@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ABL1_HUMAN: (2020-09-03 )
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLFSALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPERIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
Atome Classification :
(507 SA)
.........10........20........30........40........50........60........70........80........90........100..--....-.110.......120.......130..-....-.140.-.--.-..--...150.......160....-----.-----..----170--.........180.......190.......200.......210....--...220.......230...-------------------....240--------.......250.......260-----.---.--.....270.....---.---.280--........290.......300......-----.310........320......----.--330.......340.......350.......360.......370.......380.......390....-....400........410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
E
I
C
L
K
L
VGCKSKKGLSSS
S
S
C
Y
L
E
E
A
L
QRPVASDFEPQ
G
L
S
E
A
ARWNSKENLLAGPSENDP
N
L
F
V
A
L
Y
D
F
VASGD
N
T
L
S
ITKG
E
K
L
R
V
L
G
YNHNG
E
W
C
EAQT--KNGQ-GWVPSNYITPVNSLEKHSWYHGPVSR-
N
A
A
E
-
Y
L
L
-
S
-S--G-IN--
G
S
F
L
V
RESESSPGQ
R
S
I
S
L
R
-----Y-----E
G
----
R
----
V
Y
H
Y
R
INTASD
G
K
L
Y
VSSE
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
LHYP--APKRNKP
T
V
Y
GVSPNY
D
K
W-------------------
E
M
ERT
D
I
--------
T
M
K
HKLGGGQ
Y
G
E
V
Y
E
G
V
W
K
-----K---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
EIKHP
N
L
V
Q
L
L
G
V
CTRE-----P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
KK
N
F
I
H
R
D
L
A
ARNCLVGEN
H
L
V
K
V
A
D
F
G
L
S
R
LMTGD-TYTA-HAG
A
K
-
F
P
I
K
WTAPESLAYNKFSIK
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
YGMSPYPGI
D
L
S
Q
V
Y
E
L
L
E
K
D
YRMERPEG
C
P
E
K
V
Y
E
L
M
R
A
C
WQWNPSDRP
S
F
A
E
I
H
Q
A
F
E
T
M
F
QESSI
S
D
E
V
E
K
E
L
G
KQ
G
V
R
G
A
V
S
T
L
L
QAPELPTKTRT
S
R
RAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLN
E
D
E
RLLPKDKK
T
N
L
F
S
A
L
I
K
K
KKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNG
A
L
A
F
TPLDTADPAKSPKPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGG
S
S
S
K
R
F
L
R
SC
S
A
SCVPHGAKDTE
W
R
SVTL
P
R
D
L
Q
S
T
G
R
QFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTP
P
P
R
L
VKK
N
E
E
A
A
D
E
V
F
K
D
I
M
ESSPGSSPPNL
T
P
K
P
L
R
R
Q
V
T
VAPASGLPH
K
E
EAGKGSALGTPAAAEPVTPTSKAGSGAPGGTSKGP
A
E
E
S
R
V
R
R
HKHSSESPGRDKGKLSRLKPAPPPPPAASAGKAGGKPSQSP
S
Q
E
AAGE
A
V
LGAKT
K
A
T
S
L
V
D
A
VNSDAAKPSQPGEGLKKPVLPATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSS
T
A
F
I
P
L
IS
T
R
V
S
L
RKTRQ
P
P
E
R
I
ASGAITK
G
V
V
LDST
E
A
L
C
L
A
ISR
N
S
E
Q
M
A
S
H
S
A
V
L
E
AGK
N
L
Y
T
F
C
V
S
Y
V
D
S
I
Q
Q
M
R
N
K
F
A
F
R
E
A
I
N
K
L
E
N
N
L
R
E
L
Q
ICPATAGSGP
A
A
T
Q
D
F
S
K
L
L
S
S
V
K
E
I
S
D
I
VQR
4
PsiBlast_PDB
92.38
98%
-92
- C4 -
-
2FO0
4
ABL1_HUMAN
A:
[23-488]
---------------------------------------------
A
R
W
N
S
K
E
N
L
L
A
G
P
S
E
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
K
P
T
V
Y
G
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.27
99%
-99
- C4 -
-
1OPK
3
ABL1_MOUSE
A:
[44-492]
---------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
K
P
T
I
Y
G
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
HHSearch
91.92
99%
-99
- C4 -
-
1OPK
3
ABL1_MOUSE
A:
[44-490]
---------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
K
P
T
I
Y
G
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
HHSearch
91.56
100%
-96
- C4 -
-
2FO0
4
ABL1_HUMAN
A:
[38-488]
------------------------------------------------------------
N
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
K
P
T
V
Y
G
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.83
99%
-98
- C4 -
-
1OPL
2
ABL1_HUMAN
A:
[81-531]
-------------------------------------------------------------
D
P
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
K
P
T
V
Y
G
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
HHSearch
85.62
100%
-109
- C4 -
-
5MO4
2
ABL1_HUMAN
A:
[44-492]
---------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
K
P
T
V
Y
G
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
--------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.42
99%
-109
- C4 -
-
5MO4
2
ABL1_HUMAN
A:
[44-492]
---------------------------------------------------------------
N
L
F
V
A
L
Y
D
F
V
A
S
G
D
N
T
L
S
I
T
K
G
E
K
L
R
V
L
G
Y
N
H
N
G
E
W
C
E
A
Q
T
--
K
N
G
Q
-
G
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
R
N
K
P
T
V
Y
G
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
--------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
76.17
99%
-116
- C4 -
-
1OPL
1
ABL1_HUMAN
B:
[140-518]
---------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
--------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
HHSearch
74.70
100%
-126
- C4 -
-
4XEY
1
ABL1_HUMAN
B:
[7-389]
----------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
---
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.54
99%
-126
- C4 -
-
4XEY
1
ABL1_HUMAN
B:
[7-389]
----------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
-
N
A
A
E
-
Y
L
L
-
S
-
S
--
G
-
I
N
--
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
-----
Y
-----
E
G
----
R
----
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
---
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
--
A
P
K
------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
---
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.63
99%
-124
- C4 -
-
2F4J
1
ABL1_HUMAN
A:
[1-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
64.25
99%
-123
- C4 -
-
1OPJ
2
ABL1_MOUSE
B:
[7-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
63.98
99%
-124
- C4 -
-
3IK3
1
ABL1_MOUSE
B:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
63.94
99%
-128
- C4 -
-
6HD4
3
ABL1_MOUSE
A:
[7-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
63.69
99%
-132
- C4 -
-
2G1T
1
ABL1_HUMAN
D:
[3-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
63.61
99%
-128
- C4 -
-
6HD6
2
ABL1_MOUSE
A:
[7-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
-----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.54
99%
-127
- C4 -
-
3K5V
2
ABL1_MOUSE
A:
[7-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
63.51
99%
-128
- C4 -
-
3KF4
1
ABL1_MOUSE
A:
[2-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
-----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
63.50
99%
-119
- C4 -
-
1OPJ
2
ABL1_MOUSE
A:
[7-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.41
99%
-120
- C4 -
-
3KFA
1
ABL1_MOUSE
A:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
63.32
99%
-133
- C4 -
-
2GQG
2
ABL1_HUMAN
A:
[7-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
63.28
99%
-122
- C4 -
-
3OY3
1
ABL1_MOUSE
B:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
63.26
99%
-118
- C4 -
-
3KFA
1
ABL1_MOUSE
B:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
63.20
99%
-135
- C4 -
-
2G1T
1
ABL1_HUMAN
C:
[7-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
63.05
99%
-129
- C4 -
-
2Z60
1
ABL1_MOUSE
A:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
---------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
63.02
99%
-121
- C4 -
-
3OY3
1
ABL1_MOUSE
A:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
62.91
99%
-127
- C4 -
-
2G2H
1
ABL1_HUMAN
A:
[8-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
62.91
99%
-135
- C4 -
-
2G1T
1
ABL1_HUMAN
B:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
62.89
99%
-127
- C4 -
-
2QOH
1
ABL1_MOUSE
B:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
62.83
99%
-130
- C4 -
-
2G2H
1
ABL1_HUMAN
B:
[8-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
62.66
99%
-135
- C4 -
-
4TWP
1
ABL1_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
62.66
100%
-131
- C4 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.65
99%
-134
- C4 -
-
2G1T
1
ABL1_HUMAN
A:
[7-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
62.55
100%
-132
- C4 -
-
3QRK
1
ABL1_HUMAN
A:
[7-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
62.54
100%
-130
- C4 -
-
2HZI
1
ABL1_HUMAN
A:
[10-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
62.52
99%
-125
- C4 -
-
6HD4
2
ABL1_MOUSE
B:
[7-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
62.51
100%
-135
- C4 -
-
3PYY
1
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
62.50
99%
-133
- C4 -
-
6BL8
1
ABL1_HUMAN
A:
[1-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
F
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
62.47
99%
-129
- C4 -
-
4WA9
1
ABL1_HUMAN
B:
[7-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
62.40
99%
-134
- C4 -
-
2GQG
2
ABL1_HUMAN
B:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
62.40
99%
-129
- C4 -
-
1M52
3
ABL1_MOUSE
B:
[10-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
62.35
99%
-127
- C4 -
-
2V7A
1
ABL1_HUMAN
A:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
62.33
100%
-142
- C4 -
-
2HZI
1
ABL1_HUMAN
B:
[10-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
62.32
100%
-136
- C4 -
-
6NPE
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
-----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
62.30
99%
-125
- C4 -
-
1M52
1
ABL1_MOUSE
A:
[10-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
62.29
99%
-122
- C4 -
-
3K5V
2
ABL1_MOUSE
B:
[7-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
62.29
99%
-136
- C4 -
-
3UE4
1
ABL1_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
62.28
99%
-135
- C4 -
-
2V7A
1
ABL1_HUMAN
B:
[8-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
62.28
99%
-127
- C4 -
-
2G2F
1
ABL1_HUMAN
A:
[7-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
62.19
99%
-135
- C4 -
-
3KF4
1
ABL1_MOUSE
B:
[2-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
---
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
62.18
99%
-125
- C4 -
-
1IEP
1
ABL1_MOUSE
A:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
62.09
98%
-141
- C4 -
-
3DK6
1
ABL1_MOUSE
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
62.02
100%
-138
- C4 -
-
6NPU
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
-----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
61.99
99%
-137
- C4 -
-
3DK3
1
ABL1_MOUSE
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
F
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
61.96
99%
-137
- C4 -
-
3DK7
1
ABL1_MOUSE
A:
[4-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
61.94
99%
-133
- C4 -
-
3DK3
1
ABL1_MOUSE
B:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
F
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
61.93
99%
-122
- C4 -
-
6HD6
1
ABL1_MOUSE
B:
[7-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
61.81
99%
-128
- C4 -
-
3MS9
2
ABL1_MOUSE
B:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
---
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
61.79
99%
-130
- C4 -
-
3IK3
1
ABL1_MOUSE
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.73
99%
-125
- C4 -
-
3UE4
1
ABL1_HUMAN
A:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
61.70
100%
-136
- C4 -
-
6NPV
2
ABL1_HUMAN
A:
[18-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
-----------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
61.60
100%
-129
- C4 -
-
3QRI
1
ABL1_HUMAN
A:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
61.52
100%
-133
- C4 -
-
2HYY
1
ABL1_HUMAN
D:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
-----
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
61.43
99%
-122
- C4 -
-
2HIW
1
ABL1_HUMAN
A:
[2-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
61.40
100%
-131
- C4 -
-
3CS9
1
ABL1_HUMAN
A:
[10-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
61.28
99%
-131
- C4 -
-
4XEY
1
ABL1_HUMAN
A:
[116-388]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
61.17
99%
-137
- C4 -
-
4TWP
1
ABL1_HUMAN
A:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
61.17
100%
-126
- C4 -
-
3CS9
1
ABL1_HUMAN
D:
[10-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
---------------
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
61.17
100%
-140
- C4 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
61.14
99%
-125
- C4 -
-
2G2I
1
ABL1_HUMAN
A:
[4-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
61.12
99%
-140
- C4 -
-
4YC8
3
ABL1_HUMAN
B:
[8-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
61.10
99%
-143
- C4 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
61.08
99%
-126
- C4 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
61.05
99%
-119
- C4 -
-
1IEP
1
ABL1_MOUSE
B:
[7-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
61.04
93%
-127
- C4 -
-
3HMI
1
ABL2_HUMAN
A:
[25-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-----
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.02
99%
-127
- C4 -
-
2QOH
1
ABL1_MOUSE
A:
[2-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
---------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
60.93
93%
-137
- C4 -
-
4XLI
1
B:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
----
G
E
V
Y
V
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-----
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----
E
--
C
S
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
60.93
99%
-134
- C4 -
-
3DK7
1
ABL1_MOUSE
B:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.80
99%
-118
- C4 -
-
1FPU
1
ABL1_MOUSE
A:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
60.71
99%
-128
- C4 -
-
2G2I
1
ABL1_HUMAN
B:
[7-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
----
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
60.67
100%
-126
- C4 -
-
2HYY
1
ABL1_HUMAN
A:
[8-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
-
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
60.65
93%
-139
- C4 -
-
4XLI
1
ABL2_MOUSE
A:
[1-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-----
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----
E
--
C
S
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.64
99%
-144
- C4 -
-
4YC8
3
ABL1_HUMAN
A:
[8-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.58
99%
-120
- C4 -
-
2HZN
1
ABL1_MOUSE
A:
[7-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
---
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
--
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
60.53
100%
-135
- C4 -
-
3QRI
1
ABL1_HUMAN
B:
[10-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
60.45
100%
-127
- C4 -
-
2HYY
1
ABL1_HUMAN
B:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
-
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
60.43
99%
-125
- C4 -
-
5HU9
14
ABL1_HUMAN
A:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-----------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
60.33
100%
-136
- C4 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
---
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
60.32
100%
-121
- C4 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
60.25
93%
-137
- C4 -
-
2XYN
2
ABL2_HUMAN
A:
[26-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
--
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-----
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
60.24
99%
-132
- C4 -
-
3OXZ
1
ABL1_MOUSE
A:
[2-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
------------
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
60.19
99%
-125
- C4 -
-
2G2F
1
ABL1_HUMAN
B:
[9-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
-----
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
P
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
60.17
98%
-141
- C4 -
-
3DK6
1
ABL1_MOUSE
B:
[5-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
-------
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
60.14
99%
-118
- C4 -
-
2HIW
1
ABL1_HUMAN
B:
[2-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
D
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
59.82
93%
-138
- C4 -
-
2XYN
4
ABL2_HUMAN
C:
[27-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
--
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-----
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
59.80
93%
-134
- C4 -
-
2XYN
4
ABL2_HUMAN
B:
[26-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
--
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-----
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
59.74
99%
-133
- C4 -
-
6BL8
1
ABL1_HUMAN
B:
[1-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
---
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
F
T
A
-
H
-
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
59.34
100%
-145
- C4 -
-
6NPU
5
ABL1_HUMAN
B:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
59.09
99%
-131
- C4 -
-
3MSS
2
ABL1_MOUSE
B:
[4-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
59.04
99%
-131
- C4 -
-
3MSS
2
ABL1_MOUSE
C:
[4-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
58.95
100%
-141
- C4 -
-
6NPV
5
ABL1_HUMAN
B:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
58.87
99%
-130
- C4 -
-
3MSS
2
ABL1_MOUSE
D:
[4-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
58.83
99%
-126
- C4 -
-
3MS9
2
ABL1_MOUSE
A:
[5-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
--
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
58.77
100%
-131
- C4 -
-
2HYY
1
ABL1_HUMAN
C:
[6-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
-
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
----
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
58.74
100%
-143
- C4 -
-
6NPE
3
ABL1_HUMAN
B:
[19-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
58.59
99%
-131
- C4 -
-
3MSS
2
ABL1_MOUSE
A:
[4-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
-
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
58.46
100%
-121
- C4 -
-
2E2B
1
ABL1_HUMAN
A:
[7-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
-----
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
58.41
100%
-140
- C4 -
-
3PYY
3
ABL1_HUMAN
B:
[19-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
------------
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
58.13
93%
-127
- C4 -
-
3GVU
2
ABL2_HUMAN
A:
[25-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
-----
P
P
-
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
E
E
V
T
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
---
G
D
-
T
Y
T
-----
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
F
H
D
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
58.09
100%
-145
- C4 -
-
3CS9
1
ABL1_HUMAN
B:
[10-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
---
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
58.09
99%
-119
- C4 -
-
1FPU
1
ABL1_MOUSE
B:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
58.09
100%
-126
- C4 -
-
2E2B
1
ABL1_HUMAN
B:
[7-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
57.74
100%
-144
- C4 -
-
3CS9
1
ABL1_HUMAN
C:
[9-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-----------
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
56.84
99%
-131
- C4 -
-
4WA9
1
ABL1_HUMAN
A:
[10-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
-----------------------------
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
-
T
Y
T
A
-
H
A
G
A
K
-
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
56.65
100%
-143
- C4 -
-
2HZ0
1
ABL1_HUMAN
B:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
N
Y
D
K
W
-------------------
E
M
E
R
T
D
I
--------
T
M
K
H
K
L
------
E
V
Y
E
G
V
W
K
-----
K
---
Y
--
S
L
T
V
A
V
K
T
L
-------
M
---
E
V
E
---
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
-----
P
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
----
E
--
C
N
R
Q
E
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
56.45
43%
26
- C4 -
-
1QCF
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
56.32
43%
25
- C4 -
-
5H0E
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
56.27
43%
27
- C4 -
-
5H09
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
56.25
44%
26
- C4 -
-
6F3F
1
SRC_MOUSE
A:
[8-442]
-----------------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
E
G
D
W
W
L
A
H
S
L-
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
--
A
-
E
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D----
F
-----
D
N
AKGL
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
-
S
K
P
Q
T
Q
G
L
A
K
--
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
55.81
44%
29
- C4 -
-
4K11
1
SRC_HUMAN
A:
[3-437]
-----------------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
E
G
D
W
W
L
A
H
S
L-
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
--
A
-
E
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D----
F
-----
D
N
AKGL
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
-
S
K
P
Q
T
Q
G
L
A
K
--
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
55.76
43%
26
- C4 -
-
5H0B
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
55.52
44%
33
- C4 -
-
2H8H
1
SRC_HUMAN
A:
[87-522]
----------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
E
G
D
W
W
L
A
H
S
L-
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
--
A
-
E
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D----
F
-----
D
N
AKGL
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
-
S
K
P
Q
T
Q
G
L
A
K
--
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
55.14
44%
29
- C4 -
-
2SRC
1
SRC_HUMAN
A:
[5-439]
-----------------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
E
G
D
W
W
L
A
H
S
L-
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
--
A
-
E
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D----
F
-----
D
N
AKGL
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
-
S
K
P
Q
T
Q
G
L
A
K
--
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
55.03
43%
29
- C4 -
-
5H0G
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
54.99
43%
26
- C4 -
-
5H0H
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
54.95
43%
15
- C4 -
-
3VRY
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
HHSearch
54.90
43%
33
- C4 -
-
2H8H
1
SRC_HUMAN
A:
[87-524]
----------------------------------------------------------------
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
-
E
G
D
W
W
L
A
H
S
LS
T
G
Q
T
-
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
AE
N
-
P
R
--
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
-----
D
FDNAK
G
L
----
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
S
K
P
Q
T
-
Q
--
G
L
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
---
T
---
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
------
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
54.72
44%
26
- C4 -
-
1Y57
1
SRC_HUMAN
A:
[5-439]
-----------------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
E
G
D
W
W
L
A
H
S
L-
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
--
A
-
E
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D----
F
-----
D
N
AKGL
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
-
S
K
P
Q
T
Q
G
L
A
K
--
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
HHSearch
54.56
44%
36
- C4 -
-
5H0B
1
HCK_HUMAN
A:
[8-445]
--------------------------------------------------------------
R
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
S
-
G
-
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
-
R
Q
L
-
L
-
A
PG
N
-
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
DYDPR
Q
-----
G
D
----
T
----
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
--
C
M
S
S
K
P
Q
K
----
P
W
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
------
H
T
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-----
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
HHSearch
54.49
44%
27
- C4 -
-
1Y57
1
SRC_HUMAN
A:
[3-441]
---------------------------------------------------------------
T
T
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
N
T
-
E
G
D
W
W
L
A
H
S
LS
T
G
Q
T
-
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
AE
N
-
P
R
--
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
-----
D
FDNAK
G
L
----
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
S
K
P
Q
T
Q
---
G
L
A
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
---
T
---
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-----
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
54.20
44%
31
- C4 -
-
1KSW
1
SRC_HUMAN
A:
[5-439]
-----------------------------------------------------------------
F
V
A
L
Y
D
Y
E
S
R
T
E
T
D
L
S
F
K
K
G
E
R
L
Q
I
V
N
-
N
T
E
G
D
W
W
L
A
H
S
L-
S
T
G
Q
T
G
Y
I
P
S
N
Y
V
A
P
S
D
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
-
R
E
S
E
-
R
L
L
-
L
-
N
--
A
-
E
N
PR
G
T
F
L
V
R
E
S
E
T
T
K
G
A
Y
C
L
S
V
S
D----
F
-----
D
N
AKGL
N
----
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
--
C
P
T
-
S
K
P
Q
T
Q
G
L
A
K
--
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
54.18
43%
19
- C4 -
-
2C0O
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
556
HHSearch
53.93
38%
-47
- C4 -
-
6JMF
1
A:
[7-372]
---------------------------------------------------------------------------------------------------------------------------
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
-
A
E
V
A
-
E
L
L
-
V
------
H
S
--
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
-----
W
-----
D
G
----
L
----
P
R
H
F
I
I
Q
S
-
L
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
--
L
H
---------
R
A
V
P
K
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
E
T
L
PP-
D
---
L
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
----
T
--
E
-
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
Y
A
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
53.92
43%
19
- C4 -
-
3VS6
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
53.82
43%
21
- C4 -
-
3VS4
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
53.79
43%
16
- C4 -
-
3VS3
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
53.63
43%
19
- C4 -
-
3VS0
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
53.37
43%
19
- C4 -
-
3VS2
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
53.32
43%
23
- C4 -
-
2C0O
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
53.23
43%
19
- C4 -
-
2C0I
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
53.07
43%
16
- C4 -
-
3VS2
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
---
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
53.03
43%
20
- C4 -
-
3VS3
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
52.98
49%
-134
- C4 -
-
3U4W
4
SRC_CHICK
A:
[2-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
52.94
38%
-52
- C4 -
-
3CBL
3
A:
[9-374]
---------------------------------------------------------------------------------------------------------------------------
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
-
A
E
V
A
-
E
L
L
-
V
------
H
S
--
G
D
F
L
V
R
E
S
Q
---
Q
E
Y
V
L
S
V
-----------------------
P
R
H
F
I
I
-----
N
L
Y
R
L
-----
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
-----
V
V
--
L
H
---------
R
A
V
P
K
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
E
T
L
PP-
D
---
L
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
----
T
--
E
-
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
Y
A
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
52.87
43%
18
- C4 -
-
3VRZ
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
52.84
43%
22
- C4 -
-
2C0T
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
52.76
43%
20
- C4 -
-
3VS5
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
52.75
44%
-140
- C4 -
-
4HCV
1
A:
[5-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
52.73
43%
20
- C4 -
-
2C0I
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
52.72
43%
19
- C4 -
-
3VS6
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
52.68
43%
19
- C4 -
-
3VS1
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
52.61
43%
19
- C4 -
-
3VRZ
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
52.53
48%
-132
- C4 -
-
2OF2
1
LCK_HUMAN
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
52.46
43%
22
- C4 -
-
1AD5
1
HCK_HUMAN
B:
[4-427]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
52.45
68%
-126
- C4 -
-
4UEU
1
?
A:
[3-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
K
W
-------------------
E
I
P
R
S
E
I
--------
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
-----
N
---
Y
--
N
I
E
V
A
V
K
T
L
K
E
G
T
---
M
---
S
V
E
---
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-----
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
----
D
--
C
E
G
H
T
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
------------
A
K
-
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
HHSearch
52.39
38%
-43
- C4 -
-
3BKB
9
A:
[9-374]
---------------------------------------------------------------------------------------------------------------------------
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
-
A
E
V
A
-
E
L
L
-
V
------
H
S
--
G
D
F
L
V
R
E
S
Q
G
-
K
Q
E
Y
V
L
S
V
L
-----
W
-----
D
G
----
L
----
P
R
H
F
I
I
Q
S
-
L
D
N
L
Y
R
L
-
E
G
E
G
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
T
K
K
S
G
V
V
--
L
H
---------
R
A
V
P
K
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
E
T
L
PP-
D
---
L
K
A
---
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
----
T
--
E
-
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
Y
A
A
S
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
52.38
43%
17
- C4 -
-
2HCK
1
HCK_HUMAN
B:
[4-427]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
52.34
44%
24
- C4 -
-
2HCK
1
HCK_HUMAN
B:
[3-429]
---------------------------------------------------------------
I
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
E
E
--
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
-
R
Q
L
-
L
-
A
P-
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
DYDPR
Q
-----
G
D
----
T
----
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
--
C
M
S
S
K
P
Q
----
K
P
W
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
------
H
T
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
-
K
-----
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
G
A
------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
52.33
43%
18
- C4 -
-
3VRY
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
---------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
52.31
43%
19
- C4 -
-
2HCK
1
HCK_HUMAN
A:
[4-427]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
52.30
48%
-127
- C4 -
-
5ZJ6
1
HCK_HUMAN
A:
[19-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
52.18
43%
-130
- C4 -
-
3SXS
1
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
L
L
K
E
L
G
S
G
Q
F
G
V
V
K
L
G
K
W
K
-----
G
------
Q
Y
D
V
A
V
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-----
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
----
S
---
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
-
Q
Y
V
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
52.15
43%
20
- C4 -
-
3VS1
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
---------
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
52.14
44%
-139
- C4 -
-
3T9T
3
A:
[3-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
52.12
48%
-132
- C4 -
-
2OF4
1
LCK_HUMAN
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
52.06
43%
22
- C4 -
-
1AD5
1
HCK_HUMAN
A:
[4-427]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
52.06
43%
20
- C4 -
-
4LUE
3
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
52.03
44%
-136
- C4 -
-
4M0Y
2
A:
[5-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
52.00
43%
14
- C4 -
-
4LUD
2
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
---
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
--
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
---------
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
----
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
51.99
44%
-138
- C4 -
-
4M13
1
A:
[4-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
51.98
43%
27
- C4 -
-
3VS7
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
-----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
51.90
43%
21
- C4 -
-
3VS4
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
--------------
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
51.89
48%
-128
- C4 -
-
5ZJ6
1
HCK_HUMAN
B:
[19-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
51.88
43%
22
- C4 -
-
2C0T
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
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S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
51.83
44%
-136
- C4 -
-
4M14
2
A:
[4-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
51.78
44%
-140
- C4 -
-
4HCT
1
A:
[4-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
51.77
44%
-136
- C4 -
-
4M0Z
2
A:
[4-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
51.68
44%
-132
- C4 -
-
4M12
1
A:
[4-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
51.59
44%
-141
- C4 -
-
4HCU
1
A:
[5-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
51.56
43%
-134
- C4 -
-
3SXR
1
B:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
L
L
K
E
L
------
V
V
K
L
G
K
W
K
-----
G
------
Q
Y
D
V
A
V
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-----
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
----
S
---
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
-
Q
Y
V
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
51.53
49%
-144
- C4 -
-
6HVE
1
?
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
51.46
44%
-135
- C4 -
-
4M15
2
A:
[4-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
V
I
D
P
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
51.37
43%
-130
- C4 -
-
3SXR
1
BMX_HUMAN
A:
[4-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
--------
T
L
L
K
E
L
G
S
----
V
V
K
L
G
K
W
K
-----
G
------
Q
Y
D
V
A
V
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
K
E
-----
Y
P
-
I
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
R
----
S
---
H
G
K
G
L
E
P
S
Q
L
L
E
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
-
Q
Y
V
S
-
S
V
G
T
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
S
Q
G
H
R
L
Y
R
P
H
L
A
S
D
T
I
Y
Q
I
M
Y
S
C
W
H
E
L
P
E
K
R
P
T
F
Q
Q
L
L
S
S
I
E
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
51.36
49%
-138
- C4 -
-
5XP7
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
51.34
48%
-123
- C4 -
-
2PL0
1
LCK_HUMAN
A:
[16-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Fugue
51.32
38%
-92
- C4 -
-
3CD3
3
A:
[1-376]
-------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
-
A
E
V
A
-
E
L
L
-
V
-
H
-----
S
--
G
D
F
L
V
R
E
S
Q
----
E
Y
V
L
S
V
P
-----
R
-----
H
F
----
I
----
I
N
L
Y
R
L
---------------
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
--
A
V
P
K
------------
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
P
D
L
---
K
---
A
K
-----
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
----
T
---
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
A
A
S
-
G
G
L
R
Q
-
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
51.30
43%
21
- C4 -
-
3VS7
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
-----
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
------------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
51.21
49%
-139
- C4 -
-
4MXO
1
SRC_HUMAN
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
51.19
49%
-146
- C4 -
-
6DI5
2
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
51.16
68%
-133
- C4 -
-
4CSV
1
?
A:
[5-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
-------------------
E
I
P
R
S
E
I
--------
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
-----
N
---
Y
--
N
I
E
V
A
V
K
T
L
K
E
G
T
---
M
---
S
V
E
---
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-----
P
P
-
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
----
D
--
C
----
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
51.15
43%
17
- C4 -
-
4LUE
4
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
T
----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
-----------------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
---
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
51.07
48%
-138
- C4 -
-
3B2W
1
LCK_HUMAN
A:
[13-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
---
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
50.95
49%
-135
- C4 -
-
4U5J
1
SRC_CHICK
A:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
50.89
43%
20
- C4 -
-
3VS0
1
HCK_HUMAN
A:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
-----
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
50.82
48%
-136
- C4 -
-
5P9M
2
A:
[9-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
50.84
49%
-134
- C4 -
-
3EN4
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
50.82
49%
-136
- C4 -
-
4MXO
1
SRC_HUMAN
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
50.75
43%
23
- C4 -
-
3VS5
1
HCK_HUMAN
B:
[10-453]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
T
K
G
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
R
------
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
50.66
49%
-133
- C4 -
-
3DQX
1
SRC_CHICK
B:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
---------
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
50.65
49%
-140
- C4 -
-
4YBK
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
50.64
49%
-140
- C4 -
-
4MXX
1
SRC_HUMAN
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
50.62
49%
-139
- C4 -
-
5K9I
1
SRC_CHICK
B:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
50.52
49%
-135
- C4 -
-
5XP5
1
SRC_CHICK
A:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
50.52
49%
-139
- C4 -
-
6N9P
1
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
50.46
49%
-142
- C4 -
-
3QLG
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
-----
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
50.40
49%
-137
- C4 -
-
3DQX
1
SRC_CHICK
A:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
50.41
49%
-136
- C4 -
-
6DI0
1
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
50.40
49%
-135
- C4 -
-
3QLG
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
50.38
49%
-133
- C4 -
-
5XP5
1
SRC_CHICK
B:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
50.39
48%
-134
- C4 -
-
2ZVA
1
LYN_MOUSE
A:
[7-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
N
------
S
T
K
V
A
V
K
T
L
K
P
G
T
---
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-----
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
E
-----
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
50.38
48%
-134
- C4 -
-
2ZV8
1
LYN_MOUSE
A:
[7-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
N
------
S
T
K
V
A
V
K
T
L
K
P
G
T
---
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-----
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
---------
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
50.37
49%
-140
- C4 -
-
6J6M
1
?
A:
[5-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
50.34
49%
-141
- C4 -
-
6S90
1
BTK_HUMAN
A:
[3-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
50.33
49%
-141
- C4 -
-
3EN5
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
50.28
49%
-133
- C4 -
-
2BDJ
1
SRC_HUMAN
A:
[4-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
50.29
49%
-135
- C4 -
-
5XP7
2
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
50.28
49%
-137
- C4 -
-
3UQF
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
50.20
48%
-136
- C4 -
-
4MXY
1
SRC_HUMAN
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
50.22
43%
15
- C4 -
-
4LUD
3
HCK_HUMAN
B:
[10-452]
----------------------------------------------------------------
I
V
V
A
L
Y
D
Y
E
A
I
H
H
E
D
L
S
F
Q
K
G
D
Q
M
V
V
L
--
E
E
S
G
E
W
W
K
A
R
S
LA
T
R
K
E
-
G
Y
I
P
S
N
Y
V
A
R
V
D
S
L
E
T
E
E
W
F
F
K
G
I
S
R
-
K
D
A
E
R
Q
L
L
-
A
-
P
--
G
N
M
L
--
G
S
F
M
I
R
D
S
E
T
---
S
Y
S
L
S
V
R
D----
Y
-----
D
P
----
R
QGDT
V
K
H
Y
K
I
-----------------
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
CM
S
S
K
P
Q
K
P
W
------
E
K
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
--------
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
S
K
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
----------------
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
A
T
E
S
Q
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
50.21
49%
-139
- C4 -
-
3TZ8
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
50.20
48%
-136
- C4 -
-
4MXZ
1
SRC_HUMAN
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
50.14
49%
-139
- C4 -
-
5BPY
1
BTK_HUMAN
A:
[4-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
50.17
49%
-138
- C4 -
-
5VFI
9
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
50.17
49%
-137
- C4 -
-
6OMU
1
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
50.16
49%
-141
- C4 -
-
4O2P
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
50.15
49%
-135
- C4 -
-
5U9D
6
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
50.14
49%
-131
- C4 -
-
4U5J
1
SRC_CHICK
B:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
----------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
50.10
48%
-138
- C4 -
-
5XY1
1
LYN_HUMAN
A:
[7-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
N
------
S
T
K
V
A
V
K
T
L
K
P
G
T
---
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-----
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
--------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
50.06
47%
-138
- C4 -
-
4OTR
3
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
50.00
48%
-133
- C4 -
-
5P9I
3
A:
[9-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
50.05
49%
-131
- C4 -
-
3G6G
3
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
50.04
49%
-132
- C4 -
-
6E4F
4
A:
[23-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
50.01
47%
-139
- C4 -
-
4OT6
1
A:
[18-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
50.00
49%
-142
- C4 -
-
3TZ9
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
49.98
47%
-137
- C4 -
-
5BQ0
4
A:
[13-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
-------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
49.89
47%
-140
- C4 -
-
4RFY
3
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
49.94
49%
-138
- C4 -
-
5JRS
2
BTK_HUMAN
A:
[4-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
-------
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
49.87
48%
-136
- C4 -
-
4Y93
1
?
A:
[180-432]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
---
M
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
M
T
R
Y
V
L
D
D
-
E
Y
T
S
-
S
T
G
S
K
-
F
P
V
K
W
A
S
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
P
R
P
H
L
A
S
E
R
V
Y
A
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
49.88
49%
-130
- C4 -
-
4MCV
1
SRC_CHICK
A:
[3-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
49.90
48%
-130
- C4 -
-
4Z3V
5
A:
[13-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
49.89
49%
-137
- C4 -
-
6S90
1
B:
[3-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
49.88
48%
-134
- C4 -
-
2ZV9
1
LYN_MOUSE
A:
[7-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
I
--------
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
N
------
S
T
K
V
A
V
K
T
L
K
P
G
T
---
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
K
E
-----
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
I
----------
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
S
A
L
S
Q
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
49.87
48%
-130
- C4 -
-
5P9K
1
A:
[9-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
--
G
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
49.86
49%
-137
- C4 -
-
5J5S
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
49.79
48%
-137
- C4 -
-
6AUA
2
A:
[2-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
A
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
49.83
47%
-140
- C4 -
-
6EP9
1
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
49.77
49%
-141
- C4 -
-
3F3W
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
49.80
44%
-130
- C4 -
-
3MJ2
1
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
D
D
-
Q
Y
T
S
-
S
T
G
T
K
-
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
49.79
49%
-137
- C4 -
-
5KUP
4
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
49.76
49%
-137
- C4 -
-
5VGO
5
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
49.78
48%
-139
- C4 -
-
5P9J
1
A:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
----
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
49.77
49%
-139
- C4 -
-
3F6X
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-----------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
49.76
49%
-132
- C4 -
-
4O2P
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-----
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
D
-------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
49.69
49%
-147
- C4 -
-
5D12
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-----------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
---------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
49.73
49%
-139
- C4 -
-
3F3T
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
49.72
49%
-134
- C4 -
-
3F6X
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
49.65
47%
-136
- C4 -
-
6HRT
1
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
49.71
47%
-139
- C4 -
-
4OTQ
3
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
49.69
49%
-133
- C4 -
-
4MCV
1
SRC_CHICK
B:
[3-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
49.68
49%
-132
- C4 -
-
3G6H
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
49.61
47%
-136
- C4 -
-
4RFZ
3
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
49.62
48%
-141
- C4 -
-
5P9H
1
A:
[15-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
49.67
49%
-136
- C4 -
-
3PIX
1
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
49.65
49%
-131
- C4 -
-
3EL8
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
49.60
47%
-138
- C4 -
-
4OT5
3
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
49.59
47%
-138
- C4 -
-
4RG0
1
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
49.65
49%
-137
- C4 -
-
6AUB
1
A:
[1-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
49.64
49%
-139
- C4 -
-
4RX5
4
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
49.63
49%
-144
- C4 -
-
3G5D
2
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
------
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
49.62
49%
-158
- C4 -
-
2QLQ
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
49.61
49%
-137
- C4 -
-
3EN4
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-----
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
49.60
47%
-136
- C4 -
-
6HRP
1
A:
[20-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
A
-
R
H
A
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
A
A
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
49.59
47%
-140
- C4 -
-
3GEN
1
A:
[16-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
---
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
49.54
49%
-136
- C4 -
-
3F3W
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
49.54
49%
-147
- C4 -
-
5D11
2
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
49.58
49%
-135
- C4 -
-
6DI1
1
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
49.57
49%
-134
- C4 -
-
4ZLY
5
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
49.54
49%
-145
- C4 -
-
3G5D
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-----------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
49.56
48%
-137
- C4 -
-
3BYU
1
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
49.54
49%
-131
- C4 -
-
3UQG
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
49.53
49%
-133
- C4 -
-
4DGG
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
49.51
49%
-137
- C4 -
-
5K9I
1
SRC_CHICK
A:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
49.50
48%
-136
- C4 -
-
5P9F
5
A:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
49.49
49%
-137
- C4 -
-
3TZ8
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
49.46
49%
-137
- C4 -
-
3OCS
2
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
49.47
48%
-137
- C4 -
-
5P9G
1
A:
[14-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
49.46
49%
-138
- C4 -
-
4YBJ
1
SRC_CHICK
A:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
49.43
49%
-130
- C4 -
-
2BDF
1
SRC_HUMAN
B:
[4-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-----------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
49.45
49%
-135
- C4 -
-
5J87
1
BTK_HUMAN
B:
[8-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
49.39
49%
-135
- C4 -
-
6BKE
1
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
49.38
49%
-136
- C4 -
-
6BLN
2
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
49.43
49%
-139
- C4 -
-
5J5S
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
49.37
48%
-138
- C4 -
-
6NZM
1
BTK_HUMAN
A:
[16-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
49.41
49%
-133
- C4 -
-
3D7T
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
49.40
49%
-133
- C4 -
-
6NFH
7
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
49.39
49%
-137
- C4 -
-
6BKW
4
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
49.38
49%
-140
- C4 -
-
3TZ7
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
49.37
49%
-135
- C4 -
-
3G6G
2
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
49.36
49%
-135
- C4 -
-
4AGW
3
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
49.33
49%
-136
- C4 -
-
3F3V
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
49.33
48%
-128
- C4 -
-
3MPM
2
LCK_HUMAN
A:
[4-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
49.31
49%
-150
- C4 -
-
5FBO
2
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
----------------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
49.25
49%
-137
- C4 -
-
3QLF
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-----
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
------------------
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
49.19
49%
-134
- C4 -
-
3F3U
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
49.17
49%
-135
- C4 -
-
3OEZ
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
49.12
49%
-142
- C4 -
-
3SVV
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
49.14
49%
-133
- C4 -
-
4ZLZ
5
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
49.15
48%
-129
- C4 -
-
4C3F
1
LCK_HUMAN
A:
[4-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
N
-
E
Y
T
A
-
R
-----
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
49.10
48%
-137
- C4 -
-
6NZM
2
D:
[16-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
--
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
49.12
49%
-137
- C4 -
-
3TZ9
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
49.14
48%
-139
- C4 -
-
2OG8
1
LCK_HUMAN
A:
[2-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
49.13
49%
-134
- C4 -
-
4AGW
3
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
49.12
49%
-143
- C4 -
-
6DI3
1
A:
[5-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
-----------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
49.11
44%
-148
- C4 -
-
1SM2
1
B:
[5-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
49.10
49%
-129
- C4 -
-
3GEQ
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
49.06
49%
-136
- C4 -
-
4MXX
1
SRC_HUMAN
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
T
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
49.06
49%
-134
- C4 -
-
1YOL
1
SRC_HUMAN
B:
[9-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
49.07
49%
-143
- C4 -
-
4YBJ
1
SRC_CHICK
B:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
-----
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
49.06
39%
-16
- C4 -
-
6JMF
1
A:
[8-370]
----------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
-
L
L
V
-
H
-
S
--
G
------
D
F
L
V
R
E
S
Q
G
K
Q
-
E
Y
V
L
S
V
L
-----
W
-----
D
G
----
L
----
P
R
H
F
I
I
Q
S
L
D
N
--
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
P
--
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
E
-
T
---
L
---
P
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T---
E
--
G
A
R
L
R
V
K
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
49.08
49%
-143
- C4 -
-
5D11
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
---------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
49.07
49%
-142
- C4 -
-
5FBN
3
BTK_HUMAN
C:
[7-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
----------
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
49.03
49%
-137
- C4 -
-
5SWH
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
49.06
49%
-142
- C4 -
-
3UQF
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
-------------
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
49.05
49%
-155
- C4 -
-
3PJ2
1
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
---------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
49.03
49%
-129
- C4 -
-
3F6X
1
SRC_CHICK
D:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
49.02
49%
-136
- C4 -
-
3TZ7
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
48.97
48%
-136
- C4 -
-
4MXY
1
SRC_HUMAN
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
48.97
48%
-136
- C4 -
-
4MXZ
1
SRC_HUMAN
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
L
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
49.01
49%
-131
- C4 -
-
2BDF
1
SRC_HUMAN
A:
[4-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
48.95
49%
-155
- C4 -
-
2HWP
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
--
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
-------------------
F
L
Q
-
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
48.97
49%
-131
- C4 -
-
3OEZ
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
48.96
49%
-134
- C4 -
-
3SVV
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
48.95
49%
-135
- C4 -
-
3F3V
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
48.89
49%
-135
- C4 -
-
5T18
1
A:
[4-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
-------
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
48.94
48%
-127
- C4 -
-
4YHF
3
BTK_HUMAN
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
48.88
49%
-133
- C4 -
-
6BIK
2
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
48.93
49%
-133
- C4 -
-
6BKH
1
A:
[5-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
-
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
48.89
49%
-138
- C4 -
-
5TEH
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
48.84
49%
-147
- C4 -
-
6HVF
3
?
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
-------------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
48.85
49%
-156
- C4 -
-
3PJ1
2
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
-----------
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
---
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
48.81
49%
-136
- C4 -
-
5SWH
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
48.81
49%
-131
- C4 -
-
5T0P
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
48.84
49%
-152
- C4 -
-
2HWO
2
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
----------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-------
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
48.81
49%
-141
- C4 -
-
6O8I
1
A:
[2-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
-----------------
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
48.80
49%
-136
- C4 -
-
4DGG
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
---------------
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
----------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
48.78
48%
-122
- C4 -
-
4YHF
2
B:
[9-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
G
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
48.74
48%
-136
- C4 -
-
1YOM
1
SRC_HUMAN
B:
[8-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
48.73
49%
-129
- C4 -
-
3GEQ
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
48.68
49%
-132
- C4 -
-
5SYS
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
48.70
44%
-153
- C4 -
-
3V5J
1
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
48.68
49%
-131
- C4 -
-
1YOL
1
SRC_HUMAN
A:
[8-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
48.64
44%
-145
- C4 -
-
1SNU
1
B:
[5-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
48.63
49%
-147
- C4 -
-
6HVE
1
?
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
--------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
48.56
49%
-135
- C4 -
-
5J87
1
BTK_HUMAN
A:
[12-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
48.56
49%
-148
- C4 -
-
2QQ7
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
--------------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
48.60
48%
-136
- C4 -
-
3BYS
1
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
48.58
48%
-146
- C4 -
-
5P9L
1
A:
[12-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
----
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
48.49
44%
-149
- C4 -
-
3V8W
1
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
48.56
49%
-134
- C4 -
-
5TEH
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
48.55
49%
-153
- C4 -
-
5D10
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
48.49
49%
-137
- C4 -
-
3UQG
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
----------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
48.48
49%
-141
- C4 -
-
5FBN
5
D:
[6-256]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
-------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
48.47
49%
-134
- C4 -
-
5T0P
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
C
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
48.46
39%
-15
- C4 -
-
3BKB
9
A:
[10-372]
----------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
-
L
L
V
-
H
-
S
--
G
------
D
F
L
V
R
E
S
Q
G
K
Q
-
E
Y
V
L
S
V
L
-----
W
-----
D
G
----
L
----
P
R
H
F
I
I
Q
S
L
D
N
--
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
P
--
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
E
-
T
---
L
---
P
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T---
E
--
G
A
R
L
R
V
K
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
48.45
48%
-130
- C4 -
-
2OG8
1
?
B:
[1-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
48.43
49%
-131
- C4 -
-
3F6X
1
SRC_CHICK
C:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
----------
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
------------
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
48.42
49%
-144
- C4 -
-
2QLQ
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
48.41
49%
-135
- C4 -
-
3U51
1
SRC_CHICK
A:
[3-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
48.40
49%
-147
- C4 -
-
3EN7
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-------------
T
R
V
A
I
K
T
L
K
P
----------------
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
48.38
49%
-151
- C4 -
-
3PIZ
1
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
-----------
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
-------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
48.32
49%
-134
- C4 -
-
3U51
1
SRC_CHICK
B:
[3-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
48.35
49%
-152
- C4 -
-
3LOK
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
---
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
---------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
48.32
49%
-145
- C4 -
-
4FIC
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-----------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
48.25
49%
-128
- C4 -
-
5J87
1
BTK_HUMAN
C:
[12-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
48.28
48%
-127
- C4 -
-
1YOM
1
SRC_HUMAN
A:
[8-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
48.25
49%
-150
- C4 -
-
5BPY
1
B:
[4-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
-
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
48.22
49%
-149
- C4 -
-
6DI9
2
A:
[4-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
------
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
48.20
48%
-123
- C4 -
-
3A4O
1
LYN_HUMAN
X:
[6-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
I
--------
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
N
------
S
T
K
V
A
V
K
T
L
K
P
G
T
---
M
---
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
-----
E
P
-
I
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
----
S
--
D
E
G
G
K
V
L
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
-----------
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
K
I
P
Y
P
G
R
T
N
A
D
V
M
T
A
L
S
Q
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
48.17
49%
-140
- C4 -
-
4FIC
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
48.14
49%
-144
- C4 -
-
3QLF
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
------------------
L
Q
E
A
Q
V
M
K
K
I
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
48.13
49%
-150
- C4 -
-
3OCT
1
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
--
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
------
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
48.08
44%
-145
- C4 -
-
3V5L
1
ITK_HUMAN
C:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
47.99
49%
-132
- C4 -
-
5J87
1
D:
[12-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
47.98
49%
-132
- C4 -
-
3PIY
1
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
------------
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
-
E
Y
T
S
-
S
V
G
S
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
48.03
49%
-149
- C4 -
-
3LOK
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
------------------------
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
47.99
49%
-132
- C4 -
-
5SYS
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
47.98
49%
-151
- C4 -
-
2QQ7
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
47.95
44%
-142
- C4 -
-
3QGW
1
B:
[27-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
K
E
G
S
---
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
47.90
44%
-140
- C4 -
-
1SM2
1
ITK_HUMAN
A:
[5-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
47.83
44%
-137
- C4 -
-
4L7S
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
47.80
44%
-139
- C4 -
-
3QGW
1
ITK_HUMAN
A:
[27-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
K
E
G
S
---
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
47.78
49%
-146
- C4 -
-
5JRS
1
B:
[4-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
--
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
----------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
-------
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
-------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
47.77
49%
-132
- C4 -
-
3F3U
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
--------
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
47.69
44%
-147
- C4 -
-
3V8W
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
-
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
47.76
44%
-140
- C4 -
-
4RFM
1
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
-----------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
47.69
48%
-143
- C4 -
-
6MNY
1
?
A:
[12-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
R
E
G
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
A
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
R
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
47.67
49%
-133
- C4 -
-
3EL7
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
---------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
47.57
49%
-151
- C4 -
-
3PJ3
1
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
---
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
-------------
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
----------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
47.56
44%
-138
- C4 -
-
4L7S
1
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
47.54
49%
-144
- C4 -
-
4LGH
1
SRC_CHICK
A:
[2-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
-------
T
R
V
A
I
K
T
L
---------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
47.52
49%
-138
- C4 -
-
6HVF
2
?
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
-------------------
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
47.51
49%
-154
- C4 -
-
3EN6
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
----------------------
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
----------
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
47.49
49%
-141
- C4 -
-
4LGG
1
SRC_CHICK
A:
[1-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
----------------
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
--------
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
47.47
49%
-137
- C4 -
-
4LGG
1
B:
[1-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
S
L
--------
R
L
E
V
K
L
G
----
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
---------
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
47.45
44%
-140
- C4 -
-
3V5L
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
47.42
44%
-140
- C4 -
-
4KIO
3
ITK_HUMAN
C:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
HHSearch
47.30
39%
0
- C4 -
-
4FL3
1
KSYK_HUMAN
A:
[162-631]
---------------------------------------------------------------------------------------------------------------------------
A
H
E
K
M
P
W
F
H
G
K
I
S
R
-
E
E
S
E
-
Q
I
V
L
I
G
S
--
K
-
T
N
--
G
K
F
L
I
R
A
R
D
N
-
N
G
S
Y
A
L
C
L
L
-----
H
-----
E
G
----
K
----
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
--
C
Q
K
----------------REALPMDTEVFESPFADPE
E
I
R
P
K
E
V
YLDRKLLT
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
-----
M
---
K
KV
V
K
T
V
A
V
K
I
L
K
N
E
A
---
N
DPA
L
K
D
---
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
E
-
A
-----
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
----
Q
--
N
--
R
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
--------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
47.37
44%
-140
- C4 -
-
4PP9
1
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
47.33
44%
-136
- C4 -
-
3QGY
1
ITK_HUMAN
A:
[27-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
K
E
G
S
---
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
47.32
49%
-150
- C4 -
-
2HWP
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
-----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
47.28
39%
-27
- C4 -
-
3CBL
3
A:
[10-372]
----------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
-
L
L
V
-
H
-
S
--
G
------
D
F
L
V
R
E
S
Q
--
Q
-
E
Y
V
L
S
V
-----------------------
P
R
H
F
I
I
----
N
--
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
P
--
L
-----
V
V
L
H
R
A
V
P
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
E
-
T
---
L
---
P
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T---
E
--
G
A
R
L
R
V
K
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
-
V
Y
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
47.30
44%
-138
- C4 -
-
4PP9
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
47.22
44%
-148
- C4 -
-
4KIO
2
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
------------
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
47.29
49%
-139
- C4 -
-
5D10
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
----
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
47.28
48%
-133
- C4 -
-
2OFV
1
LCK_HUMAN
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
----------------
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------------
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
47.27
44%
-135
- C4 -
-
1SNU
1
ITK_HUMAN
A:
[5-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
47.19
44%
-141
- C4 -
-
3V8T
1
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
---
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
47.26
44%
-144
- C4 -
-
3V5L
1
D:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
--
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
-------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
47.25
44%
-149
- C4 -
-
3MIY
1
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
47.22
49%
-141
- C4 -
-
2HWO
2
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
47.12
44%
-146
- C4 -
-
3MIY
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
47.18
47%
-146
- C4 -
-
3K54
1
A:
[16-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
----------------
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
--------------------
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
47.17
44%
-139
- C4 -
-
4MF1
1
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
---
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
-----------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
47.14
49%
-131
- C4 -
-
6ATE
1
SRC_HUMAN
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
------------
P
E
---
A
F
--
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
T
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
47.12
49%
-137
- C4 -
-
5D12
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-------------
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
47.05
49%
-132
- C4 -
-
4LGH
1
SRC_CHICK
B:
[3-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
-------------------
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
47.04
44%
-149
- C4 -
-
4KIO
2
ITK_HUMAN
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
46.96
44%
-139
- C4 -
-
4MF1
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
---
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
46.78
49%
-144
- C4 -
-
3EN5
1
SRC_CHICK
A:
[13-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
-----------------------
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
------------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
46.74
49%
-152
- C4 -
-
6NFI
1
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
S
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
G
T
----
V
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
---
S
---
M
---
S
E
D
---
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
--------
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
------------------
K
-
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
K
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
46.73
44%
-142
- C4 -
-
3V5L
1
ITK_HUMAN
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
----
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
46.60
44%
-135
- C4 -
-
4PQN
2
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
--------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
46.54
44%
-143
- C4 -
-
3V5J
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
--------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
-
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
46.47
44%
-131
- C4 -
-
3QGY
1
B:
[27-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
K
E
G
S
---
M
---
S
E
D
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
46.32
44%
-143
- C4 -
-
4KIO
3
D:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
46.20
49%
-159
- C4 -
-
5XYZ
1
BTK_HUMAN
A:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
-------
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
------
M
---
S
E
D
------
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
------
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
---
F
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
46.07
44%
-153
- C4 -
-
4PPA
2
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
46.05
49%
-151
- C4 -
-
5XYZ
1
B:
[4-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
I
D
P
K
D
L
--------
T
F
L
K
E
L
-------
V
K
Y
G
K
W
R
-----
G
------
Q
Y
D
V
A
I
K
M
I
K
------
M
---
S
E
D
---
E
-
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
-----
R
P
-
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
----
E
--
M
-
R
H
R
F
Q
T
Q
Q
L
L
E
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
V
V
K
V
S
D
F
G
L
S
R
-----------------
F
P
V
R
W
S
P
P
E
V
L
M
----
S
S
K
S
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
R
L
Y
R
P
H
L
A
S
E
K
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
45.90
44%
-141
- C4 -
-
3V8T
1
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
R
E
G
A
---
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
--------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
------
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
45.55
44%
-150
- C4 -
-
4MF0
2
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
45.54
44%
-151
- C4 -
-
4PPA
2
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
45.38
39%
-7
- C4 -
-
4E93
1
A:
[10-372]
----------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
-
L
L
V
-
H
-
S
--
G
------
D
F
L
V
R
E
S
Q
--
Q
-
E
Y
V
L
S
V
L
-----
W
-----
D
G
----
L
----
P
R
H
F
I
I
Q
S
L
D
N
--
L
Y
R
L
E
G
E
G
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
P
--
L
T
K
K
S
G
V
V
L
H
R
A
V
P
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
E
-
T
---
L
---
P
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T---
E
--
G
A
R
L
R
V
K
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
----------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
45.25
48%
-127
- C4 -
-
2OFV
1
?
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
--------------
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
D
--------------
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
-------
I
Q
N
L
E
-
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
45.19
44%
-145
* C4 *
-
3MJ1
1
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
--------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
45.14
44%
-151
- C4 -
-
4MF0
2
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
---
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------
M
---
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
45.13
44%
-148
- C4 -
-
4QD6
2
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
------------
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
44.63
44%
-145
- C4 -
-
4PPB
2
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
44.59
44%
-153
- C4 -
-
4PPC
2
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
44.44
44%
-148
- C4 -
-
4PPB
2
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------------
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
---------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
44.29
44%
-142
- C4 -
-
4QD6
2
ITK_HUMAN
A:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-----------
S
E
E
---
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
-----
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-------------------
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
44.02
49%
-91
- C4 -
-
3DQW
1
SRC_CHICK
D:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
43.89
49%
-91
- C4 -
-
3DQW
1
SRC_CHICK
C:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
43.77
49%
-94
- C4 -
-
3DQW
1
SRC_CHICK
A:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
43.57
49%
-93
- C4 -
-
3DQW
1
SRC_CHICK
B:
[11-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
-----
G
------
T
T
R
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
K
----
G
--
E
M
G
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
43.49
48%
-97
- C4 -
-
1QPJ
1
LCK_HUMAN
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
43.16
48%
-92
- C4 -
-
3AC5
2
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
42.97
48%
-89
- C4 -
-
3KMM
1
LCK_HUMAN
A:
[15-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
42.91
44%
-149
- C4 -
-
4PPC
2
B:
[7-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
--------
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
W
L
-----
N
---
K
--
D
-
K
V
A
I
K
T
I
-------------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-------
A
P
-
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
----
T
---
Q
R
G
L
F
A
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
----------------------
F
P
V
K
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
42.89
48%
-88
- C4 -
-
2ZM4
2
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
42.84
48%
-92
- C4 -
-
3AD4
3
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
42.81
48%
-90
- C4 -
-
2ZYB
1
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
42.56
48%
-92
- C4 -
-
1QPD
1
?
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
A
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
A
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
42.55
48%
-92
- C4 -
-
2OFU
1
LCK_HUMAN
A:
[8-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
42.54
48%
-90
- C4 -
-
3BYO
1
?
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
42.50
48%
-92
- C4 -
-
3ACJ
2
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
42.37
48%
-90
- C4 -
-
3AC8
1
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
42.36
48%
-90
- C4 -
-
3AC1
3
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
42.33
48%
-90
- C4 -
-
1QPE
1
LCK_HUMAN
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
42.28
48%
-86
- C4 -
-
2ZM1
2
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
42.28
48%
-89
- C4 -
-
3AC3
1
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
42.24
48%
-90
- C4 -
-
3AC2
3
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
42.19
48%
-88
- C4 -
-
3AD6
2
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
42.17
48%
-90
- C4 -
-
1QPC
2
?
A:
[6-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
42.15
48%
-86
- C4 -
-
3ACK
2
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
42.01
48%
-86
- C4 -
-
3AD5
3
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
41.99
48%
-87
- C4 -
-
3BYM
1
LCK_HUMAN
A:
[7-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
41.95
48%
-81
- C4 -
-
2DQ7
1
FYN_HUMAN
X:
[2-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
W
-------------------
E
I
P
R
E
S
L
--------
Q
L
I
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
N
-----
G
------
N
T
K
V
A
I
K
T
L
K
P
G
T
---
M
---
S
P
E
---
S
F
L
E
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
Q
L
Y
A
V
V
S
E
E
-----
P
--
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
----
D
--
G
E
G
R
A
L
K
L
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
Q
G
A
K
-
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
N
R
E
V
L
E
Q
V
E
R
G
Y
R
M
P
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
D
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
41.78
48%
-85
- C4 -
-
3AC4
2
LCK_HUMAN
A:
[12-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
41.77
48%
-90
- C4 -
-
6PDJ
2
?
A:
[15-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
41.46
49%
-36
- C4 -
-
2HK5
1
HCK_HUMAN
A:
[8-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
-------------------
E
I
P
R
E
S
L
--------
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
N
-----
K
---
H
--
T
-
K
V
A
V
K
T
M
K
P
G
S
---
M
---
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
-----
P
--
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
SD--
E
--
G
S
K
Q
P
L
P
K
--
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
-
E
Y
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
41.44
48%
-86
- C4 -
-
3KXZ
1
LCK_HUMAN
A:
[16-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
E
V
P
R
E
T
L
--------
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
Y
Y
N
-----
G
---
H
--
T
-
K
V
A
V
K
S
L
K
Q
G
S
---
M
---
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
-----
P
--
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
----
T
--
P
S
G
I
K
L
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
E
-
D
-
N
E
T
A
-
R
E
G
A
K
-
F
P
I
K
W
T
A
P
E
A
I
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
Y
R
M
V
R
P
D
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
D
F
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
40.76
39%
-23
- C4 -
-
3CD3
3
A:
[10-372]
----------------------------------------------------------------------------------------------------------------------------
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
-
L
L
V
-
H
-
S
--
G
------
D
F
L
V
R
E
S
---
Q
-
E
Y
V
L
S
V
-----------------------
P
R
H
F
I
I
----
N
--
L
Y
R
L
----
F
P
S
I
P
L
L
I
D
H
-------
L
L
S
T
-
Q
Q
P
--
L
---
S
G
V
V
L
H
R
A
V
P
K
-
D
K
W
-------------------
V
L
N
H
E
D
L
--------
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
-----
A
---
D
--
N
T
L
V
A
V
K
S
C
R
-----------
P
D
LKA
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
-----
Q
P
-
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T---
E
--
G
A
R
L
R
V
K
T
--
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
-
G
V
A
A
-
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
40.52
44%
-78
- C4 -
-
4M3Q
1
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
-----
G
S
V
M
E
G
N
L
K
------------
S
L
K
V
A
V
K
T
M
------------------
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
--------
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
39.89
44%
-60
- C4 -
-
1BYG
1
CSK_HUMAN
A:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
A
L
N
M
K
E
L
--------
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
-----
G
---
N
--
K
--
V
A
V
K
C
I
K
N
D
---------
A
Q
---
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
-------G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
----
S
--
R
G
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
L
-------------------
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
39.41
44%
-66
- C4 -
-
3D7T
1
CSK_HUMAN
A:
[7-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------
A
L
N
M
K
E
L
--------
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
-----
G
---
N
--
K
--
V
A
V
K
C
I
K
N
D
A
-------
T
A
Q
---
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
E
E
-----
K
G
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
----
S
--
R
G
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
---------------------
P
V
K
W
T
A
P
E
A
L
R
E
A
A
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Fugue
39.00
46%
-40
- C4 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
-------------------
A
L
N
M
K
E
L
--------
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G------------
N
K
V
A
V
K
C
I
K
------
N
---
D
A
Q
---
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
-
E
-----
E
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
----
S
RG--
R
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
------------------
L
-
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
38.87
44%
-30
- C4 -
-
5K0K
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
L
D
N
SSQ
R
---
E
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
HHSearch
38.80
42%
-2
- C4 -
-
5FM3
1
A:
[57-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
W
-------------------
E
F
P
R
K
N
L
--------
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
HLKGR
A
---
G
--
Y
T
T
V
A
V
K
M
L
K
E
N
A
SP-
S
---
E
L
R
---
D
L
L
S
E
F
N
V
L
K
Q
V
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
-----
G
P
-
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
----
E
--
S
---
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
-
R
S
Q
G
R
-
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
38.75
44%
-43
- C4 -
-
3BPR
1
MERTK_HUMAN
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
L
----------
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
--------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
38.66
44%
-48
- C4 -
-
6MEP
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
------------------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
----------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
38.41
44%
-31
- C4 -
-
5K0X
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
L
D
N
SSQ-----
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
38.23
44%
-32
- C4 -
-
3BRB
2
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
---
N
SSQ
R
---
E
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
37.69
44%
-22
- C4 -
-
3BPR
1
MERTK_HUMAN
C:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
-----------
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S-----
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
37.48
44%
-27
- C4 -
-
3TCP
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
-----
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
L
D
N
SSQ
R
---
E
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
37.23
44%
-54
- C4 -
-
6MEP
1
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
-----------------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
-----------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
--
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
37.21
44%
-18
- C4 -
-
4MHA
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
L
D
N
SSQ
R
---
E
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
------
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
37.10
44%
-10
- C4 -
-
3BRB
2
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
L
D
N
SSQ
R
---
E
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SSQGI
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
36.52
44%
-19
- C4 -
-
3BPR
1
D:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
-----------
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SS------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
36.35
44%
-18
- C4 -
-
3BPR
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
------
R
---
E
I
E
---
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SS------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
35.32
44%
-15
- C4 -
-
5K0X
1
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
--
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
------------------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SSQGI
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
35.25
44%
-14
- C4 -
-
5K0K
1
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
--
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
----------------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SSQGI
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
35.12
44%
-17
- C4 -
-
3TCP
1
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
K
--------------------
E
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SSQGI
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
---------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
35.10
44%
-36
- C4 -
-
5TD2
1
MERTK_HUMAN
A:
[6-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
----------------------
A
A
C
M
K
D
F
S
H
P
N
V
M
R
L
L
G
V
C
I
E
M
SS------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
34.96
44%
-21
- C4 -
-
4MH7
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
-----------------------
A
A
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SSQGI
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
34.47
44%
-19
- C4 -
-
4MHA
1
B:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
M
--------------------------
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SSQGI
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
33.99
44%
-19
- C4 -
-
4M3Q
1
MERTK_HUMAN
A:
[31-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
R
N
L
L
--------
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
-----
Q
EDG
T
--
S
L
K
V
A
V
K
T
-------------------------
C
M
K
D
F
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
SSQGI
P
K
-
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
YSRL
E
--
T
G
P
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
----------------------------------------------------------------------------------------------