@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR2F1_COT1: (2021-05-27 )
MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80.........90........100.......110.......120.......130.......140.......150.....--..160.......170...--....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280---.......290-........300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
M
V
VSSWRDPQDDVAGGNPGGP
N
P
A
A
Q
AARGGGGGA
G
E
Q
Q
Q
QAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQS-
Q
Q
H
I
E
C
V
V
CGDKSSGKHY
G
Q
F
T
C
E
G
C
K
S
F
F
K
R
S
V
RRN
L
T
Y
T
C
RANRNCPI
D
Q
H
H
R
N
Q
C
Q
Y
C
R
L
K
K
C
L
K
V
G
M
R
R
E
A
V
Q--RGRMPPTQPNPG
Q
Y
ALTN--GDPLN
G
H
C
Y
L
S
G
Y
I
S
L
L
LRAEPYPTSRYGSQCMQPNNIM
G
I
E
N
I
C
E
L
A
A
R
L
L
F
S
A
V
E
W
ARNIPFFPDLQITD
Q
V
S
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
QCSMP
L
H
V
A
P
L
L
A
A
AGL---HASPMS
A
D
R
--
V
V
A
F
M
D
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
LHVDS
A
E
Y
S
C
L
K
A
I
V
L
F
TSDACGLS
D
A
A
H
I
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
QYPN
Q
P
S
R
F
G
K
L
L
L
RLPS
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
LVGKT
P
I
E
T
L
I
R
D
M
LLSGSSFNW
P
Y
M
S
I
QCS
1
PsiBlast_PDB
78.69
96%
-171
- C1 -
-
3CJW
-
COT2_HUMAN
A:
[173-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
H
S
Y
L
S
G
Y
I
S
L
L
L
R
A
E
P
Y
P
T
-------------
M
G
I
E
N
I
C
E
L
A
A
R
M
L
F
S
A
V
E
W
A
R
N
I
P
F
F
P
D
L
Q
I
T
D
Q
V
A
L
L
R
L
T
W
S
E
L
F
V
L
N
A
A
Q
C
S
M
P
L
H
V
A
P
----------------------
V
A
F
M
D
H
I
R
I
F
Q
E
Q
V
E
K
L
K
A
L
H
V
D
S
A
E
Y
S
C
L
K
A
I
V
L
F
T
S
D
A
C
G
L
S
D
V
A
H
V
E
S
L
Q
E
K
S
Q
C
A
L
E
E
Y
V
R
S
Q
Y
P
N
Q
P
T
R
F
G
K
L
L
L
R
L
P
S
L
R
T
V
S
S
S
V
I
E
Q
L
F
F
V
R
L
V
G
K
T
P
I
E
T
L
I
R
D
M
L
L
S
G
S
S
F
N
---------
2
PsiBlast_PDB
72.90
44%
-66
- C1 -
-
3DZU
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
--
E
E
R
Q
R
-------------A-
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
---------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
4
PsiBlast_PDB
72.57
44%
-16
- C1 -
-
4NQA
1
RXRA_HUMAN
A:
[31-358]
------------------------------------------------------------------------------
A
S
F
T
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
--
E
E
R
Q
R
G
-----------
S
SA
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
-
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
3
PsiBlast_PDB
71.95
44%
-68
- C1 -
-
3E00
1
RXRA_HUMAN
A:
[137-460]
----------------------------------------------------------------------------------
K
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
--
E
E
R
Q
R
-------------A-
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
-----------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
5
PsiBlast_PDB
65.82
44%
-70
- C1 -
-
5UAN
1
RXRA_HUMAN
A:
[36-358]
-----------------------------------------------------------------------------------
H
I
-
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
----------
D
C
L
I
D
K
R
Q
R
N
-
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
--
E
E
R
---------------A-
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
----------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
-
A
T
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
6
PsiBlast_PDB
61.10
38%
-48
* C1 *
-
4IQR
1
HNF4A_HUMAN
A:
[21-338]
--------------------------------------------------------------------------------------
C
A
I
C
G
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
C
K
G
F
F
R
R
S
V
R
K
N
H
M
Y
S
C
R
F
S
R
Q
C
V
V
D
K
D
K
R
N
Q
C
R
Y
C
R
L
K
K
C
F
R
A
G
M
K
K
E
A
V
Q
NE--------------------
I
N
A
L
L
Q
A
E
V
L
S
R
Q
I
T
-------
S
P
V
S
G
I
N
G
D
-
I
R
A
K
K
I
A
S
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
VPR
H
C
P
E
L
A
E
M
S
--
R
V
S
----
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
-------------
10
PsiBlast_PDB
57.61
45%
-179
- C1 -
-
4LOG
-
MALE_ECOLI (first)
A:
[1217-1408]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
I
H
E
T
S
A
R
L
L
F
M
A
V
K
W
A
K
N
L
P
V
F
S
S
L
P
F
R
D
Q
V
I
L
L
E
E
A
W
S
E
L
F
L
L
G
A
I
Q
W
S
L
P
L
D
S
C
P
L
L
A
P
P
----------------
L
T
L
A
S
M
E
T
R
V
L
Q
E
T
I
S
R
F
R
A
L
A
V
D
P
T
E
F
A
C
M
K
A
L
V
L
F
K
P
E
T
R
G
L
K
D
P
E
H
V
E
A
L
Q
D
Q
S
Q
V
M
L
S
Q
H
S
K
A
H
H
P
S
Q
P
V
R
F
G
K
L
L
L
L
L
P
S
L
R
F
I
T
A
E
R
I
E
L
L
F
F
R
K
T
I
G
N
T
P
M
E
K
L
L
S
D
M
F
----------------
8
PsiBlast_PDB
49.88
38%
-54
- C1 -
-
6HN6
4
RXRA_HUMAN
A:
[45-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SA
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
11
PsiBlast_PDB
45.62
43%
-19
- C1 -
-
1DKF
1
RXRA_MOUSE
A:
[7-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
--
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
A
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
16
PsiBlast_PDB
44.83
42%
-29
- C1 -
-
3E94
1
RXRA_HUMAN
A:
[13-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
Y
V
E
A
N
M
G
L
-----
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
12
PsiBlast_PDB
44.29
42%
-23
- C1 -
-
4OC7
1
RXRA_HUMAN
A:
[23-247]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
Y
V
E
A
N
M
G
L
N
---
P
N
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
17
PsiBlast_PDB
41.52
42%
-27
- C1 -
-
3KWY
1
RXRA_HUMAN
A:
[13-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
----
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
--
I
D
T
F
L
M
E
M
L
----------------
14
PsiBlast_PDB
37.90
42%
-18
- C1 -
-
6JNO
1
RXRA_HUMAN
A:
[45-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
19
PsiBlast_PDB
37.77
42%
-17
- C1 -
-
4N8R
1
RXRA_HUMAN
A:
[45-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
13
PsiBlast_PDB
37.04
42%
-14
- C1 -
-
5ZQU
2
RXRA_HUMAN
A:
[44-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
20
PsiBlast_PDB
36.71
42%
-16
- C1 -
-
5TBP
4
RXRA_HUMAN
A:
[45-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
18
PsiBlast_PDB
36.31
42%
-11
- C1 -
-
4N5G
1
RXRA_HUMAN
A:
[45-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
N
S
A
H
S
AG
V
G
A
I
F
D
--
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
7
PsiBlast_PDB
30.39
43%
-13
- C1 -
-
2GL8
-
RXRG_HUMAN
A:
[11-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
N
M
E
N
S
T
N
D
P
V
T
--
C
H
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
D
L
T
L
E
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
V
S
V
Q
D
G
I
L
L
A
T
-
G
L
---
H
V
H
R
S
S
A
H
S
AG
V
G
S
I
F
D
--
R
V
L
T
E
L
V
S
K
M
K
D
M
Q
M
D
K
S
E
L
G
C
L
R
A
I
V
L
F
N
P
D
A
K
G
L
S
N
P
S
E
V
E
T
L
R
E
K
V
Y
A
T
L
E
A
Y
T
K
Q
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
--------------------------
9
PsiBlast_PDB
28.53
44%
-42
- C1 -
-
3EYB
-
?
A:
[266-484]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
A
V
E
P
K
D
G
N
M
V
E
Q
P
N
-------------
K
Q
L
V
T
L
V
E
W
A
K
R
I
P
H
F
S
D
L
P
I
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
A
F
S
H
R
S
I
D
V
K
D
G
I
L
L
A
S
-
G
L
---
H
V
H
R
S
S
A
H
Q
--
A
G
V
G
T
I
F
D
R
V
L
T
E
L
V
A
K
M
R
D
M
K
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
A
K
G
L
T
D
P
S
L
V
E
S
L
R
E
K
V
Y
A
S
L
E
E
Y
C
K
Q
Q
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
----------------
15
PsiBlast_PDB
18.49
95%
-104
- C1 -
-
2EBL
-
COT1_HUMAN
A:
[8-88]
------------------------------------------------------------------------------------
I
E
C
V
V
C
G
D
K
S
S
G
K
H
Y
G
Q
F
T
C
E
G
C
K
S
F
F
K
R
S
V
R
R
N
L
T
Y
T
C
R
A
N
R
N
C
P
I
D
Q
H
H
R
N
Q
C
Q
Y
C
R
L
K
K
C
L
K
V
G
M
R
R
E
A
V
Q
--
R
G
S
G
P
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------