@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : X_NR3C1_GCR: (2019-06-04 )
MDPKDLLKPSSGSPAVRGSPHYNDKPGNVIEFFGNYRGGVSVSVSASCPTSTASQSNTRQQQHFQKQLTATGDSTNGLNNNVPQPDLSKAVSLSMGLYMGESDTKVMSSDIAFPSQEQIGISTGETDFSLLEESIANLQAKSLAPDKLIEISEDPGGFKCDISAQPRPSMGQGGSNGSSSTNLFPKDQCTFDLLRDLGISPDSPLDGKSNPWLDPLFDEQEAFNLLSPLGTGDPFFMKSEVLSEGSKTLSLEDGTQRLGDHAKDMLLPSADRPISQVKTEKEDYIELCTPGVVNEEKFGPVYCVGNFSGSGLFGNKSSAISVHGVSTSGGQMYHYDLNTATISQQDVKPVFNLGSPGTSIAEGWNRCHGSGNDTAASPGNVNFPNRSVFSNGYSSPGIRSDASPSPSTSSTSTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQSTTATARESPETSMTRTLVPASVAQLTPTLISLLEVIEPEVLYSGYDSSIPDTTRRLMSSLNMLGGRQVVSAVRWAKAIPGFRNLHLDDQMTLLQYSWMFLMVFALGWRSYKQTNGSILYFAPDLVITEDRMHLPFMQERCQEMLKIAGEMSSLQISYDEYLCMKVLLLMCTIPKEGLKSHALFEEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVAENLLAFCFLSFLDKSMSIEFPDMLSEIISNQIPKYSSGNLKKLLFHQK
Atome Classification :
(65 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......-740-.-.......750.......760.......770....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
D
P
K
D
LLKPSSGSPAVRGSPHYNDKPG
N
V
I
E
F
FGNYRG
G
V
S
V
S
V
SASCPTSTASQSN
T
R
Q
Q
Q
H
F
Q
K
Q
L
TATGDSTNGLNNNVP
Q
P
D
L
S
K
A
V
S
L
S
M
G
L
Y
MGESD
T
K
V
MSSDIAFPSQEQIGISTGE
T
D
F
S
L
L
E
E
S
I
A
N
L
Q
A
KSLAPD
K
L
I
E
ISEDPG
G
F
K
CDISAQPRPSMGQGGSNGSSSTNLFPK
D
Q
C
T
F
D
L
L
R
DLGISPDSPLDGKSNPWLDPLF
D
E
Q
E
A
F
N
L
LSPLGTGD
P
F
F
M
K
S
E
V
L
SEGS
K
T
L
SLE
D
G
T
Q
R
L
G
D
H
A
K
D
MLLPSADR
P
I
S
Q
VKTE
K
E
D
Y
I
E
LCTPGVVNEEKFG
P
V
Y
C
V
GNFSGSGLFGNKS
S
A
I
S
V
H
G
V
STSG
G
Q
M
Y
H
Y
DLNTATISQQD
V
K
P
V
FNLGSPG
T
S
I
A
E
G
W
N
RCHGSGNDTAASPGNVNFPNR
S
V
FSNGYSSPGIRSDASPSPSTSSTSTGPPP
K
L
C
L
V
CSDEASG
C
H
Y
G
V
L
TCG
S
C
K
V
F
F
K
R
A
VEGQH
N
Y
L
CAGRN
D
C
I
I
D
K
I
RRKNC
P
A
C
R
Y
R
K
C
L
Q
AGMNL
E
A
R
K
T
K
K
K
I
K
G
I
QQSTTATARESPETS
M
T
R
TLV
P
A
S
V
A
Q
L
T
P
T
L
I
S
L
L
E
VI
E
P
E
V
L
YSGYDSSI
P
D
T
T
R
R
L
M
S
S
L
N
MLG
G
R
Q
V
V
S
A
V
R
W
A
K
AIPGFRNLHLDD
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
YKQTNG
S
I
L
Y
FAPD
L
V
I
TEDRMH
L
P
F
M
Q
E
R
C
Q
E
M
L
K
I
AGEMS
S
L
Q
I
S
Y
D
E
Y
L
C
M
K
V
L
L
L
M
CTI
P
K
E
G
L
K
S
H
A
L
F
E
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
KREGNS
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
A
E
N
L
L
A
F
C
F
L
S
F
-
L
-
D
-
K
-SMSIE
F
P
D
M
L
S
E
I
I
S
NQIPKYSSG
N
L
K
K
L
LFHQK
16
PsiBlast_PDB
88.33
76%
-172
- C10 -
-
3MNP
3
A:
[4-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
-
L
-
D
-
K
-
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
134
HHSearch
87.20
77%
-172
- C10 -
-
3MNP
3
A:
[11-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
-
L
-
D
-
K
-
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
38
Blastp_CBE
87.19
77%
-174
- C10 -
-
4P6W
1
A:
[2-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
A
A
I
V
A
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
14
PsiBlast_PDB
86.46
76%
-176
- C10 -
-
3MNO
3
A:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
---
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
-
L
-
D
-
K
-
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
19
PsiBlast_PDB
85.76
75%
-165
- C10 -
-
3K22
2
GCR_HUMAN
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
-
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
48
Blastp_CBE
85.64
77%
-159
- C10 -
-
5UFS
1
?
A:
[2-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
N
-
K
-
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
35
Blastp_CBE
85.63
76%
-167
- C10 -
-
1M2Z
4
GCR_HUMAN
A:
[3-257]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
34
Blastp_CBE
85.50
76%
-165
- C10 -
-
1M2Z
1
D:
[5-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
20
PsiBlast_PDB
85.44
76%
-168
- C10 -
-
3MNE
3
A:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
-----
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
-
L
-
D
-
K
-
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
47
Blastp_CBE
85.34
77%
-158
- C10 -
-
5UFS
1
?
B:
[2-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
N
-
K
-
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
39
Blastp_CBE
85.21
76%
-163
- C10 -
-
3BQD
1
A:
[3-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
31
Blastp_CBE
84.84
76%
-166
- C10 -
-
3K23
1
GCR_HUMAN
B:
[9-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
---
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
29
Blastp_CBE
84.81
76%
-170
- C10 -
-
3E7C
3
B:
[5-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
-----
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
45
Blastp_CBE
84.71
77%
-157
- C10 -
-
4E2J
3
?
B:
[4-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
N
-
K
-
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
136
HHSearch
84.00
77%
-162
- C10 -
-
5UFS
1
?
A:
[6-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
N
-
K
-
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
15
PsiBlast_PDB
84.00
75%
-171
- C10 -
-
3E7C
2
GCR_HUMAN
A:
[6-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
46
Blastp_CBE
83.78
77%
-159
- C10 -
-
4E2J
2
?
A:
[4-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
N
-
K
-
S
-
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
3
PsiBlast_PDB
83.76
73%
-166
- C10 -
-
4UDC
2
A:
[32-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
41
Blastp_CBE
83.73
77%
-157
- C10 -
-
3GN8
1
?
A:
[2-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
N
-
K
-
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
40
Blastp_CBE
83.69
77%
-155
- C10 -
-
3GN8
1
?
B:
[2-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
N
-
K
-
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
21
Blastp_CBE
83.36
73%
-167
- C10 -
-
1P93
1
D:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
33
Blastp_CBE
83.26
75%
-176
- C10 -
-
4LSJ
2
A:
[7-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
--------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
9
PsiBlast_PDB
83.26
72%
-157
- C10 -
-
6EL6
2
A:
[33-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
6
PsiBlast_PDB
83.23
72%
-159
- C10 -
-
5G3J
3
A:
[32-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
5
PsiBlast_PDB
83.11
72%
-163
- C10 -
-
4UDD
5
A:
[32-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
7
PsiBlast_PDB
82.82
72%
-158
- C10 -
-
5G5W
2
A:
[33-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
2
PsiBlast_PDB
82.69
73%
-160
- C10 -
-
1P93
1
GCR_HUMAN
A:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
4
PsiBlast_PDB
82.68
72%
-160
- C10 -
-
4CSJ
2
A:
[33-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
17
PsiBlast_PDB
82.54
75%
-167
- C10 -
-
3CLD
1
GCR_HUMAN
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
8
PsiBlast_PDB
82.50
72%
-163
- C10 -
-
5NFP
4
A:
[33-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
32
Blastp_CBE
82.36
76%
-170
- C10 -
-
3CLD
1
B:
[10-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
22
Blastp_CBE
82.25
73%
-165
- C10 -
-
1P93
1
GCR_HUMAN
C:
[30-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
11
PsiBlast_PDB
82.24
72%
-155
- C10 -
-
6EL7
2
A:
[33-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
12
PsiBlast_PDB
82.13
72%
-158
- C10 -
-
6EL9
2
A:
[33-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
10
PsiBlast_PDB
82.00
72%
-155
- C10 -
-
5NFT
4
A:
[32-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
30
Blastp_CBE
81.99
76%
-159
- C10 -
-
3K23
1
C:
[7-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
-
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
-
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
---
N
I
K
K
L
L
F
H
--
51
Blastp_CBE
81.91
76%
-157
- C10 -
-
3H52
2
GCR_HUMAN
B:
[5-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
18
PsiBlast_PDB
81.83
75%
-153
- C10 -
-
3K23
1
GCR_HUMAN
A:
[7-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
-
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
-----
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
--
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
53
Blastp_CBE
81.10
70%
-140
- C10 -
-
3RY9
3
?
B:
[1-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
--
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
E
S
K
-
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
-
23
Blastp_CBE
81.03
73%
-159
- C10 -
-
1P93
1
GCR_HUMAN
B:
[32-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
42
Blastp_CBE
80.80
74%
-147
- C10 -
-
6DXK
1
B:
[11-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
A
L
E
T
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
43
Blastp_CBE
80.79
74%
-145
- C10 -
-
6DXK
1
GCR_HUMAN
A:
[11-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
A
L
E
T
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
54
Blastp_CBE
80.26
70%
-136
- C10 -
-
3RY9
2
?
A:
[2-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
S
T
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
E
S
K
-
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
K
49
Blastp_CBE
79.47
76%
-178
- C10 -
-
3H52
1
D:
[7-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
------------
E
M
L
A
E
I
I
T
N
Q
I
----
N
G
N
I
K
K
L
L
F
H
Q
-
44
Blastp_CBE
79.45
74%
-161
- C10 -
-
4MDD
1
GCR_HUMAN
A:
[11-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
A
L
E
T
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
37
Blastp_CBE
78.96
76%
-164
- C10 -
-
5UC3
9
GCR_HUMAN
A:
[6-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
K
P
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
-------------------
G
N
I
K
K
L
L
F
H
Q
-
52
Blastp_CBE
78.95
76%
-151
- C10 -
-
3H52
1
GCR_HUMAN
A:
[5-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
----
G
N
I
K
K
L
L
F
H
Q
-
61
Blastp_CBE
78.61
63%
-135
- C10 -
-
4LTW
4
?
A:
[3-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
Q
S
Q
-
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
60
Blastp_CBE
78.19
63%
-133
- C10 -
-
4FN9
6
?
A:
[5-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
Q
S
Q
-
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
36
Blastp_CBE
78.00
76%
-167
- C10 -
-
5UC3
3
B:
[6-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
K
P
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
-------------------
G
N
I
K
K
L
L
F
H
Q
-
59
Blastp_CBE
77.79
63%
-140
- C10 -
-
4FN9
3
?
B:
[5-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
Q
S
Q
-
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
--
142
HHSearch
77.63
63%
-138
- C10 -
-
4LTW
4
?
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
Q
-
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
50
Blastp_CBE
77.54
76%
-174
- C10 -
-
3H52
1
GCR_HUMAN
C:
[5-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-----------------
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
1
PsiBlast_PDB
77.43
73%
-157
- C10 -
-
1NHZ
4
A:
[33-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
-
L
-
D
-
K
-
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
--------
N
I
K
K
L
L
F
H
Q
-
58
Blastp_CBE
76.85
65%
-147
- C10 -
-
2Q1H
3
?
A:
[4-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
S
I
L
E
A
I
E
P
E
V
V
Y
A
G
Y
D
N
S
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
G
K
Q
M
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
R
Q
I
S
Q
E
F
V
R
L
Q
V
T
Y
E
E
F
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
R
R
A
I
A
---
N
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
Q
S
Q
-
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
D
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
K
-
131
HHSearch
76.71
58%
-131
- C10 -
-
4PF3
9
A:
[26-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
-
R
-
E
S
H
-
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
-
138
HHSearch
76.49
65%
-145
- C10 -
-
2Q1H
3
?
A:
[8-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
A
I
E
P
E
V
V
Y
A
G
Y
D
N
S
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
G
K
Q
M
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
R
Q
I
S
Q
E
F
V
R
L
Q
V
T
Y
E
E
F
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
R
R
A
I
A
---
N
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
-
Q
S
Q
-
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
D
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
K
-
140
HHSearch
75.25
58%
-144
- C10 -
-
3VHV
4
A:
[14-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-----
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
-
R
E
S
-
H
-
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
143
HHSearch
73.20
51%
-141
- C10 -
-
5JJM
4
?
B:
[6-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
N
V
L
E
A
I
E
P
G
V
V
-
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
-
I
-
K
S
H
-
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
144
HHSearch
72.87
51%
-139
- C10 -
-
5V8Q
4
A:
[5-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
A
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
-
I
-
K
S
H
-
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
-
137
HHSearch
72.70
59%
-130
- C10 -
-
2A3I
1
A:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
-
R
-
E
S
H
-
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
141
HHSearch
71.65
54%
-138
- C10 -
-
1SQN
1
PRGR_HUMAN
A:
[20-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
-
S
-
R
-
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
55
Blastp_CBE
71.49
76%
-170
- C10 -
-
5UC1
10
?
B:
[4-207]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
G
T
V
P
D
T
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
G
N
V
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
G
L
P
Y
M
Y
D
Q
C
K
Q
M
L
F
V
S
S
E
L
K
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
F
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
------------------------------------------------------
145
HHSearch
71.28
51%
-149
- C10 -
-
1Z95
1
A:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
--------
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
-
I
-
K
S
H
-
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
56
Blastp_CBE
70.29
76%
-162
- C10 -
-
5UC1
9
?
A:
[4-207]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
G
T
V
P
D
T
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
G
N
V
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
G
L
P
Y
M
Y
D
Q
C
K
Q
M
L
F
V
S
S
E
L
K
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
F
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
------------------------------------------------------