@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1I2_PXR: (2021-05-27 )
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
Atome Classification :
(52 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEVRPKESWNHA
D
F
V
H
CEDTESVPGKPSVNADEEVG
G
P
Q
I
C
R
VCGDKAT
G
Y
H
F
N
V
M
T
C
E
G
C
K
G
F
F
R
R
A
M
KRNA
R
L
RCPFRK
G
A
C
E
I
T
R
K
T
R
R
Q
C
Q
A
C
R
L
R
K
C
L
E
SGM
K
K
E
MIMS
D
E
A
V
E
E
R
R
A
L
I
K
R
K
KSERTGTQPLGVQGL
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
KNFRLPGVLSSGCEL
P
E
S
LQAP
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
RGEDGSVWNYKPPADS
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
RDLP
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
FNAETG
T
W
ECGR
L
S
Y
C
L
E
DTA
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
QLH
E
E
E
Y
V
L
M
Q
A
I
S
LFSPDRP
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
ECNRP
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
SI
N
A
Q
H
T
Q
R
L
L
R
IQDIHP
F
A
T
P
L
M
Q
E
L
FGITGS
23
Blastp_CBE
91.29
100%
0
- C- -
-
6TFI
4
NCOA1_HUMAN (first)
A:
[24-324]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-------------
P
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
27
Blastp_CBE
85.37
100%
0
- C- -
-
6HTY
5
NCOA1_HUMAN (first)
A:
[24-324]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
26
Blastp_CBE
81.52
100%
-148
- C1 -
-
6HTY
3
NR1I2_HUMAN
B:
[20-325]
-----------------------------------------------------------------------------------------------------------------------------------------
L
G
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-------------
P
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
17
PsiBlast_PDB
78.37
100%
-152
- C1 -
-
4X1G
4
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
22
Blastp_CBE
78.36
100%
-146
- C1 -
-
6TFI
7
NR1I2_HUMAN
B:
[20-342]
-----------------------------------------------------------------------------------------------------------------------------------------
L
G
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
48
Blastp_CBE
76.88
100%
-157
- C1 -
-
4S0T
1
NR1I2_HUMAN
B:
[23-312]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------
E
S
L
Q
A
P
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
13
PsiBlast_PDB
75.38
100%
-153
- C1 -
-
1NRL
1
NR1I2_HUMAN
A:
[24-315]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
-
34
Blastp_CBE
74.83
100%
-145
- C1 -
-
7AXL
3
NR1I2_HUMAN
A:
[22-316]
-------------------------------------------------------------------------------------------------------------------------------------------
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
------------------
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
-
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
31
Blastp_CBE
74.80
100%
-147
- C1 -
-
6NX1
1
NR1I2_HUMAN
B:
[20-339]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
25
Blastp_CBE
74.10
100%
-158
- C1 -
-
6P2B
3
NR1I2_HUMAN
A:
[24-326]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-------------
P
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
-----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
41
Blastp_CBE
73.73
100%
-151
- C1 -
-
7AXE
3
NR1I2_HUMAN
A:
[22-316]
-------------------------------------------------------------------------------------------------------------------------------------------
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-----------------
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
--
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
6
PsiBlast_PDB
73.73
100%
-156
- C1 -
-
6BNS
1
NCOA1_HUMAN (first)
A:
[20-324]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
------
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
37
Blastp_CBE
72.77
100%
-152
- C1 -
-
7AXI
4
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
47
Blastp_CBE
72.54
100%
-156
- C1 -
-
7AX8
1
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
16
PsiBlast_PDB
72.04
100%
-150
- C1 -
-
4X1F
3
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
-----
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
44
Blastp_CBE
71.99
100%
-153
- C1 -
-
7AXB
4
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
35
Blastp_CBE
71.92
100%
-155
- C1 -
-
7AXK
3
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
46
Blastp_CBE
71.62
100%
-151
- C1 -
-
7AX9
5
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
------------------
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
-
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
54
Blastp_CBE
70.93
100%
-152
- C1 -
-
6S41
1
NR1I2_HUMAN
B:
[1-323]
-----------------------------------------------------------------------------------------------------------------------------------------
L
G
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
---------------
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
---
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
51
Blastp_CBE
70.76
100%
-152
- C1 -
-
5A86
1
NR1I2_HUMAN
B:
[23-313]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
---
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
5
PsiBlast_PDB
69.63
100%
-159
- C1 -
-
6DUP
1
NR1I2_HUMAN
A:
[24-327]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
----------
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
8
PsiBlast_PDB
69.59
100%
-157
- C1 -
-
4S0T
1
NR1I2_HUMAN
A:
[24-310]
----------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------
E
S
L
Q
A
P
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
-----
42
Blastp_CBE
69.34
100%
-153
- C1 -
-
7AXD
5
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
------------------
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
36
Blastp_CBE
69.18
100%
-148
- C1 -
-
7AXJ
2
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
----
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
-
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
49
Blastp_CBE
68.84
100%
-155
- C1 -
-
1NRL
1
NR1I2_HUMAN
B:
[24-313]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
---------------
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
57
Blastp_CBE
68.63
99%
-143
- C1 -
-
2O9I
1
NR1I2_HUMAN
A:
[1-292]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
S
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
-
56
Blastp_CBE
68.53
99%
-142
- C1 -
-
2O9I
1
NR1I2_HUMAN
B:
[1-292]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
S
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
-
45
Blastp_CBE
68.32
100%
-148
- C1 -
-
7AXA
1
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
-----
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
2
PsiBlast_PDB
68.14
100%
-150
- C1 -
-
4J5X
1
NCOA1_HUMAN (first)
A:
[15-319]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
33
Blastp_CBE
67.63
100%
-157
- C1 -
-
6BNS
1
NR1I2_HUMAN
B:
[20-324]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
------------------
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
-----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
52
Blastp_CBE
67.56
99%
-148
- C1 -
-
6HJ2
1
NR1I2_HUMAN
A:
[22-315]
-------------------------------------------------------------------------------------------------------------------------------------------
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
------------------
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
---
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
4
PsiBlast_PDB
66.97
100%
-150
- C1 -
-
3HVL
1
NCOA1_HUMAN (first)
A:
[24-327]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
------
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
7
PsiBlast_PDB
66.41
100%
-161
- C1 -
-
4XHD
2
NR1I2_HUMAN
A:
[23-312]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
------------------
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
----
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
24
Blastp_CBE
65.14
100%
-156
- C1 -
-
6P2B
3
NR1I2_HUMAN
B:
[25-342]
----------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------------
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
-----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
32
Blastp_CBE
64.49
100%
-150
- C1 -
-
6NX1
1
NCOA1_HUMAN (first)
A:
[19-324]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
----------------
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
---
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
20
PsiBlast_PDB
63.51
100%
-154
- C1 -
-
5A86
1
NR1I2_HUMAN
A:
[25-314]
----------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
----------------
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
---
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
--
28
Blastp_CBE
63.08
100%
-147
- C1 -
-
3HVL
1
NR1I2_HUMAN
B:
[22-342]
-------------------------------------------------------------------------------------------------------------------------------------------
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
-------
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
38
Blastp_CBE
61.63
100%
-148
- C1 -
-
7AXH
4
NR1I2_HUMAN
A:
[23-316]
--------------------------------------------------------------------------------------------------------------------------------------------
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
------------------
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
55
Blastp_CBE
61.17
100%
-147
- C1 -
-
6S41
1
NR1I2_HUMAN
A:
[6-308]
----------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
----------------
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
-----
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
39
Blastp_CBE
60.30
100%
-155
- C1 -
-
7AXG
2
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-------------------
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
---
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
---
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
-
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
21
Blastp_CBE
58.95
100%
-145
- C1 -
-
4J5X
1
NCOA1_HUMAN (first)
B:
[13-334]
------------------------------------------------------------------------------------------------------------------------------------------
G
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------
S
R
E
E
A
A
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
----
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
43
Blastp_CBE
55.42
100%
-157
- C1 -
-
7AXC
6
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
-------------------
A
A
K
W
S
Q
V
R
K
D
L
C
--
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
----
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
11
PsiBlast_PDB
55.03
100%
-151
- C1 -
-
1ILH
1
NR1I2_HUMAN
A:
[24-313]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------------
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
T
A
G
G
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
58
Blastp_CBE
51.69
100%
-161
* C1 *
-
4NY9
2
NR1I2_HUMAN
A:
[1-290]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
------------------------
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
------
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
40
Blastp_CBE
50.48
100%
-156
- C1 -
-
7AXF
7
NR1I2_HUMAN
A:
[22-316]
-------------------------------------------------------------------------------------------------------------------------------------------
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------------
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
----
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
30
Blastp_CBE
47.01
100%
-155
- C1 -
-
6XP9
1
NCOA1_HUMAN (first)
A:
[20-325]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
---------------------
W
S
Q
V
R
K
D
---
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
-------
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
--------
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
50
Blastp_CBE
45.30
100%
-160
- C1 -
-
5X0R
1
NR1I2_HUMAN
B:
[21-311]
------------------------------------------------------------------------------------------------------------------------------------------
G
V
Q
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
-----------------------------
C
S
L
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
D
-----
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
-----
15
PsiBlast_PDB
40.87
100%
-152
- C1 -
-
3R8D
1
NR1I2_HUMAN
A:
[24-313]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
---------------------
K
W
S
Q
V
R
K
D
L
C
S
L
K
V
S
L
Q
L
R
G
-
D
G
S
V
W
N
Y
K
P
P
A
D
S
G
G
K
E
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
-----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
29
Blastp_CBE
36.71
100%
-163
- C1 -
-
6XP9
2
NR1I2_HUMAN
B:
[20-339]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------------------------
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
-------
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
-----
F
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
53
Blastp_CBE
28.60
100%
-163
- C1 -
-
1SKX
1
NR1I2_HUMAN
A:
[25-313]
----------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
--------------------------------
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
-------
I
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
--------
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
---
14
PsiBlast_PDB
27.04
100%
-160
- C1 -
-
2QNV
1
NR1I2_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
L
-------------------------------
K
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
-------
F
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
L
E
------
Q
Q
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
P
Q
P
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
G
S
19
PsiBlast_PDB
21.61
100%
-172
- C1 -
-
5X0R
1
NR1I2_HUMAN
A:
[24-314]
---------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
E
E
Q
R
M
M
I
R
E
L
M
D
A
Q
M
K
T
F
D
T
T
F
S
H
F
K
N
F
R
L
P
G
V
---------------------------------
V
S
L
Q
L
R
G
E
D
G
S
V
W
N
Y
K
P
P
A
--------
S
L
L
P
H
M
A
D
M
S
T
Y
M
F
K
G
I
I
S
F
A
K
V
I
S
Y
F
R
D
L
P
I
E
D
Q
I
S
L
L
K
G
A
A
F
E
L
C
Q
L
R
F
N
T
V
F
N
A
E
T
G
T
W
E
C
G
R
L
S
Y
C
----------
L
L
L
E
P
M
L
K
F
H
Y
M
L
K
K
L
Q
L
H
E
E
E
Y
V
L
M
Q
A
I
S
L
F
S
P
D
R
P
G
V
L
Q
H
R
V
V
D
Q
L
Q
E
Q
F
A
I
T
L
K
S
Y
I
E
C
N
R
---
A
H
R
F
L
F
L
K
I
M
A
M
L
T
E
L
R
S
I
N
A
Q
H
T
Q
R
L
L
R
I
Q
D
I
H
P
F
A
T
P
L
M
Q
E
L
F
G
I
T
--