
T
P
W
-----
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
19
PsiBlast_PDB
46.30
76%
-136
- C1 -
-
6S4U
1
NR1H2_HUMAN
A:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
-----
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
12
PsiBlast_PDB
45.81
76%
-126
- C1 -
-
1P8D
1
NR1H2_HUMAN
A:
[8-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
43
Blastp_CBE
44.82
77%
-123
- C1 -
-
1PQC
1
NR1H2_HUMAN
B:
[11-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
--
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
47
Blastp_CBE
44.81
77%
-125
- C1 -
-
1PQ9
2
NR1H2_HUMAN
B:
[11-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
--
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
37
Blastp_CBE
44.48
77%
-120
- C1 -
-
6S4N
1
NR1H2_HUMAN
A:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
-----
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
60
Blastp_CBE
43.89
76%
-130
- C1 -
-
5I4V
1
NCOA2_HUMAN (first)
E:
[9-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
------
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
17
PsiBlast_PDB
43.72
76%
-132
- C1 -
-
6S4N
3
NR1H2_HUMAN
D:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
------
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
48
Blastp_CBE
43.68
77%
-134
- C1 -
-
1PQ9
2
NR1H2_HUMAN
A:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
-------
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
72
Blastp_CBE
43.52
76%
-119
- C1 -
-
6JIO
1
NR1H2_HUMAN
D:
[15-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--
A
D
P
A
S
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
62
Blastp_CBE
43.35
76%
-121
- C1 -
-
6K9M
1
NR1H2_HUMAN
D:
[15-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
--
K
V
T
P
W
P
--
A
D
P
A
S
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
39
Blastp_CBE
42.88
77%
-130
- C1 -
-
3KFC
1
NR1H2_HUMAN
B:
[11-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
77
Blastp_CBE
42.83
76%
-127
- C1 -
-
5KYA
1
NR1H2_HUMAN
A:
[26-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
------
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
40
Blastp_CBE
42.46
77%
-130
- C1 -
-
3KFC
1
NR1H2_HUMAN
A:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
20
PsiBlast_PDB
42.39
76%
-139
- C1 -
-
1PQ6
2
NR1H2_HUMAN
A:
[12-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
----
P
K
V
T
P
W
-----
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
56
Blastp_CBE
42.22
77%
-133
- C1 -
-
4RAK
3
NR1H2_HUMAN
B:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
58
Blastp_CBE
42.18
76%
-133
- C1 -
-
5HJP
1
NR1H2_HUMAN
D:
[3-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--------
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
44
Blastp_CBE
42.16
77%
-133
- C1 -
-
1PQC
1
NR1H2_HUMAN
A:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
-------
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
36
Blastp_CBE
41.97
77%
-138
- C1 -
-
6S4N
2
NR1H2_HUMAN
B:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
--
P
K
V
T
P
W
P
L
G
------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
74
Blastp_CBE
41.31
76%
-122
- C1 -
-
5KYJ
1
NR1H2_HUMAN
E:
[26-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
------
G
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
64
Blastp_CBE
41.20
76%
-135
- C1 -
-
6K9M
1
NR1H2_HUMAN
B:
[13-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
-
Q
P
K
V
T
P
W
P
L
----------
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
34
Blastp_CBE
41.02
77%
-133
- C1 -
-
6S4U
1
NR1H2_HUMAN
B:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
55
Blastp_CBE
40.88
77%
-134
- C1 -
-
5JY3
2
NR1H2_HUMAN
B:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
---
P
K
V
T
P
W
P
-------
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
38
Blastp_CBE
40.78
77%
-129
- C1 -
-
3KFC
1
NR1H2_HUMAN
D:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
52
Blastp_CBE
40.44
77%
-130
- C1 -
-
4DK8
1
NR1H2_HUMAN
A:
[5-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
---
K
V
T
P
W
-----
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
42
Blastp_CBE
40.07
77%
-130
- C1 -
-
1PQC
1
NR1H2_HUMAN
C:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
----
K
V
T
P
W
P
L
----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
68
Blastp_CBE
39.35
76%
-140
- C1 -
-
6K9G
1
NR1H2_HUMAN
D:
[14-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
-------
V
T
P
W
P
L
---------
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
46
Blastp_CBE
39.27
77%
-125
- C1 -
-
1PQ9
2
NR1H2_HUMAN
C:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
----
K
V
T
P
W
P
L
----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
65
Blastp_CBE
39.09
76%
-126
- C1 -
-
6K9M
1
NR1H2_HUMAN
A:
[13-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
-
P
K
V
T
P
W
P
--------
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
73
Blastp_CBE
38.97
76%
-126
- C1 -
-
6JIO
1
NR1H2_HUMAN
A:
[13-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--------
S
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
15
PsiBlast_PDB
38.45
76%
-136
- C1 -
-
1UPV
1
NR1H2_HUMAN
A:
[15-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
-----------
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
53
Blastp_CBE
37.94
77%
-131
- C1 -
-
5JY3
2
NR1H2_HUMAN
D:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
------
K
V
T
P
W
P
-------
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
16
PsiBlast_PDB
37.91
76%
-128
- C1 -
-
1UPW
1
NR1H2_HUMAN
A:
[15-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
-----------
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
8
PsiBlast_PDB
37.91
99%
-137
- C1 -
-
1UHL
1
NR1H3_HUMAN
B:
[1-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
------------------
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
---
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
49
Blastp_CBE
37.61
77%
-151
- C1 -
-
1PQ6
1
NR1H2_HUMAN
D:
[12-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
---
K
V
T
P
W
P
L
--------
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
---
K
L
P
P
L
L
S
E
I
W
D
V
H
-
51
Blastp_CBE
36.95
77%
-136
- C1 -
-
4DK8
1
NR1H2_HUMAN
C:
[5-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
-----
P
K
V
T
P
W
P
L
-------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
63
Blastp_CBE
36.64
76%
-118
- C1 -
-
6K9M
1
NR1H2_HUMAN
C:
[13-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
----------------
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
70
Blastp_CBE
36.63
76%
-130
- C1 -
-
6K9G
1
NR1H2_HUMAN
B:
[13-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
---------
T
P
W
P
----------
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
45
Blastp_CBE
36.26
77%
-152
- C1 -
-
1PQ9
2
NR1H2_HUMAN
D:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
------
V
T
P
W
-------
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
---
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
----
K
L
P
P
L
L
S
E
I
W
D
---
35
Blastp_CBE
35.87
77%
-130
- C1 -
-
6S4N
1
NR1H2_HUMAN
C:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
-----------------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
41
Blastp_CBE
35.65
77%
-151
- C1 -
-
1PQC
1
NR1H2_HUMAN
D:
[12-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
------
V
T
P
W
-------
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
---
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
----
K
L
P
P
L
L
S
E
I
W
D
---
32
Blastp_CBE
34.85
77%
-134
- C1 -
-
6S5K
1
NR1H2_HUMAN
A:
[3-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
------------------
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
69
Blastp_CBE
34.44
76%
-147
- C1 -
-
6K9G
1
NR1H2_HUMAN
C:
[13-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
------------------------
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
66
Blastp_CBE
33.01
76%
-143
- C1 -
-
6K9H
1
NR1H2_HUMAN
B:
[13-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
-----------
V
T
P
W
P
---------
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
--
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
K
L
P
P
L
L
S
E
I
W
D
V
H
E
79
Blastp_CBE
32.78
76%
-138
- C1 -
-
4DK7
1
NR1H2_HUMAN
A:
[13-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
---
K
V
T
P
W
P
L
-----
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
L
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
67
Blastp_CBE
32.46
76%
-131
- C1 -
-
6K9H
1
NR1H2_HUMAN
A:
[13-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
----------------------
A
S
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
--
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
13
PsiBlast_PDB
30.47
76%
-120
- C1 -
-
4RAK
3
NR1H2_HUMAN
A:
[22-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
----
K
L
P
P
L
L
S
E
I
W
----
78
Blastp_CBE
30.14
76%
-139
* C1 *
-
4DK7
1
NR1H2_HUMAN
C:
[13-245]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
-----
P
K
V
T
P
W
P
L
-------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
L
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
14
PsiBlast_PDB
28.99
76%
-130
- C1 -
-
5JY3
2
NR1H2_HUMAN
A:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
-----
P
K
V
T
P
W
P
-------
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
54
Blastp_CBE
28.63
77%
-127
- C1 -
-
5JY3
2
NR1H2_HUMAN
C:
[22-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
----
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
--
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
---
K
L
P
P
L
L
S
E
I
W
D
---