@TOME V3
(Feb 2022)
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Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
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Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Z_NR3A1_ESR1: (2019-06-05 )
MYPKEEHSAGGISSSVNYLDGAYEYPNPTQTFGTSSPAEPASVGYYPAPPDPHEEHLQTLGGGSSSPLMFAPSSPQLSPYLSHHGGHHTTPHQVSYYLDSSSSTVYRSSVVSSQQAAVGLCEELCSATDRQELYTGSRAAGGFDSGKETRFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYVCPATNQCTIDRNRRKSCQACRLRKCYEVGMMKGGIRKDRGGRSVRRERRRSSNEDRDKSSSDQCSRAGVRTTGPQDKRKKRSGGVVSTLCMSPDQVLLLLLGAEPPAVCSRQKHSRPYTEITMMSLLTNMADKELVHMIAWAKKVPGFQDLSLHDQVQLLESSWLEVLMIGLIWRSIHSPGKLIFAQDLILDRSEGECVEGMAEIFDMLLATVARFRSLKLKLEEFVCLKAIILINSGAFSFCSSPVEPLMDNFMVQCMLDNITDALIYCISKSGASLQLQSRRQAQLLLLLSHIRHMSNKGMEHLYRMKCKNRVPLYDLLLEMLDAQRFQSSGKVQRVWSQSEKNPPSTPTTSSSSSNNSPRGGAAAIQSNGACHSHSPDP
Atome Classification :
(470 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......----370.......380.......390.......400.-......410.......420.......430.......440.......450.......460.......470.......480.......490.......500---.......510.......520.......530.......540.......550.......560.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MYPKEEHSAGGISSSVNYLDGAYEYPNPTQTFGTSSPAEPASVGYYPAPPDP
H
E
E
H
L
Q
T
LGGGSSS
P
L
M
FAPSSPQL
S
P
Y
L
S
HHGGHHTTP
H
Q
V
S
Y
Y
LDSSSS
T
V
Y
R
S
S
VVS
S
Q
Q
A
A
V
G
L
C
E
E
L
C
SAT
D
R
Q
E
LYTGSRAAGGFDSGKE
T
R
F
C
A
V
C
S
D
YASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHN
D
Y
VCPATN
Q
C
TIDRNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
MMKGGIRKDRGG
R
S
V
R
R
E
R
RRSSNEDRDKSSS
D
Q
C
S
RAGVRTTG
P
Q
D
K
R
K
KRSGG
V
V
S
T
LCMSPD
Q
V
L
L
L
L
LGAE
P
P
A
V
C
SRQKHSRP
Y
T
E
I
T
M
M
S
L
L
T
N
M
A
D
K
E
L
V
H
M
I
A
W
A
K
KVPGFQDL
S
L
H
D
Q
V
Q
L
L
E
S
S
W
L
E
V
L
M
I
G
L
I
W
R
S
IHSPG
K
----
L
I
F
A
Q
D
LILDRSE
G
E
C
V
E
G
M
A
E
I
F
D
M
L
L
A
T
V
A
R
F
-
R
S
L
K
L
K
L
E
E
F
V
C
L
K
A
I
I
L
INSG
A
F
S
F
C
SS
P
V
E
P
L
M
D
N
F
M
V
Q
C
M
L
D
N
I
T
D
A
L
I
Y
C
ISKSG
A
S
L
Q
L
Q
S
R
R
Q
A
Q
L
L
L
L
L
S
H
I
R
H
M
S
NK
G
M
E
H
L
Y
R
M
K
CKNRV---
P
L
Y
D
L
L
L
E
M
L
D
A
Q
R
F
QSSG
K
V
Q
R
V
W
S
QSEKNPPSTPTTSSSSSNNSPRGG
A
A
A
IQSNGACHSHSPDP
142
Blastp_CBE
84.89
62%
-164
- C7 -
-
5TLV
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
270
Blastp_CBE
84.70
62%
-161
- C7 -
-
5DRJ
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
33
Blastp_CBE
84.67
63%
-177
- C7 -
-
1XPC
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
292
Blastp_CBE
84.16
62%
-167
- C7 -
-
5DIG
1
ESR1_HUMAN
A:
[6-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
36
Blastp_CBE
84.12
63%
-171
- C7 -
-
1XP1
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
371
Blastp_CBE
84.10
63%
-170
- C7 -
-
6CHZ
2
ESR1_HUMAN
A:
[17-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
209
Blastp_CBE
84.09
62%
-164
- C7 -
-
5E1C
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
32
Blastp_CBE
84.08
63%
-173
- C7 -
-
1YIM
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
58
Blastp_CBE
84.03
62%
-162
- C7 -
-
2QSE
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
60
Blastp_CBE
83.95
62%
-161
- C7 -
-
2QR9
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
35
Blastp_CBE
83.90
63%
-173
- C7 -
-
1XP6
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
165
Blastp_CBE
83.74
62%
-163
- C7 -
-
5KRM
1
ESR1_HUMAN
A:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
140
Blastp_CBE
83.73
62%
-167
- C7 -
-
5TLX
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
263
Blastp_CBE
83.69
62%
-174
- C7 -
-
5DUE
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
---------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
93
Blastp_CBE
83.70
62%
-157
- C7 -
-
5TN4
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
34
Blastp_CBE
83.69
63%
-173
- C7 -
-
1XP9
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
262
Blastp_CBE
83.68
62%
-166
- C7 -
-
5DUE
1
B:
[7-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
133
Blastp_CBE
83.64
62%
-160
- C7 -
-
5TM3
1
B:
[6-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
99
Blastp_CBE
83.63
62%
-160
- C7 -
-
5TMZ
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
296
Blastp_CBE
83.44
62%
-162
- C7 -
-
5DID
1
ESR1_HUMAN
A:
[8-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
95
Blastp_CBE
83.52
62%
-160
- C7 -
-
5TN3
1
B:
[7-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
271
Blastp_CBE
83.49
62%
-167
- C7 -
-
5DRJ
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
88
Blastp_CBE
83.48
62%
-165
- C7 -
-
5TN7
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
146
Blastp_CBE
83.43
62%
-166
- C7 -
-
5TLT
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
64
Blastp_CBE
83.43
62%
-162
- C7 -
-
2QGW
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
41
Blastp_CBE
83.43
63%
-164
- C7 -
-
1QKU
1
ESR1_HUMAN
B:
[8-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
370
Blastp_CBE
83.38
63%
-170
- C7 -
-
6CHW
5
ESR1_HUMAN
A:
[3-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
78
Blastp_CBE
83.34
62%
-167
- C7 -
-
5U2D
1
ESR1_HUMAN
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
54
Blastp_CBE
83.33
64%
-172
- C7 -
-
1GWR
1
B:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
298
Blastp_CBE
83.32
62%
-160
- C7 -
-
5DI7
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
112
Blastp_CBE
83.31
62%
-161
- C7 -
-
5TMR
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
143
Blastp_CBE
83.26
62%
-164
- C7 -
-
5TLV
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
5
PsiBlast_PDB
83.25
62%
-154
- C7 -
-
2YJA
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
291
Blastp_CBE
83.24
62%
-161
- C7 -
-
5DIG
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
427
Blastp_CBE
83.14
61%
-178
- C7 -
-
2QXS
1
ESR1_HUMAN
A:
[10-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-
R
P
F
S
-
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
253
Blastp_CBE
83.22
62%
-175
- C7 -
-
5DWE
1
ESR1_HUMAN
A:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
53
Blastp_CBE
83.21
63%
-172
- C7 -
-
2IOG
1
A:
[2-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
341
Blastp_CBE
83.13
63%
-169
- C7 -
-
4ZNH
1
ESR1_HUMAN
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
102
Blastp_CBE
83.19
62%
-159
- C7 -
-
5TMW
1
ESR1_HUMAN
A:
[5-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
46
Blastp_CBE
83.19
63%
-166
- C7 -
-
1G50
1
ESR1_HUMAN
B:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
428
Blastp_CBE
83.18
62%
-161
- C7 -
-
3L03
1
B:
[8-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
---
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
377
Blastp_CBE
83.16
63%
-167
- C7 -
-
4IWC
1
B:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
68
Blastp_CBE
83.14
62%
-161
- C7 -
-
2QAB
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
284
Blastp_CBE
83.13
62%
-154
- C7 -
-
5DKG
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
13
PsiBlast_PDB
83.10
63%
-174
- C7 -
-
2OUZ
1
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
323
Blastp_CBE
82.98
63%
-165
- C7 -
-
2AYR
1
A:
[5-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
486
HHSearch
83.03
64%
-176
- C7 -
-
1XP1
1
A:
[7-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
210
Blastp_CBE
83.00
62%
-164
- C7 -
-
5E1C
1
ESR1_HUMAN
A:
[7-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
-
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
106
Blastp_CBE
83.00
62%
-156
- C7 -
-
5TMU
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
376
Blastp_CBE
82.99
63%
-167
- C7 -
-
4IWF
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
40
Blastp_CBE
82.98
63%
-159
- C7 -
-
1QKU
1
C:
[8-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
275
Blastp_CBE
82.89
62%
-165
- C7 -
-
5DMF
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
347
Blastp_CBE
82.92
63%
-169
- C7 -
-
5T1Z
1
ESR1_HUMAN
A:
[4-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
M
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
37
Blastp_CBE
82.91
63%
-177
- C7 -
-
1SJ0
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
--
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
109
Blastp_CBE
82.89
62%
-154
- C7 -
-
5TMS
1
B:
[5-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
244
Blastp_CBE
82.84
62%
-170
- C7 -
-
5DXK
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
164
Blastp_CBE
82.87
62%
-162
- C7 -
-
5KRM
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
295
Blastp_CBE
82.82
62%
-157
- C7 -
-
5DID
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
227
Blastp_CBE
82.85
62%
-162
- C7 -
-
5DZ1
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
100
Blastp_CBE
82.84
62%
-166
- C7 -
-
5TMZ
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
130
Blastp_CBE
82.83
62%
-167
- C7 -
-
5TM5
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
74
Blastp_CBE
82.82
62%
-161
- C7 -
-
2P15
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
98
Blastp_CBE
82.81
62%
-156
- C7 -
-
5TN1
1
ESR1_HUMAN
A:
[4-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
42
Blastp_CBE
82.80
63%
-162
- C7 -
-
1QKU
1
ESR1_HUMAN
A:
[8-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
259
Blastp_CBE
82.78
62%
-163
- C7 -
-
5DUH
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
397
Blastp_CBE
82.75
63%
-169
- C7 -
-
4PPS
1
B:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
71
Blastp_CBE
82.73
62%
-159
- C7 -
-
2QA6
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
127
Blastp_CBE
82.71
62%
-158
- C7 -
-
5TM6
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
410
Blastp_CBE
82.62
62%
-169
- C7 -
-
5UFW
1
ESR1_HUMAN
A:
[4-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
56
Blastp_CBE
82.71
62%
-161
- C7 -
-
2QXM
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
359
Blastp_CBE
82.69
63%
-166
- C7 -
-
4DMA
1
ESR1_HUMAN
A:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
221
Blastp_CBE
82.68
62%
-165
- C7 -
-
5DZI
1
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
237
Blastp_CBE
82.67
62%
-167
- C7 -
-
5DXR
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
406
Blastp_CBE
82.58
62%
-162
- C7 -
-
5W9D
1
ESR1_HUMAN
A:
[3-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
--
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
70
Blastp_CBE
82.62
62%
-161
- C7 -
-
2QA6
1
B:
[10-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
69
Blastp_CBE
82.59
62%
-165
- C7 -
-
2QAB
1
ESR1_HUMAN
A:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
67
Blastp_CBE
82.58
62%
-165
- C7 -
-
2QGT
1
ESR1_HUMAN
A:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
92
Blastp_CBE
82.56
62%
-165
- C7 -
-
5TN5
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
294
Blastp_CBE
82.55
62%
-165
- C7 -
-
5DIE
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
373
Blastp_CBE
82.54
63%
-168
- C7 -
-
1X7E
1
B:
[4-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
85
Blastp_CBE
82.50
62%
-165
- C7 -
-
5TN8
1
B:
[11-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
186
Blastp_CBE
82.48
62%
-173
- C7 -
-
5KD9
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
330
Blastp_CBE
82.45
63%
-168
- C7 -
-
5FQP
1
ESR1_HUMAN
A:
[2-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
91
Blastp_CBE
82.44
62%
-158
- C7 -
-
5TN5
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
97
Blastp_CBE
82.43
62%
-153
- C7 -
-
5TN1
1
B:
[7-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
44
Blastp_CBE
82.42
64%
-166
- C7 -
-
1GWQ
1
ESR1_HUMAN
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
1
PsiBlast_PDB
82.39
61%
-163
- C7 -
-
3ERD
1
ESR1_HUMAN
A:
[12-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
281
Blastp_CBE
82.38
62%
-163
- C7 -
-
5DL4
1
ESR1_HUMAN
A:
[7-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
195
Blastp_CBE
82.36
62%
-161
- C7 -
-
5KCE
1
?
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
45
Blastp_CBE
82.36
63%
-162
- C7 -
-
1G50
1
C:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
399
Blastp_CBE
82.35
63%
-175
- C7 -
-
4PPP
1
B:
[5-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
345
Blastp_CBE
82.32
63%
-172
- C7 -
-
4ZN7
1
ESR1_HUMAN
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
115
Blastp_CBE
82.31
62%
-163
- C7 -
-
5TMO
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
113
Blastp_CBE
82.31
62%
-160
- C7 -
-
5TMQ
1
B:
[6-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
14
PsiBlast_PDB
82.31
61%
-165
- C7 -
-
2QA8
1
B:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
434
Blastp_CBE
82.30
63%
-170
- C7 -
-
6IAR
1
?
A:
[2-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
---
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
10
PsiBlast_PDB
82.29
61%
-162
- C7 -
-
3Q95
1
ESR1_HUMAN
A:
[11-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
--
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
297
Blastp_CBE
82.28
62%
-155
- C7 -
-
5DI7
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
344
Blastp_CBE
82.21
63%
-170
- C7 -
-
4ZN7
1
B:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
398
Blastp_CBE
82.19
63%
-165
- C7 -
-
4PPS
1
ESR1_HUMAN
A:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
-
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
211
Blastp_CBE
82.25
62%
-167
- C7 -
-
5E19
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
87
Blastp_CBE
82.24
62%
-170
- C7 -
-
5TN7
1
B:
[8-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
156
Blastp_CBE
82.23
62%
-166
- C7 -
-
5TLG
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
419
Blastp_CBE
82.13
63%
-158
- C7 -
-
1PCG
1
B:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
2
PsiBlast_PDB
82.21
61%
-173
- C7 -
-
3ERT
1
A:
[13-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
55
Blastp_CBE
82.20
64%
-163
- C7 -
-
1GWR
1
ESR1_HUMAN
A:
[4-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
245
Blastp_CBE
82.19
62%
-172
- C7 -
-
5DXK
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
269
Blastp_CBE
82.14
62%
-160
- C7 -
-
5DRM
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
111
Blastp_CBE
82.18
62%
-163
- C7 -
-
5TMR
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
202
Blastp_CBE
82.17
62%
-171
- C7 -
-
5EIT
1
ESR1_HUMAN
A:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
328
Blastp_CBE
82.10
63%
-169
- C7 -
-
5FQT
1
A:
[2-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
414
Blastp_CBE
82.15
62%
-169
- C7 -
-
5W9C
1
B:
[3-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
73
Blastp_CBE
82.14
62%
-160
- C7 -
-
2Q6J
1
ESR1_HUMAN
A:
[10-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
125
Blastp_CBE
82.13
62%
-160
- C7 -
-
5TM7
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
21
Blastp_CBE
82.12
61%
-163
- C7 -
-
3ERD
3
B:
[12-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
402
Blastp_CBE
82.11
63%
-171
- C7 -
-
4PP6
1
ESR1_HUMAN
A:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
96
Blastp_CBE
82.10
62%
-165
- C7 -
-
5TN3
1
ESR1_HUMAN
A:
[6-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
66
Blastp_CBE
82.09
62%
-162
- C7 -
-
2QGT
1
B:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
103
Blastp_CBE
82.08
62%
-166
- C7 -
-
5TMV
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
---
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
216
Blastp_CBE
82.05
62%
-173
- C7 -
-
5E14
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
--
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
128
Blastp_CBE
82.05
62%
-168
- C7 -
-
5TM6
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
---------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
266
Blastp_CBE
82.02
62%
-167
- C7 -
-
5DTV
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
65
Blastp_CBE
82.05
62%
-163
- C7 -
-
2QGW
1
ESR1_HUMAN
A:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
119
Blastp_CBE
82.02
62%
-163
- C7 -
-
5TML
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
280
Blastp_CBE
81.99
62%
-165
- C7 -
-
5DL4
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
94
Blastp_CBE
81.97
62%
-165
- C7 -
-
5TN4
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
72
Blastp_CBE
81.97
62%
-162
- C7 -
-
2Q6J
1
B:
[9-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
324
Blastp_CBE
81.96
63%
-167
- C7 -
-
1QKT
1
A:
[5-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
114
Blastp_CBE
81.95
62%
-165
- C7 -
-
5TMQ
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
110
Blastp_CBE
81.95
62%
-173
- C7 -
-
5TMS
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
101
Blastp_CBE
81.94
62%
-168
- C7 -
-
5TMW
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
261
Blastp_CBE
81.90
62%
-165
- C7 -
-
5DUG
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
389
Blastp_CBE
81.91
63%
-167
- C7 -
-
4IV2
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
61
Blastp_CBE
81.90
62%
-161
- C7 -
-
2QR9
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
429
Blastp_CBE
81.89
62%
-165
- C7 -
-
3L03
2
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
311
Blastp_CBE
81.83
62%
-159
- C7 -
-
3HLV
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
385
Blastp_CBE
81.88
63%
-165
- C7 -
-
4IVW
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
--
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
386
Blastp_CBE
81.78
63%
-173
- C7 -
-
4IVW
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
154
Blastp_CBE
81.86
62%
-159
- C7 -
-
5TLL
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
380
Blastp_CBE
81.76
63%
-159
- C7 -
-
4IW8
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
75
Blastp_CBE
81.83
62%
-153
- C7 -
-
2P15
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
31
Blastp_CBE
81.83
63%
-175
- C7 -
-
1YIN
1
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
192
Blastp_CBE
81.81
62%
-164
- C7 -
-
5KCT
1
?
A:
[6-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
90
Blastp_CBE
81.81
62%
-160
- C7 -
-
5TN6
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
183
Blastp_CBE
81.78
62%
-167
- C7 -
-
5KR9
1
?
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
264
Blastp_CBE
81.76
62%
-160
- C7 -
-
5DU5
1
B:
[9-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-----
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
378
Blastp_CBE
81.67
63%
-167
- C7 -
-
4IWC
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
268
Blastp_CBE
81.68
62%
-166
- C7 -
-
5DRM
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
333
Blastp_CBE
81.65
63%
-165
- C7 -
-
4ZNV
1
B:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
177
Blastp_CBE
81.70
62%
-164
- C7 -
-
5KRC
1
?
B:
[8-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
288
Blastp_CBE
81.65
62%
-169
- C7 -
-
5DKB
1
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
134
Blastp_CBE
81.69
62%
-173
- C7 -
-
5TM3
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
149
Blastp_CBE
81.68
62%
-165
- C7 -
-
5TLP
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
163
Blastp_CBE
81.67
62%
-172
- C7 -
-
5KRO
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
150
Blastp_CBE
81.66
62%
-172
- C7 -
-
5TLO
1
ESR1_HUMAN
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
-
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
204
Blastp_CBE
81.63
62%
-164
- C7 -
-
5EI1
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
463
Blastp_CBE
81.54
61%
-176
- C7 -
-
1X7J
1
ESR2_HUMAN
A:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
155
Blastp_CBE
81.63
62%
-162
- C7 -
-
5TLL
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
327
Blastp_CBE
81.56
63%
-171
- C7 -
-
5FQV
1
A:
[2-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
424
Blastp_CBE
81.52
63%
-176
- C7 -
-
4XI3
1
ESR1_HUMAN
C:
[3-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
408
Blastp_CBE
81.61
62%
-171
- C7 -
-
5UFX
1
ESR1_HUMAN
A:
[4-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
260
Blastp_CBE
81.60
62%
-163
- C7 -
-
5DUG
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
346
Blastp_CBE
81.52
63%
-169
- C7 -
-
5T1Z
1
B:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
M
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
425
Blastp_CBE
81.57
63%
-167
- C7 -
-
4XI3
1
ESR1_HUMAN
B:
[3-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
141
Blastp_CBE
81.56
62%
-167
- C7 -
-
5TLX
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
138
Blastp_CBE
81.55
62%
-168
- C7 -
-
5TLY
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
178
Blastp_CBE
81.53
62%
-172
- C7 -
-
5KRC
1
?
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
194
Blastp_CBE
81.54
62%
-164
- C7 -
-
5KCF
1
ESR1_HUMAN
A:
[6-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
47
Blastp_CBE
81.53
63%
-157
- C7 -
-
1G50
1
ESR1_HUMAN
A:
[5-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
201
Blastp_CBE
81.51
62%
-166
- C7 -
-
5EIT
1
B:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
179
Blastp_CBE
81.51
62%
-161
- C7 -
-
5KRA
1
?
F:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
--
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
215
Blastp_CBE
81.52
62%
-169
- C7 -
-
5E14
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
116
Blastp_CBE
81.51
62%
-174
- C7 -
-
5TMO
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
242
Blastp_CBE
81.47
62%
-164
- C7 -
-
5DXM
1
B:
[8-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
236
Blastp_CBE
81.50
62%
-166
- C7 -
-
5DXR
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
243
Blastp_CBE
81.49
62%
-166
- C7 -
-
5DXM
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
159
Blastp_CBE
81.47
62%
-162
- C7 -
-
5TLF
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
172
Blastp_CBE
81.46
62%
-166
- C7 -
-
5KRI
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
176
Blastp_CBE
81.45
62%
-163
- C7 -
-
5KRF
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
43
Blastp_CBE
81.43
64%
-162
- C7 -
-
1GWQ
1
B:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
274
Blastp_CBE
81.36
62%
-161
- C7 -
-
5DMF
1
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
181
Blastp_CBE
81.40
62%
-163
- C7 -
-
5KRA
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
222
Blastp_CBE
81.37
62%
-168
- C7 -
-
5DZI
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
358
Blastp_CBE
81.32
63%
-176
- C7 -
-
4DMA
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
203
Blastp_CBE
81.39
62%
-168
- C7 -
-
5EI1
1
B:
[9-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
--
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
---------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
338
Blastp_CBE
81.38
63%
-170
- C7 -
-
4ZNS
1
B:
[8-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
129
Blastp_CBE
81.37
62%
-176
- C7 -
-
5TM5
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
431
Blastp_CBE
81.27
61%
-166
- C7 -
-
3OS8
1
ESR1_HUMAN
A:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
175
Blastp_CBE
81.36
62%
-158
- C7 -
-
5KRF
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
329
Blastp_CBE
81.34
63%
-169
- C7 -
-
5FQS
1
A:
[2-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
188
Blastp_CBE
81.32
62%
-178
- C7 -
-
5KCW
1
?
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
63
Blastp_CBE
81.32
62%
-169
- C7 -
-
2QH6
1
ESR1_HUMAN
A:
[8-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
59
Blastp_CBE
81.31
62%
-169
- C7 -
-
2QSE
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
---
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
198
Blastp_CBE
81.30
62%
-174
- C7 -
-
5KCD
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
205
Blastp_CBE
81.28
62%
-165
- C7 -
-
5EHJ
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
-
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
----
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
235
Blastp_CBE
81.27
62%
-162
- C7 -
-
5DY8
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
433
Blastp_CBE
81.16
62%
-177
- C7 -
-
6CBZ
1
ESR1_HUMAN
A:
[5-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
A
-
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
381
Blastp_CBE
81.14
63%
-168
- C7 -
-
4IW6
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
212
Blastp_CBE
81.20
62%
-168
- C7 -
-
5E19
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
293
Blastp_CBE
81.18
62%
-164
- C7 -
-
5DIE
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
276
Blastp_CBE
81.17
62%
-161
- C7 -
-
5DMC
1
B:
[8-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
-
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
---
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
--
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
89
Blastp_CBE
81.16
62%
-160
- C7 -
-
5TN6
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
392
Blastp_CBE
81.06
63%
-165
- C7 -
-
4IU7
1
B:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
105
Blastp_CBE
81.14
62%
-167
- C7 -
-
5TMU
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
336
Blastp_CBE
81.06
63%
-170
- C7 -
-
4ZNU
1
ESR1_HUMAN
A:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
104
Blastp_CBE
81.11
62%
-158
- C7 -
-
5TMV
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
174
Blastp_CBE
81.08
62%
-175
- C7 -
-
5KRH
1
?
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
492
HHSearch
81.09
63%
-174
- C7 -
-
6IAR
1
?
A:
[4-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
---
R
P
F
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
161
Blastp_CBE
81.08
62%
-173
- C7 -
-
5TLD
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
225
Blastp_CBE
81.06
62%
-162
- C7 -
-
5DZ3
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
--
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
267
Blastp_CBE
81.02
62%
-170
- C7 -
-
5DTV
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
479
Blastp_CBE
81.05
61%
-172
- C7 -
-
2NV7
1
ESR2_HUMAN
A:
[1-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
107
Blastp_CBE
81.02
62%
-162
- C7 -
-
5TMT
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
314
Blastp_CBE
81.01
63%
-169
- C7 -
-
2R6Y
1
ESR1_HUMAN
A:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
184
Blastp_CBE
81.00
62%
-169
- C7 -
-
5KR9
1
?
A:
[7-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
484
HHSearch
80.88
62%
-170
* C7 *
-
5DXE
1
ESR1_HUMAN
A:
[16-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
-
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
-
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
465
Blastp_CBE
80.82
61%
-169
- C7 -
-
1X7B
1
ESR2_HUMAN
A:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
9
PsiBlast_PDB
80.92
59%
-173
- C7 -
-
4PXM
1
ESR1_HUMAN
A:
[24-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
G
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
342
Blastp_CBE
80.84
63%
-173
- C7 -
-
4ZN9
1
B:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
---------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
363
Blastp_CBE
80.83
61%
-175
- C7 -
-
5TNB
1
?
C:
[9-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
401
Blastp_CBE
80.90
63%
-175
- C7 -
-
4PP6
1
B:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
247
Blastp_CBE
80.86
62%
-173
- C7 -
-
5DWJ
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
360
Blastp_CBE
80.81
64%
-163
- C7 -
-
5GTR
1
A:
[4-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
320
Blastp_CBE
80.83
63%
-167
- C7 -
-
2Q70
1
ESR1_HUMAN
A:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
----
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
173
Blastp_CBE
80.88
62%
-165
- C7 -
-
5KRH
1
?
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
--
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
289
Blastp_CBE
80.83
62%
-171
- C7 -
-
5DKB
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
-------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
144
Blastp_CBE
80.87
62%
-165
- C7 -
-
5TLU
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
126
Blastp_CBE
80.86
62%
-166
- C7 -
-
5TM7
1
ESR1_HUMAN
A:
[7-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
--------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
220
Blastp_CBE
80.83
62%
-163
- C7 -
-
5E0W
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
--------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
278
Blastp_CBE
80.85
62%
-154
- C7 -
-
5DLR
1
B:
[8-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
--
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
343
Blastp_CBE
80.78
63%
-177
- C7 -
-
4ZN9
1
ESR1_HUMAN
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
471
Blastp_CBE
80.73
61%
-172
- C7 -
-
1U3S
1
ESR2_HUMAN
A:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
--------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
6
PsiBlast_PDB
80.84
57%
-168
- C7 -
-
2OCF
1
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
4
PsiBlast_PDB
80.83
62%
-168
- C7 -
-
3DT3
1
ESR1_HUMAN
A:
[10-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
160
Blastp_CBE
80.82
62%
-164
- C7 -
-
5TLD
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
-
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
451
Blastp_CBE
80.71
61%
-173
- C7 -
-
4J24
1
ESR2_HUMAN
A:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
157
Blastp_CBE
80.81
62%
-174
- C7 -
-
5TLG
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
230
Blastp_CBE
80.78
62%
-175
- C7 -
-
5DYD
1
B:
[11-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
---
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
229
Blastp_CBE
80.78
62%
-156
- C7 -
-
5DZ0
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
234
Blastp_CBE
80.75
62%
-160
- C7 -
-
5DY8
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
-----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
430
Blastp_CBE
80.77
61%
-168
- C7 -
-
3OS8
1
ESR1_HUMAN
B:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
285
Blastp_CBE
80.72
62%
-163
- C7 -
-
5DKG
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
-------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
139
Blastp_CBE
80.75
62%
-165
- C7 -
-
5TLY
1
ESR1_HUMAN
A:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
---
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
405
Blastp_CBE
80.73
62%
-167
- C7 -
-
5W9D
1
B:
[3-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
--
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
223
Blastp_CBE
80.72
62%
-168
- C7 -
-
5DZH
1
B:
[8-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
--
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
393
Blastp_CBE
80.71
63%
-162
- C7 -
-
4IU7
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
400
Blastp_CBE
80.61
63%
-181
- C7 -
-
4PPP
1
ESR1_HUMAN
A:
[4-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
18
PsiBlast_PDB
80.69
60%
-174
- C7 -
-
5WGD
1
ESR1_HUMAN
A:
[15-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
390
Blastp_CBE
80.57
63%
-167
- C7 -
-
4IV2
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
124
Blastp_CBE
80.63
62%
-163
- C7 -
-
5TM8
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
-------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
449
Blastp_CBE
80.52
61%
-177
- C7 -
-
4J24
1
ESR2_HUMAN
C:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
395
Blastp_CBE
80.61
62%
-173
- C7 -
-
5FQR
1
A:
[2-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
332
Blastp_CBE
80.59
63%
-169
- C7 -
-
4ZNW
1
ESR1_HUMAN
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
77
Blastp_CBE
80.58
62%
-162
- C7 -
-
5U2D
1
B:
[6-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
272
Blastp_CBE
80.53
62%
-169
- C7 -
-
5DP0
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
158
Blastp_CBE
80.57
62%
-156
- C7 -
-
5TLF
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-----
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
350
Blastp_CBE
80.49
61%
-160
- C7 -
-
3OSA
1
ESR1_HUMAN
B:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
-
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
426
Blastp_CBE
80.55
63%
-168
- C7 -
-
4XI3
1
ESR1_HUMAN
A:
[3-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
200
Blastp_CBE
80.54
62%
-165
- C7 -
-
5KCC
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
167
Blastp_CBE
80.53
62%
-158
- C7 -
-
5KRL
1
?
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
228
Blastp_CBE
80.52
62%
-160
- C7 -
-
5DZ0
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
489
HHSearch
80.40
61%
-174
- C7 -
-
3OLL
1
B:
[5-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
-
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
-
T
---
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
384
Blastp_CBE
80.51
63%
-165
- C7 -
-
4IVY
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
467
Blastp_CBE
80.40
61%
-170
- C7 -
-
1X78
1
ESR2_HUMAN
A:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
310
Blastp_CBE
80.50
62%
-157
- C7 -
-
3HLV
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-----
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
258
Blastp_CBE
80.49
62%
-169
- C7 -
-
5DUH
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
--
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
147
Blastp_CBE
80.48
62%
-157
- C7 -
-
5TLT
1
ESR1_HUMAN
A:
[6-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
238
Blastp_CBE
80.40
62%
-170
- C7 -
-
5DXQ
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
--
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
286
Blastp_CBE
80.42
62%
-166
- C7 -
-
5DKE
1
B:
[8-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
166
Blastp_CBE
80.40
62%
-166
- C7 -
-
5KRL
1
?
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
57
Blastp_CBE
80.39
62%
-159
- C7 -
-
2QXM
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
-----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
447
Blastp_CBE
80.29
61%
-172
- C7 -
-
4J26
1
ESR2_HUMAN
A:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
----------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
197
Blastp_CBE
80.35
62%
-173
- C7 -
-
5KCD
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
-------------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
120
Blastp_CBE
80.36
62%
-178
- C7 -
-
5TML
1
ESR1_HUMAN
A:
[6-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-------
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
339
Blastp_CBE
80.29
63%
-174
- C7 -
-
4ZNS
1
ESR1_HUMAN
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
---------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
24
Blastp_CBE
80.35
62%
-156
- C7 -
-
1A52
1
B:
[9-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
409
Blastp_CBE
80.25
62%
-179
- C7 -
-
5UFW
1
B:
[3-241]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
207
Blastp_CBE
80.33
62%
-172
- C7 -
-
5EGV
1
B:
[11-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
--
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
382
Blastp_CBE
80.32
63%
-164
- C7 -
-
4IW6
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
460
Blastp_CBE
80.30
61%
-172
- C7 -
-
2YJD
1
B:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
273
Blastp_CBE
80.29
62%
-168
- C7 -
-
5DP0
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
--
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
162
Blastp_CBE
80.27
62%
-163
- C7 -
-
5KRO
1
ESR1_HUMAN
B:
[9-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
-
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
450
Blastp_CBE
80.15
61%
-174
- C7 -
-
4J24
1
ESR2_HUMAN
B:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
19
PsiBlast_PDB
80.25
60%
-170
- C7 -
-
5WGQ
1
ESR1_HUMAN
A:
[15-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
407
Blastp_CBE
80.24
62%
-181
- C7 -
-
5UFX
1
B:
[3-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
185
Blastp_CBE
80.23
62%
-164
- C7 -
-
5KD9
1
B:
[8-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
------
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
257
Blastp_CBE
80.19
62%
-167
- C7 -
-
5DVS
1
ESR1_HUMAN
A:
[9-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
-
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
337
Blastp_CBE
80.15
63%
-169
- C7 -
-
4ZNT
1
B:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
279
Blastp_CBE
80.21
62%
-161
- C7 -
-
5DLR
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
180
Blastp_CBE
80.19
62%
-177
- C7 -
-
5KRA
1
?
E:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
249
Blastp_CBE
80.18
62%
-165
- C7 -
-
5DWI
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
--
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
469
Blastp_CBE
80.17
61%
-174
- C7 -
-
1X76
1
ESR2_HUMAN
A:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
151
Blastp_CBE
80.16
62%
-164
- C7 -
-
5TLO
1
?
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
-----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
232
Blastp_CBE
80.13
62%
-164
- C7 -
-
5DYB
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
322
Blastp_CBE
80.15
63%
-173
- C7 -
-
2POG
1
ESR1_HUMAN
A:
[5-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------------
477
Blastp_CBE
80.03
61%
-171
- C7 -
-
1ZAF
1
ESR2_HUMAN
A:
[1-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
383
Blastp_CBE
80.05
63%
-164
- C7 -
-
4IVY
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
231
Blastp_CBE
80.13
62%
-175
- C7 -
-
5DYD
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
265
Blastp_CBE
80.08
62%
-166
- C7 -
-
5DU5
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
7
PsiBlast_PDB
80.11
62%
-160
- C7 -
-
1A52
1
ESR1_HUMAN
A:
[10-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
308
Blastp_CBE
80.05
63%
-179
- C7 -
-
1XQC
1
ESR1_HUMAN
A:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
361
Blastp_CBE
80.10
64%
-163
- C7 -
-
5GS4
1
A:
[4-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
239
Blastp_CBE
80.05
62%
-175
- C7 -
-
5DXQ
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
448
Blastp_CBE
80.07
61%
-181
- C7 -
-
4J24
1
D:
[4-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
-------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
182
Blastp_CBE
80.05
62%
-172
- C7 -
-
5KRA
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
420
Blastp_CBE
80.04
63%
-169
- C7 -
-
1PCG
1
ESR1_HUMAN
A:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
-
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-----------
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
208
Blastp_CBE
80.03
62%
-171
- C7 -
-
5EGV
1
ESR1_HUMAN
A:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
226
Blastp_CBE
80.02
62%
-165
- C7 -
-
5DZ3
1
ESR1_HUMAN
A:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
446
Blastp_CBE
80.01
61%
-173
- C7 -
-
4J26
1
B:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
---------
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
233
Blastp_CBE
79.96
62%
-166
- C7 -
-
5DYB
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
340
Blastp_CBE
79.88
63%
-168
- C7 -
-
4ZNH
1
B:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
246
Blastp_CBE
79.93
62%
-164
- C7 -
-
5DWJ
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
-
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
108
Blastp_CBE
79.92
62%
-158
- C7 -
-
5TMT
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
---
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
309
Blastp_CBE
79.88
63%
-166
- C7 -
-
1UOM
1
A:
[9-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
------------
P
L
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
132
Blastp_CBE
79.86
62%
-168
- C7 -
-
5TM4
3
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----------
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
218
Blastp_CBE
79.85
62%
-162
- C7 -
-
5E0X
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
396
Blastp_CBE
79.84
62%
-171
- C7 -
-
5ACC
1
?
A:
[2-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
---
P
S
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
335
Blastp_CBE
79.76
63%
-181
- C7 -
-
4ZNU
1
B:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
483
HHSearch
79.81
59%
-171
- C7 -
-
1YYE
1
ESR2_HUMAN
A:
[2-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
----------------------------------------------------
290
Blastp_CBE
79.76
62%
-165
- C7 -
-
5DK9
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-----
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
306
Blastp_CBE
79.77
63%
-174
- C7 -
-
1XQC
1
ESR1_HUMAN
C:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
283
Blastp_CBE
79.76
62%
-177
- C7 -
-
5DKS
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
248
Blastp_CBE
79.74
62%
-163
- C7 -
-
5DWI
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
--
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-----
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
461
Blastp_CBE
79.62
61%
-173
- C7 -
-
2YJD
1
ESR2_HUMAN
A:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
474
Blastp_CBE
79.59
61%
-176
- C7 -
-
1U3Q
1
ESR2_HUMAN
B:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
16
PsiBlast_PDB
79.70
60%
-172
- C7 -
-
5DX3
1
ESR1_HUMAN
A:
[14-254]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
473
Blastp_CBE
79.67
61%
-173
- C7 -
-
1U3Q
1
ESR2_HUMAN
C:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
86
Blastp_CBE
79.66
62%
-171
- C7 -
-
5TN8
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
387
Blastp_CBE
79.55
63%
-162
- C7 -
-
4IV4
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
--------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
3
PsiBlast_PDB
79.62
61%
-164
- C7 -
-
1R5K
2
ESR1_HUMAN
A:
[13-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
412
Blastp_CBE
79.50
62%
-170
- C7 -
-
5W9C
1
?
D:
[3-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
---------------------------------------------------------
403
Blastp_CBE
79.59
62%
-176
- C7 -
-
6C42
1
ESR1_HUMAN
B:
[3-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
--
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
356
Blastp_CBE
79.58
61%
-164
- C7 -
-
3OS8
1
ESR1_HUMAN
C:
[10-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
224
Blastp_CBE
79.56
62%
-167
- C7 -
-
5DZH
1
ESR1_HUMAN
A:
[7-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
38
Blastp_CBE
79.55
61%
-169
- C7 -
-
5WGQ
1
ESR1_HUMAN
B:
[13-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
491
HHSearch
79.43
60%
-175
- C7 -
-
5TOA
1
B:
[6-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
-
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
----------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
---------------------------------------------------
375
Blastp_CBE
79.53
63%
-178
- C7 -
-
4IWF
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
136
Blastp_CBE
79.52
62%
-169
- C7 -
-
5TM1
1
B:
[11-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
-
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
------
L
S
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
123
Blastp_CBE
79.50
62%
-171
- C7 -
-
5TM8
1
B:
[7-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
355
Blastp_CBE
79.49
61%
-166
- C7 -
-
3OS8
1
D:
[10-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
169
Blastp_CBE
79.48
62%
-172
- C7 -
-
5KRK
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
23
Blastp_CBE
79.47
61%
-170
- C7 -
-
1R5K
1
ESR1_HUMAN
B:
[13-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
476
Blastp_CBE
79.46
61%
-171
- C7 -
-
1ZAF
1
B:
[1-236]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
213
Blastp_CBE
79.43
62%
-160
- C7 -
-
5E15
1
B:
[8-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
475
Blastp_CBE
79.45
61%
-175
- C7 -
-
1U3Q
1
ESR2_HUMAN
A:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
316
Blastp_CBE
79.44
63%
-175
- C7 -
-
2R6W
1
ESR1_HUMAN
A:
[5-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
62
Blastp_CBE
79.43
62%
-176
- C7 -
-
2QH6
1
B:
[9-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
453
Blastp_CBE
79.27
61%
-171
- C7 -
-
3OMQ
1
ESR2_HUMAN
A:
[4-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
468
Blastp_CBE
79.26
61%
-168
- C7 -
-
1X76
1
B:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
196
Blastp_CBE
79.33
62%
-169
- C7 -
-
5KCE
1
?
A:
[6-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
---------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
485
HHSearch
79.29
62%
-182
- C7 -
-
5UFX
1
B:
[6-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
---
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
441
Blastp_CBE
79.27
61%
-176
- C7 -
-
2J7X
5
A:
[9-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
---
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
------
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
440
Blastp_CBE
79.17
61%
-179
- C7 -
-
2J7Y
7
A:
[9-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
-----
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
------
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
145
Blastp_CBE
79.26
62%
-165
- C7 -
-
5TLU
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
277
Blastp_CBE
79.23
62%
-180
- C7 -
-
5DMC
1
ESR1_HUMAN
A:
[8-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-----
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
464
Blastp_CBE
79.19
61%
-171
- C7 -
-
1X7B
1
B:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
331
Blastp_CBE
79.13
63%
-170
- C7 -
-
4ZNW
1
B:
[8-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
357
Blastp_CBE
79.17
63%
-174
- C7 -
-
5HYR
2
?
B:
[7-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
379
Blastp_CBE
79.08
63%
-157
- C7 -
-
4IW8
1
B:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
334
Blastp_CBE
79.14
63%
-166
- C7 -
-
4ZNV
1
ESR1_HUMAN
A:
[8-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
219
Blastp_CBE
79.13
62%
-162
- C7 -
-
5E0W
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
---
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
217
Blastp_CBE
79.10
62%
-171
- C7 -
-
5E0X
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
191
Blastp_CBE
79.08
62%
-165
- C7 -
-
5KCT
1
?
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
39
Blastp_CBE
79.08
61%
-177
- C7 -
-
5WGD
1
B:
[14-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
--------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
372
Blastp_CBE
78.99
63%
-167
- C7 -
-
1X7R
1
A:
[4-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
478
Blastp_CBE
79.05
61%
-168
- C7 -
-
2NV7
1
B:
[1-235]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
17
PsiBlast_PDB
79.03
60%
-177
- C7 -
-
5DXB
3
B:
[14-255]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
470
Blastp_CBE
78.79
61%
-173
- C7 -
-
1U3S
1
B:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
325
Blastp_CBE
78.99
63%
-181
- C7 -
-
5AAU
1
B:
[8-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
326
Blastp_CBE
78.93
63%
-174
- C7 -
-
5AAU
1
ESR1_HUMAN
A:
[6-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
251
Blastp_CBE
78.93
62%
-175
- C7 -
-
5DWG
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
-
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
442
Blastp_CBE
78.90
61%
-180
- C7 -
-
1QKN
1
A:
[9-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
S
A
N
Q
E
A
E
S
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
-----------
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
459
Blastp_CBE
78.79
61%
-170
- C7 -
-
3OLS
1
ESR2_HUMAN
A:
[4-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
472
Blastp_CBE
78.88
61%
-174
- C7 -
-
1U3Q
1
D:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
354
Blastp_CBE
78.80
61%
-171
- C7 -
-
3OS9
1
ESR1_HUMAN
A:
[12-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
-
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
455
Blastp_CBE
78.87
61%
-169
- C7 -
-
3OMP
1
ESR2_HUMAN
A:
[4-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
170
Blastp_CBE
78.86
62%
-168
- C7 -
-
5KRJ
1
?
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
388
Blastp_CBE
78.85
63%
-166
- C7 -
-
4IV4
1
ESR1_HUMAN
A:
[6-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
----
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
199
Blastp_CBE
78.82
62%
-170
- C7 -
-
5KCC
1
B:
[7-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
313
Blastp_CBE
78.80
63%
-177
- C7 -
-
2R6Y
1
B:
[5-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
-----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------
P
L
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
404
Blastp_CBE
78.79
62%
-161
- C7 -
-
6C42
1
ESR1_HUMAN
A:
[6-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
240
Blastp_CBE
78.78
62%
-167
- C7 -
-
5DXP
1
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
466
Blastp_CBE
78.70
61%
-164
- C7 -
-
1X78
1
B:
[3-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
315
Blastp_CBE
78.67
63%
-174
- C7 -
-
2R6W
1
B:
[5-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-----------
P
L
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
22
Blastp_CBE
78.66
61%
-168
- C7 -
-
1R5K
1
C:
[13-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
---
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
118
Blastp_CBE
78.60
62%
-172
- C7 -
-
5TMM
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
--
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
432
Blastp_CBE
78.59
62%
-179
- C7 -
-
6CBZ
2
B:
[6-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
-------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
A
-
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
M
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
457
Blastp_CBE
78.58
61%
-170
- C7 -
-
3OMO
1
ESR2_HUMAN
A:
[4-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
348
Blastp_CBE
78.56
61%
-164
- C7 -
-
3OSA
1
D:
[10-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
417
Blastp_CBE
78.55
63%
-169
- C7 -
-
2I0J
1
ESR1_HUMAN
B:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
-------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
282
Blastp_CBE
78.53
62%
-171
- C7 -
-
5DKS
1
B:
[10-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
---
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
456
Blastp_CBE
78.49
61%
-172
- C7 -
-
3OMO
1
B:
[4-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
---------------------------------------------------------
422
Blastp_CBE
78.48
62%
-178
- C7 -
-
5AK2
1
A:
[22-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
15
PsiBlast_PDB
78.47
61%
-172
- C7 -
-
2QZO
1
ESR1_HUMAN
A:
[9-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
-------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
----------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
353
Blastp_CBE
78.38
61%
-168
- C7 -
-
3OS9
1
ESR1_HUMAN
B:
[11-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
462
Blastp_CBE
78.43
61%
-170
- C7 -
-
1X7J
1
B:
[3-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
307
Blastp_CBE
78.41
63%
-179
- C7 -
-
1XQC
1
ESR1_HUMAN
B:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
------------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
152
Blastp_CBE
78.40
62%
-175
- C7 -
-
5TLM
1
?
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
415
Blastp_CBE
78.39
63%
-171
- C7 -
-
2I0J
1
D:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
349
Blastp_CBE
78.38
61%
-162
- C7 -
-
3OSA
1
ESR1_HUMAN
C:
[10-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
189
Blastp_CBE
78.35
62%
-162
- C7 -
-
5KCU
1
B:
[8-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
----------
P
L
S
D
L
L
L
E
M
L
D
--------------------------------------------------------
187
Blastp_CBE
78.34
62%
-160
- C7 -
-
5KCW
1
?
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
---
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-----------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
367
Blastp_CBE
78.31
61%
-179
- C7 -
-
5TN9
1
?
C:
[10-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
-------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
413
Blastp_CBE
78.30
62%
-165
- C7 -
-
5W9C
1
?
C:
[4-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
----
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
190
Blastp_CBE
78.26
62%
-176
- C7 -
-
5KCU
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
365
Blastp_CBE
78.23
61%
-173
- C7 -
-
5TNB
1
ESR1_HUMAN
A:
[9-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
--------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
206
Blastp_CBE
78.21
62%
-158
- C7 -
-
5EHJ
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
256
Blastp_CBE
78.20
62%
-167
- C7 -
-
5DVS
1
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
--
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
-
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
131
Blastp_CBE
78.14
62%
-176
- C7 -
-
5TM4
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----------
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
480
Blastp_CBE
78.09
61%
-181
- C7 -
-
2GIU
1
A:
[4-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
-
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-----
A
D
S
S
R
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
----
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
76
Blastp_CBE
78.06
62%
-181
- C7 -
-
6CZN
1
?
B:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
394
Blastp_CBE
78.05
62%
-170
- C7 -
-
5AAV
1
A:
[6-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------------
241
Blastp_CBE
77.95
62%
-167
- C7 -
-
5DXP
1
ESR1_HUMAN
A:
[8-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
193
Blastp_CBE
77.94
62%
-169
- C7 -
-
5KCF
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
----------
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
452
Blastp_CBE
77.90
61%
-172
- C7 -
-
3OMQ
1
B:
[4-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
---------------------------------------------------------
300
Blastp_CBE
77.89
63%
-206
- C7 -
-
6B0F
3
ESR1_HUMAN
A:
[10-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
--------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
------
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
----------------
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
--
K
S
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
214
Blastp_CBE
77.80
62%
-173
- C7 -
-
5E15
1
ESR1_HUMAN
A:
[6-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
458
Blastp_CBE
77.79
61%
-175
- C7 -
-
3OLS
1
B:
[4-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
---------------------------------------------------------
137
Blastp_CBE
77.72
62%
-181
- C7 -
-
5TM1
1
ESR1_HUMAN
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
--------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
369
Blastp_CBE
77.67
61%
-177
- C7 -
-
5TN9
1
ESR1_HUMAN
A:
[9-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
-------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
------
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
153
Blastp_CBE
77.62
62%
-161
- C7 -
-
5TLM
1
?
A:
[9-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
-
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---------
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
423
Blastp_CBE
77.40
63%
-173
- C7 -
-
4XI3
1
D:
[3-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
------------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
S
Y
D
L
L
L
E
M
----------------------------------------------------------
454
Blastp_CBE
77.37
61%
-172
- C7 -
-
3OMP
1
B:
[4-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
---------------------------------------------------------
445
Blastp_CBE
77.32
61%
-188
- C7 -
-
2YLY
1
ESR2_HUMAN
A:
[4-237]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
-------------------------------------------------------
287
Blastp_CBE
77.15
62%
-172
- C7 -
-
5DKE
1
ESR1_HUMAN
A:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
117
Blastp_CBE
77.03
62%
-173
- C7 -
-
5TMM
1
B:
[8-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----------
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
391
Blastp_CBE
77.00
63%
-169
- C7 -
-
4IUI
1
B:
[6-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
--------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------------
305
Blastp_CBE
76.92
63%
-174
- C7 -
-
1XQC
1
D:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
------------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
436
Blastp_CBE
76.82
62%
-176
- C7 -
-
2JF9
4
C:
[27-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---------------------------------------------------------------------------
8
PsiBlast_PDB
76.78
63%
-176
- C7 -
-
3UUC
1
ESR1_HUMAN
A:
[7-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
---
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----------
Y
D
L
L
L
E
M
L
---------------------------------------------------------
362
Blastp_CBE
76.74
61%
-163
- C7 -
-
5TNB
1
?
D:
[8-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
-----
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
---
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
------
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
168
Blastp_CBE
76.62
62%
-171
- C7 -
-
5KRK
1
B:
[9-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
---
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---------
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
11
PsiBlast_PDB
76.59
63%
-172
- C7 -
-
2IOK
1
ESR1_HUMAN
A:
[8-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-------
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--------
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
364
Blastp_CBE
76.53
61%
-176
- C7 -
-
5TNB
1
B:
[8-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
----
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
----
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
--------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
438
Blastp_CBE
76.47
62%
-173
- C7 -
-
2JF9
5
ESR1_HUMAN
A:
[27-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
25
Blastp_CBE
76.46
63%
-169
- C7 -
-
2IOK
1
B:
[8-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
----------
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------------
122
Blastp_CBE
75.93
62%
-163
- C7 -
-
5TM9
3
ESR1_HUMAN
A:
[8-230]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----------------------------------------------------------------------------
121
Blastp_CBE
75.74
62%
-169
- C7 -
-
5TM9
1
B:
[8-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---------------------------------------------------------------------------
250
Blastp_CBE
75.72
62%
-166
- C7 -
-
5DWG
1
B:
[13-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
-----
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
---
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-------
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
135
Blastp_CBE
75.64
62%
-178
- C7 -
-
5TM2
1
ESR1_HUMAN
A:
[9-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
---
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
-------
P
L
S
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
421
Blastp_CBE
75.60
62%
-190
- C7 -
-
5AK2
1
?
B:
[22-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
--------------
L
L
E
M
L
D
--------------------------------------------------------
439
Blastp_CBE
75.51
62%
-165
- C7 -
-
2BJ4
1
ESR1_HUMAN
A:
[27-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
312
Blastp_CBE
75.48
63%
-172
- C7 -
-
2YAT
3
A:
[9-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
---------
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
366
Blastp_CBE
75.47
61%
-170
- C7 -
-
5TN9
1
?
D:
[8-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
418
Blastp_CBE
75.42
63%
-165
- C7 -
-
2I0J
1
ESR1_HUMAN
A:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
444
Blastp_CBE
75.32
61%
-181
- C7 -
-
2YLY
1
B:
[4-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
-------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
-------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
------------------------------------------------------
368
Blastp_CBE
74.94
61%
-177
- C7 -
-
5TN9
1
B:
[8-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
S
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
321
Blastp_CBE
74.91
63%
-163
- C7 -
-
2POG
1
B:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
254
Blastp_CBE
74.90
62%
-194
- C7 -
-
5DVV
1
B:
[12-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
--------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------------
352
Blastp_CBE
74.88
61%
-169
- C7 -
-
3OS9
2
ESR1_HUMAN
C:
[10-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----
V
V
---
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------------
416
Blastp_CBE
74.82
63%
-163
- C7 -
-
2I0J
1
ESR1_HUMAN
C:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
148
Blastp_CBE
74.59
62%
-169
- C7 -
-
5TLP
1
B:
[8-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
443
Blastp_CBE
74.49
61%
-185
- C7 -
-
1HJ1
2
A:
[9-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
-
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
--------------
S
R
K
L
T
H
-
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
---------------------------------------------------------------------------
435
Blastp_CBE
74.38
62%
-163
- C7 -
-
2JFA
1
ESR1_HUMAN
A:
[27-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---------------------------------------------------------------------------
411
Blastp_CBE
74.36
62%
-190
- C7 -
-
5AAV
1
?
B:
[6-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
---
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
--------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------------
Y
D
L
L
L
E
M
L
D
--------------------------------------------------------
255
Blastp_CBE
74.33
62%
-189
- C7 -
-
5DVV
1
ESR1_HUMAN
A:
[13-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
---------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
---------
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
------
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------------
437
Blastp_CBE
74.22
62%
-178
- C7 -
-
2JF9
3
ESR1_HUMAN
B:
[27-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---------------------------------------------------------------------------
319
Blastp_CBE
74.16
63%
-163
- C7 -
-
2Q70
1
B:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
318
Blastp_CBE
73.32
63%
-171
- C7 -
-
2QE4
1
ESR1_HUMAN
A:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
317
Blastp_CBE
72.85
63%
-172
- C7 -
-
2QE4
1
B:
[5-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----------------------------------------------------------------------------
351
Blastp_CBE
72.18
61%
-179
- C7 -
-
3OS9
2
D:
[11-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
---
P
S
Y
D
L
L
L
E
M
L
---------------------------------------------------------
304
Blastp_CBE
70.11
63%
-208
- C7 -
-
5T92
1
ESR1_HUMAN
A:
[11-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
--------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
---------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
----------------
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
-------------------------------------------------------------------------------
301
Blastp_CBE
70.00
63%
-185
- C7 -
-
5T97
1
B:
[10-227]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
-------------
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
-------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
-------
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
------------------------------------------------------------------------------
303
Blastp_CBE
68.77
63%
-202
- C7 -
-
5T92
1
B:
[9-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
-------------
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
--------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
----------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
------------------------------------------------------------------------------
302
Blastp_CBE
68.50
63%
-209
- C7 -
-
5T97
1
ESR1_HUMAN
A:
[11-226]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
--------------
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
---------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
----------------
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
-------------------------------------------------------------------------------
299
Blastp_CBE
68.10
63%
-187
- C7 -
-
6B0F
2
ESR1_HUMAN
B:
[9-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
---------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
---
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
---------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
------------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
-------------------------------------------------------------------------------
506
Fugue
67.31
52%
-88
- C7 -
-
3ERT
1
A:
[13-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
-------------------
I
L
Y
S
E
Y
D
P
-------
T
R
P
F
S
------------
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
--
H
P
GKLL
F
A
--
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R-
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
----KNV
V
---
P
L
Y
D
L
L
L
E
M
L
D
--------
A
H
R
L
H
A
--------------------------------------
-
* C *
-
-
:
---------------------------
-
* C *
-
-
:
---------------------------
-
* C *
-
-
:
---------------------------