@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : X_NR3C2_MCR: (2019-06-05 )
GNEIADSTVSLVKFIKPDPDAIFSSTCFGDTVSSDPAFSIPIKQESCKNTCSSALFKGSQSANPFPFMDGSYFAFMDDKDYYSLSGILGPPVSSFGDGFEGNGFSNQSLNVAIKQETEDSSFYPENNMPSSAIVGVNSCGQSFHYRIGAQGTISLSRPLNRDQSFQNLSSFPPMSSLVESWKTQSELAQNTLSSRRNDGFPVPGYIPENMSSTTLRSMSTGPSRPSKVCLVCGDEASGCHYGVVTCGSCKVFFKRAVEGKCSRQHSYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGVHEEHPQQPLQQTPTASPKEDTTLTSSSKEPSANSNSLVPLISAVSPAITLSAAVILENIEPEIVYAGYDNTQPDTAENLLSSLNQLAGKQMVQVVKWAKVIPGFRNLPLEDQITLIQYSWMCLSSFALSWRSYKHASSQFLYFAPDLIFNEERMRQSAMYDLCQGMQQISLEFSRLQLTFEEYTLMKVLLLLSTVPKDGLKCQAAFEEMRVNYIKELRKVLLKSPHNSGQSWQRYFQLTKLLDSMQDLVGDLLEFCFYTFRESQALKVEFPAMLVEIISDQLPKVESGIAKPLYFHRK
Atome Classification :
(52 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.---......460.......470........480.....-..490.......500.......--510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
GNE
I
A
D
S
T
V
S
L
V
K
FIKP
D
P
D
A
I
FSSTCFGDTVSSDP
A
F
S
IPI
K
Q
E
S
C
K
N
T
C
S
S
A
L
FKGSQSANPFPFMDG
S
Y
F
A
F
MDDKDYYSLSGILGPP
V
S
SFGDGFEGNGFSNQ
S
L
N
V
A
I
K
QETEDSSFYPENNMPSS
A
I
V
G
V
N
SCGQS
F
H
Y
R
IGA
Q
G
T
I
S
LSRPLNR
D
Q
S
F
Q
N
L
SSFP
P
M
S
S
L
V
E
S
W
K
T
Q
S
E
L
A
Q
N
T
L
S
SRRNDGFPVPGYIPENMSS
T
T
L
RSMSTGPSRP
S
K
V
C
L
V
CGDEASG
C
H
Y
G
V
V
T
CG
S
C
K
V
F
F
K
R
AVEGKCSRQH
S
Y
L
CAGRN
D
C
I
I
D
K
I
RRKNC
P
A
C
R
L
Q
K
C
L
Q
AGMNLG
A
R
K
S
K
KL
G
K
LK
G
V
H
E
EHPQQ
P
L
Q
QTPTASPKEDTTLTSSSKEPSANSNSL
V
P
L
I
S
AVS
P
A
I
T
L
S
A
A
V
I
L
ENIEP
E
I
V
Y
AGYDNTQP
D
T
A
E
N
L
L
S
S
L
N
Q
L
A
G
K
Q
M
V
Q
V
V
K
W
A
K
VIPGFRNLPLED
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
SYKHASS
Q
---
F
L
Y
FA
P
D
LIF
N
E
E
R
M
R
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
L
E
F
-
S
R
L
Q
L
T
F
E
E
Y
T
L
M
K
V
L
L
L
L
STV--PKDG
L
K
C
Q
A
A
F
E
E
M
R
V
N
Y
I
K
E
L
R
K
V
L
L
KSPHNS
G
Q
S
W
Q
R
Y
F
Q
L
T
K
L
L
D
S
M
Q
D
L
V
G
D
L
L
E
F
C
F
Y
T
FRES
Q
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
QL
P
K
V
ESGIAKPLYFHRK
16
PsiBlast_PDB
82.66
82%
-142
- C11 -
-
3VHV
4
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-----
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
22
Blastp_CBE
82.51
81%
-141
- C11 -
-
2AB2
1
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
-
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
24
Blastp_CBE
82.44
81%
-139
- C11 -
-
2AA6
1
B:
[13-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
3
PsiBlast_PDB
82.30
81%
-139
- C11 -
-
2AA7
3
A:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
5
PsiBlast_PDB
82.17
80%
-138
- C11 -
-
2AA6
1
MCR_HUMAN
A:
[13-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
-
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
10
PsiBlast_PDB
81.54
80%
-129
- C11 -
-
4PF3
9
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
-
1
PsiBlast_PDB
81.42
81%
-140
- C11 -
-
2AA2
4
A:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
-----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
18
PsiBlast_PDB
81.36
84%
-132
- C11 -
-
2A3I
1
A:
[2-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
4
PsiBlast_PDB
81.36
80%
-144
- C11 -
-
3VHU
1
A:
[38-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
------
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
8
PsiBlast_PDB
81.32
80%
-124
- C11 -
-
3WFF
1
A:
[18-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
9
PsiBlast_PDB
81.20
80%
-128
- C11 -
-
3WFG
14
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
-
124
HHSearch
81.11
84%
-130
- C11 -
-
4PF3
9
A:
[28-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
-
7
PsiBlast_PDB
80.89
80%
-134
- C11 -
-
2AB2
1
MCR_HUMAN
A:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
-
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
132
HHSearch
80.74
85%
-138
- C11 -
-
2A3I
1
A:
[8-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
131
HHSearch
80.70
84%
-143
- C11 -
-
3VHV
4
A:
[13-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-----
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
21
Blastp_CBE
80.67
81%
-136
- C11 -
-
2AA5
1
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
-----
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
2
PsiBlast_PDB
80.44
81%
-131
- C11 -
-
2AA5
1
MCR_HUMAN
A:
[13-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
20
PsiBlast_PDB
80.23
84%
-135
- C11 -
-
4UDB
3
A:
[25-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
---
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
15
PsiBlast_PDB
79.71
85%
-148
- C11 -
-
4UDA
2
A:
[5-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
-
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
37
Blastp_CBE
79.55
85%
-142
- C11 -
-
5L7E
5
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
-----
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
36
Blastp_CBE
79.31
85%
-131
- C11 -
-
5L7G
2
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
-
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
35
Blastp_CBE
78.85
85%
-142
- C11 -
-
6GGG
1
?
A:
[37-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
Y
A
G
Y
D
--
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
12
PsiBlast_PDB
78.68
84%
-149
- C11 -
-
1Y9R
1
MCR_HUMAN
A:
[8-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
26
Blastp_CBE
78.52
85%
-146
- C11 -
-
2ABI
1
MCR_HUMAN
B:
[9-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
----
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
19
PsiBlast_PDB
78.41
85%
-135
- C11 -
-
6GG8
2
?
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
25
Blastp_CBE
78.31
85%
-147
- C11 -
-
2ABI
1
C:
[9-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
----
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
13
PsiBlast_PDB
78.24
84%
-153
- C11 -
-
1YA3
1
MCR_HUMAN
A:
[8-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
-----
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
28
Blastp_CBE
78.23
84%
-155
- C11 -
-
1YA3
1
MCR_HUMAN
B:
[9-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
-------
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
29
Blastp_CBE
78.22
84%
-143
- C11 -
-
1Y9R
1
B:
[8-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
----------
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
27
Blastp_CBE
78.16
84%
-152
- C11 -
-
1YA3
1
C:
[8-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
---
V
Y
A
G
Y
D
S
---
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
133
HHSearch
77.96
76%
-154
- C11 -
-
2Q1H
3
?
A:
[6-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
E
A
I
E
P
E
V
V
Y
A
G
Y
D
N
S
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
G
K
Q
M
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
R
Q
I
S
Q
E
F
-
V
R
L
Q
V
T
Y
E
E
F
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
R
R
A
I
A
---
N
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
D
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
K
-
40
Blastp_CBE
77.95
74%
-148
- C11 -
-
4LTW
4
?
A:
[9-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
-
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
--
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
11
PsiBlast_PDB
77.88
84%
-161
- C11 -
-
2ABI
1
MCR_HUMAN
A:
[9-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
-------
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
---------
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
17
PsiBlast_PDB
77.85
84%
-139
- C11 -
-
5HCV
1
MCR_HUMAN
A:
[11-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
----
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
---
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
-
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
-
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
--
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
-----
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
129
HHSearch
77.70
73%
-148
- C11 -
-
4LTW
4
?
A:
[8-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
-
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
--
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
38
Blastp_CBE
76.88
74%
-145
- C11 -
-
4FN9
3
?
B:
[11-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
-
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
--
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
--
127
HHSearch
76.66
56%
-163
- C11 -
-
3MNP
3
A:
[14-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
---
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
-
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
-
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
--
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
39
Blastp_CBE
76.60
74%
-142
- C11 -
-
4FN9
6
?
A:
[11-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
---
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
-
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
-
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
--
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
136
HHSearch
75.71
62%
-153
- C11 -
-
5UFS
1
?
A:
[7-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
46
Blastp_CBE
75.69
62%
-153
- C11 -
-
5UFS
1
?
A:
[7-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
43
Blastp_CBE
75.69
62%
-150
- C11 -
-
3GN8
1
?
B:
[7-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
41
Blastp_CBE
75.65
70%
-147
- C11 -
-
3RY9
3
?
B:
[7-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
--
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
---
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
-
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
-
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
-
45
Blastp_CBE
74.95
62%
-154
- C11 -
-
5UFS
1
?
B:
[7-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
44
Blastp_CBE
74.92
62%
-150
- C11 -
-
3GN8
1
?
A:
[7-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
42
Blastp_CBE
74.80
70%
-145
- C11 -
-
3RY9
2
?
A:
[7-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
S
T
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
---
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
-
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
-
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
K
47
Blastp_CBE
74.58
62%
-152
- C11 -
-
4E2J
3
?
B:
[9-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
48
Blastp_CBE
74.21
62%
-152
- C11 -
-
4E2J
2
?
A:
[9-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
---
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
-
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
-
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
--
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
-
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
135
HHSearch
71.81
52%
-143
- C11 -
-
5V8Q
4
A:
[4-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
A
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
130
HHSearch
70.73
57%
-152
- C11 -
-
1SQN
1
PRGR_HUMAN
A:
[19-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
---
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
-
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
-
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
--
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
138
HHSearch
70.42
52%
-153
- C11 -
-
1Z95
1
A:
[5-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
E
A
I
E
P
G
V
V
C
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
L
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
--------
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
--
137
HHSearch
69.93
52%
-138
* C11 *
-
5JJM
4
?
B:
[7-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
V
L
E
A
I
E
P
G
V
V
-
A
G
H
D
N
N
Q
P
D
S
F
A
A
L
L
S
S
L
N
E
L
G
E
R
Q
L
V
H
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
V
D
D
Q
M
A
V
I
Q
Y
S
W
M
G
L
M
V
F
A
M
G
W
R
S
F
T
N
V
N
S
R
---
M
L
Y
F
A
P
D
L
V
F
N
E
Y
R
M
H
K
-
S
R
M
Y
S
Q
C
V
R
M
R
H
L
S
Q
E
F
-
G
W
L
Q
I
T
P
Q
E
F
L
C
M
K
A
L
L
L
F
S
I
I
--
P
V
D
G
L
K
N
Q
K
F
F
D
E
L
R
M
N
Y
I
K
E
L
D
R
I
I
A
C
K
R
K
N
P
T
S
C
S
R
R
F
Y
Q
L
T
K
L
L
D
S
V
Q
P
I
A
R
E
L
H
Q
F
T
F
D
L
L
I
K
S
H
M
V
S
V
D
F
P
E
M
M
A
E
I
I
S
V
Q
V
P
K
I
L
S
G
K
V
K
P
I
Y
F
H
T
Q
145
Fugue
60.94
50%
-64
- C11 -
-
1A28
1
PRGR_HUMAN
A:
[5-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
---------------------
V
I
Y
A
G
H
D
N
-----------
T
K
P
D
T
------------
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
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F
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N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
-QML
Y
F
A
--
P
D
L
I
L
N
E
Q
R
M
K
-E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V-
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
PL--
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-