@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ALPK2_HUMAN: (2020-09-04 )
MKDSEGPQRPPLCFLSTLLSQKVPEKSDAVLRCIISGQPKPEVTWYKNGQAIDGSGIISNYEFFENQYIHVLHLSCCTKNDAAVYQISAKNSFGMICCSASVEVECSSENPQLSPNLEDDRDRGWKHETGTHEEERANQIDEKEHPYKEEESISPGTPRSADSSPSKSNHSLSLQSLGNLDISVSSSENPLGVKGTRHTGEAYDPSNTEEIANGLLFLNSSHIYEKQDRCCHKTVHSMASKFTDGDLNNDGPHDEGLRSSQQNPKVQKYISFSLPLSEATAHIYPGDSAVANKQPSPQLSSEDSDSDYELCPEITLTYTEEFSDDDLEYLECSDVMTDYSNAVWQRNLLGTEHVFLLESDDEEMEFGEHCLGGCEHFLSGMGCGSRVSGDAGPMVATAGFCGHHSQPQEVGVRSSRVSKHGPSSPQTGMTLILGPHQDGTSSVTEQGRYKLPTAPEAAENDYPGIQGETRDSHQAREEFASDNLLNMDESVRETEMKLLSGESENSGMSQCWETAADKRVGGKDLWSKRGSRKSARVRQPGMKGNPKKPNANLRESTTEGTLHLCSAKESAEPPLTQSDKRETSHTTAAATGRSSHADARECAISTQAEQEAKTLQTSTDSVSKEGNTNCKGEGMQVNTLFETSQVPDWSDPPQVQVQETVRETISCSQMPAFSEPAGEESPFTGTTTISFSNLGGVHKENASLAQHSEVKPCTCGPQHEEKQDRDGNIPDNFREDLKYEQSISEANDETMSPGVFSRHLPKDARADFREPVAVSVASPEPTDTALTLENVCDEPRDREAVCAMECFEAGDQGTCFDTIDSLVGRPVDKYSPQEICSVDTELAEGQNKVSDLCSSNDKTLEVFFQTQVSETSVSTCKSSKDGNSVMSPLFTSTFTLNISHTASEGATGENLAKVENSTYPLASTVHAGQEQPSPSNSGGLDETQLLSSENNPLVQFKEGGDKSPSPSAADTTATPASYSSIVSFPWEKPTTLTANNECFQATRETEDTSTVTIATEVHPAKYLAVSIPEDKHAGGTEERFPRASHEKVSQFPSQVQLDHILSGATIKSTKELLCRAPSVPGVPHHVLQLPEGEGFCSNSPLQVDNLSGDKSQTVDRADFRSYEENFQERGSETKQGVQQQSLSQQGSLSAPDFQQSLPTTSAAQEERNLVPTAHSPASSREGAGQRSGWGTRVSVVAETAGEEDSQALSNVPSLSDILLEESKEYRPGNWEAGNKLKIITLEASASEIWPPRQLTNSESKASDGGLIIPDKVWAVPDSLKADAVVPELAPSEIAALAHSPEDAESALADSRESHKGEEPTISVHWRSLSSRGFSQPRLLESSVDPVDEKELSVTDSLSAASETGGKENVNNVSQDQEEKQLKMDHTAFFKKFLTCPKILESSVDPIDEISVIEYTRAGKPEPSETTPQGAREGGQSNDGNMGHEAEIQPAILQVPCLQGTILSENRISRSQEGSMKQEAEQIQPEEAKTAIWQVLQPSEGGERIPSGCSIGQIQESSDGSLGEAEQSKKDKAELISPTSPLSSCLPIMTHASLGVDTHNSTGQIHDVPENDIVEPRKRQYVFPVSQKRGTIENERGKPLPSSPDLTRFPCTSSPEGNVTDFLISHKMEEPKIEVLQIGETKPPSSSSSSAKTLAFISGERELEKAPKLLQDPCQKGTLGCAKKSREREKSLEARAGKSPGTLTAVTGSEEVKRKPEAPGSGHLAEGVKKKILSRVAALRLKLEEKENIRKNSAFLKKMPKLETSLSHTEEKQDPKKPSCKREGRAPVLLKKIQAEMFPEHSGNVKLSCQFAEIHEDSTICWTKDSKSIAQVQRSAGDNSTVSFAIVQASPKDQGLYYCCIKNSYGKVTAEFNLTAEVLKQLSSRQDTKGCEEIEFSQLIFKEDFLHDSYFGGRLRGQIATEELHFGEGVHRKAFRSTVMHGLMPVFKPGHACVLKVHNAIAYGTRNNDELIQRNYKLAAQECYVQNTARYYAKIYAAEAQPLEGFGEVPEIIPIFLIHRPENNIPYATVEEELIGEFVKYSIRDGKEINFLRRESEAGQKCCTFQHWVYQKTSGCLLVTDMQGVGMKLTDVGIATLAKGYKGFKGNCSMTFIDQFKALHQCNKYCKMLGLKSLQNNNQKQKQPSIGKSKVQTNSMTIKKAGPETPGEKKT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60..-......70........80........90........100......--.110.......120.......130.......140.......150....----------...160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620..-....1630......1640.....-.1650......1660......1670......1680......1690......1700......1710......1720......1730.....-----.1740......1750..--....1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900-...--...1910....--...1920......1930......1940----------------------------.--------------------------......1950......--------1960......1970..--------....1980......1990......2000......2010......-------------2020-----.------...-....2030......2040......2050......2060......2070......2080...----...2090...----..-----.2100.......2110......2120......2130......2140......2150......2160......2170
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKDSEGPQRP
P
L
C
F
L
S
T
L
L
SQKVPEKS
D
A
V
L
R
C
I
ISGQPKP
E
V
T
W
YKN
G
Q
AIDGSGIIS
N
Y
E
F
-FEN
Q
Y
I
H
V
L
H
L
S
CCTKND
A
A
V
Y
Q
I
SAKNS
F
G
M
I
C
CS
A
S
V
E
V
E
CSS--ENPQLSPNLEDDRDRGWKHETGT
H
E
E
E
R
A
NQIDEKEHPYKEEESISPG----------TPRSADSSPSKSNH
S
L
S
L
Q
SLGN
L
D
I
S
VSSSENPLGVKGTRHTGEAYDPS
N
T
E
E
I
AN
G
L
L
F
LNSS
H
I
Y
E
K
Q
D
R
C
C
H
K
T
V
H
S
M
A
S
KFTDGDLNNDGPH
D
E
GLRSSQQNP
K
V
Q
K
Y
I
S
FSLPLSEA
T
A
H
IYPGDSAVANKQPSPQLSSEDSDSDYELCP
E
I
T
L
T
Y
TEEFSDDDLE
Y
L
E
C
S
D
V
M
T
D
Y
S
N
A
V
W
Q
RNLLGT
E
H
V
F
L
LESDD
E
E
M
E
F
G
E
H
C
L
G
G
C
E
H
F
L
S
GMGCGSRVSGDAG
P
M
V
A
T
A
GFCGHHS
Q
P
Q
E
VGV
R
S
SRVSKHGPSSPQT
G
M
T
L
I
L
GPHQDGTSS
V
T
EQGRYKLPTAPEAAENDYPGIQGETR
D
S
H
Q
A
R
E
E
FASDNLLN
M
D
E
S
V
R
E
T
E
M
K
L
LSGESENS
G
M
S
Q
C
W
E
T
A
ADKRVG
G
K
D
L
W
S
KRGSRKSARVRQPGMKGNPKKPNANLRESTTEG
T
L
H
L
CSAKESAEPPLTQSDKRETSHT
T
A
AATGRSSHA
D
A
R
E
CAIS
T
Q
A
E
Q
E
A
K
T
LQTSTDSVSKEGNTNCKGE
G
M
Q
V
N
T
L
F
ETSQVPDWSDPP
Q
V
Q
V
Q
E
T
V
R
E
T
I
S
CSQMPAFSEPAGEESPFT
G
T
T
T
I
S
FSNLGGVHKENASLAQHSEVKPCTCGPQHEEKQDRDGNI
P
D
N
F
R
E
D
L
K
Y
E
Q
S
ISEANDETMSP
G
V
F
S
RHL
P
K
D
A
RADFRE
P
V
A
V
SVASPEPTD
T
A
L
T
L
E
N
VCDEPR
D
R
E
A
V
C
A
M
E
C
F
EAGDQG
T
C
F
D
T
I
D
S
L
VGRPVDKY
S
P
Q
E
I
C
S
V
D
T
E
L
AE
G
Q
N
K
V
S
D
L
CSSND
K
T
L
E
V
F
F
QTQVSETS
V
S
TCKSSKDGN
S
V
M
SPLF
T
S
T
F
T
L
N
I
SHTASEGATGE
N
L
A
K
VENSTYPL
A
S
TVHAGQEQPSPSNSGGL
D
E
T
Q
LLSSENN
P
L
V
Q
F
KEGGDKSPSPSAADTTATPAS
Y
S
S
I
VSFPWEKP
T
T
LTAN
N
E
C
F
Q
A
TRETEDT
S
T
V
T
I
A
T
EVHP
A
K
Y
L
A
V
SIPEDKHAGGTEERFPRA
S
H
E
K
V
S
QF
P
S
Q
V
Q
L
D
H
ILSGA
T
I
K
S
T
K
E
L
L
CRAPSVPGVP
H
H
V
L
QLPEGEGFCSNSP
L
Q
VDNLSGDKSQTV
D
R
A
D
F
R
S
Y
E
E
N
F
Q
ERG
S
E
T
K
Q
G
V
Q
Q
Q
S
L
SQQGSLSA
P
D
F
Q
Q
SLPTTSA
A
Q
E
ERNLVPTAHSPASSREGAGQRSGWG
T
R
V
S
V
V
A
ETAGE
E
D
S
Q
A
L
SNVP
S
L
S
D
I
L
L
E
ESKEYRPGNWEAG
N
K
L
K
I
I
T
L
EA
S
A
SEIWPPRQLTNSESKASDG
G
L
IIPDKVWAVPDSLKADAVVPEL
A
P
S
E
I
A
A
LAHSP
E
D
A
E
S
A
L
A
D
S
R
E
SHKGEE
P
T
I
S
V
H
W
R
S
L
S
SRGFSQPRLLESSVDPVDEKELSVTDSLS
A
A
SETGGKENVNNVS
Q
D
Q
E
E
K
Q
LK
M
D
H
T
A
F
F
K
K
F
LT
C
P
K
I
L
E
SSVDPIDE
I
S
V
I
E
Y
TRAGKPEPSETT
P
Q
G
A
REGGQSNDGNMGHEAEIQP
A
I
L
QVPCLQ
G
T
ILSENRISRSQEG
S
M
K
Q
E
A
E
QIQ
P
E
E
A
K
T
A
I
W
Q
VLQPSEGGERIPSGCSIG
Q
I
QESSDGSLG
E
A
E
Q
SKKD
K
A
ELISPTS
P
L
S
S
C
L
P
I
M
THASLGVDTHNSTGQ
I
H
DVPENDIVEPRKR
Q
Y
V
F
P
VSQKRGTIENERGKPLPSSPDLTRFPCTSSPEGN
V
T
D
F
L
I
SH-KMEEP
K
I
E
V
L
QIGETKPPSSSSS-S
A
K
T
L
A
F
ISG
E
R
E
L
E
KA
P
K
L
L
Q
DPCQKGTLG
C
A
K
K
S
R
E
R
E
K
S
L
E
ARAGKSPG
T
L
T
A
VTG
S
E
E
V
KRKPEAPGS
G
H
L
A
E
G
V
K
K
K
I
L
S
R
V
A
A
L
-----
R
L
K
L
E
E
K
ENIR
K
N
S
A
F
L
--
K
KMP
K
L
E
T
SLSHTEEKQDPKKPSCKREGRA
P
V
L
L
K
K
I
Q
A
E
MFPEHSG
N
V
K
L
S
C
Q
F
A
EIHEDS
T
I
C
W
TKDS
K
S
I
A
Q
V
Q
R
SAGDNS
T
V
S
F
A
I
V
QASPKDQ
G
L
Y
Y
C
C
I
KNSY
G
K
V
T
A
E
FN
L
T
A
E
V
L
K
Q
L
SSRQDTKGC
E
E
I
E
F
S
Q
L
I
F
K
E
D-FLH--DSYFGG-
R
L
RG--QIATEELHFGE
G
V
H
R
K
A
F
R
S
T
V
M
H
G
L
-----------------------------
M
--------------------------
P
VFKPG
H
A
C
V
L
K
VH
N
A
--------
I
A
YGTRN
N
D
E
L
I
Q
R
N
Y
--------
K
L
A
A
Q
E
C
Y
V
Q
N
T
A
R
Y
Y
A
K
IYAAEAQPLEGFGEVP
E
I
I
P
I
F
L
I
HR-------------PE-------N------NIP-
Y
A
T
V
E
E
E
L
I
G
E
F
V
K
Y
SIRDG
K
E
I
N
F
L
RRESEAGQKC
C
T
F
Q
H
W
VYQKTSG
C
L
L
V
T
DMQGVG
M
----
K
L
T
D
V
G
I
A
T
L
----
A
K
-----GYKG-FKGNCS
M
T
F
I
D
Q
F
K
A
L
H
Q
C
N
K
Y
C
K
M
LG
L
K
S
LQNN
N
Q
K
QKQPSIGKSKVQTN
S
M
T
I
KKAGPETPGEKKT
102
Fugue
81.54
22%
-6
- C2 -
-
1IA9
2
TRPM7_MOUSE
A:
[3-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
V
P
V
P
P
R
G
--
E
P
V
T
V
Y
R
L
E
E
S
S
P
-
S
I
L
--
N
N
S
M
S
S
-
W
S
Q
L
GL
C
A
K
I
E
F
L
S
K
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
--------
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
--------
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
--
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
-------------
H
S
-------
A
------
G
Q
W
-
F
A
-
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
---
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
A
EEKR
S
C
-----
D
M
V
F
-
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
-------------------------------
84
HHSearch
81.13
26%
4
- C2 -
-
1IA9
2
TRPM7_MOUSE
A:
[28-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
NS
M
S
S
W
S
Q
L
G
L
C
A
--
K
I
E
F
L
S
K
--
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
--------
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
--------
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
--
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
-------------
H
S
--------------
A
G
Q
-
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
---
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
A
----
E
E
KRSCD
M
V
F
G
--
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
--------------------------------
85
HHSearch
80.55
26%
8
- C2 -
-
1IAH
2
TRPM7_MOUSE
A:
[28-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
NS
M
S
S
W
S
Q
L
G
L
C
A
--
K
I
E
F
L
S
K
--
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
--------
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
--------
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
--
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
-------------
H
S
--------------
A
G
Q
-
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
---
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
A
----
E
E
KRSCD
M
V
F
G
--
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
--------------------------------
86
HHSearch
80.42
26%
4
- C2 -
-
1IAH
2
B:
[28-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
P
V
T
V
Y
R
L
E
E
S
S
P
S
I
L
N
NS
M
S
S
W
S
Q
L
G
L
C
A
--
K
I
E
F
L
S
K
E
E
M
G
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
--------
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
--------
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
--
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
-------------
H
S
--------------
A
G
Q
-
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
I
---
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
A
----
E
E
KRSCD
M
V
F
G
--
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
--------------------------------
90
HHSearch
73.79
27%
-44
- C2 -
-
4NL0
-
?
B:
[52-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
S
--
T
F
R
V
E
L
A
P
F
A
K
G
G
E
R
L
A
F
R
A
I
N
G
---------------------------------------------------------------
R
G
D
R
I
V
L
K
R
F
F
Q
--------
Q
R
------------
P
L
--------
T
M
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
P
N
----
K
L
H
F
L
P
N
Y
L
F
I
P
SPTKDLDGKILTL
E
Q
TEQAVAA
T
------
C
R
T
-
P
N
F
V
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
N
-----
E
S
E
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
P
A
L
H
H
I
----
D
Q
-----
N
K
F
I
Y
S
E
T
N
L
G
E
V
G
I
S
Q
F
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
-----------------------------------
89
HHSearch
72.94
27%
-42
- C2 -
-
4KUJ
-
?
B:
[52-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
S
--
T
F
R
V
E
L
A
P
F
A
K
G
G
E
R
L
A
F
R
A
I
N
G
---------------------------------------------------------------
R
G
D
R
I
V
L
K
R
F
F
Q
--------
Q
R
------------
P
L
--------
T
M
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
P
N
----
K
L
H
F
L
P
N
Y
L
F
I
P
SPTKDLDGKILTL
E
Q
TEQAVAA
T
------
C
R
T
-
P
N
F
V
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
N
-----
E
S
E
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
P
A
L
H
H
I
----
D
Q
-----
N
K
F
I
Y
S
E
T
N
L
G
E
V
G
I
S
Q
F
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
-----------------------------------
83
HHSearch
72.30
22%
10
- C2 -
-
4ZME
1
MHCKA_DICDI
A:
[35-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
W
I
R
-
L
-
S
M
--
K
L
K
V
E
R
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
TDENYPLGTTTKLFPPIEMISPISKNNEA
M
--------------------------
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
-----------
Q
Q
-----
A
---
S
R
--------
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
-------------
I
D
-------
R
SPSSNG
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
-------
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
-
P
Q
I
H
T
P
----
D
G
-----
K
G
F
G
--
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
L
G
G
V
L
S
G
------------------------------
88
HHSearch
67.23
24%
1
- C2 -
-
3PDT
1
A:
[35-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
W
I
R
--
L
S
M
--
K
L
K
V
E
R
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
TDENYPLGTTKLFPPIEMISPISKNNEA-
M
--------------------------
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
----------
E
Q
Q
-----
A
---
S
R
--------
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
-------------
I
D
RSPSSN-
G
------
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
-------
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
P
----
D
G
-----
K
G
F
G
--
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
-------------------------------------
87
HHSearch
66.45
22%
-15
- C2 -
-
3LKM
1
A:
[35-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
W
I
R
-
L
-
S
M
--
K
L
K
V
E
R
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
-----------------------------
T
DENYPLGKLFPPIEMISPISKNNEAM
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
----------
E
Q
Q
-----
A
---
S
R
--------
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
-------------
I
D
-------
R
SPSSNG
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
-------
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
P
----
D
G
-----
K
G
F
G
--
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
--------------------------------------
82
HHSearch
66.16
22%
2
- C2 -
-
4ZMF
1
MHCKA_DICDI
A:
[35-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
W
I
R
-
L
-
S
M
--
K
L
K
V
E
R
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
TDENYPLGTKLFPPIEMISPISKNNEA--
M
--------------------------
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
--------
E
---------
A
---
S
R
--------
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
-------------
I
D
-------
R
SPSSNG
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
T
-------
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
-
P
Q
I
H
T
P
----
D
G
-----
K
G
F
G
--
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
-------------------------------------
114
Fugue
56.20
20%
13
* C2 *
-
3LKM
1
A:
[22-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
E
-
F
D
P
--
I
I
N
K
W
I
-
R
L
S
M
--
K
L
K
V
E
R
K
P
F
A
E
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
-----------------------------
T
--------------------------
D
E
N
Y
P
L
G
K
L
F
P
P
I
E
M
I
SPISKNNE
A
M
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
KKEQQASR
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
-------------
S
S
-------
N
------
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
-------
L
T
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
P
----
D
G
-----
K
G
F
G
--
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
--------------------------------------
96
HHSearch
55.27
21%
-39
- C1 -
-
6FWX
2
?
A:
[4-193]
---------
Q
A
P
T
F
T
Q
P
L
Q
S
V
V
V
L
E
G
S
T
A
T
F
E
A
H
I
S
G
F
P
V
P
E
V
S
W
F
R
D
G
Q
V
I
S
T
S
T
L
-
P
G
V
Q
I
-
S
F
S
D
G
R
A
K
L
T
I
P
A
V
T
K
A
N
S
G
R
Y
S
L
K
A
T
N
G
S
G
Q
A
T
S
T
A
E
L
L
V
K
A
E
T
--
A
P
P
N
F
V
Q
R
L
Q
S
M
T
V
R
Q
G
S
Q
V
R
L
Q
V
R
V
T
G
I
P
T
P
V
V
K
F
--
Y
R
D
G
A
E
I
Q
S
S
LDFQISQEGD
L
Y
S
L
-
L
I
A
E
A
Y
P
E
D
S
G
T
Y
S
V
N
A
T
N
S
V
G
R
A
T
S
T
A
E
L
L
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
HHSearch
54.44
22%
28
- C1 -
-
2ILL
-
A:
[2-193]
----------
A
P
H
F
K
E
E
L
R
N
L
N
V
R
Y
Q
S
N
A
T
L
V
C
K
V
T
G
H
P
K
P
I
V
K
W
Y
R
Q
G
K
E
I
I
A
D
G
L
--
K
Y
R
I
Q
E
F
K
G
G
Y
H
Q
L
I
I
A
S
V
T
D
D
D
A
T
V
Y
Q
V
R
A
T
N
Q
G
G
S
V
S
G
T
A
S
L
E
V
E
V
P
A
KI
H
L
P
K
T
L
E
G
M
G
A
V
H
A
L
R
G
E
V
V
S
I
K
I
P
F
S
G
K
P
D
P
V
I
T
W
--
Q
K
G
Q
D
L
I
D
N
N
GHYQVIVTRS
F
T
S
L
V
F
P
N
G
V
E
R
K
D
A
G
F
Y
V
V
C
A
K
N
R
F
G
I
D
Q
K
T
V
E
L
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
54.43
21%
-38
- C1 -
-
2A38
-
TITIN_HUMAN
C:
[4-192]
---------
Q
A
P
T
F
T
Q
P
L
Q
S
V
V
V
L
E
G
S
T
A
T
F
E
A
H
I
S
G
F
P
V
P
E
V
S
W
F
R
D
G
Q
V
I
S
T
S
T
L
-
P
G
V
Q
I
-
S
F
S
D
G
R
A
K
L
T
I
P
A
V
T
K
A
N
S
G
R
Y
S
L
K
A
T
N
G
S
G
Q
A
T
S
T
A
E
L
L
V
K
A
E
T
--
A
P
P
N
F
V
Q
R
L
Q
S
M
T
V
R
Q
G
S
Q
V
R
L
Q
V
R
V
T
G
I
P
T
P
V
V
K
F
--
Y
R
D
G
A
E
I
Q
S
S
LDFQISQEGD
L
Y
S
L
-
L
I
A
E
A
Y
P
E
D
S
G
T
Y
S
V
N
A
T
N
S
V
G
R
A
T
S
T
A
E
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
51.25
20%
-31
- C1 -
-
6SDB
-
TITIN_HUMAN
A:
[6-194]
---------
Q
A
P
T
F
T
Q
P
L
Q
S
V
V
V
L
E
G
S
T
A
T
F
E
A
H
I
S
G
F
P
V
P
E
V
S
W
F
R
D
G
Q
V
K
L
E
R
L
--
P
G
V
Q
I
-
S
F
S
D
G
R
A
K
L
T
I
P
A
V
T
K
A
N
S
G
R
Y
S
L
K
A
T
N
G
S
G
Q
A
T
S
T
A
E
L
L
V
K
A
E
T
--
A
P
P
N
F
V
Q
R
L
Q
S
M
T
V
R
Q
G
S
Q
V
R
L
Q
V
R
V
T
G
I
P
T
P
V
V
K
F
--
Y
R
D
G
A
E
I
Q
S
S
LDFQISQEGD
L
Y
S
L
-
L
I
A
E
A
Y
P
E
D
S
G
T
Y
S
V
N
A
T
N
S
V
G
R
A
T
S
T
A
E
L
L
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
51.14
36%
-115
- C1 -
-
2NZI
-
TITIN_HUMAN
A:
[4-98]
-------------
F
K
E
E
L
R
N
L
N
V
R
Y
Q
S
N
A
T
L
V
C
K
V
T
G
H
P
K
P
I
V
K
W
Y
R
Q
G
K
E
I
I
A
D
G
L
K
Y
R
I
Q
E
-
F
K
G
G
Y
-
H
Q
L
I
I
A
S
V
T
D
D
D
A
T
V
Y
Q
V
R
A
T
N
Q
G
G
S
V
S
G
T
A
S
L
E
V
E
V
P
A
--
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.00
36%
-119
- C1 -
-
2J8O
-
TITIN_HUMAN
A:
[7-101]
-------------
F
K
E
E
L
R
N
L
N
V
R
Y
Q
S
N
A
T
L
V
C
K
V
T
G
H
P
K
P
I
V
K
W
Y
R
Q
G
K
E
I
I
A
D
G
L
K
Y
R
I
Q
E
-
F
K
G
G
Y
-
H
Q
L
I
I
A
S
V
T
D
D
D
A
T
V
Y
Q
V
R
A
T
N
Q
G
G
S
V
S
G
T
A
S
L
E
V
E
V
P
A
--
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Fugue
50.82
18%
78
- C1 -
-
2Y23
4
A:
[6-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
E
V
V
V
N
V
D
D
D
G
V
I
S
L
N
F
E
C
D
K
M
T
P
K
S
E
F
S
W
S
K
D
Y
V
S
T
E
D
S
P
R
L
E
V
E
S
K
--
G
N
K
T
K
M
T
F
K
D
L
G
M
D
D
L
G
I
Y
S
C
D
V
T
D
T
D
G
I
A
S
S
Y
L
I
D
E
E
E
L
K
R
L
L
A
L
S
H
E
H
K
F
P
T
V
---
P
V
K
S
E
L
A
V
E
I
L
E
K
G
Q
V
R
F
W
M
Q
A
E
K
L
S
G
N
A
K
V
N
Y
I
F
N
E
K
E
I
F
E
G
P
K
Y
K
M
H
I
D
R
N
T
G
I
I
E
M
F
M
E
K
L
Q
D
E
DEGTY
T
F
Q
L
Q
D
G
K
A
T
N
H
S
T
V
V
L
VG
D
V
F
K
K
L
Q
K
E
A
E
F
Q
R
Q
E
W
I
R
K
Q
--------
G
P
H
F
V
E
Y
L
S
W
E
V
T
G
E
C
--
N
V
L
L
K
C
K
V
A
N
I
K
K
E
T
H
I
V
W
Y
K
D
E
R
E
I
S
V
D
E
K
----
H
G
I
C
T
L
L
I
T
E
F
S
K
K
D
A
G
I
Y
E
V
I
L
K
D
D
R
G
K
D
K
S
R
L
K
L
V
D
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
50.45
22%
23
- C1 -
-
2J8H
1
A:
[3-195]
---------
M
A
P
H
F
K
E
E
L
R
N
L
N
V
R
Y
Q
S
N
A
T
L
V
C
K
V
T
G
H
P
K
P
I
V
K
W
Y
R
Q
G
K
E
I
I
A
D
G
L
--
K
Y
R
I
Q
E
F
K
G
G
Y
H
Q
L
I
I
A
S
V
T
D
D
D
A
T
V
Y
Q
V
R
A
T
N
Q
G
G
S
V
S
G
T
A
S
L
E
V
E
V
P
A
KI
H
L
P
K
T
L
E
G
M
G
A
V
H
A
L
R
G
E
V
V
S
I
K
I
P
F
S
G
K
P
D
P
V
I
T
W
--
Q
K
G
Q
D
L
I
D
N
N
GHYQVIVTRS
F
T
S
L
V
F
P
N
G
V
E
R
K
D
A
G
F
Y
V
V
C
A
K
N
R
F
G
I
D
Q
K
T
V
E
L
D
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.32
36%
-112
- C1 -
-
2J8H
-
A:
[7-101]
-------------
F
K
E
E
L
R
N
L
N
V
R
Y
Q
S
N
A
T
L
V
C
K
V
T
G
H
P
K
P
I
V
K
W
Y
R
Q
G
K
E
I
I
A
D
G
L
K
Y
R
I
Q
E
-
F
K
G
G
Y
-
H
Q
L
I
I
A
S
V
T
D
D
D
A
T
V
Y
Q
V
R
A
T
N
Q
G
G
S
V
S
G
T
A
S
L
E
V
E
V
P
A
--
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------