@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ADCK3_HUMAN: (2020-09-04 )
MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQGQDKHEEYFAENFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAYVASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIEKARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQIIRAAADRDRETVRAKSIEMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTTEKIHNLIPVMLRHRLVPPPEETYSLHRKMGGSFLICSKLKARFPCKAMFEEAYSNYCKRQAQQ
Atome Classification :
(20 SA)
-----------------------------------------------------------------.........10-------......---..20......-..30........40........50--.........60........70........80..-......-90........100.--......110.......120.......130.......140...-...----------------------.150.....------..160.......170.......180.......-----------190-----.......200.....-..210--.--------------......220...---------...----------.230.......240.-----......250......-.260.......270.......280...----.----.---..290.......300--...--.....310......-----------.320.......330------------------------.......340........350........360.......370.---......--380.......390--.--........400......-.410...-----------....420.--...-....430.......440..----....--.450.......---460--.------.......--.470..---...---..480.......490....-----...500.......510..-.....520.......530--.......540......--.550-........560..------.....570.......--------580..-----..-----.-----..590.......600-......-------.610.......620.....--..630------.........640.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------MAAILG
D
T
I
M
V
-------
A
K
G
L
V
K
---
L
T
Q
A
A
V
E
T
H
L
-
Q
H
LGIG
G
E
L
I
M
A
A
R
A
L
Q
S
T
A
V
E
Q
---
I
G
M
F
L
G
KVQG
Q
D
K
H
E
E
Y
F
A
E
NFGGPEG
E
F
H
F
SV-PHAAGA-STDFSSASAPDQSA--PPSLGHAHSEGPAP
A
Y
VASGPFREAGFPGQASSPLGRAN
G
R
L
-FAN----------------------PR
D
S
F
S
A
M
G
------
F
Q
R
R
F
FHQDQSPVGGL
T
A
E
D
I
E
K
A
R
Q
AKARPE-----------
N
K
Q
-----
H
K
Q
T
L
S
E
H
A
R
ERKV
P
-
V
T
R
I
G
--
R
--------------
L
ANFG
G
L
A
V
G
L
G
---------
F
G
A
----------
L
A
E
V
A
K
K
S
LRSEDPS-----GKKAVLGSSPFLSEA-
N
A
E
R
I
V
R
T
L
C
K
VR
G
A
A
L
KLG
Q
M
LSIQD----D----A---FI
N
P
H
L
A
K
I
F
E
R
V
R
---QSA--D
F
M
P
L
K
Q
M
M
K
T
L
NN-----------DLGP
N
W
R
D
K
L
E
Y
F
E
------------------------ERPFAAAS-I
G
Q
V
H
L
A
R
MK-GG
R
E
V
A
M
K
I
QYPG
V
A
Q
S
I
N
S
D
V
N
---
N
L
M
A
V
L
--
N
M
S
NMLPEGL
F
----
P
--
E
H
L
I
D
V
L
R
R
E
L
A
LECD
Y
-
Q
R
E
A
A
C
A
-----------
R
K
F
R
D
L
-L--KGH-P
F
F
Y
V
P
E
I
V
D
E
LCSP
H
V
L
T
----
T
E
L
V--SGFPL
D
Q
A
E
G
L
---
S
----
Q
------
E
I
R
N
E
I
C
--
Y
N
I
L
V
L
---
C
L
R
---
E
L
F
E
F
H
FMQTDPNWSNFFY-----DPQQ
H
K
V
A
L
L
DFGAT
R
E
Y
-
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
ADR--D
R
E
TVRAK
S
I
E
M
K
F
LT--G
Y
-
E
-
V
K
V
M
EDAHL
D
A
I
L
------
I
L
G
E
A
FASDEPFDFG--------TQ
S
T
T
-----
E
K
-----
I
-----
H
N
L
I
P
V
M
L
R
HRLVPP-
P
E
E
T
Y
S
-------
L
H
R
KMGG
S
F
L
I
C
S
K
L
K
ARF--
P
C
K
--------
A
M
F
E
E
A
Y
S
N
Y
C
K
R
Q
AQQ
43
HHSearch
93.79
100%
-122
- C5 -
-
4PED
-
COQ8A_HUMAN
A:
[4-390]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
----
D
----
A
---
F
I
N
P
H
L
A
K
I
F
E
R
V
R
---
Q
S
A
--
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-----------
D
L
G
P
N
W
R
D
K
L
E
Y
F
E
------------------------
E
R
P
F
A
A
A
S
-
I
G
Q
V
H
L
A
R
M
K
-
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
---
N
L
M
A
V
L
--
N
M
S
N
M
L
P
E
G
L
F
----
P
--
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
-
Q
R
E
A
A
C
A
-----------
R
K
F
R
D
L
-
L
--
K
G
H
-
P
F
F
Y
V
P
E
I
V
D
E
L
C
S
P
H
V
L
T
----
T
E
L
V
--
S
G
F
P
L
D
Q
A
E
G
L
---
S
----
Q
------
E
I
R
N
E
I
C
--
Y
N
I
L
V
L
---
C
L
R
---
E
L
F
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
-----
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
-
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
--
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
--
G
Y
-
E
-
V
K
V
M
E
D
A
H
L
D
A
I
L
------
I
L
G
E
A
F
A
S
D
E
P
F
D
F
G
--------
T
Q
S
T
T
-----
E
K
-----
I
-----
H
N
L
I
P
V
M
L
R
H
R
L
V
P
P
-
P
E
E
T
Y
S
-------
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
--
P
C
K
--------
A
M
F
E
E
A
Y
S
N
Y
C
K
R
Q
---
1
PsiBlast_PDB
92.99
96%
-122
- C5 -
-
4PED
-
COQ8A_HUMAN
A:
[4-390]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
----
D
----
A
---
F
I
N
P
H
L
A
K
I
F
E
R
V
R
---
Q
S
A
--
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-----------
D
L
G
P
N
W
R
D
K
L
E
Y
F
E
------------------------
E
R
P
F
A
A
A
S
-
I
G
Q
V
H
L
A
R
M
K
-
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
---
N
L
M
A
V
L
--
N
M
S
N
M
L
P
E
G
L
F
----
P
--
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
-
Q
R
E
A
A
C
A
-----------
R
K
F
R
D
L
-
L
--
K
G
H
-
P
F
F
Y
V
P
E
I
V
D
E
L
C
S
P
H
V
L
T
----
T
E
L
V
--
S
G
F
P
L
D
Q
A
E
G
L
---
S
----
Q
------
E
I
R
N
E
I
C
--
Y
N
I
L
V
L
---
C
L
R
---
E
L
F
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
-----
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
-
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
--
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
--
G
Y
-
E
-
V
K
V
M
E
D
A
H
L
D
A
I
L
------
I
L
G
E
A
F
A
S
D
E
P
F
D
F
G
--------
T
Q
S
T
T
-----
E
K
-----
I
-----
H
N
L
I
P
V
M
L
R
H
R
L
V
P
P
-
P
E
E
T
Y
S
-------
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
--
P
C
K
--------
A
M
F
E
E
A
Y
S
N
Y
C
K
R
Q
---
2
PsiBlast_PDB
89.92
95%
-123
- C5 -
-
5I35
1
COQ8A_HUMAN
A:
[7-390]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
----
D
----
A
---
F
I
N
P
H
L
A
K
I
F
E
R
V
R
---
Q
S
A
--
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-----------
D
L
G
P
N
W
R
D
K
L
E
Y
F
E
------------------------
E
R
P
F
A
A
A
S
-
I
G
Q
V
H
L
A
R
M
K
-
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
---
N
L
M
A
V
L
--
N
M
S
N
M
L
P
E
G
L
F
----
P
--
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
-
Q
R
E
A
A
C
A
-----------
R
K
F
R
D
L
-
L
--
K
G
H
-
P
F
F
Y
V
P
E
I
V
D
E
L
C
S
P
H
V
L
T
----
T
E
L
V
--
S
G
F
P
L
D
Q
A
E
G
L
---
S
----
Q
------
E
I
R
N
E
I
C
--
Y
N
I
L
V
L
---
C
L
R
---
E
L
F
E
F
H
F
M
Q
T
D
P
N
W
S
N
F
F
Y
-----
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
-
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
--
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
--
G
Y
-
E
-
V
K
V
M
E
D
A
H
L
D
A
I
L
------
I
L
G
E
A
F
A
S
D
E
P
F
D
F
G
--------
T
Q
S
T
T
-----
E
K
-----
I
-----
H
N
L
I
P
V
M
L
R
H
R
L
V
P
P
-
P
E
E
T
Y
S
-------
L
H
K
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
--
P
C
K
--------
A
M
F
E
E
A
Y
S
N
Y
C
K
R
Q
---
27
Fugue
70.78
98%
-20
- C5 -
-
4PED
-
COQ8A_HUMAN
A:
[4-390]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
----
D
----
A
---
F
I
N
P
H
L
A
K
I
F
E
R
V
R
---
Q
S
A
--
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-----------
D
L
G
P
N
W
R
D
K
L
E
Y
F
E
------------------------
E
R
P
F
A
A
A
S
-
I
G
Q
V
H
L
A
R
M
K
-
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
---
N
L
A
V
-----
L
N
S
N
L
P
E
G
L
F
----
P
--
E
H
L
I
D
V
L
R
R
E
L
A
L
E
C
D
Y
-
Q
R
E
A
A
C
A
-----------
R
K
F
R
D
L
-
L
--
K
G
H
-
P
F
F
Y
V
P
E
I
V
D
E
L
C
S
P
H
V
L
T
----
T
E
L
V
--
S
G
F
P
L
D
Q
A
E
G
L
---
S
----
Q
------
E
I
R
N
E
I
C
--
Y
N
I
L
V
L
---
C
L
R
---
E
L
F
E
F
H
F
-
Q
T
D
P
N
W
S
N
F
F
Y
-----
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
-
D
R
S
F
T
D
L
Y
I
Q
I
I
R
A
A
A
D
R
--
D
R
E
T
V
R
A
K
S
I
E
-
K
F
L
T
--
G
Y
-
E
-
V
K
V
-
E
D
A
H
L
D
A
I
L
------
I
L
G
E
A
F
A
S
D
E
P
F
D
F
G
--------
T
Q
S
T
T
-----
E
K
-----
I
-----
H
N
L
I
P
V
-
L
R
H
R
L
V
P
P
-
P
E
E
T
Y
S
-------
L
H
R
K
-
G
G
S
F
L
I
C
S
K
L
K
A
R
F
--
P
C
K
--------
A
-
F
E
E
A
Y
S
N
Y
C
K
R
Q
---
4
PsiBlast_PDB
59.73
27%
-8
- C5 -
-
5YK0
4
?
A:
[56-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
E
K
-
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
G
Q
A
L
S
V
M
E
AAIP
D
----
E
---
F
G
E
P
Y
-
R
E
A
L
T
K
L
Q
---
K
D
A
--
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----------
Q
L
G
T
K
W
R
E
R
F
S
S
F
N
------------------------
D
T
P
V
A
S
A
S
-
I
G
Q
V
H
K
A
I
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
---
T
M
Q
R
M
V
--
G
V
L
K
Q
L
S
P
G
A
D
----
V
--
Q
G
V
V
D
E
L
V
E
R
T
E
M
E
L
D
Y
-
R
L
E
A
A
N
Q
-----------
R
A
F
A
K
A
-
Y
--
H
D
H
-
P
R
F
Q
V
P
H
V
V
--
A
S
A
P
K
V
V
I
----
Q
E
W
I
--
E
G
V
P
M
--
A
E
I
I
RHG
T
----
T
------
E
Q
R
D
L
I
G
--
T
L
L
A
E
L
---
T
F
D
---
A
P
R
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
-----
L
P
-
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
-
P
G
G
F
P
I
E
L
G
M
T
I
R
L
A
R
E
K
--
N
Y
D
L
L
-
L
P
T
M
E
K
A
G
L
I
QR
G
R
-
Q
-
V
S
V
R
E
---
I
D
E
M
L
RQYVEP
I
Q
V
E
V
F
H
Y
T
R
--
K
W
L
--------
Q
K
M
T
V
-----
S
Q
-----
I
-----
D
R
S
V
A
Q
I
R
T
A
R
Q
M
D
L
-
P
A
K
L
A
I
-------
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
--
P
I
K
--------
A
L
S
E
E
L
I
P
G
F
A
E
P
D
---
5
PsiBlast_PDB
59.50
27%
-5
- C5 -
-
5YK1
2
?
A:
[56-448]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
E
K
-
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
G
Q
A
L
S
V
M
E
AAIP
D
----
E
---
F
G
E
P
Y
-
R
E
A
L
T
K
L
Q
---
K
D
A
--
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----------
Q
L
G
T
K
W
R
E
R
F
S
S
F
N
------------------------
D
T
P
V
A
S
A
S
-
I
G
Q
V
H
K
A
I
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
---
T
M
Q
R
M
V
--
G
V
L
K
Q
L
S
P
G
A
D
----
V
--
Q
G
V
V
D
E
L
V
E
R
T
E
M
E
L
D
Y
-
R
L
E
A
A
N
Q
-----------
R
A
F
A
K
A
-
Y
--
H
D
H
-
P
R
F
Q
V
P
H
V
V
--
A
S
A
P
K
V
V
I
----
Q
E
W
I
--
E
G
V
P
M
--
A
E
I
I
RHG
T
----
T
------
E
Q
R
D
L
I
G
--
T
L
L
A
E
L
---
T
F
D
---
A
P
R
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
-----
L
P
-
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
-
P
G
G
F
P
I
E
L
G
M
T
I
R
L
A
R
E
K
--
N
Y
D
L
L
-
L
P
T
M
E
K
A
G
L
I
QR
G
R
-
Q
-
V
S
V
R
E
---
I
D
E
M
L
RQYVEP
I
Q
V
E
V
F
H
Y
T
R
--
K
W
L
--------
Q
K
M
T
V
-----
S
Q
-----
I
-----
D
R
S
V
A
Q
I
R
T
A
R
Q
M
D
L
-
P
A
K
L
A
I
-------
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
--
P
I
K
--------
A
L
S
E
E
L
I
P
G
F
A
E
P
D
---
3
PsiBlast_PDB
59.19
27%
-8
- C5 -
-
5YJZ
2
?
A:
[56-447]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
E
K
-
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
G
Q
A
L
S
V
M
E
AAIP
D
----
E
---
F
G
E
P
Y
-
R
E
A
L
T
K
L
Q
---
K
D
A
--
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----------
Q
L
G
T
K
W
R
E
R
F
S
S
F
N
------------------------
D
T
P
V
A
S
A
S
-
I
G
Q
V
H
K
A
I
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
---
T
M
Q
R
M
V
--
G
V
L
K
Q
L
S
P
G
A
D
----
V
--
Q
G
V
V
D
E
L
V
E
R
T
E
M
E
L
D
Y
-
R
L
E
A
A
N
Q
-----------
R
A
F
A
K
A
-
Y
--
H
D
H
-
P
R
F
Q
V
P
H
V
V
--
A
S
A
P
K
V
V
I
----
Q
E
W
I
--
E
G
V
P
M
--
A
E
I
I
RHG
T
----
T
------
E
Q
R
D
L
I
G
--
T
L
L
A
E
L
---
T
F
D
---
A
P
R
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
-----
L
P
-
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
-
P
G
G
F
P
I
E
L
G
M
T
I
R
L
A
R
E
K
--
N
Y
D
L
L
-
L
P
T
M
E
K
A
G
L
I
QR
G
R
-
Q
-
V
S
V
R
E
---
I
D
E
M
L
RQYVEP
I
Q
V
E
V
F
H
Y
T
R
--
K
W
L
--------
Q
K
M
T
V
-----
S
Q
-----
I
-----
D
R
S
V
A
Q
I
R
T
A
R
Q
M
D
L
-
P
A
K
L
A
I
-------
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
--
P
I
K
--------
A
L
S
E
E
L
I
P
G
F
A
E
P
----
44
HHSearch
58.55
24%
-1
- C5 -
-
5YJZ
2
?
A:
[48-445]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
------------
E
V
T
A
E
L
M
E
K
-
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
G
Q
A
L
S
V
M
E
----
A
----
A
IPD
E
F
G
E
P
Y
R
E
A
L
T
K
L
Q
---
K
D
A
--
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----------
Q
L
G
T
K
W
R
E
R
F
S
S
F
N
------------------------
D
T
P
V
A
S
A
S
-
I
G
Q
V
H
K
A
I
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
---
T
M
Q
R
M
V
--
G
V
L
K
Q
L
S
P
G
A
D
----
V
--
Q
G
V
V
D
E
L
V
E
R
T
E
M
E
L
D
Y
-
R
L
E
A
A
N
Q
-----------
R
A
F
A
K
A
-
Y
--
H
D
H
-
P
R
F
Q
V
P
H
V
V
A
--
S
A
P
K
V
V
I
----
Q
E
W
I
--
E
G
V
P
M
A
E
I
I
R
H
---
G
T---
T
------
E
Q
R
D
L
I
G
--
T
L
L
A
E
L
---
T
F
D
---
A
P
R
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
-----
L
P
D
-
G
R
M
G
I
I
D
F
G
A
V
A
P
M
-
P
G
G
F
P
I
E
L
G
M
T
I
R
L
A
R
E
K
--
N
Y
D
L
L
L
P
T
M
E
K
A
G
L
I
Q
--
R
G
-
R
Q
V
S
V
--
R
E
I
D
E
M
L
R
------
Q
Y
V
E
P
I
Q
V
-
E
V
F
H
Y
T
--------
R
K
W
L
Q
KMTVS
Q
I
-----
D
-----
R
S
V
A
Q
I
R
T
A
R
Q
M
D
L
P
-
A
K
L
A
I
--------
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
--
P
I
K
--------
A
L
S
E
E
L
I
P
G
F
A
------
46
HHSearch
58.54
24%
-3
- C5 -
-
5YK0
4
?
A:
[50-445]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
------------
E
V
T
A
E
L
M
E
K
-
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
G
Q
A
L
S
V
M
E
----
A
----
A
IPD
E
F
G
E
P
Y
R
E
A
L
T
K
L
Q
---
K
D
A
--
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----------
Q
L
G
T
K
W
R
E
R
F
S
S
F
N
------------------------
D
T
P
V
A
S
A
S
-
I
G
Q
V
H
K
A
I
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
---
T
M
Q
R
M
V
--
G
V
L
K
Q
L
S
P
G
A
D
----
V
--
Q
G
V
V
D
E
L
V
E
R
T
E
M
E
L
D
Y
-
R
L
E
A
A
N
Q
-----------
R
A
F
A
K
A
-
Y
--
H
D
H
-
P
R
F
Q
V
P
H
V
V
A
--
S
A
P
K
V
V
I
----
Q
E
W
I
--
E
G
V
P
M
A
E
I
I
R
H
---
G
T---
T
------
E
Q
R
D
L
I
G
--
T
L
L
A
E
L
---
T
F
D
---
A
P
R
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
-----
L
P
D
-
G
R
M
G
I
I
D
F
G
A
V
A
P
M
-
P
G
G
F
P
I
E
L
G
M
T
I
R
L
A
R
E
K
--
N
Y
D
L
L
L
P
T
M
E
K
A
G
L
I
Q
--
R
G
R
Q
-
V
S
V
--
R
E
I
D
E
M
L
R
------
Q
Y
V
E
P
I
Q
V
-
E
V
F
H
Y
T
--------
R
K
W
L
Q
-----
K
M
-----
T
VSQID
R
S
V
A
Q
I
R
T
A
R
Q
M
D
L
P
-
A
K
L
A
I
--------
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
--
P
I
K
--------
A
L
S
E
E
L
I
P
G
F
A
------
6
PsiBlast_PDB
58.21
27%
-16
- C5 -
-
5YK2
1
?
A:
[56-447]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
E
K
-
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
G
Q
A
L
S
V
M
E
AAIP
D
----
E
---
F
G
E
P
Y
-
R
E
A
L
T
K
L
------
A
--
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----------
Q
L
G
T
K
W
R
E
R
F
S
S
F
N
------------------------
D
T
P
V
A
S
A
S
-
I
G
Q
V
H
K
A
I
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
---
T
M
Q
R
M
V
--
G
V
L
K
Q
L
S
P
G
A
D
----
V
--
Q
G
V
V
D
E
L
V
E
R
T
E
M
E
L
D
Y
-
R
L
E
A
A
N
Q
-----------
R
A
F
A
K
A
-
Y
--
H
D
H
-
P
R
F
Q
V
P
H
V
V
--
A
S
A
P
K
V
V
I
----
Q
E
W
I
--
E
G
V
P
M
--
A
E
I
I
RHG
T
----
T
------
E
Q
R
D
L
I
G
--
T
L
L
A
E
L
---
T
F
D
---
A
P
R
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
-----
L
P
-
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
-
P
G
G
F
P
I
E
L
G
M
T
I
R
L
A
R
E
K
--
N
Y
D
L
L
-
L
P
T
M
E
K
A
G
L
I
QR
G
R
-
Q
-
V
S
V
R
E
---
I
D
E
M
L
RQYVEP
I
Q
V
E
V
F
H
Y
T
R
--
K
W
L
--------
Q
K
M
T
V
-----
S
Q
-----
I
-----
D
------
R
T
A
R
Q
M
D
L
-
P
A
K
L
A
I
-------
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
--
P
I
K
--------
A
L
S
E
E
L
I
P
G
F
A
E
P
----
45
HHSearch
58.01
24%
-3
- C5 -
-
5YK1
2
?
A:
[48-445]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
------------
E
V
T
A
E
L
M
E
K
-
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
G
Q
A
L
S
V
M
E
----
A
----
A
IPD
E
F
G
E
P
Y
R
E
A
L
T
K
L
Q
---
K
D
A
--
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----------
Q
L
G
T
K
W
R
E
R
F
S
S
F
N
------------------------
D
T
P
V
A
S
A
S
-
I
G
Q
V
H
K
A
I
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
---
T
M
Q
R
M
V
--
G
V
L
K
Q
L
S
P
G
A
D
----
V
--
Q
G
V
V
D
E
L
V
E
R
T
E
M
E
L
D
Y
-
R
L
E
A
A
N
Q
-----------
R
A
F
A
K
A
-
Y
--
H
D
H
-
P
R
F
Q
V
P
H
V
V
A
--
S
A
P
K
V
V
I
----
Q
E
W
I
--
E
G
V
P
M
A
E
I
I
R
H
---
G
T---
T
------
E
Q
R
D
L
I
G
--
T
L
L
A
E
L
---
T
F
D
---
A
P
R
R
L
G
L
M
H
G
D
A
H
P
G
N
F
M
L
-----
L
P
D
-
G
R
M
G
I
I
D
F
G
A
V
A
P
M
-
P
G
G
F
P
I
E
L
G
M
T
I
R
L
A
R
E
K
--
N
Y
D
L
L
L
P
T
M
E
K
A
G
L
I
Q
--
R
G
R
Q
-
V
S
V
--
R
E
I
D
E
M
L
R
------
Q
Y
V
E
P
I
Q
V
-
E
V
F
H
Y
T
--------
R
K
W
L
Q
-----
K
M
TVSQI
D
-----
R
S
V
A
Q
I
R
T
A
R
Q
M
D
L
P
-
A
K
L
A
I
--------
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
--
P
I
K
--------
A
L
S
E
E
L
I
P
G
F
A
------
39
Fugue
40.07
17%
33
- C2 -
-
5T0A
21
H6S3B_DANRE (first)
A:
[3-680]
--------------------------------------------------------------------
I
E
E
G
K
L
V
I
WINGDKG
Y
N
G
L
A
E
---
V
G
K
K
F
E
K
D
T
G
-
I
K
V
T
V
E
H
P
D
K
L
E
E
K
F
P
Q
V
A
A
T
G
D
GPD
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
A
E
I
--
T
P
A
A
A
F
Q
D
K
L
Y
P
F
T
W
D
A
V
R
Y
N
G
K
L
I
A
Y
P
I
A
V
E
--
A
L
S
L
I
Y
N
K
D
L
L
P
N
P
P
----
K
T
W
E
E
I
P
A
L
D
K
E
L
K
A
K
G
K
S
A
L
M
F
N
L
Q
E
----------------------
P
Y
F
T
W
P
L
I
A
ADGGYA
F
K
Y
A
A
G
K
Y
D
I
K
D
V
G
V
D
N
A
G
A
K
A
G
L
T
F
L
V
D
L
I
K
-----------
N
K
H
MNADT
D
Y
S
I
A
E
A
A
F
N
K
G
E
T
A
-
M
T
I
N
G
PW
A
--------------
W
S
N
I
D
T
S
A
V
N
Y
G
---------
V
T
V
----------
L
P
T
F
------
K
G
Q
P
S
-----
K
P
F
V
G
V
L
S
A
G
I
N
A
A
S
-
P
N
K
E
L
A
K
E
F
L
E
N
Y
--
L
L
T
D
E
G
L
E
A
V
N
K
----
D
KPLG
A
---
V
A
L
K
S
Y
E
E
E
L
A
K
D
P
---
R
I
A
--
A
T
M
E
N
A
Q
K
G
E
I
M
P
N
-----------
I
--
P
Q
M
S
A
F
W
Y
A
V
R
------------------------
T
A
V
I
N
A
A
S
G
R
Q
T
V
D
A
A
L
A
A
-
A
Q
T
N
A
A
A
K
F
N
F
T
E
R
D
L
T
R
D
V
D
F
N
IKG
D
D
V
I
V
F
--
L
H
I
Q
K
T
G
G
T
T
F
----
G
--
R
H
L
V
R
N
I
R
L
E
Q
P
C
D
C
K
A
G
Q
K
K
C
T
C
H
-----------
R
P
G
-------
K
Q
E
-
S
W
L
F
S
R
F
S
T
G
W
S
C
G
L
H
A
D
W
----
T
E
L
T
--
N
C
V
P
V
I
M
D
R
N
----------------------
F
--
Y
Y
I
T
M
L
RDP
V
S
R
---
Y
L
S
E
W
K
H
V
Q
R
G
A
T
W
K
T
S
L
H
MCDGR
S
P
T
Q
D
E
L
P
T
C
Y
N
G
D
-----
D
W
S
G
V
T
L
H
D
F
M
D
C
P
S
N
L
A
--
N
N
R
Q
V
R
M
L
A
-
D
L
S
L
V
G
--
C
Y
-
N
-
L
S
T
M
N
E
S
E
R
N
P
I
L
------
L
A
S
A
K
S
N
L
K
N
M
A
F
Y
G
--------
L
T
E
F
Q
-----
R
K
-----
T
-----
Q
Y
L
F
E
R
T
F
H
L
R
F
I
S
A
-
F
T
Q
I
N
S
TRAANVE
L
R
D
D
M
R
S
R
I
E
Q
L
N
M
L
D
M
Q
L
YE
F
A
K
--------
D
L
F
L
Q
R
Y
Q
F
V
R
Q
R
E
R
Q
E
29
Fugue
34.91
15%
-9
- C5 -
-
3VWA
-
CEX1_YEAST
A:
[5-544]
---------------------------------------------------------------------------------------------------
P
L
H
M
S
I
S
N
F
Q
F
P
Y
T
I
E
E
T
A
I
T
E
T
A
L
-----
W
Q
C
F
D
G
T
R
K
A
D
S
L
P
V
T
V
F
K
A
K
R
S
P
E
N
E
S
L
I
L
N
A
-
V
H
K
S
K
I
-
L
K
I
P
G
L
C
T
-----------
V
L
E
T
F
D
S
D
P
Q
S
T
F
I
V
T
E
R
V
V
P
--
F
P
W
D
N
L
G
S
L
S
Q
N
K
F
G
V
-
E
L
G
----------------------
I
S
Q
L
L
A
T
L
G
------
F
L
K
N
F
V
------
L
G
T
L
S
K
D
S
--------------------------------------------
V
F
-
I
N
I
K
G
--
E
--------------
W
V
L
F
G
L
E
L
C
S
S
K
---------
E
G
L
----------
S
A
F
E
F
A
S
R
A
R
S
Y
Y
N
I
-----
I
G
S
Q
L
P
C
E
D
P
N
T
I
D
S
M
G
L
G
L
L
I
K
S
L
M
A
P
S
C
L
P
K
D
W
I
V
N
V
N
I
S
D
----
G
----
K
---
I
T
I
E
N
F
R
K
R
L
E
N
T
E
---
T
W
R
--
S
-
N
P
L
I
N
F
Y
Q
E
L
R
E
-----------
L
H
I
K
D
-----------------------------------
P
Q
G
K
L
V
-
V
S
N
L
E
N
L
Y
L
E
-
S
-
R
E
I
F
R
N
L
T
-
P
G
I
E
N
F
I
I
P
E
L
C
---
E
I
I
K
L
L
TQ
S
I
S
S
N
A
S
H
K
L
V
----
P
FL
A
I
V
L
D
L
T
S
E
T
N
T
F
P
V
G
F
-
N
D
L
I
T
Q
S
-----------
F
K
L
P
D
R
Q
V
--
R
F
L
-
L
L
I
Y
L
P
K
L
I
G
----------------------
P
L
S
K
S
E
-
I
---
S
----
S
------
R
I
-------
Y
P
H
F
I
Q
---
G
L
T
DSD
A
T
L
R
L
Q
T
L
K
T
I
P
C
I
V
S
C
L
T
-----
E
R
Q
L
N
N
E
L
L
R
F
L
A
K
T
Q
V
D
S
D
V
E
I
R
T
W
T
V
I
I
I
S
K
I
S
T
I
LS
T
S
V
G
N
R
S
N
I
L
A
T
A
F
T
K
--
S
L
-
K
-
D
P
-
Q
V
K
P
R
L
A
A
L
Y
------
G
L
E
K
S
I
E
L
-----
F
D
--------
V
N
T
I
A
-----
N
K
-----
I
-----
L
T
V
I
A
P
G
L
L
D
K
-------------------------------
S
P
I
V
R
G
--
R
A
K
--------
I
L
F
E
E
Y
L
E
K
L
E
K
E
A
Q
L
I
62
HHSearch
32.79
17%
-107
- C5 -
-
6FDM
1
RIOK2_HUMAN
A:
[99-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Q
M
G
V
G
K
-
E
S
D
I
Y
I
V
A
N
E
-
E
G
Q
Q
F
A
L
K
L
H
R
L
G
R
T
------------------------------------------
N
V
S
W
L
Y
L
S
R
L
S
A
-
M
K
E
F
A
Y
M
-----------
K
A
L
Y
E
---------
R
K
F
P
V
P
K
P
I
D
Y
--
N
R
H
A
V
V
----
M
E
L
I
--
N
G
Y
P
L
C
Q
I
H
H
V
---------------
E
D
P
A
S
V
Y
--
D
E
A
M
E
L
----
I
V
---
K
L
A
N
H
G
L
I
H
G
D
F
N
E
F
N
L
I
L
-----
D
E
S
-
D
H
I
T
M
I
D
F
P
Q
M
V
S
T
-
S
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
31.38
13%
-2
- C5 -
-
3V5W
1
ARBK1_HUMAN
A:
[95-361]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
-
T
E
E
E
R
V
A
R
S
R
E
I
F
D
S
Y
I
M
--
K
E
L
L
A
C
S
----
H
----
P
----
F
S
K
S
A
T
E
H
V
Q
G
H
L
---
G
K
K
QV
P
P
D
L
F
Q
P
Y
I
E
E
I
C
Q
-----------
N
L
R
G
D
V
F
Q
K
F
I
E
S
D
KFTRFCQWKNVELNIHLTMNDFSV
H
R
I
I
G
R
G
G
-
F
G
E
V
Y
G
C
R
K
A
D
T
G
K
M
Y
A
M
K
C
L
D
K
K
R
I
K
M
-------------------------------------------------
K
Q
G
-
E
T
L
A
L
N
E
-----------
R
I
M
L
S
L
-
V
ST
G
D
C
-
P
F
I
V
C
M
S
Y
A
F
H
T
P
D
K
L
S
F
I
----
L
D
L
M
--
N
G
G
D
L
H
Y
H
L
S
Q
---
H
GVFS
E
------
A
D
M
R
F
Y
A
--
A
E
I
I
L
G
----
L
E
---
H
M
H
N
R
F
V
V
Y
R
D
L
K
P
A
N
I
L
L
-----
D
E
H
-
G
H
V
R
I
S
D
L
G
L
A
C
D
F
-
S
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
30.51
14%
-12
* C5 *
-
4GYI
3
?
A:
[3-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
----------
L
D
T
R
A
M
R
H
L
T
A
E
D
W
R
-----
V
L
T
A
V
E
M
G
S
K
N
H
E
I
V
-
P
T
P
L
I
E
K
I
A
R
L
R
G
G
S
S
G
V
H
K
S
I
A
T
L
A
K
----
A
----
G
---
L
I
A
R
M
K
E
A
K
Y
D
G
Y
R
LTY
G
G
L
--
D
Y
L
A
L
H
T
H
A
A
---------------------
R
K
D
V
-
Y
S
V
------------------------
G
S
R
I
G
V
G
K
-
E
S
D
I
M
I
V
A
D
E
-
K
G
K
Q
K
V
L
K
I
H
R
L
G
R
I
S
----------------------------
F
----
R
--
T
V
K
R
D
Y
L
R
N
R
S
T
G
S
W
M
Y
-
L
S
R
L
A
A
I
-----------
K
E
F
A
F
M
-
K
--
A
L
Y
E
E
G
F
P
V
P
E
P
I
A
Q
S
--
R
H
T
I
V
----
M
S
L
V
--
D
A
L
P
M
R
Q
V
S
S
V
---
P
-------------
D
P
A
S
L
--
Y
A
D
L
I
A
---
L
I
L
---
R
L
A
K
H
G
L
I
H
G
D
F
N
E
F
N
I
L
I
-----
R
E
E
K
D
A
E
-----
D
P
S
S
I
T
-
L
T
P
I
I
I
P
F
P
Q
M
V
S
M
D
H
P
N
--
A
E
M
Y
F
D
R
D
V
Q
C
I
K
R
F
F
--
E
R
-
R
-
F
H
F
V
S
T
T
P
G
P
F
Y
K
------
D
A
K
K
T
V
G
K
D
G
A
K
R
L
D
AALEASGF
T
K
K
M
A
-----
K
D
-----
L
-----
E
A
A
I
R
E
Q
Q
E
S
R
-------------------------------------------------------------------
52
HHSearch
30.42
14%
-57
- C5 -
-
5H0B
1
HCK_HUMAN
A:
[123-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
----
E
----
L
----
V
D
H
Y
K
K
G
N
D
G
L
C
Q
---
K
L
S
--
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
-----------
D
A
W
E
I
P
R
E
S
L
K
L
E
--------------------------
K
K
L
G
A
G
Q
-
F
G
E
V
W
M
A
T
Y
N
-
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-------------------------------------------------
V
E
A
F
-
L
A
E
A
N
V
M
-----------
K
T
L
Q
-------
H
D
-
K
L
V
K
L
H
A
V
V
--
T
K
E
P
I
Y
I
I
----
T
E
F
M
--
A
K
G
S
L
L
D
F
L
K
S
---
D
----
E
GSKQPL
P
K
L
I
D
F
S
--
A
Q
I
A
E
G
----
M
A
---
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
-----
S
A
S
-
L
V
C
K
I
A
D
F
G
L
A
R
V
I
-
E
D
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
30.16
11%
22
- C- -
-
4FVM
-
DPOA_YEAST
A:
[349-1228]
TDTFQMFWLDYCEVNNTLILFGKVKLKDDNCVSAMVQINGLCRELFFLPREGKTPTDIHEEIIPL
L
M
D
K
Y
G
L
D
N
I
R
-------
A
K
P
Q
K
M
KYS
F
E
L
P
D
I
P
S
E
S
-
D
Y
L
K
V
L
L
P
Y
Q
T
P
K
S
S
R
D
T
I
P
S
D
L
---
S
S
D
T
F
Y
H
V
F
G
G
N
S
N
I
F
E
S
F
V
I
Q
N
R
I
M
G
P
C
W
L
D
I
-
K
G
A
D
F
N
-
S
I
R
N
A
S
H
C
A
V
E
V
S
V
DK
P
Q
N
I
T
P
T
T
T
K
T
M
P
N
L
R
C
L
S
L
S
I
Q
T
L
M
N
P
K
E
N
K
Q
E
I
V
S
I
T
L
S
A
-
Y
R
N
ISLDSPIPENIKPDDLCTLVRP
P
Q
S
T
S
F
P
L
G
------
L
A
A
L
A
K
Q
K
L
P
G
R
V
R
L
F
N
N
E
K
A
M
L
S
C
F
C
A
M
L
K
V
EDPDVIIGHRL
Q
N
V
-----
Y
L
D
V
L
A
H
R
M
H
D
L
N
I
P
T
F
S
S
I
G
--
R
RLRRTWPEKFGNSN
M
N
H
F
F
I
S
D
I
C
S
G
RLICDIANE
M
G
Q
SLTPKCQSWD
L
S
E
M
Y
Q
V
T
C
E
K
E
H
K
P
LDIDY
Q
N
P
Q
Y
Q
N
D
V
N
S
M
T
M
A
-
L
Q
E
N
I
T
N
C
M
I
S
A
E
V
S
Y
R
I
Q
L
L
T
L
T
K
Q
L
----
T
----
N
---
L
A
G
N
A
W
A
Q
T
L
G
G
T
R
---
A
G
R
--
N
E
Y
I
L
L
H
E
F
S
R
N
G
F
IVPDKVFEPEK
G
L
H
K
N
Y
V
L
V
M
D
F
N
S
------------------------
L
Y
P
S
I
I
Q
E
-
F
N
I
C
F
T
T
V
D
R
-
N
K
E
D
I
D
E
L
P
S
V
P
P
S
E
V
D
Q
G
V
L
P
R
---
L
L
A
N
L
V
--
D
R
R
R
E
V
K
K
V
M
K
TETD
P
--
H
K
R
V
Q
C
D
I
R
Q
Q
A
L
K
L
T
A
-
N
S
M
Y
G
C
L
GYVNSRFYAKP
L
A
M
L
V
T
-
N
--
K
G
R
-
E
I
L
M
N
T
R
Q
L
A
E
S
M
N
L
L
V
V
Y
GDTD
S
V
M
I
DT
G
C
D
N
Y
A
D
A
I
K
I
---
G
----
L
------
G
F
K
R
L
V
N
ER
Y
R
L
L
E
I
---
D
I
D
---
N
V
F
K
K
L
L
L
H
A
K
K
K
Y
A
A
L
T
V
-----
N
T
T
V
L
E
V
K
G
L
D
--
M
K
R
R
E
-
F
C
P
L
S
R
D
V
S
I
H
V
L
N
T
I
L
S
--
D
K
D
P
E
E
A
L
Q
E
V
Y
D
Y
L
E
--
D
I
-
R
-
I
K
V
E
T
N
N
I
R
I
D
K
Y
------
K
I
N
M
K
L
S
K
D
-
P
K
A
Y
P
--------
G
G
K
N
M
-----
P
A
-----
V
-----
Q
V
A
L
R
M
R
K
A
G
R
V
V
K
A
G
S
V
I
T
F
V
-------
I
T
K
Q
A
L
S
V
A
E
R
A
H
A
L
N
E
V
M
--
I
K
S
NNLIPDPQ
Y
Y
L
E
K
Q
I
F
A
P
V
E
R
L
L
E
R
55
HHSearch
29.98
19%
-45
- C5 -
-
6BYR
1
KAPCA_HUMAN
C:
[102-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
-
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
----
K
---
Q
I
E
--------------------------------------
H
T
-
L
N
E
K
R
I
L
-----------
Q
A
V
--------
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
----
M
E
Y
V
--
P
G
G
E
M
F
S
H
L
R
R
---
I
GRFS
E
------
P
H
A
R
F
Y
A
--
A
Q
I
V
L
T
----
F
E
---
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
-----
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
G
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
29.16
19%
-38
- C5 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[102-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
L
G
T
G
S
-
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
----
K
---
Q
I
E
--------------------------------------
H
T
-
L
N
E
K
R
I
L
-----------
Q
A
V
--------
N
F
-
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
----
M
E
Y
V
--
P
G
G
E
M
F
S
H
L
R
R
---
I
GRFS
E
------
P
H
A
R
F
Y
A
--
A
Q
I
V
L
T
----
F
E
---
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
-----
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
G
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------