@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ALPK1_HUMAN: (2020-09-04 )
MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20-.........30........40........50........60........70......--..80.-------.......90...-------.....100.......-110.......-120......-.130.-.....---------.140.......150......-.160.......170.......180.......190.....----..200.......210..------.....220.......230.......240..-------...----..250.......260.......270--..---.....280.......290.......300.......310.......320.......330.......340.......350....-...360.......370.......380.......390.........--------------400...-....410.......420.......430.......440..--.....450.......460.......470----......---.480.......490.......500.-......510.....------....520..--..-...530....-...540.......550.......560........570.......580........590.......600.......610.......620...--------....630-.....------------.-.640.......650.......660.......670.......680.......690....-...700.........710.......720.......730.......740.......750.......760..-.....770....---...780-----...------......790.......800.......810.......820.......830.......840.......850---.......860.......870.......880.......890.....--..900.......910.......920.......930.......940.......950.......960........970.......980.......990.......1000.....-------.1010......-1020......1030..-.--...1040......--1050....---------------------------------.----.1060-.......1070------------..------------....1080..----------------.---...1090......1100--......1110......------------1120---------.-.-----.......1130--.....------..1140..-...-------------.1150.-----......1160......1170......1180......1190--........1200-----....------.-------..1210......1220......1230......-1240.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------MN
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
LEAPDVSEEDK
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
EMKWPFVPEKW
Q
Y
KQAVGPEDK--T
N
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y-GLDVS
G
K
L
L
-
Q
V
A
K
G
-
L
H
KLQ---------PATPI
A
P
Q
V
V
I
R
Q
A
R
I
SVNS-G
K
L
L
K
A
E
Y
I
L
S
S
L
I
SNNGA
T
G
T
W
L
Y
RNES
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
LALPQPDKKG
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----SMSKN
D
Y
E
K
FKNNPQ
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
SAYT
P
L
F
V
L
T
A
VNI
R
G
T
C
L
L
S
YSSSNDC
P
P
E
LKNLHLCEA
K
E
A
F
E
I
G
L
L
TKRDDEPVT
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
LHGETG
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
LY--NFSTSSRS
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
VQSFSNVDDRSYVP
E
S
F
E
C
R
L
D
K
L
--
I
LHGQG
D
F
Q
K
I
L
D
T
Y
S
Q
H
H
T
S
V
C
E
V
F
E
S
----DCGNNK---N
E
Q
K
DAKT
G
V
C
I
T
A
L
K
T
E
I
KNIDTV-STTQEKP--HCQRD------TGI
S
S
S
L
M
G
--
K
N
-
V
Q
R
E
L
R
RGGR-RNWTHS
D
A
F
R
V
SLDQDVETETEPSD-YSNGEG
A
V
F
NKSLSGSQTS-
S
A
WSNLSGFSSSASW
E
E
V
N
Y
HVDDRSARKEPGKEHLVD
T
Q
C
S
T
A
L
--------
S
E
E
L
END-RE
G
R
A
------------
M
-
H
S
L
H
S
Q
L
H
DLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTP
G
I
F
LAPGAGLLEGA
P
E
-
G
I
Q
E
--
V
R
NMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSV
Q
K
E
E
A
F
E
I
I
V
EFPETNCDVKDRQGKE-Q
G
E
E
I
S
E
RGAGP---TFKA-------SPS------WVDPEGETAESTEDAP
L
D
F
H
R
V
L
H
NSLGN
I
S
MLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVD---EEGQ
L
L
DSMDVPCTNGHGS
H
R
L
C
I
L
RQPPGQRAETPNSSVSG
N
I
L
--
F
P
VLSEDCTTTEEGNQPG
N
M
L
NCSQNSSSS
S
V
W
W
LKSPAFSSGSSEGDS
P
W
S
Y
LNSSGSSWVS-L
P
G
K
M
R
K
E
I
L
E
ARTLQ
P
D
D
F
E
K
L
L
A
G
V
R
H
D
W
L
F
Q
R
L
E
NTGVF
K
P
S
Q
L
H
-------
R
A
H
S
A
L
L
L
K
YS-KKSELWTAQ
E
T
I
V
Y
LG-
D
--
Y
L
T
V
KKKGRQRN
A
--
F
W
V
H
HL
H
Q
---------------------------------
E
----
E
I
L
G
--
R
Y
VGK
D
Y
K
E
QK------------GL------------
W
H
H
F
T
D
V
E
R
Q
----------------
M
---
T
A
Q
H
Y
V
T
E
F
N
K
R
L
Y
EQN--IP
T
Q
I
F
Y
IP
S
T
I
L
L
I
L
------------E------------D-K-----TI
K
G
C
ISV
E
P
---
Y
I
L
G
E
------
F
V
KLSNN
T
-
K
V
V
-------------
K
T
-EYK-----ATEYG
L
A
Y
G
H
F
S
Y
EFSNH
R
D
V
V
V
D
L
Q
G
W
V
TGNG
K
G
L
I
Y
----LTDPQIHSV
D
Q
------
K
V
FT------T-------NFGK
R
G
I
F
Y
F
FNNQHV
E
C
N
E
I
C
H
R
LSLTRPSM-EKPCT
26
Blastp_CBE
96.08
100%
-123
- C3 -
-
5Z2C
1
ALPK1_HUMAN
B:
[2-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
Y
K
Q
A
V
G
P
E
D
K
--
T
N
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
R
D
D
E
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
95.29
100%
-119
- C3 -
-
5Z2C
1
ALPK1_HUMAN
A:
[2-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
Y
K
Q
A
V
G
P
E
D
K
--
T
N
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
R
D
D
E
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.29
100%
-119
- C3 -
-
5Z2C
1
ALPK1_HUMAN
A:
[2-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
Y
K
Q
A
V
G
P
E
D
K
--
T
N
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
R
D
D
E
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
94.89
100%
-129
- C3 -
-
5Z2C
1
ALPK1_HUMAN
F:
[2-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
Y
-------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
R
D
D
E
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
94.83
100%
-128
- C3 -
-
5Z2C
1
ALPK1_HUMAN
E:
[2-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
-
W
Q
Y
-------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
R
D
D
E
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
94.46
100%
-133
- C3 -
-
5Z2C
1
ALPK1_HUMAN
G:
[2-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
-----------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
R
-
D
E
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
94.27
100%
-127
- C3 -
-
5Z2C
1
ALPK1_HUMAN
D:
[2-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
Y
K
------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
R
-
D
E
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
V
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
93.04
100%
-129
- C3 -
-
5Z2C
1
ALPK1_HUMAN
C:
[2-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
--------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
----
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
-
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
93.04
100%
-129
- C3 -
-
5Z2C
1
ALPK1_HUMAN
C:
[2-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
--------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
----
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
-
D
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Blastp_CBE
92.78
100%
-136
- C3 -
-
5Z2C
1
ALPK1_HUMAN
H:
[2-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
-----------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
E
L
K
N
L
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
----
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
Q
V
Q
S
F
S
N
--
D
R
S
Y
V
P
E
S
F
E
C
R
L
D
K
L
--
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Blastp_CBE
91.04
100%
-134
- C3 -
-
5Z2C
1
ALPK1_HUMAN
I:
[2-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
Q
K
V
V
A
V
L
L
Q
E
C
K
Q
V
L
D
Q
--
L
L
L
E
A
P
D
V
S
E
E
D
K
S
E
D
Q
R
C
R
A
L
L
P
S
E
L
R
T
L
I
Q
E
A
K
E
M
K
W
P
F
V
P
E
K
W
Q
--------------
L
K
D
-------
V
I
G
A
G
L
Q
Q
L
L
A
S
-------
L
R
A
S
I
L
A
R
D
C
A
A
A
A
A
-
I
V
F
L
V
D
R
F
L
Y
-
G
L
D
V
S
G
K
L
L
-
Q
V
A
K
G
-
L
H
K
L
Q
---------
P
A
T
P
I
A
P
Q
V
V
I
R
Q
A
R
I
S
V
N
S
-
G
K
L
L
K
A
E
Y
I
L
S
S
L
I
S
N
N
G
A
T
G
T
W
L
Y
R
N
E
S
D
K
V
L
V
Q
S
V
C
I
----
Q
I
R
G
Q
I
L
Q
K
L
G
M
W
Y
E
A
A
------
E
L
I
W
A
S
I
V
G
Y
L
A
L
P
Q
P
D
K
K
G
L
S
T
S
L
G
I
L
A
D
-------
I
F
V
----
S
M
S
K
N
D
Y
E
K
F
K
N
N
P
Q
I
N
L
S
L
L
K
E
F
D
--
H
H
---
L
L
S
A
A
E
A
C
K
L
A
A
A
F
S
A
Y
T
P
L
F
V
L
T
A
V
N
I
R
G
T
C
L
L
S
Y
S
S
S
N
D
C
P
P
-----
H
L
C
E
A
K
E
A
F
E
I
G
L
L
T
K
----
P
V
T
G
K
Q
E
L
H
S
F
V
K
-
A
A
F
G
L
T
T
V
H
R
R
L
H
G
E
T
G
T
V
H
A
A
S
Q
L
C
K
E
A
M
G
K
L
Y
--
N
F
S
T
S
S
R
S
Q
--------------
D
R
E
A
L
S
-
Q
E
V
M
S
V
I
A
Q
V
K
E
H
L
--------
D
D
R
S
Y
V
P
E
S
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Fugue
52.68
16%
31
- C2 -
-
5U1T
-
ESP1_YEAST
A:
[39-1595]
NNIDLAIEDITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWNDYYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQ
Y
I
K
Q
F
K
L
P
F
K
K
F
I
T
V
E
C
F
S
K
--
N
L
L
H
K
N
Y
L
E
M
G
P
N
K
I
Y
L
N
S
F
Y
L
S
Y
S
M
L
Y
D
G
L
D
K
I
M
L
L
D
I
L
S
Y
E
E
T
T
E
V
Q
R
A
I
K
S
K
E
Y
--
C
N
M
S
E
NRLLWSC
I
S
V
D
D
L
N
V
I
L
E
N
-------
A
T
N
F
L
Q
N
H
I
S
A
T
L
K
C
-
L
V
C
L
W
S
T
I
R
L
E
G
L
P
K
N
K
D
I
L
R
Q
F
D
C
T
-
V
I
Y
I
N
SNIKSINDE
S
A
A
A
L
L
S
E
L
L
G
V
L
S
E
I
C
I
D
Y
-
K
E
P
K
R
L
S
N
I
I
S
V
L
F
N
A
S
V
L
F
K
S
H
S
F
L
L
K
T
A
N
L
E
I
S
N
V
L
I
SNDS
K
T
S
H
R
T
I
L
K
F
E
K
F
I
S
S
A
QSAQKK
I
E
I
F
S
C
L
F
N
V
Y
C
M
L
R
N
D
T
--
L
S
F
V
F
D
F
C
Q
N
-------
A
F
I
HCFT
R
L
K
I
T
K
F
I
E
F
S
N
S
S
E
I
M
L
S
V
L
Y
G
N
S
SI
E
N
---
I
P
S
E
N
W
S
Q
L
S
R
M
I
F
C
S
L
R
G
I
F
D
L
D
P
L
E
L
N
N
T
--------------
F
D
K
L
H
L
L
N
K
Y
E
L
L
I
R
I
V
Y
L
L
N
L
D
M
S
K
H
L
T
T
N
L
S
K
I
T
K
-
L
Y
I
N
K
W
L
Q
K
S
D
E
K
A
E
R
I
S
-
S
F
E
M
D
F
V
K
M
L
L
C
Y
L
N
FN
N
F
-----------------------
D
K
L
S
-
I
E
L
S
L
C
I
K
S
K
E
K
Y
Y
S
--
S
I
V
P
Y
A
D
N
Y
L
L
E
A
Y
L
S
L
Y
M
I
D
D
--
A
L
M
M
K
N
Q
L
Q
K
T
M
N
L
S
T
A
K
I
E
Q
A
L
L
H
A
S
S
LINV
H
L
W
D
S
D
---
L
T
A
F
Q
I
Y
F
G
K
T
L
P
A
M
K
P
E
L
F
D
I
N
N
----
D
H
N
L
P
--
M
S
L
Y
I
------
K
V
I
L
L
N
I
K
I
--
F
N
-
E
S
A
K
L
N
I
K
A
G
-
N
V
I
S
A
V
I
D
C
R
K
A
Q
N
L
A
L
S
L
L
K
K
K
N
K
-
L
S
Q
G
S
R
L
A
L
L
K
S
L
S
F
S
F
F
Q
-
L
I
K
I
H
I
R
----
I
G
S
A
R
D
C
E
F
Y
S
K
E
L
S
R
I
I
S
D
L
E
E
P
I
I
V
Y
R
C
L
H
F
L
HRYYMITE
Q
T
C
L
Q
N
I
-
T
L
G
K
A
NKAFDYLDAEAD
I
-
T
S
L
T
M
F
L
Y
D
N
K
E
F
V
K
L
E
Q
S
L
V
L
Y
F
G
D
Q
L
E
K
T
F
L
P
N
L
W
K
L
H
-
L
G
K
D
I
D
D
S
I
C
L
S
E
Y
M
P
K
N
V
I
N
R
--
V
H
N
M
W
Q
K
V
M
S
Q
L
E
E
D
P
F
F
K
G
M
F
E
S
T
L
G
I
P
---
S
S
L
P
V
I
Q
K
F
D
R
I
A
A
I
S
K
L
K
Q
M
K
E
L
L
E
S
L
K
L
D
T
L
D
N
H
E
L
S
K
I
S
S
L
S
---
S
L
T
L
TILSNIT
S
I
H
------
N
A
E
S
S
L
I
T
N
F
S
L
T
D
L
P
R
H
M
P
L
L
F
D
K
V
L
N
N
I
D
N
K
N
Y
R
E
F
N
I
S
T
I
T
E
S
I
R
V
S
A
A
Q
K
D
L
M
E
S
N
L
N
I
N
V
I
T
I
D
FCP
I
T
G
N
L
L
L
S
K
L
E
P
R
-----
R
K
R
R
T
H
L
R
L
P
L
H
-----
L
S
F
P
E
A
T
K
K
L
--
L
S
I
I
N
E
S
N
Q
T
T
S
V
E
V
T
-----
N
K
I
K
T
R
E
E
R
K
S
W
W
T
T
R
Y
D
L
D
K
R
M
Q
Q
------
L
L
N
N
I
E
N
S
W
F
N
G
V
Q
G
F
F
S
P
E
V
V
D
N
S
L
F
E
--
K
F
K
D
K
F
Y
E
I
L
H
Q
N
L
P
S
R
K
L
Y
G
N
P
A
M
F
I
K
V
E
-------
D
W
V
I
E
L
F
L
K
L
N
P
Q
E
I
D
F
L
S
K
M
E
D
L
I
Y
F
V
L
D
--
I
L
L
F
H
G
E
E
N
A
Y
D
E
ID
F
S
M
L
H
V
Q
L
---------------------------------
E
----
E
Q
I
K
--
K
Y
R
A
T
--
M
T
T
N
------------
S
I
------------
F
H
T
F
L
V
V
S
S
S
CHLFPWECLSFLKDLS
I
---
T
R
V
P
S
Y
V
C
L
N
K
L
L
S
R
F
H
YQ
L
P
L
Q
V
T
-
I
E
D
N
I
S
M
I
L
------------
N
PNGDLSRTESKF
K
-
G
-----
M
F
Q
K
I
I
D
A
K
P
SSQ
L
V
M
N
E
KPEEET
L
L
K
M
L
Q
N
S
-
N
L
F
VYIGHGGGEQYVR
S
K
-
E
I
K
KCTKI
A
P
S
F
L
L
G
C
S
S
A
A
M
K
Y
Y
G
K
L
E
P
T
G
T
I
Y
T
Y
L
L
G
G
C
P
M
V
L
G
NLWD
V
T
D
K
D
I
D
K
F
S
E
------
E
L
F
E
------
K
MGFRCNT
N
G
N
S
L
S
V
S
Y
A
V
S
K
S
R
G
V
C
H
--
L
R
Y
L
N
G
A
A
P
V
I
Y
G
L
P
I
K
81
Fugue
48.97
14%
69
- C1 -
-
5ID6
-
?
A:
[1-1228]
---------------------------------------------------------------------------------------------------------------------------------------------------AASKLEKFTNCYSL
S
K
T
L
R
F
K
A
I
P
V
G
K
T
Q
E
N
I
D
N
KR
L
L
V
E
D
E
K
R
A
E
D
Y
K
G
V
K
K
L
L
D
R
Y
Y
L
S
F
I
N
D
V
L
H
S
I
K
L
K
N
L
N
N
Y
I
S
L
F
R
K
K
T
R
T
E
K
E
N
K
EL
E
N
L
E
I
-------
N
L
R
K
E
I
A
K
A
F
K
G
AAGYKSL
F
K
K
D
I
I
E
T
I
L
P
E
A
A
K
D
E
I
A
L
V
N
S
F
N
G
-
F
T
T
A
F
T
G
F
F
-
D
N
R
E
N
M
F
S
E
E
A
---------
K
S
T
S
I
A
F
R
C
I
N
E
N
L
T
R
Y
I
S
N
M
D
I
F
E
K
V
D
A
I
F
D
K
H
E
V
Q
E
I
K
E
K
I
L
N
S
D
Y
D
V
E
D
F
F
------------
E
G
E
F
F
N
F
V
-
L
T
Q
E
G
I
------
D
V
Y
N
A
I
I
G
G
F
V
T
E
S
G
E
K
I
K
G
L
N
E
Y
I
N
L
Y
N
A
KTKQALP
K
F
K
----
P
L
Y
K
Q
V
-
E
G
Y
T
S
D
E
E
V
L
E
V
F
R
N
T
L
N
--
K
N
SEI
F
S
S
I
K
K
L
E
K
L
F
K
N
F
D
E
Y
S
S
----
A
G
I
F
V
K
N
G
P
A
I
S
-
T
I
S
K
D
I
F
G
E
W
N
L
I
R
D
K
W
N
A
E
Y
D
D
I
H
L
K
K
K
A
V
V
T
E
K
Y
E
D
D
R
R
K
S
F
K
K
I
G
S
F
S
L
E
Q
L
Q
E
Y
A
D
A
D
L
S
V
V
E
K
L
K
E
I
I
I
Q
K
V
D
E
I
Y
--
K
V
Y
G
S
S
E
K
L
FDADFVLEKSLKKN
D
A
V
V
A
I
M
K
D
L
L
D
S
V
K
S
F
E
N
Y
I
K
--
A
F
F
G
E
G
K
E
T
N
R
D
E
S
F
Y
G
D
F
V
L
A
YD
I
L
L
K
V
D
H
I
Y
D
A
I
R
N
Y
V
T
Q
K
P
Y
S
K
D
K
F
K
L
----
Y
F
Q
N
P
Q
FMG
G
W
D
K
D
K
E
T
D
Y
R
A
T
I
L
R
Y
G
S
K
Y
Y
L
A
I
M
D
K
K
Y
A
K
C
LQ
K
I
D
K
D
DVNGNY
E
K
I
N
Y
K
L
L
P
GP
N
K
M
L
P
K
V
F
F
S
K
K
W
M
A
Y
Y
N
P
S
E
D
I
Q
K
I
Y
K
N
G
---
T
F
K
K
G
D
M
F
N
L
N
D
C
H
K
L
I
D
F
F
K
D
S
I
S
R
Y
P
K
W
S
N
A
Y
D
F
N
F
S
E
T
E
K
-----
Y
K
D
I
A
G
F
Y
R
E
V
E
E
Q
G
Y
K
V
S
F
E
S
A
S
--------
K
K
E
V
D
K
L
V
E
E
G
K
L
------------
Y
M
F
Q
I
Y
N
--
K
D
F
S
D
K
S
H
G
T
P
N
L
H
T
M
-------
Y
F
K
L
L
F
D
E
N
N
H
G
Q
I
R
L
S
G
G
A
E
L
F
R
R
A
S
L
-
K
K
E
E
LV
V
H
P
A
N
S
P
I
A
N
K
N
P
D
N
P
K
K
T
T
T
L
S
Y
D
V
Y
K
D
K
R
F
S
-------
E
D
Q
Y
E
L
H
I
P
I
A
I
N
K
C
P
K
N
I
F
K
I
N
T
-
E
V
R
V
L
L
K
H
D
D
N
P
YVI
G
I
D
R
-------
G
E
R
NLLYIV
V
V
D
G
K
G
N
I
V
E
Q
Y
S
-----
L
N
E
I
I
N
N
F
N
G
---
I
R
I
K
T
D
Y
H
S
L
L
D
K
K
E
K
E
R
F
E
A
R
-----
Q
N
W
T
S
I
E
N
I
K
E
---
L
K
A
G
Y
I
S
Q
V
V
H
K
I
C
E
L
V
E
K
Y
D
A
V
I
A
L
E
D
L
N
S
G
F
K
N
S
R
V
K
V
E
K
Q
V
Y
QK
F
E
K
L
I
D
K
L
N
Y
V
D
K
K
S
N
P
C
A
------
T
G
G
A
L
K
G
Y
Q
I
T
N
K
F
E
S
F
K
S
S
T
Q
N
G
F
I
F
Y
I
P
A
W
L
T
S
K
I
D
--
P
S
T
G
F
V
N
L
L
K
T
K
Y
T
S
I
A
D
S
K
K
F
I
S
S
F
D
R
I
Y
V
----
P
E
E
D
L
F
E
F
A
L
D
Y
-------
K
N
F
S
R
T
D
A
D
Y
I
-
K
K
W
K
L
Y
S
--------------------
Y
G
N
R
I
R
--
I
F
A
A
A
A
W
E
---------------------------------
E
----
V
C
L
T
--
S
A
Y
K
E
L
F
N
K
Y
-------------
G
I
------------
N
Y
Q
Q
G
D
I
R
A
L
----------------
L
CEQ
S
D
K
A
F
Y
S
S
F
A
L
S
L
L
Q
R
N
--
S
I
T
G
---------------------------------------------------
R
T
D
V
---
D
F
L
I
S
------
P
V
K
N
S
D
----------------------------------
G
I
F
Y
D
S
R
N
Y
E
A
Q
E
N
A
I
L
P
K
N
------
A
D
A
N
G
A
Y
N
----
I
A
R
K
V
L
W
A
I
G
Q
FK----
K
A
E
D
------
E
-------
K
L
D
K
V
K
I
-------
A
I
S
N
K
E
W
L
E
Y
A
Q
T
S
V
K
--------
57
HHSearch
40.85
26%
-50
- C3 -
-
4KUJ
-
?
B:
[42-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
-
Q
R
I
N
Q
F
L
F
Q
H
S
T
F
R
V
E
-
L
--
A
P
F
--
A
K
G
G
E
R
L
A
--
F
R
A
I
N
G
R
-----------------------------------------
G
D
--
R
I
V
L
K
R
F
F
Q
Q
R
------------
P
L
------------
T
M
L
L
E
T
I
E
R
Q
----------------
L
---
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
-----
P
N
K
L
H
F
L
P
N
Y
L
F
I
P
S
PTKDLDGKILTL
E
------------
Q
T
E
QAVAA
T
C
R
T
P
N
F
V
E
P
---
Y
L
S
G
Y
------
F
I
K
Y
I
D
N
N
-
G
W
I
-------------
N
E
--
S
E
-----
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
N
---
N
K
F
Y
----
L
T
D
P
A
L
H
H
I
D
Q
NKF---
I
Y
S
E
------
T
-------
N
L
G
E
V
G
I
S
Q
F
F
R
T
--
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
-
Q
----
56
HHSearch
40.39
26%
-51
- C3 -
-
4NL0
-
?
B:
[42-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
-
Q
R
I
N
Q
F
L
F
Q
H
S
T
F
R
V
E
-
L
--
A
P
F
--
A
K
G
G
E
R
L
A
--
F
R
A
I
N
G
R
-----------------------------------------
G
D
--
R
I
V
L
K
R
F
F
Q
Q
R
------------
P
L
------------
T
M
L
L
E
T
I
E
R
Q
----------------
L
---
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
-----
P
N
K
L
H
F
L
P
N
Y
L
F
I
P
S
PTKDLDGKILTL
E
------------
Q
T
E
QAVAA
T
C
R
T
P
N
F
V
E
P
---
Y
L
S
G
Y
------
F
I
K
Y
I
D
N
N
-
G
W
I
-------------
N
E
--
S
E
-----
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
N
---
N
K
F
Y
----
L
T
D
P
A
L
H
H
I
D
Q
NKF---
I
Y
S
E
------
T
-------
N
L
G
E
V
G
I
S
Q
F
F
R
T
--
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
-
Q
----
55
HHSearch
40.35
23%
22
- C3 -
-
1IAH
2
TRPM7_MOUSE
A:
[3-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
-
R
L
S
Q
S
I
P
F
V
P
V
P
P
R
GEPVTVY
R
L
E
E
S
S
P
S
I
L
N
-
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
-
F
LS
K
----
M
G
G
G
L
R
R
A
--
V
K
V
L
C
T
W
S
---------------------------------
E
HDIL
K
S
G
H
--
L
Y
I
I
K
S
F
L
P
E
V
INTWSSIYKEDT
V
L
------------
H
L
C
L
R
E
I
Q
Q
Q
----------------
R
---
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
--
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
----------------------------
H
-----
S
A
G
Q
W
F
A
V
E
E
---
C
M
T
G
E
------
F
R
K
Y
N
N
N
N
-
G
D
E
-------------
I
I
P
T
N
T
-----
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
-------
E
N
----
L
T
D
P
S
V
I
K
A
E
E
KRSCDM
V
F
G
P
------
A
-------
N
L
G
E
D
A
I
K
N
F
R
A
K
--
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
-
N
D
---
53
HHSearch
40.16
23%
23
- C3 -
-
1IA9
2
TRPM7_MOUSE
A:
[3-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
-
R
L
S
Q
S
I
P
F
V
P
V
P
P
R
GEPVTVY
R
L
E
E
S
S
P
S
I
L
N
-
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
-
F
LS
K
----
M
G
G
G
L
R
R
A
--
V
K
V
L
C
T
W
S
---------------------------------
E
HDIL
K
S
G
H
--
L
Y
I
I
K
S
F
L
P
E
V
INTWSSIYKEDT
V
L
------------
H
L
C
L
R
E
I
Q
Q
Q
----------------
R
---
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
--
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
----------------------------
H
-----
S
A
G
Q
W
F
A
V
E
E
---
C
M
T
G
E
------
F
R
K
Y
N
N
N
N
-
G
D
E
-------------
I
I
P
T
N
T
-----
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
-------
E
N
----
L
T
D
P
S
V
I
K
A
E
E
KRSCDM
V
F
G
P
------
A
-------
N
L
G
E
D
A
I
K
N
F
R
A
K
--
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
-
N
D
---
54
HHSearch
40.10
23%
25
- C3 -
-
1IAH
2
B:
[2-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
Y
Y
S
A
V
E
R
N
N
L
M
-
R
L
S
Q
S
I
P
F
V
P
V
P
P
R
GEPVTVY
R
L
E
E
S
S
P
S
I
L
N
-
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
-
F
LS
K
E
E
--
M
G
G
G
L
R
R
A
--
V
K
V
L
C
T
W
S
---------------------------------
E
HDIL
K
S
G
H
--
L
Y
I
I
K
S
F
L
P
E
V
INTWSSIYKEDT
V
L
------------
H
L
C
L
R
E
I
Q
Q
Q
----------------
R
---
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
-
K
S
--
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
----------------------------
H
-----
S
A
G
Q
W
F
A
V
E
E
---
C
M
T
G
E
------
F
R
K
Y
N
N
N
N
-
G
D
E
-------------
I
I
P
T
N
T
-----
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
-------
E
N
----
L
T
D
P
S
V
I
K
A
E
E
KRSCDM
V
F
G
P
------
A
-------
N
L
G
E
D
A
I
K
N
F
R
A
K
--
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
-
N
D
---
50
HHSearch
39.67
27%
12
- C3 -
-
4ZME
1
MHCKA_DICDI
A:
[21-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
T
G
E
M
G
I
L
W
E
F
D
-
P
I
I
N
K
W
I
R
L
S
M
K
L
K
V
E
-
R
--
K
P
F
--
A
E
G
A
L
R
E
A
--
Y
H
T
V
S
L
G
V
GTDENYPLGTTTKLFPPIEMISPISKNNEAMTQ
L
----
K
N
G
T
--
K
F
V
L
K
L
Y
K
K
--QQA---------
S
R
------------
E
L
Y
F
E
D
V
K
M
Q
----------------
M
---
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
------
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
------------
D
------------
R
-
S
PSSN-
G
Q
P
I
L
C
S
I
E
P
---
L
L
V
G
E
------
F
K
K
N
N
S
N
Y
-
G
A
V
-------------
L
T
-
N
--------
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
-------
D
L
----
Y
T
-
P
Q
I
H
T
P
D
G
K-----
G
F
G
L
------
G
-------
N
L
G
K
A
G
I
N
K
F
I
T
T
--
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
L
G
-
G
----
69
Fugue
38.29
20%
23
- C3 -
-
1IA9
2
TRPM7_MOUSE
A:
[3-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
P
P
R
G
--
E
P
V
T
V
Y
-------
R
L
E
E
S
S
P
S
I
L
N
-
N
S
M
S
S
W
S
Q
L
G
L
C
A
K
I
E
-
F
--
L
S
K
M
G
G
G
L
R
R
A
V
K
--
V
L
C
T
W
S
E
H
---------------------------------
D
----
I
L
K
S
GH
L
Y
I
I
K
S
F
L
P
E
V
------------
I
N
TWSSIYKEDTVL
H
L
C
L
R
E
I
Q
Q
Q
----------------
R
---
A
A
Q
K
L
T
F
A
F
N
Q
M
K
-
P
K
S
--
I
P
Y
S
P
R
F
L
E
---
V
F
L
L
------------
Y
------------
C
-
H
-----
S
A
G
Q
W
F
A
V
E
E
---
C
M
T
G
E
------
F
R
K
Y
N
N
N
N
G
D
E
I
-------------
I
P
-
T
N
T
-----
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
--
V
G
E
-----
N
----
L
T
D
P
S
V
I
K
A
E
E
------
K
R
S
C
DMVFGP
A
-------
N
L
G
E
D
A
I
K
N
F
R
A
K
H
--
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
-
N
D
Y
T
-