@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACV1B_HUMAN: (2020-09-04 )
MAESAGASSFFPLVVLLLAGSGGSGPRGVQALLCACTSCLQANYTCETDGACMVSIFNLDGMEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYTDYCNRIDLRVPSGHLKEPEHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNSGGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI
Atome Classification :
(80 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.....--.--.-230......-----..240--.--..-----....250.......260--........270.....---..280.....---..290...----.---..---.300...--------.....310.......320..-.--....330.......340.......350.......360.......370.--......380.......390.......400.......410.......420........430.......440.......450.......460.......470.......480.......490.......500...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAESAGA
S
S
F
F
P
L
V
V
L
L
L
AGSGGSG
P
R
G
V
Q
A
L
L
C
A
C
T
S
C
L
QANYTCETDG
A
C
M
V
S
I
F
NLDG
M
E
H
H
V
R
T
CIP
K
V
E
L
VPAGK
P
F
Y
CL
S
S
E
DLRNT
H
C
C
Y
T
DYC
N
R
I
D
L
RVPSGHLKEPEHPSMWG
P
V
E
L
V
G
I
I
A
G
P
V
F
L
L
F
L
I
I
I
I
V
F
L
V
I
N
Y
H
Q
R
V
Y
H
N
R
QRLDMEDP
S
C
E
M
CLSKDK
T
L
Q
D
L
V
Y
D
LSTSGSGSG
L
P
L
F
V
Q
R
T
V
A
R
T
I
V
L
Q
E
I
IGKGRF
G
E
V
WRGRWR--G--
G
-
D
-
V
A
V
K
I
FS-----S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
RHE
N
I
---
L
G
F
I
AADNKDNG
T
W
T
Q
---
L
W
L
V
S
D
Y
H
EH---G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
I
E
G
M
--------
I
K
L
A
L
S
AASG
L
A
H
L
H
M
E
I
VG-T--QGKPGIAHRDLKSK
N
I
L
V
KKNG
M
C
A
I
ADL
G
L
A
V
RHDAVT
D
T
I
DIAPNQ--RVGTKRYM
A
P
E
V
L
D
E
TINMKHFDSFK
C
A
D
I
Y
A
L
G
L
V
Y
W
E
I
A
R
RCNSG-GVHEEYQL
P
Y
Y
DLVPSDP
S
I
E
E
M
R
K
V
V
CDQKLRPNI
P
N
W
W
Q
S
Y
E
A
L
R
V
M
G
K
M
M
R
E
C
WYANG
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
V
QEDVKI
22
Blastp_CBE
95.11
86%
-108
- C1 -
-
3KCF
1
TGFR1_HUMAN
D:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
32
Blastp_CBE
94.61
86%
-105
- C1 -
-
2X7O
1
TGFR1_HUMAN
B:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
23
Blastp_CBE
94.39
86%
-110
- C1 -
-
3KCF
1
TGFR1_HUMAN
C:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
30
Blastp_CBE
94.01
86%
-105
- C1 -
-
2X7O
1
TGFR1_HUMAN
D:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
28
Blastp_CBE
93.85
86%
-114
- C1 -
-
3FAA
1
TGFR1_HUMAN
B:
[10-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-------
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
---
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
26
Blastp_CBE
93.82
86%
-109
- C1 -
-
3FAA
1
TGFR1_HUMAN
D:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
21
Blastp_CBE
93.82
86%
-103
- C1 -
-
3KCF
1
TGFR1_HUMAN
E:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
29
Blastp_CBE
93.71
86%
-105
- C1 -
-
2X7O
1
TGFR1_HUMAN
E:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
25
Blastp_CBE
93.51
86%
-110
- C1 -
-
3FAA
1
TGFR1_HUMAN
E:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
27
Blastp_CBE
93.41
86%
-117
- C1 -
-
3FAA
1
TGFR1_HUMAN
C:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
4
PsiBlast_PDB
93.39
86%
-110
- C1 -
-
3KCF
1
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
--
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
5
PsiBlast_PDB
93.24
86%
-104
- C1 -
-
2X7O
1
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
31
Blastp_CBE
93.16
86%
-104
- C1 -
-
2X7O
1
TGFR1_HUMAN
C:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
3
PsiBlast_PDB
92.99
86%
-113
- C1 -
-
3FAA
1
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
--
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
2
PsiBlast_PDB
92.82
86%
-106
- C1 -
-
1IAS
-
TGFR1_HUMAN
A:
[10-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
24
Blastp_CBE
92.70
86%
-108
- C1 -
-
3KCF
1
TGFR1_HUMAN
B:
[10-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
E
G
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
-------
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
---
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
--
50
Blastp_CBE
91.36
87%
-119
- C1 -
-
5E8X
2
TGFR1_HUMAN
A:
[4-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
T
D
F
H
E
H
---
G
N
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
K
M
1
PsiBlast_PDB
91.07
86%
-104
- C1 -
-
1B6C
-
TGFR1_HUMAN
B:
[14-339]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
L
K
D
L
I
Y
D
M
T
T
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
425
HHSearch
90.91
87%
-119
- C1 -
-
5E8X
2
TGFR1_HUMAN
A:
[5-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
T
D
F
H
E
H
---
G
N
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
K
-
47
Blastp_CBE
90.29
90%
-114
- C1 -
-
5USQ
1
TGFR1_HUMAN
A:
[1-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
-----
427
HHSearch
89.05
90%
-113
- C1 -
-
5USQ
1
TGFR1_HUMAN
A:
[3-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
------
426
HHSearch
87.80
90%
-104
- C1 -
-
4X2J
1
TGFR1_HUMAN
A:
[4-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
--
G
--
E
-
E
-
V
A
V
K
I
F
S
-----
S
R
E
E
R
--
S
--
W
F
-----
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
---
L
W
L
V
S
D
Y
H
E
H
---
G
S
L
F
D
Y
L
N
----
R
---
Y
T
---
V
T
-
V
E
G
M
--------
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
-
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
---
91
Blastp_CBE
81.26
65%
-105
- C1 -
-
3MTF
12
ACVR1_HUMAN
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
--
G
--
E
-
N
-
V
A
V
K
I
F
S
-----
S
R
D
E
K
--
S
--
W
F
-----
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
---
L
W
L
I
T
H
Y
H
E
M
---
G
S
L
Y
D
Y
L
Q
----
L
---
T
T
---
L
D
-
T
V
S
C
--------
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
90
Blastp_CBE
80.99
65%
-107
- C1 -
-
3MTF
8
ACVR1_HUMAN
B:
[4-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
--
G
--
E
-
N
-
V
A
V
K
I
F
S
-----
S
R
D
E
K
--
S
--
W
F
-----
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
---
L
W
L
I
T
H
Y
H
E
M
---
G
S
L
Y
D
Y
L
Q
----
L
---
T
T
---
L
D
-
T
V
S
C
--------
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
89
Blastp_CBE
80.77
65%
-106
- C1 -
-
3OOM
16
ACVR1_HUMAN
A:
[5-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
--
G
--
E
-
N
-
V
A
V
K
I
F
S
-----
S
R
D
E
K
--
S
--
W
F
-----
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
---
L
W
L
I
T
H
Y
H
E
M
---
G
S
L
Y
D
Y
L
Q
----
L
---
T
T
---
L
D
-
T
V
S
C
--------
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
429
HHSearch
80.19
65%
-101
- C1 -
-
5OXG
1
ACVR1_HUMAN
C:
[7-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
--
G
--
E
-
N
-
V
A
V
K
I
F
S
-----
S
R
D
E
K
--
S
--
W
F
-----
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
---
L
W
L
I
T
H
Y
H
E
M
---
G
S
L
Y
D
Y
L
Q
----
L
---
T
T
---
L
D
-
T
V
S
C
--------
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
428
HHSearch
80.06
65%
-104
- C1 -
-
3MDY
1
BMR1B_HUMAN
A:
[30-335]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
--
G
--
E
-
K
-
V
A
V
K
V
F
F
-----
T
T
E
E
A
--
S
--
W
F
-----
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
---
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
---
L
Y
L
I
T
D
Y
H
E
N
---
G
S
L
Y
D
Y
L
K
----
S
---
T
T
---
L
D
-
A
K
S
M
--------
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
S
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
---------
P
N
T
--
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
-
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
--
86
Blastp_CBE
79.84
65%
-103
- C1 -
-
3Q4U
6
ACVR1_HUMAN
C:
[6-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
--
G
--
E
-
N
-
V
A
V
K
I
F
S
-----
S
R
D
E
K
--
S
--
W
F
-----
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
---
L
W
L
I
T
H
Y
H
E
M
---
G
S
L
Y
D
Y
L
Q
----
L
---
T
T
---
L
D
-
T
V
S
C
--------
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
430
HHSearch
78.74
65%
-110
- C1 -
-
6SRH
11
ACVR1_HUMAN
A:
[7-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
--
G
--
E
-
N
-
V
A
V
K
I
F
S
-----
S
R
D
E
K
--
S
--
W
F
-----
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
---
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
---
L
W
L
I
T
H
Y
H
E
M
---
G
S
L
Y
D
Y
L
Q
----
L
---
T
T
---
L
D
-
T
V
S
C
--------
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
-
T
--
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
-----------
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
-
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
--------
431
HHSearch
62.04
38%
-12
- C1 -
-
5E8Y
1
TGFR2_HUMAN
A:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
--
Q
QF
E
-
T
-
V
A
V
K
I
F
P
-----
Y
E
E
Y
A
--
S
--
W
K
-----
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
---
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
---
Y
W
L
I
T
A
F
H
A
K
---
G
N
L
Q
E
Y
L
T
----
R
---
H
V
---
I
S
-
W
E
D
L
--------
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
G
--
R
P
K
M
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
S
G
--
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
432
HHSearch
61.73
38%
-10
- C1 -
-
5QIN
2
TGFR2_HUMAN
A:
[9-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
---QF
E
-
T
-
V
A
V
K
I
F
P
-----
Y
E
E
Y
A
--
S
--
W
K
-----
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
---
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
K
Q
---
Y
W
L
I
T
A
F
H
A
K
---
G
N
L
Q
E
Y
L
T
----
R
---
H
V
---
I
S
-
W
E
D
L
--------
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
-
C
G-
R
P
K
M
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
D
P
T
L
S
V
D
D
L
A
N
----
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
L
E
N
V
E
S
F
K
Q
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
-
G
E
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
--------
438
HHSearch
58.64
39%
4
- C1 -
-
4ASX
4
AVR2A_HUMAN
A:
[24-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
--
N
--
E
-
Y
-
V
A
V
K
I
F
P
-----
I
Q
D
K
Q
SW
Q
--
N
E
-----
Y
E
V
Y
S
L
P
--
G
M
K
H
E
N
I
---
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
---
L
W
L
I
T
A
F
H
E
K
---
G
S
L
S
D
F
L
K
----
A
---
N
V
---
V
S
-
W
N
E
L
--------
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
-
L
KD
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
G
-
T
H
G
--
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
437
HHSearch
56.14
39%
7
- C1 -
-
3SOC
7
AVR2A_HUMAN
A:
[24-320]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
--
N
--
E
-
Y
-
V
A
V
K
I
F
P
-----
I
Q
D
K
Q
--
S
WQ
N
E
-----
Y
E
V
Y
S
L
P
--
G
M
K
H
E
N
I
---
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
V
D
---
L
W
L
I
T
A
F
H
E
K
---
G
S
L
S
D
F
L
K
----
A
---
N
V
---
V
S
-
W
N
E
L
--------
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
-
L
KD
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
--
G
D
T
H
G
--
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
-
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
----
326
Blastp_CBE
37.38
32%
-14
- C1 -
-
6MOM
1
?
A:
[35-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
-----
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
311
Blastp_CBE
35.77
32%
-22
- C1 -
-
2OID
1
IRAK4_HUMAN
D:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
-
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
------------------------
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
323
Blastp_CBE
35.68
32%
-12
- C1 -
-
6MOM
2
?
D:
[35-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
AMVDI
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
R
I
S
------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
313
Blastp_CBE
35.39
32%
-25
- C1 -
-
2OID
1
IRAK4_HUMAN
B:
[30-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
-----------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
344
Blastp_CBE
35.28
32%
-6
- C1 -
-
6EGF
1
IRAK4_HUMAN
B:
[34-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
AMVDI
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
----------------
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
315
Blastp_CBE
35.18
32%
-19
- C1 -
-
2OIC
1
IRAK4_HUMAN
D:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
----------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
346
Blastp_CBE
34.78
32%
-37
- C1 -
-
6EGE
1
IRAK4_HUMAN
A:
[34-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
---------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
--------------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
-------------
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
242
Blastp_CBE
34.70
32%
-10
- C1 -
-
2NRY
1
IRAK4_HUMAN
D:
[39-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
---------
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
----
T
V
---
M
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
324
Blastp_CBE
34.48
32%
15
- C1 -
-
6MOM
1
?
C:
[35-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
DI---
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
316
Blastp_CBE
34.33
32%
-18
- C1 -
-
2OIC
1
IRAK4_HUMAN
C:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
--------
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
-------
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
268
Blastp_CBE
34.28
32%
-9
- C1 -
-
6N8G
1
IRAK4_HUMAN
B:
[29-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
-----
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
--
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
283
Blastp_CBE
34.01
32%
-13
- C1 -
-
5KX8
1
IRAK4_HUMAN
C:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
A----
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
318
Blastp_CBE
33.78
32%
-18
- C1 -
-
2OIC
1
IRAK4_HUMAN
A:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
-----------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
301
Blastp_CBE
33.73
32%
-25
- C1 -
-
4YP8
1
IRAK4_HUMAN
B:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
----------------
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
286
Blastp_CBE
33.63
32%
-15
- C1 -
-
5KX7
1
IRAK4_HUMAN
B:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
A----
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
368
Blastp_CBE
33.59
32%
-21
- C1 -
-
4U9A
1
IRAK4_HUMAN
A:
[44-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
A--------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
--------------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
--------
T
--
V
M
T
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
298
Blastp_CBE
33.53
32%
-25
- C1 -
-
4ZTL
1
IRAK4_HUMAN
A:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
-----
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
----
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
267
Blastp_CBE
33.41
32%
12
- C1 -
-
6N8G
1
IRAK4_HUMAN
C:
[29-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
DI---
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
370
Blastp_CBE
33.22
32%
-22
- C1 -
-
4U97
1
IRAK4_HUMAN
A:
[44-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
A--------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
--------------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
--------
T
--
V
M
T
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
243
Blastp_CBE
33.17
32%
-18
- C1 -
-
2NRY
1
IRAK4_HUMAN
C:
[39-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
----------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
---
M
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
314
Blastp_CBE
33.07
32%
-24
- C1 -
-
2OID
1
IRAK4_HUMAN
A:
[32-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
---------------------------
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
---------------
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
317
Blastp_CBE
32.92
32%
-18
- C1 -
-
2OIC
1
IRAK4_HUMAN
B:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
--
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
----------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
---
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
194
Blastp_CBE
32.71
31%
-62
- C1 -
-
3UQF
1
B:
[19-179]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
----------
P
E
--
A
--
F
L
-----
Q
E
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
E
E
P
--------
I
Y
I
V
T
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
GEMG
K
---
Y
----
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
32.59
32%
-34
- C1 -
-
6F3E
1
IRAK4_HUMAN
A:
[29-232]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
----------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
--------------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
------
V
M
----
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
369
Blastp_CBE
32.41
32%
-22
- C1 -
-
4U97
1
IRAK4_HUMAN
B:
[44-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
A--------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
---
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
--------------
V
M
T
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
325
Blastp_CBE
32.37
32%
17
- C1 -
-
6MOM
2
?
B:
[35-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
AI---
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
-
A
Q
V
M
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
367
Blastp_CBE
32.33
32%
-23
- C1 -
-
4U9A
1
IRAK4_HUMAN
B:
[44-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
A--------
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
---
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
--------------
V
M
T
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
232
Blastp_CBE
32.22
31%
-41
- C1 -
-
3DQW
1
SRC_CHICK
A:
[19-161]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
L
K
PG---
T
M
S
P
E
--
A
--
F
L
-----
Q
E
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
E
E
P
--------
I
Y
I
V
I
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
GEMG
K
---
Y
----
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
32.22
31%
-42
- C1 -
-
3DQW
1
D:
[19-161]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
L
K
PG---
T
M
S
P
E
--
A
--
F
L
-----
Q
E
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
E
E
P
--------
I
Y
I
V
I
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
GEMG
K
---
Y
----
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
31.73
31%
-44
- C1 -
-
3DQW
1
SRC_CHICK
C:
[19-161]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
L
K
PG---
T
M
S
P
E
--
A
--
F
L
-----
Q
E
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
E
E
P
--------
I
Y
I
V
I
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
GEMG
K
---
Y
----
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
31.70
32%
-23
- C1 -
-
5W84
1
IRAK4_HUMAN
B:
[37-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
--------------------------
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
---------------
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
--
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
307
Blastp_CBE
31.70
32%
-9
- C1 -
-
4XS2
1
IRAK4_HUMAN
D:
[33-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
--
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
A------
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
--
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
231
Blastp_CBE
31.56
31%
-35
- C1 -
-
3DQW
1
SRC_CHICK
B:
[19-161]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
L
K
PG---
T
M
S
P
E
--
A
--
F
L
-----
Q
E
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
E
E
P
--------
I
Y
I
V
I
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
GEMG
K
---
Y
----
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
31.48
32%
-5
- C1 -
-
5W84
1
IRAK4_HUMAN
A:
[37-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
-I----
T
T
-----
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
--
R
I
-------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
244
Blastp_CBE
31.44
32%
24
- C1 -
-
2NRY
1
IRAK4_HUMAN
B:
[39-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
AI---
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
---
M
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
245
Blastp_CBE
31.28
32%
22
- C1 -
-
2NRY
1
IRAK4_HUMAN
A:
[39-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
--
N
--
T
-
T
-
V
A
V
K
K
L
A
AI---
T
T
E
E
L
--
K
--
Q
Q
-----
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
VEL
L
G
F
-
S
S
D
G
D
D
---------
L
C
L
V
Y
V
Y
M
P
N
---
G
S
L
L
D
R
L
S
--------------
C
-
L
D
G
T
PPLSWHMR
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-----------
E
N
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
----
Q
T
V
---
M
S
R
--
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
P
K
-------
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
-
D
E
H
R
E
P
Q
L
-----------------------------------------------------------------------------
218
Blastp_CBE
31.16
31%
-28
- C1 -
-
1Y57
1
SRC_HUMAN
A:
[185-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
L
K
PG---
T
M
S
P
E
--
A
--
F
L
-----
Q
E
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
E
E
-----
P
---
I
Y
I
V
T
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
----
G
---
E
T
GKY
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
30.94
31%
-79
- C1 -
-
3EN6
1
B:
[19-220]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
L
-------------------------
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
-----------
I
Y
I
V
T
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
GEMG
K
---
Y
----
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
30.29
31%
-31
- C1 -
-
2DQ7
1
X:
[17-152]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
N
G
Q
F
G
E
V
W
M
G
T
W
N
--
G
--
N
T
K
-
V
A
I
K
T
L
K
PG---
T
M
S
P
E
--
S
--
F
L
-----
E
E
A
Q
I
M
K
K
--
L
K
H
D
K
L
---
V
Q
L
Y
A
V
V
S
E
E
-----
P
---
I
Y
I
V
T
E
Y
M
N
K
---
G
S
L
L
D
F
L
K
----
D
GEG
R
A
---
L
K
-
L
P
N
L
--------
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
-----------
R
M
N
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
28.90
31%
-23
- C1 -
-
2SRC
1
SRC_HUMAN
A:
[185-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
N
--
G
--
T
-
T
R
V
A
I
K
T
L
K
PG---
T
M
S
P
E
--
A
--
F
L
-----
Q
E
A
Q
V
M
K
K
--
L
R
H
E
K
L
---
V
Q
L
Y
A
V
V
S
E
E
-----
P
---
I
Y
I
V
T
E
Y
M
S
K
---
G
S
L
L
D
F
L
K
----
G
---
E
T
GKY
L
R
-
L
P
Q
L
--------
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
-----------
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
28.42
32%
-28
- C1 -
-
4BCI
1
CDK9_HUMAN
A:
[26-201]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
KT
G
--
Q
-
K
-
V
A
L
K
K
V
L
-----
M
E
N
E
K
--
E
--
G
F
PITAL
R
E
I
K
I
L
Q
--
L
L
K
H
E
N
V
---
V
N
L
I
E
I
C
R
T
-------GS-
I
Y
L
V
F
D
F
C
E
H
DLA
G
L
L
S
N
V
L
V
----
K
---
F
T
---
L
S
E
I
K
R
V
--------
M
Q
M
L
L
N
---
G
L
Y
Y
I
H
-----------
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
---
R
A
F
S
L
A
----
P
N
R
YN
R
V
V
T
L
W
Y
R
P
P
E
L
L
------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
28.39
32%
-30
- C1 -
-
3BLQ
1
CDK9_HUMAN
A:
[26-207]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
KT
G
--
Q
-
K
-
V
A
L
K
K
V
L
-----
M
E
N
E
K
--
E
--
G
F
PITAL
R
E
I
K
I
L
Q
--
L
L
K
H
E
N
V
---
V
N
L
I
E
I
C
R
T
-------S--
I
Y
L
V
F
D
F
C
E
H
DLA
G
L
L
S
N
V
L
V
----
K
---
F
T
---
L
S
E
I
K
R
V
--------
M
Q
M
L
L
N
---
G
L
Y
Y
I
H
-----------
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
---
R
A
F
S
-------
N
R
YN
R
V
V
T
L
W
Y
R
P
P
E
L
L
------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
27.13
32%
-22
- C1 -
-
3BLR
1
CDK9_HUMAN
A:
[26-206]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
KT
G
--
Q
-
K
-
V
A
L
K
K
V
L
-----
M
E
N
E
K
--
E
--
G
F
PITAL
R
E
I
K
I
L
Q
--
L
L
K
H
E
N
V
---
V
N
L
I
E
I
C
R
T
-------S--
I
Y
L
V
F
D
F
C
E
H
DLA
G
L
L
S
N
V
L
V
----
K
---
F
T
---
L
S
E
I
K
R
V
--------
M
Q
M
L
L
N
---
G
L
Y
Y
I
H
-----------
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
---
R
A
F
S
L
A
----
P
N
R
YN
R
V
V
T
L
W
Y
R
P
P
E
L
L
------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
26.81
32%
-30
- C1 -
-
3TNH
1
CDK9_HUMAN
A:
[26-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
KT
G
--
Q
-
K
-
V
A
L
K
K
V
L
-----
M
E
N
E
K
--
E
--
G
F
PITAL
R
E
I
K
I
L
Q
--
L
L
K
H
E
N
V
---
V
N
L
I
E
I
C
R
T
-------S--
I
Y
L
V
F
D
F
C
E
H
DLA
G
L
L
S
N
V
L
V
----
K
---
F
T
---
L
S
E
I
K
R
V
--------
M
Q
M
L
L
N
---
G
L
Y
Y
I
H
-----------
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
---
R
A
F
S
-------
N
R
YN
R
V
V
T
L
W
Y
R
P
P
E
L
L
------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
26.20
32%
-8
- C1 -
-
3LQ5
1
CDK9_HUMAN
A:
[24-201]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
KT
G
--
Q
-
K
-
V
A
L
K
K
V
L
-----
M
E
N
E
K
--
E
--
G
F
PITAL
R
E
I
K
I
L
Q
--
L
L
K
H
E
N
V
---
V
N
L
I
E
I
C
R
T
-------KGS
I
Y
L
V
F
D
F
C
E
H
DLA
G
L
L
S
N
V
L
V
----
K
---
F
T
---
L
S
E
I
K
R
V
--------
M
Q
M
L
L
N
---
G
L
Y
Y
I
H
-----------
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
---
R
A
F
S
L
A
----
P
N
R
YN
R
V
V
T
L
W
Y
R
P
P
E
L
L
------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
26.10
32%
-14
- C1 -
-
3TN8
2
CDK9_HUMAN
A:
[26-201]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
KT
G
--
Q
-
K
-
V
A
L
K
K
V
L
-----
M
E
N
E
K
--
E
--
G
F
PITAL
R
E
I
K
I
L
Q
--
L
L
K
H
E
N
V
---
V
N
L
I
E
I
C
R
T
-------GS-
I
Y
L
V
F
D
F
C
E
H
DLA
G
L
L
S
N
V
L
V
----
K
---
F
T
---
L
S
E
I
K
R
V
--------
M
Q
M
L
L
N
---
G
L
Y
Y
I
H
-----------
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
---
R
A
F
S
L
----
Q
P
N
R
YN
R
V
V
T
L
W
Y
R
P
P
E
L
L
------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
24.84
32%
-1
- C1 -
-
3MIA
1
CDK9_HUMAN
A:
[25-200]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
R
KT
G
--
Q
-
K
-
V
A
L
K
K
V
L
-----
M
E
N
E
K
--
E
--
G
F
PITAL
R
E
I
K
I
L
Q
--
L
L
K
H
E
N
V
---
V
N
L
I
E
I
C
R
T
-------KGS
I
Y
L
V
F
D
F
C
E
H
DLA
G
L
L
S
N
V
L
V
----
K
---
F
T
---
L
S
E
I
K
R
V
--------
M
Q
M
L
L
N
---
G
L
Y
Y
I
H
-----------
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
D
G
V
L
K
L
A
D
F
G
L
A
---
R
A
F
S
L
A
K
N
S
Q
P
N
R
YN
R
V
V
T
L
W
Y
R
P
P
E
L
L
------------------------------------------------------------------------------------------------------------------------