@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1C3_PPARg: (2019-08-14 )
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Atome Classification :
(247 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGETLGDSPIDPESDSFT
D
T
L
SANISQ
E
M
T
M
VDTEMPFWPTNFGISSV
D
L
S
V
MEDHSHSFDI
K
P
F
T
T
V
DFSSISTPHYEDIPFTRTDP
V
V
AD
Y
K
YDL
K
L
Q
E
Y
Q
S
A
IKVEPASPPYY
S
E
K
T
Q
LYNKPHEEPSN
S
L
M
A
I
E
C
R
VCGDKASGF
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
DRCD
L
N
C
R
I
HKKSRN
K
C
Q
Y
C
R
F
Q
K
C
L
A
VGMSHNAIRFGRMP
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
QLNPE
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
SFPLT
K
A
K
A
R
A
I
L
TGKTTDKS
P
F
V
I
Y
D
M
N
S
LMMGED
K
I
K
F
KHIT
P
L
Q
E
Q
S
K
E
V
A
I
R
I
FQGCQFR
S
V
E
A
V
Q
E
I
T
E
Y
A
K
SIP
G
F
V
N
LDLND
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
MNKD
G
V
L
ISEGQ
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
FMEP
K
F
E
F
A
V
K
F
N
A
L
ELDDS
D
L
A
I
F
I
A
V
I
I
LSGDRPGLLNVK
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
LNHP
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
KTETDM
S
L
H
P
L
L
Q
E
I
Y
K
DLY
3
PsiBlast_PDB
89.43
100%
-144
- C1 -
-
3E00
1
PPARG_HUMAN
D:
[49-419]
--------------------------------------------------------------------------------------------------------------------------------------
M
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
--------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
1
PsiBlast_PDB
85.44
100%
-143
- C1 -
-
3DZU
1
PPARG_HUMAN
D:
[50-419]
---------------------------------------------------------------------------------------------------------------------------------------
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
26
Blastp_CBE
64.14
99%
-159
- C1 -
-
5DVC
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
201
Blastp_CBE
61.88
99%
-158
- C1 -
-
6IZN
1
?
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
89
Blastp_CBE
61.77
100%
-159
- C1 -
-
3OSW
2
PPARG_HUMAN
A:
[14-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
117
Blastp_CBE
61.40
99%
-145
- C1 -
-
6FZG
1
?
A:
[2-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
M
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
8
PsiBlast_PDB
60.75
99%
-145
- C1 -
-
3ADW
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
202
Blastp_CBE
60.51
99%
-152
- C1 -
-
6IZM
1
?
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
223
Blastp_CBE
60.21
100%
-144
- C1 -
-
5UGM
3
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
151
Blastp_CBE
60.19
100%
-156
- C1 -
-
2VST
1
PPARG_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
27
Blastp_CBE
60.10
99%
-149
- C1 -
-
5DV8
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
---
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
25
Blastp_CBE
59.99
99%
-149
- C1 -
-
5DWL
1
PPARG_HUMAN
A:
[15-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
--
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
67
Blastp_CBE
59.52
99%
-143
- C1 -
-
2ZK6
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
69
Blastp_CBE
59.39
99%
-143
- C1 -
-
2ZK5
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
124
Blastp_CBE
59.31
99%
-139
- C1 -
-
6FZF
1
?
B:
[5-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
M
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
157
Blastp_CBE
59.28
100%
-142
- C1 -
-
2OM9
3
PPARG_HUMAN
A:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
234
Blastp_CBE
59.26
100%
-155
- C1 -
-
3G9E
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
235
Blastp_CBE
59.25
100%
-155
- C1 -
-
3FEJ
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
274
Blastp_CBE
59.23
99%
-156
* C1 *
-
3ET0
1
PPARG_HUMAN
A:
[22-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
85
Blastp_CBE
59.19
100%
-152
- C1 -
-
3PBA
1
PPARG_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
207
Blastp_CBE
59.18
99%
-156
- C1 -
-
3V9V
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
246
Blastp_CBE
59.16
100%
-154
- C1 -
-
2FVJ
2
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
92
Blastp_CBE
59.12
99%
-143
- C1 -
-
2ZVT
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
S
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
11
PsiBlast_PDB
59.10
99%
-151
- C1 -
-
2YFE
1
PPARG_HUMAN
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
9
PsiBlast_PDB
59.09
99%
-143
- C1 -
-
3ADX
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
42
Blastp_CBE
58.96
100%
-150
- C1 -
-
5YCN
1
PPARG_HUMAN
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
60
Blastp_CBE
58.91
99%
-145
- C1 -
-
3CDP
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
236
Blastp_CBE
58.90
100%
-152
- C1 -
-
3ET3
1
PPARG_HUMAN
A:
[22-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
87
Blastp_CBE
58.88
100%
-158
- C1 -
-
1I7I
1
PPARG_HUMAN
A:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
81
Blastp_CBE
58.88
100%
-153
- C1 -
-
6AN1
1
PPARG_HUMAN
A:
[13-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
155
Blastp_CBE
58.84
100%
-141
- C1 -
-
2OM9
2
PPARG_HUMAN
C:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
242
Blastp_CBE
58.64
100%
-153
- C1 -
-
2GTK
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
240
Blastp_CBE
58.61
100%
-156
- C1 -
-
2HWR
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
54
Blastp_CBE
58.59
99%
-152
- C1 -
-
3VJI
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
12
PsiBlast_PDB
58.53
99%
-150
- C1 -
-
4A4V
1
PPARG_HUMAN
A:
[13-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
45
Blastp_CBE
58.42
100%
-148
- C1 -
-
5GTO
3
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
56
Blastp_CBE
58.38
99%
-145
- C1 -
-
3HOD
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
160
Blastp_CBE
58.35
100%
-150
- C1 -
-
3B0R
1
PPARG_HUMAN
A:
[1-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
13
PsiBlast_PDB
58.27
99%
-149
- C1 -
-
4A4W
1
PPARG_HUMAN
A:
[13-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
245
Blastp_CBE
58.26
100%
-143
- C1 -
-
2G0G
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
74
Blastp_CBE
58.25
99%
-140
- C1 -
-
2ZK2
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
156
Blastp_CBE
58.21
100%
-154
- C1 -
-
2OM9
3
PPARG_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
43
Blastp_CBE
58.21
99%
-157
- C1 -
-
5LSG
1
PPARG_HUMAN
A:
[34-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
125
Blastp_CBE
58.20
99%
-142
- C1 -
-
6FZF
1
?
A:
[9-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
M
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
213
Blastp_CBE
58.12
99%
-152
- C1 -
-
3B1M
1
PPARG_HUMAN
A:
[12-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
83
Blastp_CBE
58.12
100%
-152
- C1 -
-
3PO9
1
PPARG_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
29
Blastp_CBE
58.04
99%
-151
- C1 -
-
5DV3
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
208
Blastp_CBE
57.98
99%
-153
- C1 -
-
3V9T
1
PPARG_HUMAN
A:
[12-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
103
Blastp_CBE
57.94
100%
-155
- C1 -
-
6FZP
1
?
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
--
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
90
Blastp_CBE
57.93
100%
-152
- C1 -
-
3OSI
1
PPARG_HUMAN
A:
[14-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
140
Blastp_CBE
57.88
100%
-155
- C1 -
-
3X1H
1
PPARG_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
165
Blastp_CBE
57.87
99%
-152
- C1 -
-
4R6S
1
PPARG_HUMAN
A:
[1-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
F
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
4
PsiBlast_PDB
57.85
99%
-152
- C1 -
-
3ADS
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
191
Blastp_CBE
57.83
100%
-157
- C1 -
-
3FUR
1
PPARG_HUMAN
A:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
154
Blastp_CBE
57.83
100%
-154
- C1 -
-
2OM9
2
PPARG_HUMAN
D:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
79
Blastp_CBE
57.78
99%
-144
- C1 -
-
2I4J
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
58
Blastp_CBE
57.74
99%
-145
- C1 -
-
3D6D
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
107
Blastp_CBE
57.73
100%
-155
- C1 -
-
6AVI
2
PPARG_HUMAN
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
183
Blastp_CBE
57.59
100%
-139
- C1 -
-
5TWO
1
PPARG_HUMAN
A:
[2-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
10
PsiBlast_PDB
57.57
99%
-144
- C1 -
-
3R8I
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
134
Blastp_CBE
57.50
100%
-147
- C1 -
-
4XUH
2
PPARG_HUMAN
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
53
Blastp_CBE
57.42
99%
-148
- C1 -
-
3VSO
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
166
Blastp_CBE
57.39
100%
-153
- C1 -
-
5U5L
1
PPARG_HUMAN
A:
[1-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
251
Blastp_CBE
57.34
100%
-163
- C1 -
-
4HEE
1
PPARG_HUMAN
X:
[14-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
153
Blastp_CBE
57.33
100%
-152
- C1 -
-
2VSR
2
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
230
Blastp_CBE
57.30
100%
-139
- C1 -
-
3NOA
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
59
Blastp_CBE
57.25
99%
-144
- C1 -
-
3CDS
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
77
Blastp_CBE
57.22
99%
-142
- C1 -
-
2I4Z
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
224
Blastp_CBE
57.21
100%
-140
- C1 -
-
5UGM
3
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
7
PsiBlast_PDB
57.15
99%
-151
- C1 -
-
3ADV
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
120
Blastp_CBE
57.10
100%
-153
- C1 -
-
3R5N
2
PPARG_HUMAN
A:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
249
Blastp_CBE
57.05
100%
-139
- C1 -
-
2ATH
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
185
Blastp_CBE
57.03
100%
-149
- C1 -
-
4CI5
1
PPARG_HUMAN
A:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
88
Blastp_CBE
56.98
100%
-150
- C1 -
-
3VN2
1
PPARG_HUMAN
A:
[15-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
132
Blastp_CBE
56.94
100%
-149
- C1 -
-
4XUM
2
PPARG_HUMAN
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
78
Blastp_CBE
56.92
99%
-141
- C1 -
-
2I4P
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
206
Blastp_CBE
56.80
99%
-152
- C1 -
-
3V9Y
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
55
Blastp_CBE
56.79
99%
-150
- C1 -
-
3VJH
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
6
PsiBlast_PDB
56.67
99%
-156
- C1 -
-
3ADU
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
62
Blastp_CBE
56.66
99%
-149
- C1 -
-
3AN4
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
222
Blastp_CBE
56.65
100%
-158
- C1 -
-
6DHA
3
?
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
71
Blastp_CBE
56.57
99%
-139
- C1 -
-
2ZK4
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
168
Blastp_CBE
56.56
100%
-150
- C1 -
-
5TTO
1
PPARG_HUMAN
A:
[2-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
143
Blastp_CBE
56.56
100%
-159
- C1 -
-
2VV4
1
PPARG_HUMAN
A:
[4-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
76
Blastp_CBE
56.45
99%
-138
- C1 -
-
2ZK1
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
52
Blastp_CBE
56.44
99%
-146
- C1 -
-
3VSP
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
187
Blastp_CBE
56.43
100%
-152
- C1 -
-
3KMG
1
PPARG_HUMAN
A:
[4-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
94
Blastp_CBE
56.38
100%
-151
- C1 -
-
6MD4
1
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
130
Blastp_CBE
56.29
100%
-149
- C1 -
-
5AZV
1
PPARG_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
40
Blastp_CBE
56.24
99%
-151
- C1 -
-
6F2L
1
PPARG_HUMAN
A:
[34-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
205
Blastp_CBE
56.23
99%
-150
- C1 -
-
4F9M
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
118
Blastp_CBE
56.22
99%
-144
- C1 -
-
6FZJ
1
?
B:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
I
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
---
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
258
Blastp_CBE
56.12
99%
-152
- C1 -
-
6E5A
1
?
A:
[1-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
243
Blastp_CBE
56.12
100%
-138
- C1 -
-
2G0H
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
216
Blastp_CBE
56.00
99%
-148
- C1 -
-
5Y2O
1
PPARG_HUMAN
A:
[24-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
142
Blastp_CBE
56.00
100%
-149
- C1 -
-
3SZ1
2
PPARG_HUMAN
A:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
46
Blastp_CBE
55.99
100%
-140
- C1 -
-
5GTN
1
PPARG_HUMAN
A:
[8-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-----
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
57
Blastp_CBE
55.90
99%
-142
- C1 -
-
3HO0
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
211
Blastp_CBE
55.88
100%
-156
- C1 -
-
3S9S
1
PPARG_HUMAN
A:
[15-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
174
Blastp_CBE
55.88
100%
-151
- C1 -
-
2Q61
1
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
203
Blastp_CBE
55.86
99%
-146
- C1 -
-
5Z6S
1
PPARG_HUMAN
A:
[12-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
184
Blastp_CBE
55.86
100%
-155
- C1 -
-
4CI5
1
PPARG_HUMAN
B:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
106
Blastp_CBE
55.81
100%
-152
- C1 -
-
6AVI
3
PPARG_HUMAN
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
100
Blastp_CBE
55.80
100%
-154
- C1 -
-
6MD0
1
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
96
Blastp_CBE
55.69
100%
-152
- C1 -
-
6MD2
2
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
113
Blastp_CBE
55.65
100%
-149
- C1 -
-
3BC5
1
PPARG_HUMAN
A:
[22-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
---
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
--
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
244
Blastp_CBE
55.62
100%
-137
- C1 -
-
2G0H
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
63
Blastp_CBE
55.62
99%
-147
- C1 -
-
3AN3
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
267
Blastp_CBE
55.60
99%
-154
- C1 -
-
2Q59
1
PPARG_HUMAN
A:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
221
Blastp_CBE
55.56
100%
-151
- C1 -
-
6DHA
1
?
B:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
28
Blastp_CBE
55.48
99%
-146
- C1 -
-
5DV6
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
176
Blastp_CBE
55.35
100%
-151
- C1 -
-
2Q5S
1
PPARG_HUMAN
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
102
Blastp_CBE
55.35
100%
-151
- C1 -
-
6MCZ
1
?
A:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
233
Blastp_CBE
55.33
100%
-137
- C1 -
-
3GBK
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
109
Blastp_CBE
55.33
100%
-151
- C1 -
-
6AUG
2
PPARG_HUMAN
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
30
Blastp_CBE
55.31
99%
-153
- C1 -
-
5DSH
1
PPARG_HUMAN
A:
[16-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
146
Blastp_CBE
55.29
100%
-151
- C1 -
-
2VV2
1
PPARG_HUMAN
A:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
247
Blastp_CBE
55.22
100%
-135
- C1 -
-
2F4B
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
241
Blastp_CBE
55.10
100%
-149
- C1 -
-
2HWQ
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
231
Blastp_CBE
55.10
100%
-154
- C1 -
-
3IA6
1
PPARG_HUMAN
B:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
---
138
Blastp_CBE
55.04
100%
-151
- C1 -
-
3X1I
1
PPARG_HUMAN
A:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
15
PsiBlast_PDB
54.89
99%
-142
- C1 -
-
4E4Q
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
23
Blastp_CBE
54.84
99%
-161
- C1 -
-
5HZC
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
147
Blastp_CBE
54.73
100%
-150
- C1 -
-
2VV1
1
PPARG_HUMAN
A:
[5-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
199
Blastp_CBE
54.66
99%
-135
- C1 -
-
2HFP
2
PPARG_HUMAN
A:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
119
Blastp_CBE
54.65
99%
-143
- C1 -
-
6FZJ
1
?
A:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
I
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
--
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
262
Blastp_CBE
54.60
100%
-140
- C1 -
-
4PRG
1
PPARG_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
204
Blastp_CBE
54.58
99%
-145
- C1 -
-
5Z5S
1
PPARG_HUMAN
A:
[12-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
65
Blastp_CBE
54.57
99%
-145
- C1 -
-
2ZNO
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
--------
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
212
Blastp_CBE
54.56
99%
-142
- C1 -
-
3LMP
1
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
51
Blastp_CBE
54.48
99%
-147
- C1 -
-
3WMH
1
PPARG_HUMAN
A:
[15-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
61
Blastp_CBE
54.44
99%
-139
- C1 -
-
3B3K
1
PPARG_HUMAN
A:
[17-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
44
Blastp_CBE
54.43
100%
-148
- C1 -
-
5GTP
2
PPARG_HUMAN
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
144
Blastp_CBE
54.33
100%
-148
- C1 -
-
2VV3
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
268
Blastp_CBE
54.29
100%
-148
- C1 -
-
6D3E
1
?
A:
[11-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
158
Blastp_CBE
54.27
99%
-139
- C1 -
-
1WM0
1
PPARG_HUMAN
X:
[18-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
269
Blastp_CBE
54.26
100%
-146
- C1 -
-
4Y29
1
PPARG_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
149
Blastp_CBE
54.10
100%
-150
- C1 -
-
2VV0
1
PPARG_HUMAN
A:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
98
Blastp_CBE
54.09
100%
-147
- C1 -
-
6MD1
1
?
A:
[5-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
178
Blastp_CBE
54.04
100%
-150
- C1 -
-
2Q5P
1
PPARG_HUMAN
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
5
PsiBlast_PDB
54.04
99%
-151
- C1 -
-
3ADT
2
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
80
Blastp_CBE
53.97
100%
-152
- C1 -
-
6ENQ
1
PPARG_HUMAN
A:
[9-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
218
Blastp_CBE
53.94
99%
-149
- C1 -
-
3WJ5
1
PPARG_HUMAN
A:
[4-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
126
Blastp_CBE
53.95
100%
-147
- C1 -
-
5WR1
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
215
Blastp_CBE
53.94
99%
-145
- C1 -
-
5Y2T
1
PPARG_HUMAN
A:
[24-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
73
Blastp_CBE
53.91
99%
-133
- C1 -
-
2ZK3
1
PPARG_HUMAN
A:
[13-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
193
Blastp_CBE
53.90
100%
-149
- C1 -
-
2POB
1
PPARG_HUMAN
A:
[2-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
162
Blastp_CBE
53.82
100%
-150
- C1 -
-
6C1I
2
PPARG_HUMAN
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
L
-
237
Blastp_CBE
53.79
100%
-154
- C1 -
-
2Q8S
1
PPARG_HUMAN
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
14
PsiBlast_PDB
53.76
99%
-138
- C1 -
-
4E4K
2
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
163
Blastp_CBE
53.67
100%
-142
- C1 -
-
6C1I
2
PPARG_HUMAN
A:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
116
Blastp_CBE
53.61
100%
-143
- C1 -
-
1ZEO
1
PPARG_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
108
Blastp_CBE
53.43
100%
-147
- C1 -
-
6AUG
1
PPARG_HUMAN
B:
[6-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
21
Blastp_CBE
53.41
99%
-148
- C1 -
-
6AD9
1
PPARG_HUMAN
A:
[18-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
272
Blastp_CBE
53.31
99%
-145
- C1 -
-
6C5Q
2
PPARG_HUMAN
A:
[11-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
128
Blastp_CBE
53.20
100%
-145
- C1 -
-
5WQX
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
32
Blastp_CBE
53.16
99%
-145
- C1 -
-
4A4W
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
72
Blastp_CBE
53.12
99%
-142
- C1 -
-
2ZK3
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
189
Blastp_CBE
53.07
100%
-148
- C1 -
-
3K8S
1
PPARG_HUMAN
A:
[2-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
----
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
----
L
H
P
L
L
Q
E
I
Y
K
D
L
-
219
Blastp_CBE
53.01
99%
-153
- C1 -
-
3WJ4
1
PPARG_HUMAN
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
---
H
P
L
L
Q
E
I
Y
K
D
--
186
Blastp_CBE
53.01
100%
-147
- C1 -
-
3KMG
1
PPARG_HUMAN
D:
[3-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
229
Blastp_CBE
52.95
100%
-134
- C1 -
-
3NOA
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
95
Blastp_CBE
52.91
100%
-153
- C1 -
-
6MD2
2
?
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
33
Blastp_CBE
52.83
99%
-144
- C1 -
-
4A4V
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
169
Blastp_CBE
52.75
100%
-153
- C1 -
-
4R06
1
PPARG_HUMAN
A:
[2-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
--
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
170
Blastp_CBE
52.67
100%
-155
- C1 -
-
2Q6S
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
---------
H
P
L
L
Q
E
I
Y
K
D
--
227
Blastp_CBE
52.58
100%
-142
- C1 -
-
4EM9
4
PPARG_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
179
Blastp_CBE
52.43
100%
-152
- C1 -
-
2Q59
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
---------
H
P
L
L
Q
E
I
Y
K
D
--
127
Blastp_CBE
52.26
100%
-143
- C1 -
-
5WR0
1
PPARG_HUMAN
A:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
266
Blastp_CBE
52.19
100%
-139
- C1 -
-
4FGY
1
PPARG_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-----
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
232
Blastp_CBE
52.14
100%
-148
- C1 -
-
3IA6
1
PPARG_HUMAN
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
97
Blastp_CBE
52.14
100%
-147
- C1 -
-
6MD1
2
?
B:
[5-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
--
105
Blastp_CBE
52.05
100%
-142
- C1 -
-
4R2U
1
PPARG_HUMAN
A:
[3-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
188
Blastp_CBE
52.00
100%
-143
- C1 -
-
3K8S
2
PPARG_HUMAN
B:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
256
Blastp_CBE
51.94
100%
-142
- C1 -
-
3CWD
1
PPARG_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
-------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
133
Blastp_CBE
51.92
100%
-149
- C1 -
-
4XUH
2
PPARG_HUMAN
B:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
Y
220
Blastp_CBE
51.90
99%
-146
- C1 -
-
3WJ4
1
PPARG_HUMAN
A:
[4-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
75
Blastp_CBE
51.89
99%
-140
- C1 -
-
2ZK1
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
257
Blastp_CBE
51.71
99%
-153
- C1 -
-
6E5A
1
?
B:
[3-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
D
L
-
101
Blastp_CBE
51.57
100%
-151
- C1 -
-
6MCZ
1
?
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
175
Blastp_CBE
51.51
100%
-149
- C1 -
-
2Q5S
1
PPARG_HUMAN
B:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
D
L
-
159
Blastp_CBE
51.51
100%
-158
- C1 -
-
3B0R
1
PPARG_HUMAN
B:
[5-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-------
H
P
L
L
Q
E
I
Y
----
68
Blastp_CBE
51.43
99%
-139
- C1 -
-
2ZK5
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
248
Blastp_CBE
51.42
100%
-129
- C1 -
-
2ATH
1
PPARG_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
99
Blastp_CBE
51.39
100%
-150
- C1 -
-
6MD0
1
?
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
19
PsiBlast_PDB
51.38
99%
-148
- C1 -
-
4PWL
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
47
Blastp_CBE
51.35
99%
-151
- C1 -
-
4YT1
1
PPARG_HUMAN
B:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
214
Blastp_CBE
51.29
99%
-148
- C1 -
-
5Y2T
1
PPARG_HUMAN
B:
[21-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
131
Blastp_CBE
51.21
100%
-147
- C1 -
-
4XUM
1
PPARG_HUMAN
B:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
190
Blastp_CBE
50.99
100%
-133
- C1 -
-
3H0A
1
PPARG_HUMAN
D:
[1-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-------
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
91
Blastp_CBE
50.99
99%
-138
- C1 -
-
2ZVT
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
S
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
17
PsiBlast_PDB
50.94
99%
-133
- C1 -
-
4JL4
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
255
Blastp_CBE
50.93
100%
-140
- C1 -
-
3CWD
1
PPARG_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
141
Blastp_CBE
50.79
100%
-147
- C1 -
-
3SZ1
2
PPARG_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
--
L
H
P
L
L
Q
E
I
Y
K
D
L
-
148
Blastp_CBE
50.68
100%
-151
- C1 -
-
2VV0
1
PPARG_HUMAN
B:
[7-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
16
PsiBlast_PDB
50.67
99%
-132
- C1 -
-
4JAZ
1
PPARG_HUMAN
A:
[17-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
39
Blastp_CBE
50.60
99%
-142
- C1 -
-
2YFE
1
PPARG_HUMAN
B:
[16-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
----
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
---
273
Blastp_CBE
50.51
99%
-146
- C1 -
-
3ET0
1
PPARG_HUMAN
B:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
150
Blastp_CBE
50.50
100%
-155
- C1 -
-
2VST
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
----
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
135
Blastp_CBE
50.49
100%
-163
- C1 -
-
4XTA
1
PPARG_HUMAN
B:
[9-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
--------------------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
---
H
P
L
L
Q
E
I
Y
K
D
--
93
Blastp_CBE
50.46
100%
-144
- C1 -
-
1NYX
1
PPARG_HUMAN
A:
[1-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
---------------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
182
Blastp_CBE
50.31
99%
-157
- C1 -
-
2VV4
1
PPARG_HUMAN
B:
[5-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
Q
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
K
---
152
Blastp_CBE
50.29
100%
-148
- C1 -
-
2VSR
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
35
Blastp_CBE
50.29
99%
-144
- C1 -
-
3ADW
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
104
Blastp_CBE
50.24
100%
-146
- C1 -
-
4R2U
1
PPARG_HUMAN
D:
[6-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
136
Blastp_CBE
50.03
100%
-156
- C1 -
-
4XTA
1
PPARG_HUMAN
A:
[9-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
--
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
--
L
H
P
L
L
Q
E
I
Y
----
164
Blastp_CBE
50.00
99%
-149
- C1 -
-
4R6S
1
PPARG_HUMAN
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
F
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
---
38
Blastp_CBE
49.86
99%
-151
- C1 -
-
3ADS
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
173
Blastp_CBE
49.70
100%
-142
- C1 -
-
2Q61
1
PPARG_HUMAN
B:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
--
H
P
L
L
Q
E
I
Y
K
D
L
-
167
Blastp_CBE
49.69
100%
-146
- C1 -
-
5TTO
1
PPARG_HUMAN
B:
[3-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
226
Blastp_CBE
49.40
100%
-164
- C1 -
-
4EM9
4
PPARG_HUMAN
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---
F
K
H
I
--------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
---------
L
H
P
L
L
Q
E
I
Y
K
---
145
Blastp_CBE
49.28
100%
-146
- C1 -
-
2VV2
2
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
260
Blastp_CBE
49.26
100%
-131
- C1 -
-
4PRG
1
PPARG_HUMAN
C:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
181
Blastp_CBE
49.22
99%
-163
- C1 -
-
2VV1
1
PPARG_HUMAN
B:
[8-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
----
24
Blastp_CBE
49.15
99%
-156
- C1 -
-
5F9B
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
261
Blastp_CBE
49.01
100%
-133
- C1 -
-
4PRG
1
PPARG_HUMAN
B:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
50
Blastp_CBE
48.87
99%
-149
- C1 -
-
3WMH
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
70
Blastp_CBE
48.86
99%
-134
- C1 -
-
2ZK4
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
82
Blastp_CBE
48.73
100%
-153
- C1 -
-
3PO9
5
PPARG_HUMAN
B:
[16-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
L
Y
36
Blastp_CBE
48.64
99%
-147
- C1 -
-
3ADV
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
---
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
171
Blastp_CBE
48.62
100%
-145
- C1 -
-
2Q6R
1
PPARG_HUMAN
B:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
228
Blastp_CBE
48.54
100%
-131
- C1 -
-
3QT0
1
PPARG_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
86
Blastp_CBE
48.40
100%
-144
- C1 -
-
1I7I
1
PPARG_HUMAN
B:
[22-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
139
Blastp_CBE
48.32
100%
-146
- C1 -
-
3X1H
1
PPARG_HUMAN
B:
[7-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
31
Blastp_CBE
48.31
99%
-149
- C1 -
-
4PVU
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
--------------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
180
Blastp_CBE
48.11
99%
-141
- C1 -
-
4OJ4
1
PPARG_HUMAN
A:
[8-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
---------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
M
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
129
Blastp_CBE
48.10
100%
-152
- C1 -
-
5AZV
1
PPARG_HUMAN
B:
[6-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
K
---
192
Blastp_CBE
47.96
100%
-158
- C1 -
-
2POB
1
PPARG_HUMAN
B:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
--------------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
---
L
H
P
L
L
Q
E
I
Y
K
---
271
Blastp_CBE
47.95
99%
-140
- C1 -
-
6C5T
1
PPARG_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-----
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
-
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
217
Blastp_CBE
47.43
99%
-146
- C1 -
-
3WJ5
1
PPARG_HUMAN
B:
[3-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
22
Blastp_CBE
46.67
99%
-152
- C1 -
-
5HZC
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
115
Blastp_CBE
46.44
100%
-149
- C1 -
-
2P4Y
2
PPARG_HUMAN
A:
[5-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
------------------------
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
263
Blastp_CBE
46.28
99%
-142
- C1 -
-
4L98
2
PPARG_HUMAN
B:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
64
Blastp_CBE
46.29
99%
-144
- C1 -
-
2ZNO
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
253
Blastp_CBE
46.28
100%
-140
- C1 -
-
3R8A
1
PPARG_HUMAN
A:
[12-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
-------
34
Blastp_CBE
46.21
99%
-143
- C1 -
-
3ADX
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
66
Blastp_CBE
46.13
99%
-138
- C1 -
-
2ZK6
1
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
37
Blastp_CBE
45.88
99%
-137
- C1 -
-
3ADU
3
PPARG_HUMAN
B:
[17-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
177
Blastp_CBE
45.58
100%
-153
- C1 -
-
2Q5P
1
PPARG_HUMAN
B:
[4-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
----
F
K
H
I
T
--------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
--------
L
H
P
L
L
Q
E
I
Y
K
D
--
137
Blastp_CBE
45.46
100%
-159
- C1 -
-
3X1I
1
PPARG_HUMAN
B:
[9-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
--------
P
L
L
Q
E
I
Y
----
265
Blastp_CBE
44.94
99%
-138
- C1 -
-
4L96
1
PPARG_HUMAN
A:
[5-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
259
Blastp_CBE
44.62
100%
-124
- C1 -
-
4PRG
1
PPARG_HUMAN
D:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
252
Blastp_CBE
43.23
100%
-155
- C1 -
-
3R8A
1
PPARG_HUMAN
B:
[12-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
------------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
----------
H
P
L
L
Q
E
I
Y
K
D
--
114
Blastp_CBE
38.17
100%
-161
- C1 -
-
2P4Y
1
PPARG_HUMAN
B:
[9-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
-------
S
P
F
V
I
Y
D
M
N
S
-----------------------
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
------------
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
264
Blastp_CBE
36.45
99%
-140
- C1 -
-
4L98
2
PPARG_HUMAN
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
--------------------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
172
Blastp_CBE
33.72
100%
-146
- C1 -
-
2Q6R
1
PPARG_HUMAN
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
----
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
-----------------
H
P
L
L
Q
E
I
Y
K
D
L
-
270
Blastp_CBE
22.87
100%
-
- C1 -
-
3U9Q
1
PPARG_HUMAN
A:
[208-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
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