@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ADCK4_HUMAN: (2020-09-04 )
MWLKVGGLLRGTGGQLGQTVGWPCGALGPGPHRWGPCGGSWAQKFYQDGPGRGLGEEDIRRAREARPRKTPRPQLSDRSRERKVPASRISRLANFGGLAVGLGLGVLAEMAKKSMPGGRLQSEGGSGLDSSPFLSEANAERIVQTLCTVRGAALKVGQMLSIQDNSFISPQLQHIFERVRQSADFMPRWQMLRVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAVKIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQNFRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDLRNQICFQLLTLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAADGDRDCVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGPYDFGSGETARRIQDLIPVLLRHRLCPPPEETYALHRKLAGAFLACAHLRAHIACRDLFQDTYHRYWASRQPDAATAGSLPTKGDSWVDPS
Atome Classification :
(20 SA)
-.........10........20........30........-40........50........60........70.........80........90........100.-----------......110.......120.......130....-....140.......150....---...160..----.---....-----170...--....180.......190.....-----..200...----------.-...210..-...-..220.....-..-230.......240.......250.......260......-.270-------........280...-....290.......300.......310........320.......--330...--...----.------340.......350.......360---.......370..-.....380.......390.......400-.....-...-410.......420.......-430........440......-..450.....------..460.-----...-----...470--....----....480.......490.......500.....-..510.......520.......530.......540..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-M
W
L
K
V
G
G
L
L
RGTGGQLGQTVGWPCGALGPGPHRWGPC
G
G
-
S
W
A
Q
K
F
Y
QDGPGRGL
G
E
E
D
I
R
R
A
R
EARPRKT-PRPQLSD
R
S
R
ERKV
P
A
S
R
I
S
R
L
A
N
FG
G
L
A
V
G
L
G
-----------
L
G
V
L
A
E
M
A
K
KSMPGGRLQSEGGSGLDS-SPFLS-EA
N
A
E
R
I
V
Q
T
L
C
T
VRG
A
A
LKV---
G
Q
M
L
S
IQD----N---SFI
S
-----
P
Q
L
Q
H
I
--
F
E
R
V
R
Q
SADFM
P
R
W
Q
M
L
R
V
L
E
E
-----
E
LG
R
D
W
Q
A
----------
K
-
V
A
S
L
EEVP-
F
A
A
-
A
S
I
G
Q
V
H
Q
G
L
-LR-DG
T
E
V
A
V
K
I
QYPG
I
A
Q
S
I
Q
S
D
V
Q
N
L
L
A
V
L
K
M
S
AAL
P
A
G
L
-
F
A
E
--------
Q
S
L
Q
A
L
Q
Q
E
L
A
WEC-DYR
R
E
A
A
C
A
Q
N
F
R
Q
L
LANDPFFR
V
P
A
-
V
V
K
E
L
C
T
T
R
VL
G
M
ELAGG--V
P
L
D
Q
C
--
Q
G
L
----
S
------
Q
D
L
R
N
Q
I
C
F
Q
L
L
T
L
C
L
R
E
L
F
E
F
R
---FMQTDP
N
W
A
N
F
L
-YDASS
H
Q
V
T
L
L
DFGASREF
G
T
E
F
T
D
H
Y
--
I
E
V
V
K
-
A
AA-DGD
R
D
C
V
LQKSRD
L
K
F
L
TGF-E-TKAFSDAH
V
E
A
-
V
M
I
LGE-PFATQGPYDF------GS
G
E
T
A
-----
R
R
I
-----
Q
D
L
I
P
---
V
L
L
R
----HRLCPP
P
E
E
T
Y
A
L
H
R
K
L
A
G
A
F
L
A
C
A
H
L
R
A
H
I
A
-
C
R
D
L
F
Q
D
T
Y
H
R
Y
WASRQPDAATAGSLPTKGDSWVDPS
29
HHSearch
93.15
61%
-122
- C4 -
-
4PED
-
COQ8A_HUMAN
A:
[4-390]
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
---
G
Q
M
L
S
I
Q
D
----
D
---
A
F
I
N
-----
P
H
L
A
K
I
--
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-----
D
L
G
P
N
W
R
D
----------
K
-
L
E
Y
F
E
E
R
P
-
F
A
A
-
A
S
I
G
Q
V
H
L
A
R
-
M
K
-
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
-
F
P
E
--------
H
L
I
D
V
L
R
R
E
L
A
L
E
C
-
D
Y
Q
R
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
V
P
E
-
I
V
D
E
L
C
S
P
H
V
L
T
T
E
L
V
S
G
--
F
P
L
D
Q
A
--
E
G
L
----
S
------
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
R
E
L
F
E
F
H
---
F
M
Q
T
D
P
N
W
S
N
F
F
-
Y
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
L
Y
--
I
Q
I
I
R
-
A
A
A
-
D
R
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
G
Y
-
E
-
V
K
V
M
E
D
A
H
L
D
A
-
I
L
I
L
G
E
-
A
F
A
S
D
E
P
F
D
F
------
G
T
Q
S
T
T
-----
E
K
I
-----
H
N
L
I
P
---
V
M
L
R
----
H
R
L
V
P
P
P
E
E
T
Y
S
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
P
-
C
K
A
M
F
E
E
A
Y
S
N
Y
C
K
R
Q
---------------------
1
PsiBlast_PDB
92.31
60%
-123
- C4 -
-
4PED
-
COQ8A_HUMAN
A:
[4-386]
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
---
G
Q
M
L
S
I
Q
D
----
D
---
A
F
I
N
-----
P
H
L
A
K
I
--
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-----
D
L
G
P
N
W
R
D
----------
K
-
L
E
Y
F
E
E
R
P
-
F
A
A
-
A
S
I
G
Q
V
H
L
A
R
-
M
K
-
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
-
F
P
E
--------
H
L
I
D
V
L
R
R
E
L
A
L
E
C
-
D
Y
Q
R
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
V
P
E
-
I
V
D
E
L
C
S
P
H
V
L
T
T
E
L
V
S
G
--
F
P
L
D
Q
A
--
E
G
L
----
S
------
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
R
E
L
F
E
F
H
---
F
M
Q
T
D
P
N
W
S
N
F
F
-
Y
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
L
Y
--
I
Q
I
I
R
-
A
A
A
-
D
R
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
G
Y
-
E
-
V
K
V
M
E
D
A
H
L
D
A
-
I
L
I
L
G
E
-
A
F
A
S
D
E
P
F
D
F
------
G
T
Q
S
T
T
-----
E
K
I
-----
H
N
L
I
P
---
V
M
L
R
----
H
R
L
V
P
P
P
E
E
T
Y
S
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
P
-
C
K
A
M
F
E
E
A
Y
S
N
Y
-------------------------
2
PsiBlast_PDB
89.99
60%
-125
- C4 -
-
5I35
1
COQ8A_HUMAN
A:
[7-386]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
---
G
Q
M
L
S
I
Q
D
----
D
---
A
F
I
N
-----
P
H
L
A
K
I
--
F
E
R
V
R
Q
S
A
D
F
M
P
L
K
Q
M
M
K
T
L
N
N
-----
D
L
G
P
N
W
R
D
----------
K
-
L
E
Y
F
E
E
R
P
-
F
A
A
-
A
S
I
G
Q
V
H
L
A
R
-
M
K
-
G
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
P
E
G
L
-
F
P
E
--------
H
L
I
D
V
L
R
R
E
L
A
L
E
C
-
D
Y
Q
R
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
V
P
E
-
I
V
D
E
L
C
S
P
H
V
L
T
T
E
L
V
S
G
--
F
P
L
D
Q
A
--
E
G
L
----
S
------
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
R
E
L
F
E
F
H
---
F
M
Q
T
D
P
N
W
S
N
F
F
-
Y
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
L
Y
--
I
Q
I
I
R
-
A
A
A
-
D
R
D
R
E
T
V
R
A
K
S
I
E
M
K
F
L
T
G
Y
-
E
-
V
K
V
M
E
D
A
H
L
D
A
-
I
L
I
L
G
E
-
A
F
A
S
D
E
P
F
D
F
------
G
T
Q
S
T
T
-----
E
K
I
-----
H
N
L
I
P
---
V
M
L
R
----
H
R
L
V
P
P
P
E
E
T
Y
S
L
H
K
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
P
-
C
K
A
M
F
E
E
A
Y
S
N
Y
-------------------------
14
Fugue
61.44
59%
-17
- C4 -
-
4PED
-
COQ8A_HUMAN
A:
[4-390]
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
---
G
Q
M
L
S
I
Q
D
----
D
---
A
F
I
N
-----
P
H
L
A
K
I
--
F
E
R
V
R
Q
S
A
D
F
P
L
K
Q
K
M
M
-
T
L
N
N
-----
D
L
G
P
N
W
R
D
----------
K
-
L
E
Y
F
E
E
R
P
-
F
A
A
-
A
S
I
G
Q
V
H
--
L
-
A
R
-
K
G
G
R
E
V
A
K
I
Q
Y
P
G
V
A
Q
S
I
N
S
D
V
N
N
L
A
---
V
L
N
S
N
L
P
E
G
L
M
F
P
E
--------
H
L
I
D
V
L
R
R
E
L
A
L
E
C
-
D
Y
Q
R
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
V
P
E
-
I
V
D
E
L
C
S
P
H
V
L
T
T
E
L
V
S
G
--
F
P
L
D
Q
A
--
E
G
L
----
S
------
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
R
E
L
F
E
F
H
---
F
-
Q
T
D
P
N
W
S
N
F
F
-
Y
D
P
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
L
Y
--
I
Q
I
I
R
-
A
A
A
-
D
R
D
R
E
T
V
R
A
K
S
I
E
-
K
F
L
T
G
Y
-
E
-
V
K
V
-
E
D
A
H
L
D
A
-
I
L
I
L
G
E
-
A
F
A
S
D
E
P
F
D
F
------
G
T
Q
S
T
T
-----
E
K
I
-----
H
N
L
I
P
---
V
L
-
R
----
H
R
L
V
P
P
P
E
E
T
Y
S
L
H
R
K
-
G
G
S
F
L
I
C
S
K
L
K
A
R
F
P
-
C
K
A
-
F
E
E
A
Y
S
N
Y
C
K
R
Q
---------------------
31
HHSearch
57.21
23%
-10
- C4 -
-
5YK1
2
?
A:
[48-446]
-----------------------------------------------------------------------------------------------------------------------------------
S
K
--------
D
E
V
-
T
A
E
L
M
-
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
---
G
Q
A
L
S
V
M
E
--------
A
A
I
P
DEFG-
E
P
Y
R
E
A
--
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----
Q
L
G
T
K
W
R
E
----------
R
-
F
S
S
F
N
D
T
P
-
V
A
S
-
A
S
I
G
Q
V
H
K
A
I
-
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
S
P
G
A
-
D
V
Q
--------
G
V
V
D
E
L
V
E
R
T
E
M
E
L
-
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
V
P
H
-
V
V
A
--
S
A
P
K
V
V
I
Q
E
W
I
E
G
--
V
P
M
A
E
I
--
I
R
H
----
G
T-----
T
E
Q
R
D
L
I
G
T
L
L
A
E
L
T
F
D
A
P
R
R
L
G
---
L
M
H
G
D
A
H
P
G
N
F
M
-
L
L
P
-
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
P
G
G
F
P
I
E
L
--
G
M
T
I
R
-
L
A
R
-
E
K
N
Y
D
L
L
L
P
T
M
E
K
A
G
L
I
Q
R
G
R
Q
-
V
S
V
--
R
E
I
D
E
M
-
L
R
Q
Y
V
E
-
P
I
Q
V
-
E
V
F
H
Y
------
T
R
K
W
L
Q
-----
K
M
T
VSQID
R
S
V
A
Q
---
I
R
T
A
----
R
Q
M
D
L
P
A
K
L
A
I
-
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
P
-
I
K
A
L
S
E
E
L
I
P
G
F
A
E
-----------------------
32
HHSearch
56.68
23%
-9
- C4 -
-
5YK0
4
?
A:
[50-446]
---------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
-
T
A
E
L
M
-
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
---
G
Q
A
L
S
V
M
E
----
A
AIP
D
E
F
G
-----
E
P
Y
R
E
A
--
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----
Q
L
G
T
K
W
R
E
----------
R
-
F
S
S
F
N
D
T
P
-
V
A
S
-
A
S
I
G
Q
V
H
K
A
I
-
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
S
P
G
A
-
D
V
Q
--------
G
V
V
D
E
L
V
E
R
T
E
M
E
L
-
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
V
P
H
-
V
V
A
--
S
A
P
K
V
V
I
Q
E
W
I
E
G
--
V
P
M
A
E
I
--
I
R
H
----
G
T-----
T
E
Q
R
D
L
I
G
T
L
L
A
E
L
T
F
D
A
P
R
R
L
G
---
L
M
H
G
D
A
H
P
G
N
F
M
-
L
L
P
-
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
P
G
G
F
P
I
E
L
--
G
M
T
I
R
-
L
A
R
-
E
K
N
Y
D
L
L
L
P
T
M
E
K
A
G
L
I
Q
R
G
R
Q
-
V
S
V
--
R
E
I
D
E
M
-
L
R
Q
Y
V
E
-
P
I
Q
V
-
E
V
F
H
Y
------
T
R
K
W
L
Q
-----
K
M
T
VSQID
R
S
V
A
Q
---
I
R
T
A
----
R
Q
M
D
L
P
A
K
L
A
I
-
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
P
-
I
K
A
L
S
E
E
L
I
P
G
F
A
E
-----------------------
30
HHSearch
55.60
22%
-3
- C4 -
-
5YJZ
2
?
A:
[48-446]
-----------------------------------------------------------------------------------------------------------------------------------
S
K
D
--------
E
V
-
T
A
E
L
M
-
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
---
G
Q
A
L
S
V
M
E
----
A
AIP
D
E
F
G
-----
E
P
Y
R
E
A
--
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----
Q
L
G
T
K
W
R
E
----------
R
-
F
S
S
F
N
D
T
P
-
V
A
S
-
A
S
I
G
Q
V
H
K
A
I
-
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
S
P
G
A
-
D
V
Q
--------
G
V
V
D
E
L
V
E
R
T
E
M
E
L
-
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
V
P
H
-
V
V
A
--
S
A
P
K
V
V
I
Q
E
W
I
E
G
--
V
P
M
A
E
I
--
I
R
H
----
G
T-----
T
E
Q
R
D
L
I
G
T
L
L
A
E
L
T
F
D
A
P
R
R
L
G
---
L
M
H
G
D
A
H
P
G
N
F
M
-
L
L
P
-
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
P
G
G
F
P
I
E
L
--
G
M
T
I
R
-
L
A
R
-
E
K
N
Y
D
L
L
L
P
T
M
E
K
A
G
L
I
Q
R
G
-
R
Q
V
S
--
V
R
E
-
I
D
E
M
L
R
Q
Y
V
E
-
P
I
Q
V
-
E
V
F
H
Y
------
T
R
K
W
L
Q
KMTVS
Q
I
D
-----
R
S
V
A
Q
---
I
R
T
A
----
R
Q
M
D
L
P
A
K
L
A
I
-
P
M
R
V
I
A
S
V
G
A
I
L
C
Q
L
D
A
H
V
P
-
I
K
A
L
S
E
E
L
I
P
G
F
A
E
-----------------------
5
PsiBlast_PDB
44.77
28%
-9
- C4 -
-
5YK1
2
?
A:
[48-340]
-------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
E
V
-
T
A
E
L
M
-
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
---
G
Q
A
L
S
V
M
E
AAIP
D
---
E
F
G
E
-----
P
-
Y
R
E
A
--
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----
Q
L
G
T
K
W
R
E
----------
R
-
F
S
S
F
N
D
T
P
-
V
A
S
-
A
S
I
G
Q
V
H
K
A
I
-
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
S
P
G
A
-
D
V
Q
--------
G
V
V
D
E
L
V
E
R
T
E
M
E
L
-
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
V
P
H
-
V
V
A
--
S
A
P
K
V
V
I
Q
E
W
I
E
G
--
V
P
M
A
E
I
IR
H
G
T
----
T
------
E
Q
-
R
D
L
I
G
T
L
L
A
E
L
T
F
D
A
P
R
R
L
G
---
L
M
H
G
D
A
H
P
G
N
F
M
-
L
-
L
P
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
P
G
G
F
P
I
E
L
--
G
M
T
I
R
-
L
A
R
-
E
K
N
Y
D
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
44.27
28%
-11
- C4 -
-
5YK0
4
?
A:
[50-340]
---------------------------------------------------------------------------------------------------------------------------------------------
D
E
V
-
T
A
E
L
M
-
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
---
G
Q
A
L
S
V
M
E
AAIP
D
---
E
F
G
E
-----
P
-
Y
R
E
A
--
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----
Q
L
G
T
K
W
R
E
----------
R
-
F
S
S
F
N
D
T
P
-
V
A
S
-
A
S
I
G
Q
V
H
K
A
I
-
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
S
P
G
A
-
D
V
Q
--------
G
V
V
D
E
L
V
E
R
T
E
M
E
L
-
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
V
P
H
-
V
V
A
--
S
A
P
K
V
V
I
Q
E
W
I
E
G
--
V
P
M
A
E
I
IR
H
G
T
----
T
------
E
Q
-
R
D
L
I
G
T
L
L
A
E
L
T
F
D
A
P
R
R
L
G
---
L
M
H
G
D
A
H
P
G
N
F
M
-
L
-
L
P
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
P
G
G
F
P
I
E
L
--
G
M
T
I
R
-
L
A
R
-
E
K
N
Y
D
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
43.61
28%
-7
- C4 -
-
5YJZ
2
?
A:
[48-340]
-------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
E
V
-
T
A
E
L
M
-
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
---
G
Q
A
L
S
V
M
E
AAIP
D
---
E
F
G
E
-----
P
-
Y
R
E
A
--
L
T
K
L
Q
K
D
A
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----
Q
L
G
T
K
W
R
E
----------
R
-
F
S
S
F
N
D
T
P
-
V
A
S
-
A
S
I
G
Q
V
H
K
A
I
-
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
S
P
G
A
-
D
V
Q
--------
G
V
V
D
E
L
V
E
R
T
E
M
E
L
-
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
V
P
H
-
V
V
A
--
S
A
P
K
V
V
I
Q
E
W
I
E
G
--
V
P
M
A
E
I
IR
H
G
T
----
T
------
E
Q
-
R
D
L
I
G
T
L
L
A
E
L
T
F
D
A
P
R
R
L
G
---
L
M
H
G
D
A
H
P
G
N
F
M
-
L
-
L
P
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
P
G
G
F
P
I
E
L
--
G
M
T
I
R
-
L
A
R
-
E
K
N
Y
D
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
43.33
28%
-12
- C4 -
-
5YK2
1
?
A:
[48-346]
-------------------------------------------------------------------------------------------------------------------------------------------
S
K
D
E
V
-
T
A
E
L
M
-
E
K
A
A
N
Q
L
F
T
V
L
G
E
L
K
G
G
A
M
K
V
---
G
Q
A
L
S
V
M
E
AAIP
D
---
E
F
G
E
-----
P
-
Y
R
E
A
--
L
T
K
L
---
A
P
P
L
P
A
S
K
V
H
R
V
L
D
G
-----
Q
L
G
T
K
W
R
E
----------
R
-
F
S
S
F
N
D
T
P
-
V
A
S
-
A
S
I
G
Q
V
H
K
A
I
-
W
S
-
D
G
R
E
V
A
V
K
I
Q
Y
P
G
A
D
E
A
L
R
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
Q
L
S
P
G
A
-
D
V
Q
--------
G
V
V
D
E
L
V
E
R
T
E
M
E
L
-
D
Y
R
L
E
A
A
N
Q
R
A
F
A
K
A
Y
H
D
H
P
R
F
Q
V
P
H
-
V
V
A
--
S
A
P
K
V
V
I
Q
E
W
I
E
G
--
V
P
M
A
E
I
IR
H
G
T
----
T
------
E
Q
-
R
D
L
I
G
T
L
L
A
E
L
T
F
D
A
P
R
R
L
G
---
L
M
H
G
D
A
H
P
G
N
F
M
-
L
-
L
P
D
G
R
M
G
I
I
D
F
G
A
V
A
P
M
P
G
G
F
P
I
E
L
--
G
M
T
I
R
-
L
A
R
-
E
K
N
Y
D
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
40.25
17%
24
- C1 -
-
5B86
-
TNAP2_MOUSE
A:
[17-600]
D
G
P
L
P
T
V
E
E
L
K
E
A
L
E
H
G
R
L
E
V
A
W
Q
V
L
A
L
E
R
Q
L
E
A
A
A
A
A
G
G
M
S
N
E
E
L
V
W
R
Q
S
K
V
E
A
L
Y
V
L
L
C
D
Q
V
L
G
V
L
R
R
P
L
E
A
A
P
E
R
L
S
Q
A
L
A
V
V
S
Q
E
E
L
E
D
R
R
A
S
G
G
P
L
A
A
A
L
E
ATRPRRWLQRW
R
G
V
V
A
E
V
A
A
E
R
L
D
A
Q
P
G
R
S
E
A
E
S
R
F
L
H
M
G
R
--
T
M
K
E
D
L
E
V
V
V
E
R
L
K
P
L
F
P
D
E
F
N
V
---
V
R
T
Y
A
E
S
Y
----
H
---
Y
H
F
A
-----
S
H
L
C
A
L
AQ
F
E
L
C
E
R
D
T
Y
L
L
L
L
W
V
Q
N
L
Y
P
N
D
ILNSP
K
L
A
Q
E
L
Q
G
VGLGSLLPPK
Q
-
I
R
L
L
E
--
A
M
F
L
S
-
N
E
V
T
S
V
K
Q
-
L
M
A
R
-
A
L
E
L
E
S
Q
R
W
T
Q
D
V
A
P
Q
S
L
D
G
H
C
H
S
E
L
A
I
D
I
L
Q
I
I
S
Q
G
Q
T
-
K
A
E
NITSDVGM
Q
I
K
Q
L
L
L
V
E
L
A
A
L
L
R
S
Y
Q
R
A
F
D
E
F
L
E
K
S
K
L
L
R
N
---
Y
R
V
N
I
M
A
N
I
N
N
C
L
F
F
W
T
S
V
E
Q
K
W
Q
--
I
S
H
D
S
L
--
N
R
L
----
L
------
E
P
L
K
-----
D
L
K
A
H
G
F
D
T
L
L
Q
S
L
---
F
L
D
L
K
P
L
F
K
K
F
T
Q
T
R
W
A
N
P
V
E
T
L
E
E
I
I
T
T
V
S
S
S
L
P
E
F
S
E
L
--
Q
D
C
F
R
-
E
E
L
M
E
-
T
V
H
L
H
L
V
K
E
Y
I
I
R
L
C
K
R
R
-
L
-
V
L
K
T
A
E
Q
Q
Q
Q
L
-
A
R
H
I
L
A
-
N
A
D
A
I
Q
G
F
C
T
------
E
N
G
S
T
A
-----
T
W
L
-----
H
R
A
L
P
MIA
E
I
I
R
----
L
Q
D
S
S
A
I
K
I
E
V
A
T
Y
A
T
W
Y
P
D
F
-
S
K
G
H
L
N
A
I
L
A
-
I
K
G
N
L
P
S
S
E
V
R
S
I
R
N
I
L
D
I
N
T
G
V
Q
E
P
P
R
P
L
F
S
L
I
K
V
T
19
Fugue
35.47
16%
-105
* C5 *
-
4CZB
-
NAH1_METJA
A:
[1-415]
-
M
E
L
M
M
A
I
G
Y
L
G
L
A
L
V
L
G
S
L
V
A
K
I
A
E
K
L
K
I
----------------------------
P
D
I
P
L
L
L
L
L
G
L
I
I
G
-
P
F
L
Q
I
--------
I
P
S
D
S
A
M
E
I
F
E
Y
A
G
-
P
I
G
L
I
-----------
F
I
L
L
G
G
A
F
T
M
R
I
S
L
L
K
R
V
I
K
T
V
V
R
L
D
T
-
I
T
F
L
I
-
T
L
L
I
S
G
F
I
F
N
M
V
L
N
L
P
Y
T
S
P
V
---
G
Y
L
F
G
A
I
T
----
A
---
A
T
D
P
-----
A
T
L
I
P
V
--
F
S
R
V
R
T
N
--------------
P
-----
E
V
A
I
T
L
E
A
----------
E
-
S
I
F
N
D
P
L
G
-
I
V
S
-
T
S
V
I
L
G
L
F
G
L
-
F
S
-------------------
S
S
N
P
L
I
D
L
I
T
L
A
G
G
A
I
V
V
G
L
L
-
L
A
K
--------
I
Y
E
K
I
I
I
H
-----
C
-
D
F
H
----------------------
E
-
Y
V
A
P
L
V
L
G
G
A
M
L
L
L
Y
V
G
D
--
D
L
L
P
S
I
--
C
G
Y
----
G
--------
F
S
G
Y
M
A
V
A
I
M
G
L
Y
L
G
D
A
L
F
R
A
---
D
D
I
D
Y
K
Y
I
V
S
F
C
-
D
D
L
S
L
L
A
R
V
F
I
F
V
F
L
G
A
C
I
K
L
S
M
L
E
N
Y
--
F
I
P
G
L
-
L
V
A
-
L
G
S
I
F
----
L
A
R
P
L
G
V
F
L
G
L
-
I
-
G
S
K
H
S
--
F
K
E
K
-
L
Y
F
A
L
E
------
G
P
R
--------
G
V
V
P
A
A
-----
L
A
V
-----
T
V
G
I
E
---
I
L
K
N
----
A
D
K
I
P
A
S
I
T
K
Y
I
T
P
T
D
I
A
G
T
I
I
I
G
T
F
M
T
I
L
L
S
-
V
--
I
L
E
A
S
W
A
G
M
L
A
L
K
L
L
G
E
-----------------
20
Fugue
32.54
13%
-78
- C4 -
-
3DZO
-
?
A:
[13-382]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
G
----
F
---
R
G
T
D
-----
P
G
D
V
V
I
--
E
E
L
F
N
R
I
P
Q
A
N
V
R
T
T
S
E
Y
A
A
D
S
-----
L
V
S
T
S
L
W
N
----------
T
-
G
Q
P
F
R
V
E
S
-
E
L
G
-
E
R
P
R
T
L
V
R
G
T
-
V
L
--
G
Q
E
D
P
Y
A
Y
L
---
E
A
T
D
Q
E
T
G
E
S
F
E
V
H
V
P
Y
F
T
E
R
A
I
K
Q
M
-
K
E
E
--------
V
L
R
L
R
L
L
R
G
I
K
N
Q
K
-
Q
A
K
V
H
L
R
F
I
F
P
F
D
L
V
K
D
P
Q
V
L
S
R
F
F
L
-
Y
P
R
M
Q
S
N
L
Q
T
F
G
E
V
L
L
S
H
--
S
S
T
H
----
K
S
L
----
V
------
H
H
A
R
L
Q
L
T
L
Q
V
I
-
R
L
L
A
S
L
H
H
Y
G
---
L
V
H
T
Y
L
R
P
V
D
I
V
-
L
D
Q
R
G
G
-
V
F
L
T
G
F
E
H
L
V
R
D
G
-
A
S
A
V
S
P
--
I
G
R
G
F
-
A
P
P
-
E
T
T
A
E
R
M
L
P
F
G
Q
H
H
P
T
L
M
T
F
-
A
-
F
D
T
W
T
L
G
L
A
I
Y
-
W
I
W
C
A
D
L
P
N
T
D
D
A
A
L
G
G
SEWIFR
S
C
K
N
I
P
-----
Q
P
V
-----
R
A
L
L
E
---
G
F
L
R
YPKE
D
R
L
L
P
L
Q
A
M
E
T
P
E
Y
E
Q
L
R
T
E
L
S
A
A
L
P
L
Y
Q
-----------------------------------------
17
Fugue
30.54
18%
26
- C4 -
-
3CD3
3
A:
[1-376]
------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
-
Q
L
W
Y
H
-
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
ESQ
E
Y
V
L
S
V
P
R
----
H
---
F
I
I
N
LYRLF
P
S
I
P
L
L
--
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
-----
D
---
K
W
V
L
----------
N
-
H
E
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
R
A
D
N
T
L
V
A
V
K
S
C
R
P
D
L
K
A
K
--------------------------------------------------
F
L
Q
E
A
R
I
L
K
Q
Y
S
----
H
P
N
I
V
R
L
I
G
-
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
--
D
F
L
T
F
L
--
R
T
E
----
G
------
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
SKC
C
I
H
R
D
L
A
A
R
N
C
L
-
V
T
-
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
----------
V
A
-
A
S
G
-
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
-
S
---
S
E
S
D
V
W
S
F
G
-
I
L
L
W
E
T
-
F
S
L
G
A
S
P
Y
P
N
------
L
S
N
Q
Q
T
-----
R
E
F
-----
V
E
K
--------
G
----
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-------------------------
38
HHSearch
29.55
15%
-66
- C4 -
-
5H0B
1
HCK_HUMAN
A:
[121-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
---
R
S
T
F
S
T
L
Q
--------
E
L
V
D
-----
H
Y
K
K
G
N
--
D
G
L
C
Q
K
L
S
V
P
C
M
S
S
K
P
Q
K
P
W
E
K
-----
D
A
W
E
I
P
R
E
----------
S
-
L
K
L
E
--
K
K
-
L
G
A
-
G
Q
F
G
E
V
W
M
A
T
-
Y
N
-
K
H
T
K
V
A
V
K
T
M
K
P
G
S
M
S
-----------------------------------------------
V
E
-
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
----
D
K
L
V
K
L
H
A
-
V
V
--
T
K
E
P
I
Y
I
I
T
E
F
M
A
K
--
G
S
L
L
D
F
--
L
K
S
----
D
EGSKQP
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
-
M
A
F
I
E
Q
R
N
---
Y
I
H
R
D
L
R
A
A
N
I
L
-
V
S
A
-
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
27.89
7%
-25
- C4 -
-
2QG7
-
?
A:
[50-458]
--------------------------------------------
Y
P
I
T
E
S
N
L
R
I
L
E
G
E
D
R
S
E
K
A
K
E
L
L
K
K
Y
V
-
S
N
V
F
E
N
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
K
D
L
V
N
P
N
E
V
D
S
-----------
L
E
F
Q
I
I
-----------------
N
G
T
N
-
I
L
I
K
V
-
K
D
M
S
K
Q
--------
A
K
Y
L
I
R
L
---
Y
G
P
T
D
E
I
I
----
N
---
R
E
R
E
-----
K
K
I
S
C
I
--
L
Y
N
K
N
I
A
K
K
I
Y
V
F
F
T
N
G
R
I
E
E
F
-----
M
D
G
Y
A
L
S
R
----------
E
D
I
K
N
P
K
F
Q
K
-
L
I
A
-
K
N
L
K
L
L
H
D
I
K
-
L
N
-
E
N
L
Y
K
E
L
Q
V
T
Q
K
V
P
G
T
R
P
S
F
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
E
R
K
K
I
-
C
S
F
--------
D
A
K
A
N
I
L
K
L
I
-----
D
F
D
V
L
R
D
S
I
V
E
V
E
S
L
C
K
R
E
N
S
--------------------------------------------------------------------
P
I
V
---
L
C
H
C
D
L
L
S
S
N
I
I
-
N
T
V
G
E
G
D
S
I
S
F
---------------------------------------------
I
D
F
-
E
-
Y
S
C
P
M
E
R
A
Y
D
I
-
A
N
H
F
N
E
-
Y
A
G
F
N
C
D
W
D
L
------
T
P
--
S
K
-----
E
E
E
-----
Y
H
F
I
M
---
H
Y
L
G
----
T
---
D
D
E
E
L
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
-
L
L
Q
G
M
H
S
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
-------
7
PsiBlast_PDB
27.85
34%
-194
- C4 -
-
1VZO
-
KS6A5_HUMAN
A:
[162-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
Y
V
G
E
I
V
L
A
L
E
H
L
H
K
L
G
---
I
I
Y
R
D
I
K
L
E
N
I
L
-
L
D
S
N
G
H
-
V
V
L
T
D
F
G
L
S
K
E
F
V
A
D
E
T
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
27.66
17%
-34
- C4 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[101-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
T
-
L
G
T
-
G
S
F
G
R
V
M
L
V
K
-
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
K
Q
----
I
---------------------------------------
E
-
H
T
L
N
E
K
R
I
L
Q
A
V
-----
N
F
P
F
L
V
K
L
E
-
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
--
G
E
M
F
S
H
--
L
R
R
IGRF
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
-
F
E
Y
L
H
S
L
D
---
L
I
Y
R
D
L
K
P
E
N
L
L
-
I
D
Q
-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
27.66
16%
-23
- C4 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
-----
S
V
S
S
G
Q
A
H
----------
S
-
L
T
S
L
A
K
T
W
-
A
A
R
-
G
S
R
S
R
E
P
S
P
K
-
T
E
-
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
-
H
R
M
--------
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
-
R
L
E
V
F
R
A
E
E
L
M
A
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-
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SL
G
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--
Q
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----
L
------
P
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D
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Y
Y
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Q
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G
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R
---
I
L
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K
A
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-
L
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P
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--------------
P
-----
P
S
C
-----
A
P
L
T
A
---
Q
A
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Q
----
E
G
L
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I
-----
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--
G
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P
-------------------