@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ALPK3_HUMAN: (2020-09-04 )
MEVAWLVYVLGQQPLARQGEGQSRLVPGRGLVLWLPGLPRSSPSWPAVDLAPLAPARPRGPLICHTGHEQAGREPGPGSSTKGPVLHDQDTRCAFLPRPPGPLQTRRYCRHQGRQGSGLGAGPGAGTWAPAPPGVSKPRCPGRARPGEGQQQVTTARPPAINRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAVGEGGAMGSRRAPSRGWGAGGRSGAGGDGEDDGPVWIPSPASRSYLLSVRPETSLSSNRLSHPSSGRSTFCSIIAQLTEETQPLFETTLKSRSVSEDSDVRFTCIVTGYPEPEVTWYKDDTELDRYCGLPKYEITHQGNRHTLQLYRCREEDAAIYQASAQNSKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRKAAAKLREIEQSWKHEKAVPGEVDTLRKLSPDRFQRKRRLSGAQAPGPSVPTREPEGGTLAAWQEGETETAQHSGLGLINSFASGEVTTNGEAAPENGEDGEHGLLTYICDAMELGPQRALKEESGAKKKKKDEESKQGLRKPELEKAAQSRRSSENCIPSSDEPDSCGTQGPVGVEQVQTQPRGRAARGPGSSGTDSTRKPASAVGTPDKAQKAPGPGPGQEVYFSLKDMYLENTQAVRPLGEEGPQTLSVRAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKPISSLSQAPECGAQSLGKAPPQASVQVPTPPARRRHGTRDSTLQGQAGHRTPGEVLECQTTTAPTMSASSSSDVASIGVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQADGKIQVDGRTRGDGTQTAQRTRADRKTQVDAGTQESKRPQSDRSAQKGMMTQGRAETQLETTQAGEKIQEDRKAQADKGTQEDRRMQGEKGMQGEKGTQSEGSAPTAMEGQSEQEVATSLGPPSRTPKLPPTAGPRAPLNIECFVQTPEGSCFPKKPGCLPRSEEAVVTASRNHEQTVLGPLSGNLMLPAQPPHEGSVEQVGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGSTATFLPSEDQVLMSSAPTLHLGLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGPRSCDPGLIDSLKNYLLLLLKLSSTETSGAGGESQVGAATGGLVPSATLTPTVEVAGLSPRTSRRILERVENNHLVQSAQTLLLSPCTSRRLTGLLDREVQAGRQALAAARGSWGPGPSSLTVPAIVVDEEDPGLASEGASEGEGEVSPEGPGLLGASQESSMAGRLGEAGGQAAPGQGPSAESIAQEPSQEEKFPGEALTGLPAATPEELALGARRKRFLPKVRAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPRAEEELAAGDLGPSPKAGGLDTEVALDEGKQETLAKPRKAKDLLKAPQVIRKIRVEQFPDASGSLKLWCQFFNILSDSVLTWAKDQRPVGEVGRSAGDEGPAALAIVQASPVDCGVYRCTIHNEHGSASTDFCLSPEVLSGFISREEGEVGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSEELRGGGYGCGLRKASQAKVIYGLEPIFESGRTCIIKVSSLLVFGPSSETSLVGRNYDVTIQGCKIQNMSREYCKIFAAEARAAPGFGEVPEIIPLYLIYRPANNIPYATLEEDLGKPLESYCSREWGCAEAPTASGSSEAMQKCQTFQHWLYQWTNGSFLVTDLAGVDWKMTDVQIATKLRGYQGLKESCFPALLDRFASSHQCNAYCELLGLTPLKGPEAAHPQAKAKGSKSPSAGRKGSQLSPQPQKKGLPSPQGTRKSAPSSKATPQASEPVTTQLLGQPPTQEEGSKAQGMR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......---120--.---.......130--------...----------.....140.......150---.--..--.....160.......170.......180.......190.......200-.....--.--.210.......220.......230-.......240.......-250-.........260-.........270....-------..-----.------280...---.....290.......300.......310.......320.......330.......340.......350.......360.......370....-------.-------.-------.380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570--......----..1580.------.....1590......1600.......1610......1620......1630.-----------------------------.--------------------------....1640......1650......1660......1670......1680......1690......1700......1710------------.-------.------...-..1720......1730......1740......1750......1760......1770......1780-.........----1790----.--......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
ME
V
A
W
L
V
Y
VLGQQPLARQGEGQSRLVPGR
G
L
V
L
WLPGLPRSSPSWPAVDLAPLAPARPRG
P
L
I
C
HTG
H
E
QAGREPGPGSSTKGPVLHDQDT
R
C
A
FLPRPPG
P
L
Q
T
R
R
Y
C
R
HQGRQGSGL---GA---G---PGAGTWAPA---------PPG----------VSKPRCPGRARPGEGQQ----Q--VT--TARPPAINRGARQPRAGAAAAGRGPGAGAWRTGEAAASAGPAVGEGGA-MGSRR--A--PSRGWGAGGRSGAGGDGEDDG
P
V
W-IPSPASR
S
Y
L
L
S
VRPET-S---LSSNRLSHPS---SG
R
S
T
F
C
S
I
I
A
Q
L
T
E
E-------T
Q
-----
P
------
L
F
-
E
T
T
---
L
KSRSVSEDS
D
V
R
F
T
C
I
VTGYPEP
E
V
T
W
YKDDT
E
L
D
R
YCGLPK
Y
E
I
THQGNR
H
T
L
Q
L
Y
R
CREED
A
A
I
Y
Q
ASAQNSK
G
I
V
S
CSG
V
L
E
VGTM
T
E
-------
Y
-------
K
-------
I
H
Q
R
W
F
A
K
L
K
R
K
A
A
A
K
L
R
E
I
E
Q
S
WKHEKAVPG
E
V
D
T
L
R
KL
S
P
D
R
F
Q
R
K
R
RLSGAQAPGPSVPTREPEG
G
T
L
A
A
WQEGETETAQHSG
L
G
L
I
N
S
FASG
E
V
TTNGEAAPENGEDGE
H
G
L
L
T
Y
I
C
D
A
M
EL
G
P
Q
R
A
L
K
E
ESGAKKKKK
D
E
E
S
K
QGLR
K
P
E
L
E
K
A
A
Q
SRRSSENCIPSSDEPDSCGTQGPV
G
V
E
Q
V
QTQPRGRAARGPGSSGTDSTRKPASAVGTP
D
K
AQKAPGPGPG
Q
E
V
Y
F
S
L
K
D
M
YLEN
T
Q
AVRPLGEEGP
Q
T
L
S
V
RAPGESPKGKAPLRARSEGVPGAPGQPTHSLTPQPTRPFNRKRFAPPKPKGEATTDSKP
I
S
S
L
SQAPEC
G
A
Q
S
LGKAPPQA
S
V
QVPT
P
P
A
R
RRHGTRDSTLQGQAGHRTPG
E
V
L
E
C
QTTTAPTMSASSSSD
V
A
S
I
GVSTSGSQGIIEPMDMETQEDGRTSANQRTGSKKNVQAD
G
K
I
Q
VDGRTRGDGT
Q
T
A
Q
R
TRADRKTQVDAGTQESKRPQSD
R
S
A
QKGMMTQGRAE
T
Q
LE
T
T
QA
G
E
K
I
Q
E
D
R
K
AQADKG
T
Q
E
D
R
RMQGEKGMQGEKGTQSEGSAPTAMEGQ
S
E
Q
E
V
A
TSLGPPSRTPKLPPTAGPRAP
L
N
I
E
C
F
V
QTPEGSCFPKKPGCLPRSE
E
A
V
V
T
ASRNHE
Q
T
V
L
GPLSG
N
L
MLPAQPPHEG
S
V
E
Q
VGGERCRGPQSSGPVEAKQEDSPFQCPKEERPGGVPCMDQGGCPLAGLSQEVPTMPSLPGTGLTASPKAGPCSTPTSQHGS
T
A
TFLPSED
Q
V
L
MSSA
P
T
L
H
L
GLGTPTQSHPPETMATSSEGACAQVPDVEGRTPGPRSCD
P
G
L
I
D
S
L
K
N
Y
L
L
L
L
LKLSSTETSGAGGESQVGAATGGLVPSATLT
P
T
V
E
VAGLSP
R
T
S
R
R
I
L
E
R
VENN
H
L
V
Q
S
A
Q
T
L
LLSPCT
S
R
R
L
T
G
L
L
D
R
E
V
Q
A
G
R
Q
A
L
A
AARGSWGPGPSS
L
T
V
P
A
I
V
VDEEDPGLASEGASEGEGEVSPEGPGLLGAS
Q
E
S
S
M
A
GRLGEAGGQAAPGQGP
S
A
E
S
I
A
QEPSQEEKFPGEALTGLPAA
T
P
E
E
L
A
L
G
A
R
R
K
R
F
L
P
KVRAAGDGEATTPEERESPTVSPRGPRKSLVPGSPGTPGRERRSPTQGRKASMLEVPR
A
E
E
E
LAAGDLGPSPKAGGLD
T
E
V
ALDEG
K
Q
E
T
LAK
P
R
K
A
K
D
L
L
K
A
P
Q
V
I
R
K
I
R
V
E
QFPDASG
S
L
K
L
W
C
Q
F
F
N
I
L
S
D
S
V
L
T
W
AKDQR
P
V
G
E
VGRSAGDEG
P
A
A
L
A
I
V
QASPVD
C
G
V
Y
R
C
T
I
HNEHGSASTDFCL
S
P
E
V
L
S
G
F
----
I
S
REEG----EVGEEIE------M
T
P
M
V
F
AKGLADSGC
W
G
D
-
K
L
F
G
R
L
V
S
E
E
LRGGGYGCGLRKASQ
A
K
V
I
Y
G
L
-----------------------------
E
--------------------------
P
I
F
ESG
R
T
C
I
I
K
V
S
S
L
L
V
FGPSSET
S
L
VGRN
Y
D
V
T
I
QG
C
K
IQ
N
M
S
R
E
Y
C
K
I
F
A
A
EARAAPGFGEVP
E
I
I
P
L
Y
L
I
Y
RP-------------A-------N------NIP-
Y
A
T
L
E
E
D
L
G
K
P
L
E
S
Y
CSREWGCAEAPTASG
S
S
E
A
M
Q
K
C
Q
T
F
Q
H
W
L
Y
QWTNG
S
F
L
V
T
DLAGV
D
W
----
K
M
TD
V
Q
I
A
T
----
K
LR-----G--YQG
L
K
E
S
C
F
P
A
L
L
D
R
FASSH
Q
C
N
A
Y
C
E
L
LGLTPLKGPEAAHPQAKAKGSKSPSAGRKGSQLSPQ
P
Q
KKGLPSPQGTRKSAPSSKATPQASE
P
V
T
T
Q
LLGQPPTQEEGSKAQGMR
116
HHSearch
72.70
20%
5
- C3 -
-
4ZME
1
MHCKA_DICDI
A:
[34-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
N
K
W
I
R
-
L
-
S
M
K
L
K
V
E
R
K
P
F
A
E
--
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
TDENYPLGTTTKLFPPIEMISPISKNNEA
M
--------------------------
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
---
Q
Q
--------
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
I
-------------
D
-------
R
SPSSNG
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
---------
T
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
-
P
Q
I
H
T
----
P
D
G
-----
K
--
G
F
G
L
G
N
L
G
-
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
L
G
G
V
----------------------------------------------------------------------------
118
HHSearch
71.87
22%
-11
- C3 -
-
3PDT
1
A:
[35-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
K
W
I
R
--
L
S
M
K
L
K
V
E
R
K
P
F
A
E
--
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
TDENYPLGTTKLFPPIEMISPISKNNEA-
M
--------------------------
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
--
E
Q
Q
--------
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
I
-------------
D
-------
R
SPSSNG
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
---------
T
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
----
P
D
G
-----
K
--
G
F
G
L
G
N
L
G
-
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
---------------------------------------------------------------------------------
115
HHSearch
71.68
20%
-18
- C3 -
-
4ZMF
1
MHCKA_DICDI
A:
[34-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
N
K
W
I
R
-
L
-
S
M
K
L
K
V
E
R
K
P
F
A
E
--
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
TDENYPLGTKLFPPIEMISPISKNNEA--
M
--------------------------
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
E
------------
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
I
-------------
D
-------
R
SPSSNG
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
-
T
--------
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
-
P
Q
I
H
T
----
P
D
G
-----
K
--
G
F
G
L
G
N
L
G
-
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
K
--------------------------------------------------------------------------------
120
HHSearch
70.75
20%
-34
- C3 -
-
4NL0
-
?
B:
[53-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
T
F
R
V
E
L
A
P
F
A
K
--
G
G
E
R
L
A
F
R
A
I
N
G
---------------------------------------------------------------
R
G
D
R
I
V
L
K
R
F
F
Q
Q
R
------------
P
L
T
M
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
P
----
N
K
L
H
F
L
P
N
Y
L
F
I
P
S
PTKDLDGKILTLE
Q
TEQAVAA
T
------
C
R
T
-
P
N
F
V
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
-
N
------
E
S
E
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
P
A
L
H
H
----
I
D
Q
-----
N
KF
I
Y
S
E
T
N
L
G
-
E
V
G
I
S
Q
F
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
------------------------------------------------------------------------------
119
HHSearch
70.13
20%
-31
- C3 -
-
4KUJ
-
?
B:
[53-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
S
T
F
R
V
E
L
A
P
F
A
K
--
G
G
E
R
L
A
F
R
A
I
N
G
---------------------------------------------------------------
R
G
D
R
I
V
L
K
R
F
F
Q
Q
R
------------
P
L
T
M
L
L
E
T
I
E
R
Q
L
I
C
I
Y
L
A
N
I
F
N
K
L
N
V
S
P
----
N
K
L
H
F
L
P
N
Y
L
F
I
P
S
PTKDLDGKILTLE
Q
TEQAVAA
T
------
C
R
T
-
P
N
F
V
E
P
Y
L
S
G
Y
F
I
K
Y
I
D
N
N
G
W
I
-
N
------
E
S
E
F
H
S
T
L
H
A
F
A
H
W
T
W
V
H
T
K
G
A
L
L
I
C
D
I
Q
G
V
N
A
NNKF
Y
L
T
D
P
A
L
H
H
----
I
D
Q
-----
N
KF
I
Y
S
E
T
N
L
G
-
E
V
G
I
S
Q
F
F
R
T
H
Q
C
N
A
I
C
Q
G
L
H
L
P
K
H
K
E
------------------------------------------------------------------------------
117
HHSearch
69.78
21%
-24
- C3 -
-
3LKM
1
A:
[34-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
N
K
W
I
R
--
L
S
M
K
L
K
V
E
R
K
P
F
A
E
--
G
A
L
R
E
A
Y
H
T
V
S
L
G
V
G
-----------------------------
T
DENYPLGKLFPPIEMISPISKNNEAM
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
K
K
--
E
Q
Q
--------
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
-----
K
K
I
E
F
L
M
S
W
V
V
E
L
I
-------------
D
-------
R
SPSSNG
Q
P
I
-
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
G
A
V
L
---------
T
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
----
P
D
G
-----
K
--
G
F
G
L
G
N
L
G
-
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
---------------------------------------------------------------------------------
128
HHSearch
69.30
17%
24
- C2 -
-
4X83
3
?
D:
[27-353]
-----------------------------------------------------------------------------------------
E
I
E
C
K
A
S
---
G
N
P
M
P
E
I
I
W
I
R
S
D
G
T
A
V
G
D
V
---
P
G
LR-
Q
---
I
S
S
D
G
K
L
V
F
---------
P
P
F
RAEDYRQEVH
A
Q
V
Y
A
C
L
A
R
N
Q
F
G
S
I
I
S
R---
D
--
V
H
VR
A
V
V
N
Q
F
Y
E
A
E
I
--------------------
M
T
E
Y
V
I
R
G
N
A
A
V
L
K
C
S
I
-
P
S
F
V
A
--
D
FV
R
V
E
S
W
I
D
D
E
G
N
V
-
L
S
F
S
D
N
Y
D
G
K
Y
-
L
V
L
P
S
G
E
L
H
I
R
E
V
G
P
E
D
-
G
YKS
Y
Q
C
R
-
T
K
H
R
L
---
T
G
E
T
R
L
S
A
T
K
G
R
L
V
I
T
EPVGS--
K
A
-----
P
------
T
F
-
A
T
A
SK-
I
S
S
L
L
G
S
S
S
S
D
I
V
L
L
C
Q
A
Q
A
F
P
V
P
Y
T
R
W
Y
K
F
I
E
G
T
T
R
K
Q
-
A
V
V
L
N
D
R
V
K
Q
V
S
G
T
L
I
I
K
D
A
V
V
E
D
S
G
K
Y
L
C
V
V
N
N
S
V
G
G
E
S
V
E
T
V
L
T
V
T
A
P
L
S
-------
A
KIDPPTQ
T
-------
V
D
F
G
R
P
A
V
F
T
C
Q
Y
T
G
N
P
-
I
K
T
V
S
W
M
K
D
G
K
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
68.62
21%
-2
- C3 -
-
1IA9
2
TRPM7_MOUSE
A:
[28-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
P
V
T
VYRLEE
S
S
P
S
I
L
N
N
S
M
---
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
--
M
G
--
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
--
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
---------------------
S
------
A
G
Q
-
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
-
I
----
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
----
A
E
E
KRSCD
M
--
V
F
G
P
A
N
L
G
-
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
-----------------------------------------------------------------------------
99
Fugue
68.56
19%
-0
- C3 -
-
1IA9
2
TRPM7_MOUSE
A:
[3-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
Y
S
A
V
E
R
N
N
L
M
R
L
S
Q
S
I
P
F
VPVP
P
R
G
E
P
V
----
T
V
Y
R
L
E
E
------
S
S
P
S
I
L
N
N
S
M
S
S
W
S
Q
------
L
G
L
C
A
K
I
E
F
L
S
K
M
G
G
-
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
--
P
K
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
-------------
S
-------
A
------
G
Q
W
-
F
A
-
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
-----
G
D
E
I
I
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
AEEK
R
S
C
-----
D
--
M
V
F
G
P
A
N
L
G
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
D
Y
T
--------------------------------------------------------------------------
96
Fugue
68.35
19%
15
- C3 -
-
3LKM
1
A:
[22-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
E
M
G
I
L
W
----
E
F
D
P
I
I
NKWI
R
L
S
M
K
L
K
------
V
E
R
K
P
F
A
E
G
-
A
L
R
E
A
Y
H
T
-
V
S
L
G
V
G
T
D
E
N
Y
P
L
G
K
L
F
P
P
I
E
M
I
S
P
I
S
K
N
N
E
A
-----------------------------
M
--------------------------
T
Q
L
K
N
G
T
K
F
V
L
K
L
Y
----------
K
K
E
Q
Q
A
S
R
E
L
Y
F
E
D
V
K
M
Q
M
V
C
R
D
W
G
N
K
F
N
Q
K
K
P
P
K
K
I
E
F
L
M
S
W
V
V
E
L
I
D
R
S
P
S
-------------
S
-------
N
------
G
Q
P
I
L
C
S
I
E
P
L
L
V
G
E
F
K
K
N
N
S
N
Y
---------
G
A
V
L
T
N
R
S
T
P
Q
A
F
S
H
F
T
Y
E
L
S
N
K
Q
M
I
V
V
D
I
Q
G
V
D
D
----
L
Y
T
D
P
Q
I
H
T
----
P
D
G
-----
K
--
G
F
G
-
L
G
N
L
G
K
A
G
I
N
K
F
I
T
T
H
K
C
N
A
V
C
A
L
L
D
L
D
V
---------------------------------------------------------------------------------
112
HHSearch
67.88
21%
2
* C3 *
-
1IAH
2
B:
[28-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
P
V
T
VYRLEE
S
S
P
S
I
L
N
N
S
M
---
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
E
E
M
G
--
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
--
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
---------------------
S
------
A
G
Q
-
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
-
I
----
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
----
A
E
E
KRSCD
M
--
V
F
G
P
A
N
L
G
-
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
-----------------------------------------------------------------------------
113
HHSearch
67.48
21%
1
- C3 -
-
1IAH
2
TRPM7_MOUSE
A:
[28-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
E
P
V
T
VYRLEE
S
S
P
S
I
L
N
N
S
M
---
S
S
W
S
Q
L
G
L
C
A
K
I
E
F
L
S
K
--
M
G
--
G
G
L
R
R
A
V
K
V
L
C
T
W
S
E
-----------------------------
H
--------------------------
D
I
L
K
S
G
H
L
Y
I
I
K
S
F
L
P
E
V
I
N
T
W
S
S
I
Y
K
E
D
T
V
L
H
L
C
L
R
E
I
Q
Q
Q
R
A
A
Q
K
L
T
F
A
F
N
Q
M
K
P
K
--
S
I
P
Y
S
P
R
F
L
E
V
F
L
L
Y
C
H
---------------------
S
------
A
G
Q
-
W
F
A
V
E
E
C
M
T
G
E
F
R
K
Y
N
N
N
N
G
D
E
I
-
I
----
P
T
N
T
L
E
E
I
M
L
A
F
S
H
W
T
Y
E
Y
T
R
G
E
L
L
V
L
D
L
Q
G
V
G
E
----
N
L
T
D
P
S
V
I
K
----
A
E
E
KRSCD
M
--
V
F
G
P
A
N
L
G
-
E
D
A
I
K
N
F
R
A
K
H
H
C
N
S
C
C
R
K
L
K
L
P
D
L
K
R
N
-----------------------------------------------------------------------------
124
HHSearch
64.40
15%
40
- C2 -
-
3P3Y
1
NFASC_HUMAN
A:
[36-353]
-----------------------------------------------------------------------------------------
L
I
E
C
E
A
K
---
G
N
P
A
P
S
F
H
W
T
R
N
S
R
F
F
N
I
A
K
DPR
V
S
---
M
---
R
R
R
S
G
T
L
V
I
DFRSGGRP-
E
E
Y
----------
E
G
E
Y
Q
C
F
A
R
N
K
F
G
T
A
L
S
NRI-
R
--
L
Q
--
V
S
K
S
P
L
W
P
K
E
N
L
-------------------
D
P
V
V
V
Q
E
G
A
P
L
T
L
Q
C
N
P
P
P
G
L
P
S
-----
P
V
I
F
W
M
S
S
S
M
E
P
-----
I
T
Q
D
K
R
V
-
S
Q
G
H
N
G
D
L
Y
F
S
N
V
M
L
Q
D
M
Q
TD-
Y
S
C
N
-
A
R
F
H
F
---
T
H
T
I
Q
Q
-
K
N
P
F
T
L
K
V
L
TTRGVAE
R
T
-----
P
------
S
F
-
M
Y
P
QGT
A
S
S
Q
M
V
L
R
G
M
D
L
L
L
E
C
I
A
S
G
V
P
T
P
D
I
A
W
Y
K
K
G
G
D
L
P
S
D
----
K
A
K
F
--
E
N
F
N
K
A
L
R
I
T
N
V
S
E
E
D
S
G
E
Y
F
C
L
A
S
N
K
M
G
S
I
R
H
T
I
S
V
R
V
K
A
A
P
Y
-------
W
LDEPKNL
I
-------
L
A
P
G
E
D
G
R
L
V
C
R
A
N
G
N
P
-
K
P
T
V
Q
W
M
V
N
G
E
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
63.52
16%
31
- C2 -
-
2V5M
1
?
A:
[23-348]
-----------------------------------------------------------------------------------------
E
I
E
C
K
A
S
---
G
N
P
M
P
E
I
I
W
I
R
S
D
G
T
A
V
G
D
V
---
P
G
LR-
Q
---
I
S
S
D
G
K
L
V
F
---------
P
P
F
RAEDYRQEVH
A
Q
V
Y
A
C
L
A
R
N
Q
F
G
S
I
I
S
R---
D
VH
V
R
--
A
V
V
A
Q
Y
Y
E
A
D
V
--------------------
N
K
E
H
V
I
R
G
N
S
A
V
I
K
C
L
I
-
P
S
F
V
A
DF
V
--
E
V
V
S
W
H
T
D
E
E
E
N
-
Y
F
P
G
A
E
Y
D
G
K
Y
-
L
V
L
P
S
G
E
L
H
I
R
E
V
G
P
E
D
-
G
YKS
Y
Q
C
R
-
T
K
H
R
L
---
T
G
E
T
R
L
S
A
T
K
G
R
L
V
I
T
-------
E
P
ISSSA
P
------
R
T
P
A
L
V
---
Q
K
P
L
E
L
M
V
A
H
T
I
S
L
L
C
P
A
Q
G
F
P
A
P
S
F
R
W
Y
K
F
I
E
G
T
T
R
K
Q
-
A
V
V
L
N
D
R
V
K
Q
V
S
G
T
L
I
I
K
D
A
V
V
E
D
S
G
K
Y
L
C
V
V
N
N
S
V
G
G
E
S
V
E
T
V
L
T
V
T
A
P
L
S
AKIDPPT
Q
-------
T
-------
V
D
F
G
R
P
A
V
F
T
C
Q
Y
T
G
N
P
-
I
K
T
V
S
W
M
K
D
G
K
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
63.46
16%
28
- C2 -
-
2V5S
-
?
B:
[29-354]
-----------------------------------------------------------------------------------------
E
I
E
C
K
A
S
---
G
N
P
M
P
E
I
I
W
I
R
S
D
G
T
A
V
G
D
V
---
P
G
LR-
Q
---
I
S
S
D
G
K
L
V
F
---------
P
P
F
RAEDYRQEVH
A
Q
V
Y
A
C
L
A
R
N
Q
F
G
S
I
I
S
RDV-
H
--
V
R
--
A
V
V
A
Q
Y
Y
E
A
D
V
--------------------
N
K
E
H
V
I
R
G
N
S
A
V
I
K
C
L
I
-
P
S
F
V
A
DF
V
--
E
V
V
S
W
H
T
D
E
E
E
N
-
Y
F
P
G
A
E
Y
D
G
K
Y
-
L
V
L
P
S
G
E
L
H
I
R
E
V
G
P
E
D
-
G
YKS
Y
Q
C
R
-
T
K
H
R
L
---
T
G
E
T
R
L
S
A
T
K
G
R
L
V
I
T
-------
E
P
ISSSA
P
------
R
T
P
A
L
V
---
Q
K
P
L
E
L
M
V
A
H
T
I
S
L
L
C
P
A
Q
G
F
P
A
P
S
F
R
W
Y
K
F
I
E
G
T
T
R
K
Q
-
A
V
V
L
N
D
R
V
K
Q
V
S
G
T
L
I
I
K
D
A
V
V
E
D
S
G
K
Y
L
C
V
V
N
N
S
V
G
G
E
S
V
E
T
V
L
T
V
T
A
P
L
S
-------
A
KIDPPTQ
T
-------
V
D
F
G
R
P
A
V
F
T
C
Q
Y
T
G
N
P
-
I
K
T
V
S
W
M
K
D
G
K
A
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.81
27%
22
- C2 -
-
6FWX
2
?
A:
[34-193]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
E
V
S
W
F
R
D
G
Q
V
I
S
S
G
---
S
S
P
G
V
Q
-
I
S
F
S
D
G
R
A
K
L
-
T
I
P
A
V
T
-
K
---
A
N
S
G
R
Y
S
L
K
A
TNG
S
G
Q
A
T
S
T
A
E
L
L
V
K
A
E
T
-------
A
P
-----
P
------
N
F
-
V
Q
R
---
L
Q
S
M
T
V
R
Q
G
S
Q
V
R
L
Q
V
R
V
T
G
I
P
T
P
V
V
K
F
Y
R
D
G
A
E
I
Q
S
S
L
---
D
F
Q
I
S
Q
E
G
D
L
Y
S
L
L
I
A
E
A
Y
P
E
D
S
G
T
Y
S
V
N
A
T
N
S
V
G
R
A
T
S
T
A
E
L
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
56.50
15%
-
- C2 -
-
3B43
-
A:
[212-514]
-----------------------------------------------------------------------------------------
T
F
K
C
H
V
T
---
G
T
A
P
I
K
I
T
W
A
K
D
N
R
E
I
R
P
G
G
---
N
Y
KMT
L
---
V
E
N
T
A
T
L
T
V
---------
L
K
V
TKGD------
A
G
Q
Y
T
C
Y
A
S
N
V
A
G
K
D
S
C
SA--
Q
--
L
G
--
V
Q
E
P
P
R
F
I
K
K
L
E
P
-------------------
S
R
I
V
K
Q
D
E
H
T
R
Y
E
C
K
I
-
G
G
S
P
E
-----
I
K
V
L
W
Y
K
D
E
T
E
I
-
Q
---
E
S
S
K
F
R
M
S
F
V
E
S
V
A
V
L
E
M
Y
N
L
S
V
E
D
-
S
GD-
Y
T
C
E
-
A
H
N
A
A
---
G
S
A
S
S
----
S
T
S
L
K
V
K
-------
E
P
-----
P
------
V
F
-
R
K
K
---
P
H
P
V
E
T
L
K
G
A
D
V
H
L
E
C
E
L
Q
G
T
P
P
F
Q
V
S
W
H
K
D
K
R
E
L
R
S
G
---
K
K
Y
K
I
M
S
E
N
F
L
T
S
I
H
I
L
N
V
D
S
A
D
I
G
E
Y
Q
C
K
A
S
N
D
V
G
S
D
T
C
V
G
S
I
T
L
K
A
P
P
R
-------
F
-------
V
KKLSDIS
T
V
V
G
E
E
V
Q
L
Q
A
T
I
E
G
A
E
-
P
I
S
V
A
W
F
K
D
K
G
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
53.86
15%
50
- C2 -
-
5Z5K
6
DCC_RAT
A:
[20-333]
-----------------------------------------------------------------------------------------
L
L
N
C
S
A
E
--
S
D
R
G
V
P
V
I
K
W
K
K
D
G
L
I
L
A
L
G
M
---
D
D
---
R
KQQ
L
P
N
G
-
S
L
L
I
QNILHSRHH
K
P
D
----------
E
G
L
Y
Q
C
E
A
S
L
G
D
S
G
S
I
I
SRTA
K
--
V
M
--
V
A
G
P
L
R
F
L
S
Q
T
--------------------
E
S
I
T
A
F
M
G
D
T
V
L
L
K
C
E
V
-
I
G
D
P
M
-----
P
T
I
H
W
Q
K
N
Q
Q
D
L
--
N
P
-
I
P
G
D
S
R
V
-
V
V
L
P
S
G
A
L
Q
I
S
R
L
Q
P
G
D
-
S
GV-
Y
R
C
S
-
A
R
N
P
A
---
S
T
R
T
G
---
N
E
A
E
V
R
I
L
-------
S
D
-----
P
GLHRQL
Y
F
-
L
Q
R
---
P
S
N
V
I
A
I
E
G
K
D
A
V
L
E
C
C
V
S
G
Y
P
P
P
S
F
T
W
L
R
G
E
E
V
I
Q
L
R
--
S
K
K
Y
S
L
---
L
G
G
S
N
L
L
I
S
N
V
T
D
D
D
S
G
T
Y
T
C
V
V
T
Y
K
N
E
N
I
S
A
S
A
E
L
T
V
L
V
P
P
W
-------
F
LNHPSNL
Y
-------
A
Y
E
S
M
D
I
E
F
E
C
A
V
S
G
K
P
-
V
P
T
V
N
W
M
K
N
G
D
V
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.20
29%
-82
- C2 -
-
6SDB
-
TITIN_HUMAN
A:
[87-194]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
Q
A
T
S
T
A
E
L
L
V
K
A
E
T
-------
A
P
-----
P
------
N
F
-
V
Q
R
---
L
Q
S
M
T
V
R
Q
G
S
Q
V
R
L
Q
V
R
V
T
G
I
P
T
P
V
V
K
F
Y
R
D
G
A
E
I
Q
S
S
L
---
D
F
Q
I
S
Q
E
G
D
L
Y
S
L
L
I
A
E
A
Y
P
E
D
S
G
T
Y
S
V
N
A
T
N
S
V
G
R
A
T
S
T
A
E
L
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
52.93
36%
-81
- C2 -
-
6C6M
-
MYLK_HUMAN
A:
[10-100]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
------
K
F
-
E
S
K
---
P
Q
S
Q
E
V
K
E
N
Q
T
V
K
F
R
C
E
V
S
G
I
P
K
P
E
V
A
W
F
L
E
G
T
P
V
R
R
Q
E
G
--
S
I
E
V
Y
E
D
A
G
S
H
Y
L
C
L
L
K
A
R
T
R
D
S
G
T
Y
S
C
T
A
S
N
A
Q
G
Q
L
S
C
S
W
T
L
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------