@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR2A2_HNF4g: (2021-05-27 )
MNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQEIQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLSQDPLTGQTILLGPMSTLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLSKQKQL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130..-.-....140.......150.......160.......170.......180.......190.......200......-.-210........220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNTTDN
G
V
N
C
L
C
A
ICGDRATGKHYGASSC
D
G
C
K
G
F
F
R
R
S
I
R
K
SH
V
Y
S
C
RFSRQCVVDKDKR
N
Q
C
R
Y
C
R
L
R
K
C
F
R
AGM
K
K
E
A
V
Q
N
E
R
D
R
I
S
TRRSTFDGSNIP
S
I
N
T
L
A
Q
A
E
VRS
R
Q
I
S
VSSPGSSTDI
N
V
K
K
I
A
-
S
-
I
G
D
V
C
E
S
M
K
Q
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
CELPLD
D
Q
V
A
L
L
R
AHAGE
H
L
L
LGA
T
K
R
S
M
M
Y
K
D
I
L
L
LGN
N
Y
V
I
HRNSC-
E
-
V
-
E
I
S
R
V
A
N
R
V
L
D
E
L
V
R
P
F
Q
E
IQIDDN
E
Y
A
C
L
K
A
I
V
F
FDPDAKGLSDP
V
K
I
K
N
M
R
F
Q
V
Q
IG
L
E
D
YINDRQYDSRGRF
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
V
K
L
F
G
M
V
K
I
D
N
L
L
Q
E
M
L
LGGASNDGSHLHHPMHPHLSQDPLTG
Q
T
I
L
L
G
P
M
S
T
L
V
HADQISTPETPLPSPPQGSGQ
E
Q
Y
K
IAAN
Q
A
S
V
I
S
H
Q
H
L
S
K
QKQL
1
PsiBlast_PDB
84.39
82%
-77
- C1 -
-
4IQR
1
HNF4A_HUMAN
A:
[19-338]
---------
A
L
C
A
I
C
G
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
C
K
G
F
F
R
R
S
V
R
K
N
H
M
Y
S
C
R
F
S
R
Q
C
V
V
D
K
D
K
R
N
Q
C
R
Y
C
R
L
K
K
C
F
R
A
G
M
K
K
E
A
V
Q
N
E
------------------
I
N
A
L
L
Q
A
E
V
L
S
R
Q
I
T
S
P
V
S
G
I
N
G
D
I
R
A
K
K
I
A
-
S
-
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
-
E
-
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
--------------------------------------------------------------------------------
2
PsiBlast_PDB
64.77
100%
-147
- C1 -
-
1LV2
1
HNF4G_HUMAN
A:
[4-229]
------------------------------------------------------------------------------------------------------
S
I
N
T
L
A
Q
A
E
V
R
S
R
Q
I
S
V
----
S
S
T
D
I
N
V
K
K
I
A
-
S
-
I
G
D
V
C
E
S
M
K
Q
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
M
Y
K
D
I
L
L
L
G
N
N
Y
V
I
H
R
N
S
C
-
E
-
V
-
E
I
S
R
V
A
N
R
V
L
D
E
L
V
R
P
F
Q
E
I
Q
I
D
D
N
E
Y
A
C
L
K
A
I
V
F
F
D
P
D
A
K
G
L
S
D
P
V
K
I
K
N
M
R
F
Q
V
Q
I
G
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
V
K
L
F
G
M
V
K
I
D
N
L
L
Q
E
M
L
L
G
G
--------------------------------------------------------------------------------
9
PsiBlast_PDB
61.73
42%
-83
- C1 -
-
3E00
1
RXRA_HUMAN
A:
[139-460]
----------
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
---------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
----------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
-
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
10
PsiBlast_PDB
61.16
42%
-23
- C1 -
-
4NQA
1
RXRA_HUMAN
A:
[37-358]
----------
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
G
------
S
S
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
-
E
A
N
M
G
L
N
P
S
S
P
N
-
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
6
PsiBlast_PDB
58.24
78%
-74
- C1 -
-
1PZL
1
HNF4A_HUMAN
A:
[5-237]
-------------------------------------------------------------------------------------------------
L
A
S
L
P
S
I
N
A
L
L
Q
A
E
V
L
S
R
Q
I
T
------
N
G
D
I
R
A
K
K
I
A
-
S
-
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
-
E
-
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
S
-------------------------------------------------------------------------------
8
PsiBlast_PDB
56.93
42%
-32
- C1 -
-
3DZU
1
RXRA_HUMAN
A:
[139-460]
----------
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
Q
R
---------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
---------------------D
P
-
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
-
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
7
PsiBlast_PDB
56.41
80%
-75
- C1 -
-
3FS1
1
HNF4A_HUMAN
A:
[1-230]
---------------------------------------------------------------------------------------------------
S
L
P
S
I
N
A
L
L
Q
A
E
V
L
S
R
Q
I
T
S
P
V
S
G
I
N
G
D
I
R
A
K
K
I
A
-
S
-
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
-
E
-
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
G
--------------------------------------------------------------------------------
11
PsiBlast_PDB
50.53
42%
-24
- C1 -
-
5UAN
1
RXRA_HUMAN
A:
[37-358]
----------
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
----------
C
L
I
D
K
R
Q
R
N
-
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
K
R
E
A
V
Q
E
E
R
-----------
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
---------------------P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
50.32
76%
-80
- C1 -
-
1M7W
1
HNF4A_RAT
A:
[10-235]
------------------------------------------------------------------------------------------------------
S
I
N
A
L
L
Q
A
E
V
L
S
Q
Q
I
T
S
P
I
S
---
G
D
I
R
A
K
R
I
A
-
S
-
I
T
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
L
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
-
E
-
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
C
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
---------------------------------------------------------------------------------
4
PsiBlast_PDB
45.80
78%
-82
- C1 -
-
6CHT
1
HNF4A_HUMAN
A:
[5-230]
------------------------------------------------------------------------------------------------------
S
I
N
A
L
L
Q
A
E
V
L
----------------
A
K
K
I
A
-
S
-
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
-
E
-
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
---------------------------------------------------------------------------------
5
PsiBlast_PDB
37.23
79%
-73
- C1 -
-
4B7W
-
HNF4A_HUMAN
A:
[175-376]
------------------------------------------------------------------------------------------------------------------------------
D
I
R
A
K
K
I
A
-
S
-
I
A
D
V
C
E
S
M
K
E
Q
L
L
V
L
V
E
W
A
K
Y
I
P
A
F
C
E
L
P
L
D
D
Q
V
A
L
L
R
A
H
A
G
E
H
L
L
L
G
A
T
K
R
S
M
V
F
K
D
V
L
L
L
G
N
D
Y
I
V
P
R
H
C
P
-
E
-
L
A
E
M
S
R
V
S
I
R
I
L
D
E
L
V
L
P
F
Q
E
L
Q
I
D
D
N
E
Y
A
Y
L
K
A
I
I
F
F
D
P
D
A
K
G
L
S
D
P
G
K
I
K
R
L
R
S
Q
V
Q
V
S
L
E
D
Y
I
N
D
R
Q
Y
D
S
R
G
R
F
G
E
L
L
L
L
L
P
T
L
Q
S
I
T
W
Q
M
I
E
Q
I
Q
F
I
K
L
F
G
M
A
K
I
D
N
L
L
Q
E
M
L
L
G
---------------------------------------------------------------------------------
19
PsiBlast_PDB
25.50
44%
-89
- C1 -
-
3KWY
1
RXRA_HUMAN
A:
[47-237]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
--
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
18
PsiBlast_PDB
25.42
44%
-83
* C1 *
-
3E94
1
RXRA_HUMAN
A:
[47-237]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
15
PsiBlast_PDB
25.33
44%
-80
- C1 -
-
4OC7
1
RXRA_HUMAN
A:
[57-247]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
14
PsiBlast_PDB
22.90
45%
-86
- C1 -
-
1DKF
1
RXRA_MOUSE
A:
[41-231]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
A
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
-
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
17
PsiBlast_PDB
21.95
44%
-106
- C1 -
-
6JNO
1
RXRA_HUMAN
A:
[46-236]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
16
PsiBlast_PDB
21.77
44%
-107
- C1 -
-
5ZQU
2
RXRA_HUMAN
A:
[46-236]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
20
PsiBlast_PDB
18.95
44%
-102
- C1 -
-
4N5G
1
RXRA_HUMAN
A:
[47-237]
-----------------------------------------------------------------------------------------------------------------------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
-
H
S
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
17.47
38%
-105
- C1 -
-
1Z5X
-
?
U:
[66-256]
-----------------------------------------------------------------------------------------------------------------------------------------
V
S
D
I
C
Q
A
A
D
R
Q
L
Y
Q
L
I
E
W
A
K
H
I
P
H
F
T
E
L
P
V
E
D
Q
V
I
L
L
K
S
G
W
N
E
L
L
I
A
G
F
S
H
R
S
M
S
V
K
D
G
I
M
L
A
T
G
L
V
V
H
R
N
C
A
H
Q
-
A
-
G
V
G
A
I
F
D
R
V
L
T
E
L
V
A
K
M
R
E
M
K
M
D
K
T
E
L
G
C
L
R
S
I
V
L
F
N
P
E
A
K
G
L
K
S
T
Q
Q
V
E
N
L
R
E
K
V
Y
A
I
L
E
E
Y
C
R
Q
T
Y
P
D
Q
S
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
V
G
N
T
S
I
D
S
F
L
L
S
M
L
-----------------------------------------------------------------------------------
12
PsiBlast_PDB
14.58
38%
11
- C1 -
-
6HN6
4
RXRA_HUMAN
A:
[45-275]
------------------------------------------------------------------------------------------------
S
A
N
E
D
M
P
V
E
R
I
L
E
A
E
L
A
V
E
P
K
T
E
T
Y
V
E
A
N
M
G
L
N
P
S
S
P
N
-
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
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