@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1C1_PPARa: (2019-04-19 )
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVDTESPLCPLSPLEAGDLES
P
L
S
E
E
F
L
Q
E
MG
N
I
Q
E
I
S
Q
SIGEDSSGSFGF
T
E
Y
Q
Y
LGSCPGSDG
S
V
I
T
DTLSPASSPS
S
V
T
YPVVPGSVDESPS
G
A
L
N
I
E
C
R
I
CGDKASGYHYGV
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
V
Y
DKCDRS
C
K
IQKKNR
N
K
C
Q
Y
C
R
F
H
K
C
L
S
VGMSHNAIRFGRMP
R
S
E
K
A
K
L
K
A
E
I
L
T
CEHDIEDS
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
NFNMN
K
V
K
A
R
V
I
L
SGKASNNP
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
NGIQNKEA
E
V
R
I
F
H
C
CQCT
S
V
E
T
V
T
E
L
T
E
F
A
K
AIPGFANLDLND
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
MNKD
G
M
L
V
A
YGN
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
IMEPKF
D
F
A
M
K
F
N
A
L
ELDD
S
D
I
S
L
F
V
A
A
I
I
CCGDRPGLLN
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
QSNHPDD
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
KTESD
A
A
L
H
P
L
L
Q
E
I
Y
R
DMY
13
PsiBlast_PDB
72.91
100%
-170
- C1 -
-
2P54
1
PPARA_HUMAN
A:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
27
Blastp_CBE
72.64
100%
-164
- C1 -
-
3ET1
1
PPARA_HUMAN
B:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
11
PsiBlast_PDB
66.88
99%
-157
- C1 -
-
2NPA
1
PPARA_HUMAN
A:
[199-467]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
25
Blastp_CBE
66.77
99%
-171
- C1 -
-
3KDU
1
PPARA_HUMAN
B:
[4-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
6
PsiBlast_PDB
66.64
100%
-163
- C1 -
-
3SP6
1
PPARA_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
---
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
26
Blastp_CBE
65.71
99%
-171
- C1 -
-
3KDT
1
PPARA_HUMAN
B:
[4-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
28
Blastp_CBE
65.05
99%
-172
- C1 -
-
2NPA
1
PPARA_HUMAN
C:
[199-468]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
---
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
2
PsiBlast_PDB
60.70
100%
-163
- C1 -
-
4BCR
3
PPARA_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
8
PsiBlast_PDB
59.93
100%
-163
- C1 -
-
3ET1
1
PPARA_HUMAN
A:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
-------
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
5
PsiBlast_PDB
59.72
99%
-173
- C1 -
-
3KDU
1
PPARA_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
4
PsiBlast_PDB
59.66
99%
-182
- C1 -
-
3KDT
1
PPARA_HUMAN
A:
[7-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
24
Blastp_CBE
59.19
100%
-169
- C1 -
-
4BCR
3
PPARA_HUMAN
B:
[2-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
29
Blastp_CBE
51.58
100%
-160
- C1 -
-
1KKQ
1
PPARA_HUMAN
D:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
10
PsiBlast_PDB
51.03
100%
-161
- C1 -
-
3VI8
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
30
Blastp_CBE
50.44
100%
-166
- C1 -
-
1KKQ
1
PPARA_HUMAN
C:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
15
PsiBlast_PDB
50.44
99%
-174
- C1 -
-
5AZT
1
PPARA_HUMAN
A:
[5-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
----
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
L
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
7
PsiBlast_PDB
49.73
100%
-176
- C1 -
-
3G8I
1
PPARA_HUMAN
A:
[4-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
-------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
31
Blastp_CBE
49.21
100%
-165
- C1 -
-
1KKQ
1
PPARA_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
9
PsiBlast_PDB
48.63
100%
-162
- C1 -
-
2ZNN
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
3
PsiBlast_PDB
47.57
100%
-179
- C1 -
-
4CI4
1
PPARA_HUMAN
A:
[10-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
----------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
12
PsiBlast_PDB
47.28
100%
-164
- C1 -
-
1KKQ
1
PPARA_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
32
Blastp_CBE
46.36
99%
-168
* C1 *
-
5AZT
1
PPARA_HUMAN
B:
[5-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
-
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
-----------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
L
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
14
PsiBlast_PDB
41.84
100%
-174
- C1 -
-
3FEI
1
PPARA_HUMAN
A:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
--------------
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y