@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3A2_ERb: (2019-04-23 )
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Atome Classification :
(65 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDIKNSPSSLNSPSSYNCSQS
I
L
PLEHG
S
I
Y
I
P
S
S
YV
D
S
HHEYPA
M
T
F
YS
P
A
V
MNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGH
L
S
P
L
V
V
H
R
Q
L
S
H
L
YAEPQKSPWCEARSLEHTLPV
N
R
E
T
L
K
R
KVSGNRCASPVTGPGSKRD
A
H
F
C
A
V
C
S
D
YASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHN
D
Y
ICPATN
Q
C
TIDKNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
M
V
KCG
S
R
R
E
R
C
G
Y
R
L
V
R
R
QRSADE
Q
L
HCAGKAKRSGGH
A
P
R
V
R
E
L
L
L
D
AL
S
P
E
Q
L
V
L
T
L
LEAEPP
H
V
L
I
SRPSAPF
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
KIPG
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
RSIDHPG
K
L
I
FAPD
L
V
LDRDE
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
LNSSM
Y
P
L
V
T
ATQDAD
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
KSGI
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
HASNK
G
M
E
H
L
L
NMKCKNVV
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
G
C
K
SSITGSECSPAEDSKSKEGSQNPQSQ
61
Blastp_CBE
81.51
99%
-175
- C1 -
-
3OLL
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
T
--
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
60
Blastp_CBE
80.22
99%
-180
- C1 -
-
3OLL
1
B:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
T
---
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
35
Blastp_CBE
76.40
100%
-176
- C1 -
-
4J24
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
33
Blastp_CBE
75.08
100%
-180
- C1 -
-
4J24
1
ESR2_HUMAN
C:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
28
Blastp_CBE
74.79
99%
-176
- C1 -
-
5TOA
1
B:
[2-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
37
Blastp_CBE
73.03
100%
-178
- C1 -
-
3OMQ
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
32
Blastp_CBE
72.50
100%
-186
- C1 -
-
4J24
1
D:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
-------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
29
Blastp_CBE
71.70
100%
-180
- C1 -
-
1U3R
1
B:
[3-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
3
PsiBlast_PDB
70.07
100%
-178
- C1 -
-
1QKM
1
A:
[6-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-----
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
13
PsiBlast_PDB
70.01
100%
-178
- C1 -
-
1U3R
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-------
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
43
Blastp_CBE
69.44
100%
-175
- C1 -
-
3OLS
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
41
Blastp_CBE
68.06
100%
-175
- C1 -
-
3OMO
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
45
Blastp_CBE
67.87
100%
-178
- C1 -
-
2YJD
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
39
Blastp_CBE
67.61
100%
-175
- C1 -
-
3OMP
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
59
Blastp_CBE
66.58
99%
-188
- C1 -
-
2YLY
1
ESR2_HUMAN
A:
[2-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
4
PsiBlast_PDB
65.58
97%
-185
- C1 -
-
1L2J
1
ESR2_HUMAN
A:
[27-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
-----
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
----
L
V
T
A
T
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
34
Blastp_CBE
65.56
100%
-176
- C1 -
-
4J24
1
ESR2_HUMAN
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
44
Blastp_CBE
65.24
100%
-178
- C1 -
-
2YJD
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
26
Blastp_CBE
65.10
100%
-186
- C1 -
-
2JJ3
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
--
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
9
PsiBlast_PDB
64.86
99%
-175
- C1 -
-
4ZI1
1
A:
[2-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
-----------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
G
----------------------------
42
Blastp_CBE
64.79
100%
-181
- C1 -
-
3OLS
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
14
PsiBlast_PDB
64.78
100%
-183
- C1 -
-
2GIU
1
A:
[1-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
-
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-----
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
----
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
20
PsiBlast_PDB
64.55
100%
-175
- C1 -
-
1U3S
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
--------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
10
PsiBlast_PDB
63.68
99%
-176
- C1 -
-
5TOA
1
ESR2_HUMAN
A:
[2-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
-
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
50
Blastp_CBE
62.75
100%
-175
- C1 -
-
1U3S
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
40
Blastp_CBE
62.62
100%
-180
- C1 -
-
3OMO
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
38
Blastp_CBE
62.52
100%
-181
* C1 *
-
3OMP
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
12
PsiBlast_PDB
61.44
100%
-177
- C1 -
-
1U9E
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
52
Blastp_CBE
61.40
100%
-179
- C1 -
-
1U3Q
1
ESR2_HUMAN
C:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
56
Blastp_CBE
61.14
99%
-177
- C1 -
-
1ZAF
1
B:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
19
PsiBlast_PDB
61.01
100%
-177
- C1 -
-
1U3Q
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
36
Blastp_CBE
60.97
100%
-179
- C1 -
-
3OMQ
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
51
Blastp_CBE
60.24
100%
-179
- C1 -
-
1U3Q
1
D:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
31
Blastp_CBE
60.14
100%
-173
- C1 -
-
4J26
1
ESR2_HUMAN
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
----------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
2
PsiBlast_PDB
59.54
100%
-179
- C1 -
-
1YYE
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
17
PsiBlast_PDB
59.50
100%
-177
- C1 -
-
1X7B
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
30
Blastp_CBE
59.14
100%
-174
- C1 -
-
4J26
1
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
---------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
55
Blastp_CBE
59.09
100%
-178
- C1 -
-
2NV7
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
22
Blastp_CBE
58.99
100%
-182
- C1 -
-
1YY4
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
18
PsiBlast_PDB
58.90
100%
-181
- C1 -
-
1X7J
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
11
PsiBlast_PDB
57.65
100%
-172
- C1 -
-
1NDE
1
A:
[15-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
--
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
----
A
T
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
16
PsiBlast_PDB
56.41
100%
-176
- C1 -
-
1X78
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
62
Blastp_CBE
56.01
92%
-180
- C1 -
-
2J7Y
7
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
S
-----
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
------
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
53
Blastp_CBE
55.43
100%
-180
- C1 -
-
1U3Q
1
ESR2_HUMAN
B:
[1-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
47
Blastp_CBE
55.30
100%
-175
- C1 -
-
1X7B
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
63
Blastp_CBE
55.19
92%
-178
- C1 -
-
2J7X
5
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
S
---
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
------
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
57
Blastp_CBE
54.12
99%
-173
- C1 -
-
1ZAF
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
24
Blastp_CBE
53.64
100%
-181
- C1 -
-
2Z4B
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
46
Blastp_CBE
53.57
100%
-175
- C1 -
-
1X7J
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
15
PsiBlast_PDB
53.20
100%
-177
- C1 -
-
1X76
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
25
Blastp_CBE
52.84
100%
-186
- C1 -
-
2QTU
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
------
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
6
PsiBlast_PDB
51.24
100%
-175
- C1 -
-
2JJ3
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
--
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
49
Blastp_CBE
50.83
100%
-174
- C1 -
-
1X76
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
5
PsiBlast_PDB
50.63
100%
-179
- C1 -
-
2I0G
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
48
Blastp_CBE
50.48
100%
-170
- C1 -
-
1X78
1
B:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
64
Blastp_CBE
49.71
91%
-182
- C1 -
-
1QKN
1
A:
[8-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
S
A
N
Q
E
A
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
--------
D
L
L
L
E
M
L
N
A
---------------------------------
54
Blastp_CBE
49.71
100%
-172
- C1 -
-
2NV7
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
27
Blastp_CBE
49.56
100%
-181
- C1 -
-
2I0G
1
B:
[12-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
58
Blastp_CBE
48.94
99%
-178
- C1 -
-
2YLY
1
B:
[1-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
23
Blastp_CBE
48.16
97%
-186
- C1 -
-
1L2J
1
ESR2_HUMAN
B:
[21-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
L
L
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
-------------
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
--
L
V
T
A
T
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
-----
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
1
PsiBlast_PDB
47.72
100%
-175
- C1 -
-
1YY4
1
ESR2_HUMAN
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
7
PsiBlast_PDB
47.53
100%
-180
- C1 -
-
2Z4B
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
21
Blastp_CBE
46.46
100%
-174
- C1 -
-
1YYE
1
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
----------------------------------
8
PsiBlast_PDB
42.92
100%
-180
- C1 -
-
2QTU
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
------
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
65
Blastp_CBE
16.31
91%
-183
- C1 -
-
1HJ1
2
A:
[9-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
--------------
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
--------------------------------------------------