@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AMHR2_HUMAN: (2020-09-04 )
MLGSLGLWALLPTAVEAPPNRRTCVFFEAPGVRGSTKTLGELLDTGTELPRAIRCLYSRCCFGIWNLTQDRAQVEMQGCRDSDEPGCESLHCDPSPRAHPSPGSTLFTCSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAPGESIWMALVLLGLFLLLLLLLGSIILALLQRKNYRVRGEPVPEPRPDSGRDWSVELQELPELCFSQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQFQAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGMALRRADIYSLALLLWEILSRCPDLRPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQESHPFPESCPRGCPPLCPEDCTSIPAPTILPCRPQRSACHFSVQQGPCSRNPQPACTLSPV
Atome Classification :
(33 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190....---...200.......210.......220.......230.......240.......250.......260.---..--....270.......280.......290.......300.......310......--.320........330.......340.......350.......360.........370.......380.......390.......400.......410.......420....--...430.......440.......450.......460.......470......--..480.......490.......500.......510.......520.......530.......540.......550.......560.......570.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MLGS
L
G
L
W
A
LL
P
T
A
VEAPPNR
R
T
C
V
F
F
EAPGVRG
S
T
K
T
L
G
E
L
L
DTGTE
L
P
R
A
I
R
C
L
Y
S
R
C
C
F
G
I
WNLT
Q
D
R
A
Q
V
E
M
QGCRDSDEPGCESLHCDPSPRAHPSPG
S
T
L
F
T
CSCGTDFCNANYSHLPPPGSPGTPGSQGPQAAP
G
E
S
I
W
M
A
L
V
L
L
G
L
F
L
L
L
L
L
L
L
G
S
I
I
L
A
L
L
Q
RKN
Y
R
VRGEPVPEPRPDSGRD
W
S
V
E
---
L
Q
E
L
P
E
L
C
F
S
Q
V
I
R
EGG
H
A
V
V
W
AGQLQ
G
K
L
V
A
I
K
AFP
P
R
S
V
A
Q
F
Q
A
E
R
A
L
Y
ELPGL
Q
H
D
H
I
V
R
F
I
TA---SR--GGPGRLLSG
P
L
L
V
L
E
LHPK
G
S
L
C
H
Y
L
T
Q
Y
T
S
D
W
G
S
S
L
R
M
A
L
S
L
A
Q
G
L
A
F
L
H
E
E
--
R
WQ-NGQYKPGIAHRDLSSQ
N
V
L
I
REDGSC
A
I
G
D
L
G
L
A
L
VLPG--LTQPPAWTPTQPQG
P
A
A
I
M
E
AGTQRYM
A
P
E
L
L
D
K
TL
D
L
Q
D
W
G
M
A
L
R
R
A
D
I
Y
S
L
A
L
L
L
W
E
I
L
S
RCPD--LRPDSSPP
P
F
Q
L
A
Y
E
AELGNTPT
S
D
E
L
W
A
L
A
V
Q
ERRRPYIPS
T
W
R
-
C
FAT
D
P
--
D
G
L
R
E
L
L
E
D
C
WDADP
E
A
R
L
T
A
E
C
V
Q
Q
R
L
A
A
LAHPQESHPFPESCPRGCPPL
C
P
E
D
CTSIPAPTILPCRPQRS
A
C
H
F
SVQQGPCSRNPQPACTLSPV
143
HHSearch
96.31
42%
-106
- C1 -
-
3G2F
4
BMPR2_HUMAN
A:
[10-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
R
P
V
A
V
K
V
F
S
F
A
N
R
Q
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
---
D
E
--
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
--
L
P
R
-
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
--
N
R
L
V
R
P
-------------
E
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
C
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
--
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
-
E
N
S
L
A
V
--
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
C
A
E
E
R
M
A
E
L
M
M
I
W
E
R
N
----------------------------------------------------------
27
Blastp_CBE
86.07
34%
-87
- C1 -
-
4X2J
1
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
26
Blastp_CBE
86.07
34%
-87
- C1 -
-
4X2K
1
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
20
PsiBlast_PDB
85.54
33%
-88
- C1 -
-
4X2G
2
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
28
Blastp_CBE
85.31
34%
-87
- C1 -
-
4X2F
1
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
144
HHSearch
85.21
33%
-111
- C1 -
-
5E8X
2
TGFR1_HUMAN
A:
[7-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
-
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
V
G
-
T
-
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
--
A
T
D
T
I
--------
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
-
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
--
G
G
I
H
---
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
-
S
-
C
E
A
L
--
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
--------------------------------------------------------------
29
Blastp_CBE
85.14
34%
-87
- C1 -
-
4X0M
1
TGFR1_HUMAN
A:
[7-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
37
Blastp_CBE
84.97
34%
-89
- C1 -
-
5USQ
1
TGFR1_HUMAN
A:
[6-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------------------------------------------------------------
58
Blastp_CBE
84.79
32%
-91
- C1 -
-
5E8X
2
TGFR1_HUMAN
A:
[8-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
33
Blastp_CBE
84.74
34%
-84
- C1 -
-
5QIM
2
TGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
145
HHSearch
84.73
34%
-107
- C1 -
-
4X2J
1
TGFR1_HUMAN
A:
[5-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
V
G
-
T
-
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
--------
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
-
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
--
G
G
I
---
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
-
S
C
-
E
A
L
--
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
--------------------------------------------------------------
9
PsiBlast_PDB
84.69
33%
-87
- C1 -
-
6B8Y
1
TGFR1_HUMAN
A:
[8-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
11
PsiBlast_PDB
84.66
33%
-83
- C1 -
-
5QIL
1
TGFR1_HUMAN
A:
[8-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
36
Blastp_CBE
84.41
34%
-87
- C1 -
-
5FRI
3
TGFR1_HUMAN
A:
[8-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------------------------------------------------------------
35
Blastp_CBE
84.35
34%
-83
- C1 -
-
2WOT
2
TGFR1_HUMAN
A:
[8-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
7
PsiBlast_PDB
84.35
33%
-85
- C1 -
-
5E8W
3
TGFR1_HUMAN
A:
[8-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
146
HHSearch
84.10
35%
-109
- C1 -
-
5USQ
1
TGFR1_HUMAN
A:
[5-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
V
G
--
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
--------
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
-
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
--
G
G
I
H
---
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
-
S
C
-
E
A
L
--
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------------------------------------------------------------
8
PsiBlast_PDB
83.76
33%
-83
- C1 -
-
5E8Z
1
TGFR1_HUMAN
A:
[8-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
38
Blastp_CBE
83.72
34%
-84
- C1 -
-
3KCF
1
TGFR1_HUMAN
E:
[44-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
---
I
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
43
Blastp_CBE
83.71
34%
-89
- C1 -
-
3FAA
1
TGFR1_HUMAN
D:
[44-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
---
I
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
18
PsiBlast_PDB
82.52
33%
-88
- C1 -
-
3TZM
1
TGFR1_HUMAN
A:
[11-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
----------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------------------------------------------------------------
17
PsiBlast_PDB
81.57
33%
-82
- C1 -
-
1RW8
1
TGFR1_HUMAN
A:
[6-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
---
D
N
--
K
D
N
G
-
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
--
I
-
V
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
--
A
T
D
T
I
D
I
A
P
N
H
--------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
-
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
-----
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
----
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
-------------------------------------------------------------
1
PsiBlast_PDB
81.50
42%
-29
- C1 -
-
3G2F
4
BMPR2_HUMAN
A:
[11-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
R
P
V
A
V
K
V
F
S
F
A
N
R
Q
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
---
D
E
RV
T
A
D
G
R
M
--
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
--
L
P
R
-
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
NR
L
V
R
P
---------------
E
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
R
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
--
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
-
E
N
S
L
A
V
--
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
L
A
E
E
R
M
A
E
L
-----------------------------------------------------------------
21
Blastp_CBE
78.18
42%
-16
- C1 -
-
3G2F
2
BMPR2_HUMAN
B:
[11-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
R
P
V
A
V
K
V
F
S
F
A
N
R
Q
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
---
D
E
RV
T
A
D
G
R
M
--
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
T
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
--
L
P
R
-
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
NR
L
-------------------
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
E
S
C
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
--
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
-
E
N
S
L
A
V
--
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
A
-
E
E
R
M
A
E
L
-----------------------------------------------------------------
156
HHSearch
73.30
34%
-51
- C1 -
-
4ASX
4
AVR2A_HUMAN
A:
[23-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
--
R
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
--
I
P
G
L
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
--
G
K
S
A
----------
G
-
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
--
A
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
-
A
G
M
--
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
---------------------------------------------------------------
157
HHSearch
71.59
34%
-48
- C1 -
-
3SOC
7
AVR2A_HUMAN
A:
[22-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
--
R
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
--
I
P
G
L
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
--
G
K
S
A
----------
G
D
T
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
--
A
D
G
P
V
--
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
-
A
G
M
--
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
---------------------------------------------------------------
60
Blastp_CBE
71.59
35%
-39
- C1 -
-
6EIX
10
ACVR1_HUMAN
A:
[38-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
DMT
S
R
--
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
F
--
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
--
Q
S
T
N
Q
L
D
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
TL
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
97
Blastp_CBE
71.56
34%
-35
- C1 -
-
4DYM
5
ACVR1_HUMAN
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
DMT
S
R
--
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
F
--
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
--
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
TL
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
68
Blastp_CBE
70.39
34%
-33
- C1 -
-
6SZM
4
?
B:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
DMT
S
R
--
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
F
--
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
--
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
TL
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
92
Blastp_CBE
69.45
34%
-36
- C1 -
-
3OOM
16
ACVR1_HUMAN
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
DMT
S
R
--
H
S
S
T
Q
L
W
----
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
--
I
F
--
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
--
S
T
N
Q
L
D
-
V
G
N
N
P
R
-------
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
NG
I
V
E
D
Y
K
P
P
F
Y
D
V
-----
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
----
F
S
D
P
TL
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------------------------------------------------------------
22
Blastp_CBE
64.83
34%
13
- C1 -
-
4ASX
6
AVR2A_HUMAN
B:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
NLY
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
--
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
IP
G
L
K
-
D
G
-
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
-----
G
K
S
A
G
D
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------------------------------------------------------------
5
PsiBlast_PDB
64.50
34%
13
- C1 -
-
4ASX
5
AVR2A_HUMAN
A:
[10-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
V
D
L
G
T
E
NLY
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
E
Y
V
A
V
K
I
F
P
I
Q
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
---
E
K
--
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
IP
G
L
K
-
D
G
-
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
-----
G
K
S
A
G
-
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------------------------------------------------------------
4
PsiBlast_PDB
63.90
34%
15
- C1 -
-
3SOC
7
AVR2A_HUMAN
A:
[14-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
T
E
NLY
F
Q
S
M
P
-
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
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A
Q
L
L
N
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A
V
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W
Q
N
E
Y
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V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
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A
---
E
K
--
R
G
T
S
V
D
V
D
-
L
W
L
I
T
A
F
H
E
K
G
S
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D
F
L
K
A
N
V
V
S
W
N
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L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
IP
G
L
K
-
D
G
-
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
-----
G
K
S
A
G
D
T
H
G
Q
-------
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
R
--
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
----
A
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
---
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
-----------------------------------------------------------------