@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ANKK1_HUMAN: (2020-09-04 )
MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPGAEMEI
Atome Classification :
(100 SA)
.........10........20........30........40..-----.-.-.-...50.......--.60........70........80........90..--.--......100......-.110--------.-----..-.----.-....120.......130....-...140........150.-------.--------.....-160.......-170-----.........180...-....190.......200...-....210.......220....-.--.-.-230.......240.....-..250.--......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAADPT
E
L
RLGSL
P
V
F
TRDDFEG
D
W
R
L
V
ASG
G
F
S
Q
V
F
Q
A
R
H
R
R
-----
W
-
R
-
T
-
E
Y
A
I
K
CAPCLPP--DAAS
S
D
V
N
Y
L
I
E
E
A
A
K
M
K
K
I
K
F
Q
H
I
V
S
I
Y
G
V
C
-KQ--
P
--
L
G
I
V
M
E
F
M
ANG
S
L
E
K
-
V
L
----------
S
-----
T
H
-
S
----
L
-
C
W
K
L
R
F
R
I
I
H
E
T
S
L
A
M
N
F
L
H
S-IKP
P
-
L
L
H
L
DLKPG
N
I
L
L-------D--------SN
M
H
V
-
K
I
S
D
F
G
L
S
K
W
-
M
-------
E
Q
S
T
R
M
Q
Y
I
E
R
S
A
L
R
-
G
M
L
S
YI
P
P
E
M
F
LESNKAPGP-KY
D
V
Y
S
F
A
I
V
I
W
E
L
L
TQKKPY-S--G-
F
-
N
M
M
M
I
I
I
R
V
AAGMRPSLQ-PVSDQW--
P
S
E
A
Q
Q
M
V
D
L
M
K
R
C
WDQDPKKR
P
C
F
L
D
I
T
I
E
T
D
I
L
L
S
L
L
Q
S
R
VAVP
E
S
K
A
L
A
R
K
V
S
C
K
L
SLRQPGEV
N
E
D
I
S
Q
E
L
M
DSDS
G
N
Y
L
K
R
A
L
Q
LSDRKNLVPRDE
E
L
C
I
YENKVT
P
L
H
F
L
VAQG
S
V
E
Q
V
R
L
L
L
AHEVD
V
D
CQTASGY
T
P
L
L
I
A
AQDQQ
P
D
L
C
A
L
L
L
AHGADANRVDEDGWA
P
L
H
F
A
AQNGDDG
T
A
R
L
L
LDHGACVD
A
Q
EREGWT
P
L
H
L
AAQN
N
F
E
N
V
A
R
L
L
V
SRQADPNLHEAEGKT
P
L
H
V
A
A
Y
F
G
H
V
S
L
V
K
L
L
T
SQGAEL
D
A
Q
QRNLRT
P
L
H
L
A
VERG
K
V
R
A
I
Q
H
L
L
KSGAVPDALDQSGYGPL
H
T
A
AAR
G
K
Y
L
I
C
K
M
L
L
RYGASLELPTHQGWT
P
L
H
L
A
A
YK
G
H
L
E
I
I
H
L
L
A
E
SHANMGALGAV
N
W
T
P
L
H
L
A
A
RH
G
E
E
A
V
V
S
A
L
L
QCGADPNAAEQSGW
T
P
L
H
L
A
V
Q
R
S
T
F
L
S
V
I
N
L
L
E
H
HANVHARNKVGW
T
P
A
H
L
A
ALKG
N
T
A
I
L
K
V
L
V
EAG
A
Q
L
DVQDGVSC
T
P
L
Q
L
A
L
R
S
R
K
Q
G
I
M
S
F
L
EGKEP
S
V
A
TLGGSKPGAEMEI
4
PsiBlast_PDB
70.61
45%
-121
- C5 -
-
5WNL
1
RIPK4_MOUSE
A:
[11-288]
---------
L
G
L
L
R
T
F
D
A
G
E
F
A
G
-
W
E
K
V
G
S
G
G
F
G
Q
V
Y
K
V
R
H
V
H
-----
W
-
K
-
T
-
W
L
A
I
K
C
S
P
---
V
--
D
--
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
--
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
-
L
L
----------
A
-----
S
E
-
P
----
L
-
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
C
-
M
S
P
P
-
L
L
H
L
N
L
K
P
A
N
I
L
L
-------
D
--------
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
--
C
---------------------
F
-
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
-
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
-
A
--
D
E
K
-
N
I
L
H
I
M
M
K
V
V
K
G
H
R
P
E
L
P
-
P
I
C
R
P
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.66
45%
-116
- C5 -
-
5WNM
1
RIPK4_MOUSE
A:
[11-289]
---------
L
G
L
L
R
T
F
D
A
G
E
F
A
G
-
W
E
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
-----
W
-
K
-
T
-
W
L
A
I
K
C
S
P
S
L
H
V
--
D
--
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
--
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
-
L
L
----------
A
-----
S
E
-
P
----
L
-
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
C
-
M
S
P
P
-
L
L
H
L
N
L
K
P
A
N
I
L
L
-------
D
--------
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
------------------------
F
-
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
-
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
-
A
--
D
E
K
-
N
I
L
H
I
M
M
K
V
V
K
G
H
R
P
E
L
P
-
P
I
C
R
P
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.53
45%
-115
- C5 -
-
5WNJ
1
RIPK4_MOUSE
A:
[11-289]
---------
L
G
L
L
R
T
F
D
A
G
E
F
A
G
-
W
E
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
-----
W
-
K
-
T
-
W
L
A
I
K
C
S
P
S
L
H
V
--
D
--
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
--
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
-
L
L
----------
A
-----
S
E
-
P
----
L
-
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
C
-
M
S
P
P
-
L
L
H
L
N
L
K
P
A
N
I
L
L
-------
D
--------
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
--
C
---------------------
F
-
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
-
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
-
A
--
D
E
K
-
N
I
L
H
I
M
M
K
V
V
K
G
H
R
P
E
L
P
-
P
I
C
R
P
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
68.43
45%
-112
- C5 -
-
5WNK
1
RIPK4_MOUSE
A:
[11-288]
---------
L
G
L
L
R
T
F
D
A
G
E
F
A
G
-
W
E
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
-----
W
-
K
-
T
-
W
L
A
I
K
C
S
P
S
L
H
V
--
D
--
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
--
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
-
L
L
----------
A
-----
S
E
-
P
----
L
-
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
C
-
M
S
P
P
-
L
L
H
L
N
L
K
P
A
N
I
L
L
-------
D
--------
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
--
C
---------------------
F
-
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
-
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
-
A
--
D
E
K
-
N
I
L
H
I
M
M
K
V
V
K
G
H
R
P
E
L
P
-
P
I
C
R
P
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
67.97
45%
-114
- C5 -
-
5WNI
1
RIPK4_MOUSE
A:
[11-288]
---------
L
G
L
L
R
T
F
D
A
G
E
F
A
G
-
W
E
K
V
G
S
----
Q
V
Y
K
V
R
H
V
H
-----
W
-
K
-
T
-
W
L
A
I
K
C
S
P
S
L
H
V
--
D
--
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
--
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
-
L
L
----------
A
-----
S
E
-
P
----
L
-
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
C
-
M
S
P
P
-
L
L
H
L
N
L
K
P
A
N
I
L
L
-------
D
--------
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
--
C
-------
N
-------------
F
-
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
-
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
-
A
--
D
E
K
-
N
I
L
H
I
M
M
K
V
V
K
G
H
R
P
E
L
P
-
P
I
C
R
P
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
55.18
38%
-37
- C5 -
-
6HMX
1
RIPK2_HUMAN
B:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
----------
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------------
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
55.03
38%
-41
- C5 -
-
6ES0
1
RIPK2_HUMAN
B:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
--------
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
54.70
38%
-50
- C5 -
-
5AR3
1
RIPK2_HUMAN
B:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
--------
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
------------------------
T
I
I
Y
M
P
P
E
N
Y
E
P
-----
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
54.43
38%
-37
- C5 -
-
5J79
1
RIPK2_HUMAN
B:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
----------
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
----
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
54.13
38%
-34
- C5 -
-
5J7B
1
RIPK2_HUMAN
B:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
--------
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
-------------------------
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
53.93
38%
-29
- C5 -
-
6RN8
1
RIPK2_HUMAN
B:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
A
-
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
--
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------------
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
53.91
38%
-42
- C5 -
-
5AR7
1
RIPK2_HUMAN
B:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
----L-
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
----------------------------
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
-
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
53.90
38%
-59
- C5 -
-
5W5J
1
RIPK2_HUMAN
B:
[18-297]
----------------------
A
D
L
R
Y
L
S
R
-
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
-----------
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
---
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
-------------------------------
T
I
I
Y
M
P
P
E
N
Y
E
--------I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
53.86
38%
-37
- C5 -
-
5J79
1
RIPK2_HUMAN
A:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
----------
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-----------------
S
A
P
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
53.71
38%
-42
- C5 -
-
5AR4
1
RIPK2_HUMAN
A:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
----L-
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
-----------------------------
T
I
I
Y
M
P
P
E
N
Y
E
------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
53.68
38%
-39
- C5 -
-
5AR8
1
RIPK2_HUMAN
B:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
----------
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
--------------------------
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
53.47
38%
-32
- C5 -
-
6RNA
1
RIPK2_HUMAN
A:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
-
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
------LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------------
G
-
G
T
I
I
Y
M
P
P
E
N
Y
--------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
53.34
38%
-34
- C5 -
-
6RN8
1
RIPK2_HUMAN
A:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
---
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
53.10
38%
-25
- C5 -
-
6HMX
1
RIPK2_HUMAN
A:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
-----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R----------------------
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
53.07
38%
-28
- C5 -
-
5NG0
1
RIPK2_HUMAN
A:
[23-302]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
F
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
53.04
38%
-26
- C5 -
-
5AR5
1
RIPK2_HUMAN
A:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------------
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
52.53
38%
-22
- C5 -
-
6S1F
1
?
D:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
-------------------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
52.47
38%
-28
- C5 -
-
6S1F
1
?
C:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
52.42
38%
-30
- C5 -
-
6UL8
1
?
A:
[15-294]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
---LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
C
K
W
-------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
52.39
38%
-13
- C5 -
-
5AR4
1
RIPK2_HUMAN
B:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
------LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
----------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
52.25
38%
-12
- C5 -
-
6UL8
1
?
B:
[15-294]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
------LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
C
K
W
-------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
52.19
38%
-25
- C5 -
-
5NG2
1
RIPK2_HUMAN
A:
[23-302]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
N
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-------
M
---------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.13
38%
-49
- C5 -
-
5W5J
1
RIPK2_HUMAN
A:
[18-297]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
-----------------------
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
F-
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
-------------------------------
T
I
I
Y
M
P
P
E
N
Y
E
P
-------I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
52.06
38%
-19
- C5 -
-
5NG2
1
RIPK2_HUMAN
B:
[23-302]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
N
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
52.02
38%
-31
- C5 -
-
5AR7
1
RIPK2_HUMAN
A:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
----L-
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
------------------------
T
I
I
Y
M
P
P
E
N
Y
E
------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
51.84
38%
-21
- C5 -
-
5J7B
1
RIPK2_HUMAN
A:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
-----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
----------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
----
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
51.81
38%
-8
- C5 -
-
6RNA
1
RIPK2_HUMAN
B:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
---
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
------L-
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------------
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
51.69
38%
-23
- C5 -
-
5AR5
1
RIPK2_HUMAN
B:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R-------------------------
T
I
I
Y
M
P
P
E
N
Y
E
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
51.44
38%
-22
- C5 -
-
5AR3
1
RIPK2_HUMAN
A:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
----L-
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------------
G
-
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
51.35
38%
-43
- C5 -
-
5AR8
1
RIPK2_HUMAN
A:
[35-314]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
-----------------
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
------
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
------------------------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
51.11
38%
-12
- C5 -
-
6SZJ
1
?
A:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
---
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
----------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
----
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
51.07
38%
-6
- C5 -
-
5NG0
1
RIPK2_HUMAN
B:
[23-302]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-----------------
S
A
P
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
---
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
F
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
51.06
38%
-8
- C5 -
-
6S1F
1
?
A:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
-----
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
51.00
38%
-23
- C5 -
-
6SZE
1
?
A:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
-----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
----------------------------
T
I
I
Y
M
P
P
E
N
Y
E
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
50.92
38%
-7
- C5 -
-
6SZJ
1
?
B:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
------LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
------------------------
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
50.88
38%
-13
- C5 -
-
4C8B
1
RIPK2_HUMAN
B:
[36-315]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
-----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
------------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.82
38%
-23
- C5 -
-
4C8B
2
RIPK2_HUMAN
A:
[36-315]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
------------------------------
G
T
I
I
Y
M
P
P
E
N
Y
--------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
50.67
38%
-11
- C5 -
-
6FU5
1
RIPK2_HUMAN
B:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
------------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
50.01
38%
-21
- C5 -
-
6FU5
1
RIPK2_HUMAN
A:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
---
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
----------------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
49.99
38%
-8
- C5 -
-
6ES0
1
RIPK2_HUMAN
A:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
H
I
H
T
P
LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
-------------------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
49.77
31%
-42
- C5 -
-
4L53
3
M3K7_HUMAN
A:
[1-256]
----------
G
S
L
H
M
I
D
Y
K
E
I
E
V
E
-
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
--------------------------
K
-
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
49.72
38%
-8
- C5 -
-
6SZE
1
?
B:
[20-299]
----------------------
A
D
L
R
Y
L
S
R
---
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
------LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
----------------------
E
G
-
G
T
I
I
Y
M
P
P
E
N
Y
E
P
------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
49.65
38%
-12
- C5 -
-
6S1F
1
?
B:
[19-298]
----------------------
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
-----
W
-
R
-
V
-
Q
V
A
V
K
H
L
-----LL
D
S
E
R
K
D
V
---
L
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
--
P
EF
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
-
L
L
----------
H
-----
R
K
-
T
EYPD
V
-
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
-
M
T
P
P
-
L
L
H
H
D
L
K
T
Q
N
I
L
L
-------
D
--------
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-------
M
S
---------------
T
I
I
Y
M
P
P
E
------
K
S
R
A
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
-
E
--
D
-
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
H
R
P
V
I
N
-
E
E
S
L
P
Y
DI
P
H
R
A
-
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
49.12
31%
-40
- C5 -
-
4L3P
1
M3K7_HUMAN
A:
[1-256]
----------
G
S
L
H
M
I
D
Y
K
E
I
E
V
E
-
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
-----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
49.07
31%
-42
- C5 -
-
4L52
1
M3K7_HUMAN
A:
[1-256]
----------
G
S
L
H
M
I
D
Y
K
E
I
E
V
E
-
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
48.48
32%
-74
- C5 -
-
5J9L
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
G
--
G
V
V
C
K
A
---------
W
-
R
-
A
-
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
--
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
------------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
47.86
33%
-45
- C5 -
-
5VO2
1
M3K12_HUMAN
A:
[16-255]
-----------------------
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
F
H
G
---------
E
-
E
V
A
V
K
K
V
R
------
D
L
K
E
T
D
I
K
H
L
-------
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
-
T
Q
--
A
PC
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
-
V
L
----------
R
AGRPV
T
P
-
S
----
L
-
L
V
D
W
S
M
G
I
----
A
G
G
M
N
Y
L
H
L
-
H
K
---
I
I
H
R
D
L
K
S
P
N
M
L
I
-------
T
--------
Y
D
D
V
V
-
K
I
S
D
F
G
--------------------
F
------
A
-
G
T
V
A
W
M
A
P
E
V
I
--
R
N
E
P
V
S
E
-
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
-
K
--
D
-
V
-
D
S
S
A
I
I
W
G
V
G
S
N
---
S
L
H
L
P
V
P
S
S
C
--
P
D
G
F
K
I
---
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
47.84
33%
-46
- C5 -
-
5CEP
1
M3K12_HUMAN
A:
[16-255]
-----------------------
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
F
H
G
---------
E
-
E
V
A
V
K
K
V
R
------
D
L
K
E
T
D
I
K
H
L
-------
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
-
T
Q
--
A
PC
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
-
V
L
----------
R
AGRPV
T
P
-
S
----
L
-
L
V
D
W
S
M
G
I
----
A
G
G
M
N
Y
L
H
L
-
H
K
---
I
I
H
R
D
L
K
S
P
N
M
L
I
-------
T
--------
Y
D
D
V
V
-
K
I
S
D
F
G
--------------------
F
------
A
-
G
T
V
A
W
M
A
P
E
V
I
--
R
N
E
P
V
S
E
-
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
-
K
--
D
-
V
-
D
S
S
A
I
I
W
G
V
G
S
N
---
S
L
H
L
P
V
P
S
S
C
--
P
D
G
F
K
I
---
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
47.73
33%
-44
- C5 -
-
5VO1
1
M3K12_HUMAN
A:
[16-255]
-----------------------
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
F
H
G
---------
E
-
E
V
A
V
K
K
V
R
------
D
L
K
E
T
D
I
K
H
L
-------
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
-
T
Q
--
A
PC
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
-
V
L
----------
R
AGRPV
T
P
-
S
----
L
-
L
V
D
W
S
M
G
I
----
A
G
G
M
N
Y
L
H
L
-
H
K
---
I
I
H
R
D
L
K
S
P
N
M
L
I
-------
T
--------
Y
D
D
V
V
-
K
I
S
D
F
G
--------------------
F
------
A
-
G
T
V
A
W
M
A
P
E
V
I
--
R
N
E
P
V
S
E
-
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
-
K
--
D
-
V
-
D
S
S
A
I
I
W
G
V
G
S
N
---
S
L
H
L
P
V
P
S
S
C
--
P
D
G
F
K
I
---
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
47.45
32%
-40
- C5 -
-
5JGA
1
M3K7_HUMAN
A:
[16-256]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
A
---------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
47.44
33%
-42
- C5 -
-
5CEQ
1
M3K12_HUMAN
A:
[16-255]
-----------------------
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
F
H
G
---------
E
-
E
V
A
V
K
K
V
R
------
D
L
K
E
T
D
I
K
H
L
-------
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
-
T
Q
--
A
PC
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
-
V
L
----------
R
AGRPV
T
P
-
S
----
L
-
L
V
D
W
S
M
G
I
----
A
G
G
M
N
Y
L
H
L
-
H
K
---
I
I
H
R
D
L
K
S
P
N
M
L
I
-------
T
--------
Y
D
D
V
V
-
K
I
S
D
F
G
--------------------
F
------
A
-
G
T
V
A
W
M
A
P
E
V
I
--
R
N
E
P
V
S
E
-
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
-
K
--
D
-
V
-
D
S
S
A
I
I
W
G
V
G
S
N
---
S
L
H
L
P
V
P
S
S
C
--
P
D
G
F
K
I
---
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
47.21
33%
-40
* C5 *
-
5CEO
1
M3K12_HUMAN
A:
[16-255]
-----------------------
D
L
Q
W
V
G
S
G
A
Q
G
A
V
F
L
G
R
F
H
G
---------
E
-
E
V
A
V
K
K
V
R
------
D
L
K
E
T
D
I
K
H
L
-------
R
K
L
K
H
P
N
I
I
T
F
K
G
V
C
-
T
Q
--
A
PC
Y
C
I
L
M
E
F
C
A
Q
G
Q
L
Y
E
-
V
L
----------
R
AGRPV
T
P
-
S
----
L
-
L
V
D
W
S
M
G
I
----
A
G
G
M
N
Y
L
H
L
-
H
K
---
I
I
H
R
D
L
K
S
P
N
M
L
I
-------
T
--------
Y
D
D
V
V
-
K
I
S
D
F
G
--------------------
F
------
A
-
G
T
V
A
W
M
A
P
E
V
I
--
R
N
E
P
V
S
E
-
K
V
D
I
W
S
F
G
V
V
L
W
E
L
L
T
G
E
I
P
Y
-
K
--
D
-
V
-
D
S
S
A
I
I
W
G
V
G
S
N
---
S
L
H
L
P
V
P
S
S
C
--
P
D
G
F
K
I
---
L
L
R
Q
C
W
N
S
K
P
R
N
R
P
S
F
R
Q
I
L
L
H
L
D
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
47.17
32%
-41
- C5 -
-
5V5N
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
46.74
32%
-43
- C5 -
-
5GJD
1
M3K7_HUMAN
A:
[16-260]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
A
---
C
-----------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
46.61
32%
-70
- C5 -
-
5JK3
1
M3K7_HUMAN
A:
[10-255]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
------------------
A
I
K
Q
I
---------
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
-----
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
-------------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
46.50
32%
-42
- C5 -
-
2EVA
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
46.25
32%
-39
- C5 -
-
5JGB
1
M3K7_HUMAN
A:
[16-256]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
46.16
32%
-34
- C5 -
-
5JGD
1
M3K7_HUMAN
A:
[16-256]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
A
---------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
45.53
32%
-35
- C5 -
-
5GJG
1
M3K7_HUMAN
A:
[16-260]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
------------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
45.00
32%
-35
- C5 -
-
2YIY
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
-----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
44.47
32%
-32
- C5 -
-
4O91
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
-----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
44.46
32%
-31
- C5 -
-
5GJF
1
M3K7_HUMAN
A:
[16-260]
--------------------------
V
V
G
R
G
A
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
-------------
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
T
A
---
C
-------
D
I
Q
T
H
M
-----
T
N
N
K
-
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
44.40
31%
-32
- C5 -
-
3DTC
1
M3K9_HUMAN
A:
[14-264]
--------------------------
I
I
G
I
G
G
F
G
K
V
Y
R
A
F
--------
W
I
G
-
D
-
E
V
A
V
K
A
A
------------
T
I
E
N
V
R
Q
E
A
K
L
F
A
M
L
K
H
P
N
I
I
A
L
R
G
V
C
L
K
E
-----
L
C
L
V
M
E
F
A
R
G
G
P
L
N
R
-
V
L
----------
S
-----
G
K
-
R
----
I
-
P
P
D
I
L
V
N
W
A
V
Q
I
A
R
G
M
N
Y
L
H
D
E
A
I
V
P
-
I
I
H
R
D
L
K
S
S
N
I
L
I
-------
L
QKVENGDL
S
N
K
I
L
-
K
I
T
D
F
G
L
----------------------------
G
A
Y
A
W
M
A
P
E
V
I
R
A
S
M
F
S
K
G
S
---
D
V
W
S
Y
G
V
L
L
W
E
L
L
T
G
E
V
P
F
-
R
--
G
-
I
-
D
G
L
A
V
A
Y
G
V
A
--
M
N
K
L
A
L
-
P
I
P
S
T
C
--
P
---
E
P
F
A
K
L
M
E
D
C
W
N
P
D
P
H
S
R
P
S
F
T
N
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
44.31
33%
-17
- C5 -
-
4ITJ
1
RIPK1_HUMAN
A:
[17-278]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLN-----------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
43.78
31%
-31
- C5 -
-
4UYA
1
M3K21_HUMAN
A:
[33-285]
--------------------------
L
I
G
A
G
---
Q
V
Y
R
A
T
--------
W
-
Q
G
Q
-
E
V
A
V
K
A
A
------------
A
A
E
S
V
R
R
E
A
R
L
F
A
M
L
R
H
P
N
I
I
E
L
R
G
V
C
L
Q
Q
--
P
H-
L
C
L
V
L
E
F
A
R
G
G
A
L
N
R
-
A
L
----------
A
-----
G
R
-
R
----
I
-
P
P
H
V
L
V
N
W
A
V
Q
I
A
R
G
M
L
Y
L
H
E
E
A
F
V
P
-
I
L
H
R
D
L
K
S
S
N
I
L
L
LEKIEHD
I
--------
C
N
K
T
L
-
K
I
T
D
F
------------------------------
G
A
Y
A
W
M
A
P
E
V
I
K
S
S
L
F
S
K
G
S
---
D
I
W
S
Y
G
V
L
L
W
E
L
L
T
G
E
V
P
Y
-
R
--
G
-
I
-
D
G
L
A
V
A
Y
G
V
A
V
N
-
K
L
T
L
--
P
I
P
S
T
C
--
P
---
E
P
F
A
K
L
M
K
E
C
W
Q
Q
D
P
H
I
R
P
S
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
43.33
33%
-22
- C5 -
-
4NEU
1
RIPK1_HUMAN
B:
[34-287]
-----------------------------
S
G
G
F
G
K
V
S
L
C
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
C
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
-----------------------------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
C
E
Q
Q
L
I
M
C
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
43.30
33%
-15
- C5 -
-
6R5F
1
RIPK1_HUMAN
D:
[23-287]
-----------------------------
S
G
G
F
-
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
-------
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN----------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
43.22
32%
-31
- C5 -
-
5JH6
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
G
A
F
-
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
----
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
------------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
42.94
33%
-4
- C5 -
-
6RLN
1
RIPK1_HUMAN
B:
[23-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
-----------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
42.83
33%
-13
- C5 -
-
6NW2
1
RIPK1_HUMAN
A:
[30-294]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
-----------
T
L
Y
Y
M
A
P
E
H
L
----
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
42.71
33%
-4
- C5 -
-
5TX5
1
RIPK1_HUMAN
B:
[23-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
-----------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
42.70
33%
-7
- C5 -
-
5HX6
1
RIPK1_HUMAN
B:
[24-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
-----------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
42.69
32%
-30
- C5 -
-
5J8I
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
--
F
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
--------
E
S
E
S
E
R
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
-
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
-------------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
42.62
33%
-10
- C5 -
-
6C4D
1
RIPK1_HUMAN
C:
[23-281]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
----
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLN-----------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
42.44
33%
-21
- C5 -
-
6NW2
1
RIPK1_HUMAN
B:
[31-294]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
-------
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
-G-
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLN-----------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E-------
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
42.28
33%
-12
- C5 -
-
6C3E
1
RIPK1_HUMAN
A:
[28-281]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
----
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN----------------
G
T
L
Y
Y
M
A
P
E
H
L
------
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
L
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
42.24
33%
-1
- C5 -
-
6RLN
1
RIPK1_HUMAN
A:
[24-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
----------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
41.99
33%
0
- C5 -
-
4ITJ
1
RIPK1_HUMAN
B:
[25-278]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
-----------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
41.65
33%
-2
- C5 -
-
6HHO
1
RIPK1_HUMAN
B:
[24-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
-----------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
41.64
33%
-7
- C5 -
-
6R5F
1
RIPK1_HUMAN
B:
[23-287]
-----------------------------
S
G
G
F
-
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN----------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
41.46
33%
2
- C5 -
-
6R5F
1
RIPK1_HUMAN
A:
[19-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
------
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
---------------
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
41.33
33%
3
- C5 -
-
6C4D
1
RIPK1_HUMAN
A:
[21-281]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
41.32
33%
-12
- C5 -
-
4NEU
1
RIPK1_HUMAN
A:
[34-287]
-----------------------------
S
G
G
F
G
K
V
S
L
C
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
C
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MW---------------------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
C
E
Q
Q
L
I
M
C
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
41.07
33%
5
- C5 -
-
6HHO
1
RIPK1_HUMAN
A:
[31-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
----------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
40.98
33%
6
- C5 -
-
6NYH
1
RIPK1_HUMAN
A:
[17-280]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
-----------
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
39.47
33%
4
- C5 -
-
4ITI
1
RIPK1_HUMAN
A:
[25-278]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
---------G
G
T
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
---------
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
39.20
32%
-26
- C5 -
-
5E7R
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
---
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
Q
I
-----------------------
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
G
-----------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
37.68
32%
-12
- C5 -
-
5J7S
1
M3K7_HUMAN
A:
[15-255]
--------------------------
V
V
G
R
G
--
G
V
V
C
K
A
K
--------
W
-
R
-
A
K
D
V
A
I
K
----------------
K
A
F
I
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
----
L
N
--
P
--
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
-
V
L
HGAEPLPYYT
A
-----
A
H
-
A
----
M
-
S
W
C
L
------
Q
C
S
Q
G
V
A
Y
L
H
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
-------
V
--------
A
G
G
T
V
L
K
I
C
D
F
------------------------------
G
S
A
A
W
M
A
P
E
V
F
E
G
S
N
Y
S
--
E
-
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
-
D
EI
G
-
G
-
P
A
F
R
I
M
W
A
V
H
N
G
T
R
P
----
P
L
I
K
N
L
--
P
K
P
I
E
---
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
35.78
31%
-47
- C5 -
-
6CTH
1
?
A:
[23-215]
---------------------------
L
G
E
G
G
F
G
S
V
Y
R
G
F
L
R
D
-----
S
-
D
-
T
-
Y
I
A
V
K
K
V
S
------
R
A
S
K
Q
G
I
K
E
Y
A
S
E
V
K
I
I
S
R
L
R
H
K
N
L
V
K
L
I
G
W
C
-
H
E
RG
E
--
L
M
L
V
Y
E
F
M
A
N
G
S
L
D
S
H
I
F
----------
K
-----
G
K
-
S
----
L
L
T
W
E
V
R
Y
R
I
V
K
D
L
A
S
A
L
L
Y
L
H
E
-
E
G
D
H
C
V
L
H
R
D
I
K
T
S
N
I
M
L
-------
D
--------
S
S
F
N
A
-
K
L
G
D
F
G
L
A
R
L
-
V
-------
D
---------
K
T
L
L
A
-
G
T
V
G
Y
M
A
P
E
C
-
L
S
S
G
K
A
-
S
K
-
E
S
D
V
Y
S
F
G
V
V
A
L
E
I
A
S
G
R
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
32.32
33%
-13
- C5 -
-
6C4D
1
RIPK1_HUMAN
B:
[17-281]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
---------------
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
31.86
33%
4
- C5 -
-
6C3E
1
RIPK1_HUMAN
B:
[17-281]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
------------------
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
L
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
31.40
33%
17
- C5 -
-
4ITI
1
RIPK1_HUMAN
B:
[14-278]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
L
R
E
V
D
----------
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
30.91
33%
8
- C5 -
-
6C4D
1
RIPK1_HUMAN
D:
[17-281]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
E
---------------
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
30.47
33%
7
- C5 -
-
6OCQ
1
RIPK1_HUMAN
A:
[23-287]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
QGLMI
M
-
K
-
T
-
V
Y
--
K
G
P
N
C
I
E
H
--
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M
S
----
T
-
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
E
H
N
------------------
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
29.61
33%
2
- C5 -
-
6NYH
1
RIPK1_HUMAN
B:
[16-280]
-----------------------------
S
G
G
F
G
K
V
S
L
A
F
H
R
T
LMI--
M
-
K
-
T
-
V
Y
--
K
---------
N
E
A
------
L
L
E
E
A
K
M
M
N
R
L
R
H
S
R
V
V
K
L
L
G
V
I
-
I
E
EG
K
--
Y
S
L
V
M
E
Y
M
E
K
G
N
L
M
H
-
V
L
----------
K
-----
A
E
M-------
P
L
S
V
K
G
R
I
I
L
E
I
I
E
G
M
A
Y
L
H
G
---
K
G
-
V
I
H
K
D
L
K
P
E
N
I
L
V
-------
D
--------
N
D
F
H
I
-
K
I
A
D
L
G
L
A
S
F
-
K
MWSKLNN
E
-----------------
L
Y
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
-
K
S
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
N
K
E
P
Y
E
N
--
A
-
I
-
A
E
Q
Q
L
I
M
A
I
K
S
G
N
R
P
D
V
D
-
D
I
T
E
Y
C
--
P
R
E
---
I
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------