@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AVR2A_HUMAN: (2020-09-05 )
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Atome Classification :
(235 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190-........200.......210.--......-------220.-----...-----...230.......240.......250.......260........270.......----280--.-..-...--.--..290.......300.......310........320.......330.......340..-.....------350.--..--.--...-360.......370....---.-.--.-380-..-.....390.......400..--...--..410.......420.......430.......440.......-450.......460.......470.......480.......490.......500.......510.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MG
A
A
A
K
L
A
F
A
V
F
L
I
SCSS
G
A
I
LGRSET
Q
E
C
L
F
FNANWEKDRTNQTGVEPCYGD
K
D
K
R
R
H
C
F
A
T
W
KNISG
S
I
E
I
V
KQGCWLDDINCYDRTDCVEKKDSP
E
V
Y
F
C
CCEGNMCN
E
K
F
SYFPE
M
E
VTQPTSNPVTPKPP
Y
Y
N
I
L
L
Y
S
L
V
P
L
M
L
I
A
G
I
V
I
C
A
F
W
V
Y
R
HHKMAYPPVLVPTQDPGPPPPSPLLGLKP--
L
Q
L
L
E
V
KARGRFG
C
V
W
K
A
Q
L
L
N--E
Y
V
A
V
K
-------
I
F
PI-----QD
K
-----
Q
S
W
Q
NEY
E
V
YSLPGM
K
H
E
N
I
L
Q
F
IGAEKRGT
S
V
D
-
V
D
L
W
L
I
T
A
FHEKG
S
L
S
D
F
L
----
K
----
A
-NV-V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
EDIPGLK-DGHKPAISHRDIKSK
N
V
L
LKNN
L
T
A
C
I
A
DFG
L
A
-
L
K
F
EA------GKSA--GD--T--HGQ-VGTRRYM
A
P
E
V
L
E
G
A
IN---F-Q--R-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
CTAA--DG
P
--
V
D
E
YML
P
F
E
E
E
IGQHP
S
L
E
D
M
Q
E
V
V
V
HKKKR
P
V
L
R
D
Y
W
Q
K
HA-
G
M
A
M
L
C
E
T
I
E
E
C
WDH
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
N
II
T
T
E
D
I
V
T
V
V
T
M
V
TNVDFPPKESSL
479
HHSearch
98.44
98%
-109
- C4 -
-
4ASX
5
AVR2A_HUMAN
A:
[20-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
S
M
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
--
G
---
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
23
Blastp_CBE
98.17
100%
-106
- C4 -
-
3Q4T
10
AVR2A_HUMAN
B:
[25-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
------
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
----------------------------
22
Blastp_CBE
97.77
100%
-107
- C4 -
-
3SOC
5
AVR2A_HUMAN
B:
[25-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
------
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
3
PsiBlast_PDB
97.38
100%
-107
- C4 -
-
4ASX
4
AVR2A_HUMAN
A:
[25-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
--
G
---
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
21
Blastp_CBE
97.21
100%
-99
- C4 -
-
4ASX
6
AVR2A_HUMAN
B:
[25-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
--
G
D
--
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
480
HHSearch
96.29
98%
-100
- C4 -
-
3SOC
7
AVR2A_HUMAN
A:
[19-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
--
G
D
--
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
1
PsiBlast_PDB
95.75
100%
-98
- C4 -
-
3Q4T
13
AVR2A_HUMAN
A:
[25-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
--
G
D
--
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-----------------------------
2
PsiBlast_PDB
95.42
100%
-97
- C4 -
-
3SOC
7
AVR2A_HUMAN
A:
[25-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
V
A
V
K
-------
I
F
P
I
-----
Q
D
K
-----
Q
S
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
----
K
----
A
-
N
V
-
V
S
W
--
N
--
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
-
L
K
F
E
A
------
G
K
S
A
--
G
D
--
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
7
PsiBlast_PDB
76.66
44%
-66
- C4 -
-
5E91
1
TGFR2_HUMAN
A:
[8-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
--
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
---
E
T
V
A
V
K
-------
I
F
P
Y
-----
E
E
Y
-----
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
-
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
----
T
----
R
-
H
V
-
I
S
W
--
E
--
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
G
-
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
-
L
R
L
D
P
------
T
L
S
V
--
D
D
LA
N
--
S
G
Q
-
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
-
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
E
H
-----------------------------
485
HHSearch
76.47
40%
-73
- C4 -
-
5E8X
2
TGFR1_HUMAN
A:
[5-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
D
--
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
-
V
R
H
D
S
------
A
T
D
T
ID
I
A
--
P
--
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
H-
F
-
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
--
G
I
H
--
E
-
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
4
PsiBlast_PDB
76.06
76%
-1
- C4 -
-
2QLU
1
AVR2B_HUMAN
A:
[15-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GS
L
Q
L
L
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
M
N
--
D
F
V
A
V
K
-------
I
F
P
L
-----
Q
D
K
-----
Q
S
W
Q
S
E
R
E
I
F
S
T
P
G
M
K
H
E
N
L
L
Q
F
I
A
A
E
K
R
G
S
N
L
E
-
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
----
K
----
G
-
N
I
-
I
T
W
--
N
--
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
P
W
C
R
G
E
G
H
K
P
S
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
-
V
R
F
E
P
------
G
K
P
P
--
G
D
--
T
--
H
G
Q
-
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
-
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
K
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
T
I
K
D
H
W
L
K
H
P
-
G
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
S
----------------------------
39
Blastp_CBE
74.89
40%
-71
- C4 -
-
5E8X
2
TGFR1_HUMAN
A:
[7-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
484
HHSearch
74.36
40%
-65
- C4 -
-
4X2J
1
TGFR1_HUMAN
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
ID
I
A
--
P
--
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
H-
F
-
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
--
G
I
H
---
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
40
Blastp_CBE
74.01
40%
-65
- C4 -
-
5E8U
3
TGFR1_HUMAN
A:
[7-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
31
Blastp_CBE
73.54
40%
-64
- C4 -
-
4X2G
2
TGFR1_HUMAN
A:
[5-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
30
Blastp_CBE
73.41
40%
-64
- C4 -
-
4X2J
1
TGFR1_HUMAN
A:
[5-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
29
Blastp_CBE
73.41
40%
-64
- C4 -
-
4X2K
1
TGFR1_HUMAN
A:
[5-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
33
Blastp_CBE
73.14
40%
-62
- C4 -
-
4X0M
1
TGFR1_HUMAN
A:
[5-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
38
Blastp_CBE
72.80
40%
-64
- C4 -
-
5E90
1
TGFR1_HUMAN
A:
[7-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
32
Blastp_CBE
72.76
40%
-65
- C4 -
-
4X2F
1
TGFR1_HUMAN
A:
[5-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
41
Blastp_CBE
72.62
40%
-65
- C4 -
-
6B8Y
1
TGFR1_HUMAN
A:
[7-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
43
Blastp_CBE
72.46
40%
-62
- C4 -
-
5QIK
3
TGFR1_HUMAN
A:
[7-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
486
HHSearch
72.39
41%
-70
- C4 -
-
5USQ
1
TGFR1_HUMAN
A:
[4-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
ID
I
A
--
P
--
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
H-
F
-
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
--
G
I
H
--
E
-
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------
34
Blastp_CBE
72.28
41%
-63
- C4 -
-
5FRI
3
TGFR1_HUMAN
A:
[6-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------
78
Blastp_CBE
72.27
40%
-59
- C4 -
-
6T6D
2
?
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
---
L
D
V-----
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
102
Blastp_CBE
72.19
40%
-60
- C4 -
-
3Q4U
7
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
76
Blastp_CBE
72.18
40%
-73
- C4 -
-
6T6D
2
?
C:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--------
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
---------------------
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
496
HHSearch
72.10
40%
-77
- C4 -
-
3MDY
1
BMR1B_HUMAN
A:
[36-333]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
Q
--
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
K
V
A
V
K
-------
V
F
F
T
-----
T
E
E
-----
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
-
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
----
K
----
S
-
T
T
-
L
D
A
--
K
--
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
S
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
K
F
I
-----------------
P
--
N
T
R
-
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
---
R
-
N
H-
F
-
Q
S
Y
-
I
M
-
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
--
G
I
V
---
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
---------------------------
111
Blastp_CBE
72.05
40%
-63
- C4 -
-
6ACR
1
ACVR1_HUMAN
A:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
---
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
35
Blastp_CBE
72.00
40%
-64
- C4 -
-
5QIM
2
TGFR1_HUMAN
A:
[6-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
37
Blastp_CBE
71.99
40%
-63
- C4 -
-
2WOT
2
TGFR1_HUMAN
A:
[6-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
--------------------------
26
Blastp_CBE
71.93
41%
-68
- C4 -
-
5USQ
1
TGFR1_HUMAN
A:
[4-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------
18
PsiBlast_PDB
71.89
40%
-64
- C4 -
-
1VJY
1
TGFR1_HUMAN
A:
[3-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
----
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
45
Blastp_CBE
71.88
40%
-65
- C4 -
-
5E8W
3
TGFR1_HUMAN
A:
[7-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
I
-------------------------
46
Blastp_CBE
71.68
40%
-62
- C4 -
-
5E8T
3
TGFR1_HUMAN
A:
[7-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
44
Blastp_CBE
71.62
40%
-62
- C4 -
-
5E8Z
1
TGFR1_HUMAN
A:
[7-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
98
Blastp_CBE
71.59
40%
-56
- C4 -
-
4BGG
2
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
100
Blastp_CBE
71.52
40%
-54
- C4 -
-
3Q4U
6
ACVR1_HUMAN
C:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
42
Blastp_CBE
71.49
40%
-60
- C4 -
-
5QIL
1
TGFR1_HUMAN
A:
[7-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
487
HHSearch
71.48
40%
-58
- C4 -
-
5OXG
1
ACVR1_HUMAN
C:
[7-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
LD
V
G
--
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
--
G
I
---
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
86
Blastp_CBE
71.36
40%
-62
- C4 -
-
6GI6
11
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
101
Blastp_CBE
71.15
40%
-59
- C4 -
-
3Q4U
3
ACVR1_HUMAN
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
112
Blastp_CBE
71.12
40%
-64
- C4 -
-
4DYM
5
ACVR1_HUMAN
A:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
105
Blastp_CBE
71.11
40%
-57
* C4 *
-
3MTF
12
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
68
Blastp_CBE
71.05
41%
-75
- C4 -
-
3MDY
1
BMR1B_HUMAN
A:
[37-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
--
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
K
V
A
V
K
-------
V
F
F
T
-----
T
E
E
-----
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
-
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
----
K
----
S
-
T
T
-
L
D
A
--
K
--
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
--
F
S
-
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
K
F
I
------------------P-
N
T
R
-
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
RNH
F
-
Q
-----
S
Y
-
I
M
-
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
---
G
I
--
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
-------------------------
92
Blastp_CBE
70.90
40%
-53
- C4 -
-
5OXG
1
ACVR1_HUMAN
C:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
8
PsiBlast_PDB
70.85
44%
-29
- C4 -
-
5E92
1
TGFR2_HUMAN
A:
[8-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
--
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-F-
E
T
V
A
V
K
-------
I
F
P
Y
-----
E
E
Y
-----
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
-
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
----
T
----
R
-
H
V
-
I
S
W
--
E
--
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
G
-
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
-
L
R
L
D
P
------
T
L
S
V
--
D
D
LA
N
--
S
G
Q
-
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
-
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
E
H
-----------------------------
75
Blastp_CBE
70.80
40%
-72
- C4 -
-
6T6D
1
?
D:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
---------------------
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
93
Blastp_CBE
70.76
40%
-52
- C4 -
-
5OXG
1
ACVR1_HUMAN
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
27
Blastp_CBE
70.71
41%
-63
- C4 -
-
1RW8
1
TGFR1_HUMAN
A:
[4-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------
490
HHSearch
70.67
40%
-77
- C4 -
-
6SRH
11
ACVR1_HUMAN
A:
[7-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
---------------------
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
--
G
I
---
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
17
PsiBlast_PDB
70.64
40%
-68
- C4 -
-
3TZM
1
TGFR1_HUMAN
A:
[9-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP--
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
------------------------------
36
Blastp_CBE
70.57
40%
-66
- C4 -
-
2WOU
2
TGFR1_HUMAN
A:
[6-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
------------------------------
72
Blastp_CBE
70.56
40%
-60
- C4 -
-
6TN8
8
?
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
108
Blastp_CBE
70.49
40%
-78
- C4 -
-
3H9R
4
ACVR1_HUMAN
A:
[37-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
-----------------------
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
77
Blastp_CBE
70.48
40%
-57
- C4 -
-
6T6D
1
?
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
11
PsiBlast_PDB
70.32
42%
-35
- C4 -
-
3G2F
4
BMPR2_HUMAN
A:
[9-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
D
L
D
N
--
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
P
V
A
V
K
-------
V
F
S
F
-----
A
N
R
-----
Q
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
----
S
----
L
-
H
T
-
S
D
W
--
V
--
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
-
G
-
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
-
M
R
L
T
G
NRLVRP---------------
E
-
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
---
L
-
R
DR
E
-
S
A
L
-
K
Q
-
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
FP
G
E
S
--
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
L
A
E
E
R
M
A
E
L
-------------------------------
19
PsiBlast_PDB
70.28
40%
-63
- C4 -
-
3GXL
1
TGFR1_HUMAN
A:
[3-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
-----
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
-------
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
------
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
--
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
----------------------------
81
Blastp_CBE
70.26
40%
-59
- C4 -
-
6SRH
7
ACVR1_HUMAN
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
80
Blastp_CBE
70.25
40%
-74
- C4 -
-
6SZM
8
?
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
--------------------
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
73
Blastp_CBE
70.20
40%
-58
- C4 -
-
6T8N
4
?
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
----
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
103
Blastp_CBE
70.17
40%
-58
- C4 -
-
3OOM
16
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
82
Blastp_CBE
70.17
40%
-73
- C4 -
-
6SRH
11
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
---------------------
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
97
Blastp_CBE
70.16
40%
-58
- C4 -
-
4BGG
1
ACVR1_HUMAN
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
----
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
91
Blastp_CBE
70.11
40%
-54
- C4 -
-
5OXG
2
ACVR1_HUMAN
D:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
107
Blastp_CBE
70.07
40%
-59
- C4 -
-
4C02
11
ACVR1_HUMAN
A:
[37-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
--
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
V-----
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
83
Blastp_CBE
69.97
40%
-55
- C4 -
-
6GIP
3
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
94
Blastp_CBE
69.92
40%
-55
- C4 -
-
5OXG
2
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
87
Blastp_CBE
69.87
40%
-55
- C4 -
-
5OY6
1
ACVR1_HUMAN
D:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
----------
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
109
Blastp_CBE
69.60
39%
-55
- C4 -
-
6EIX
10
ACVR1_HUMAN
A:
[37-334]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
N
S
L
D
--------------------------
106
Blastp_CBE
69.52
40%
-57
- C4 -
-
6I1S
8
ACVR1_HUMAN (first)
A:
[37-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
88
Blastp_CBE
69.43
40%
-57
- C4 -
-
5OY6
1
ACVR1_HUMAN
C:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
----------
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
85
Blastp_CBE
69.43
40%
-59
- C4 -
-
6GIN
4
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
89
Blastp_CBE
69.37
40%
-59
- C4 -
-
5OY6
1
ACVR1_HUMAN
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
----------
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
79
Blastp_CBE
69.37
40%
-57
- C4 -
-
6SZM
4
?
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
74
Blastp_CBE
69.08
40%
-59
- C4 -
-
6T8N
3
?
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
---
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
84
Blastp_CBE
68.99
40%
-55
- C4 -
-
6GIN
2
ACVR1_HUMAN
B:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
90
Blastp_CBE
68.81
40%
-57
- C4 -
-
5OY6
3
ACVR1_HUMAN
A:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
----------
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
47
Blastp_CBE
68.78
41%
-57
- C4 -
-
1PY5
1
TGFR1_HUMAN
A:
[29-323]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
AP
N
H
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------
9
PsiBlast_PDB
68.36
44%
1
- C4 -
-
5QIN
2
TGFR2_HUMAN
A:
[8-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
--
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-QF
E
T
V
A
V
K
-------
I
F
P
Y
-----
E
E
Y
-----
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
-
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
----
T
----
R
-
H
V
-
I
S
W
--
E
--
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
G
-
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
-
L
R
L
D
P
------
T
L
S
V
--
D
D
LA
N
----
Q
-
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
-
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------------------------
67
Blastp_CBE
68.27
41%
-48
- C4 -
-
3MDY
1
BMR1B_HUMAN
C:
[37-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
--
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
K
V
A
V
K
-------
V
F
F
T
-----
T
E
E
-----
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
-
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
----
K
----
S
-
T
T
-
L
D
A
--
K
--
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
--
F
S
-
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
K
F
I
-----------------
I
PP
N
T
R
-
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
RNH
F
-
Q
-----
S
Y
-
I
M
-
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
---
G
I
--
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
I
-------------------------
20
PsiBlast_PDB
68.10
40%
-46
- C4 -
-
3HMM
1
TGFR1_HUMAN
A:
[3-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
--
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
V
A
V
K
-------
I
F
S
S
-----
R
E
E
-----
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
----
N
----
R
-
Y
T
-
V
T
V
--
E
--
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
-
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
-
V
R
H
D
S
------
A
T
D
T
--
I
D
--
I
A------
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
-
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
---
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
----------------------------
498
HHSearch
67.96
46%
-2
- C4 -
-
5E8Y
1
TGFR2_HUMAN
A:
[7-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
P
--
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
QF
E
T
V
A
V
K
-------
I
F
P
Y
-----
E
E
Y
-----
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
-
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
----
T
----
R
-
H
V
-
I
S
W
--
E
--
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
--
G
R
P
K
M
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
-
L
R
L
D
P
------
T
L
S
V
DD
L
A
--
N
--
S
G
Q
-
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
E
N
--
V
-
E
S
F
-
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
--
G
E
V
--
K
D
-
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------------------------
110
Blastp_CBE
67.69
40%
-58
- C4 -
-
6ACR
1
ACVR1_HUMAN
B:
[10-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
----
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
95
Blastp_CBE
67.61
40%
-56
- C4 -
-
4BGG
1
ACVR1_HUMAN
D:
[8-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
-------
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
----
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
Q
--
L
D
VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
-
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
96
Blastp_CBE
67.12
40%
-52
- C4 -
-
4BGG
1
ACVR1_HUMAN
C:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
--
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
V
A
V
K
-------
I
F
S
S
-----
R
D
E
-----
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
-
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
----
Q
----
L
-
T
T
-
L
D
T
--
V
--
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-----
G
--
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
-
V
M
H
S
Q
------
S
T
N
-----VG
N
--
N
P
R
-
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
-
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
-------------
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
--------------------------------
6
PsiBlast_PDB
66.95
44%
1
- C4 -
-
5E8Y
1
TGFR2_HUMAN
A:
[8-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
--
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
QF
E
T
V
A
V
K
-------
I
F
P
Y
-----
E
E
Y
-----
A
S
W
K
T
E
K
D
I
F
S
D
I
N
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
K
T
E
L
G
-
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
----
T
----
R
-
H
V
-
I
S
W
--
E
--
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
G
-
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
-
L
R
L
D
P
------
T
L
S
V
--
D
D
LA
N
--
S
G
Q
-
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
-
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------------------------
25
Blastp_CBE
61.62
42%
-22
- C4 -
-
3G2F
2
BMPR2_HUMAN
B:
[10-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
D
N
--
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
P
V
A
V
K
-------
V
F
S
F
-----
A
N
R
-----
Q
N
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
K
A
Y
L
----
S
----
L
-
H
T
-
S
D
W
--
V
--
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
-
G
-
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
-
M
R
L
T
G
NRL--------------------
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
---
L
-
R
--
D
-
E
S
A
-
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
FP
G
E
S
--
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
A
-
E
E
R
M
A
E
L
-------------------------------
326
Blastp_CBE
44.05
33%
-35
- C4 -
-
5LPY
1
A:
[28-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
I
L
K
D
G-
S
A
V
A
I
K
K------
L
I
H
V
-----
S
G
Q
-----
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HDPK
K
----
A
-
G
V
K
L
N
W
--
S
--
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
M
S
A
------
M
D
H
L
--
V
T
--
L
--
A
G
T
-
P
G
---
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
-
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
-------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
42.97
35%
-26
- C4 -
-
2OIC
1
IRAK4_HUMAN
A:
[34-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
K----------------
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
-----
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
42.93
36%
-25
- C4 -
-
2NRY
1
IRAK4_HUMAN
A:
[40-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAA---
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
S
--------------
Q
T
--
V
--
M
S
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
42.91
33%
-62
- C4 -
-
5HIE
1
BRAF_HUMAN
B:
[47-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
T
P
-----
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
-----------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
42.64
33%
-60
- C4 -
-
5HIE
1
BRAF_HUMAN
A:
[47-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
T
P
-----
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
42.51
35%
-23
- C4 -
-
2OID
1
IRAK4_HUMAN
B:
[31-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
K----------------
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
-----
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
42.04
35%
-36
- C4 -
-
6EG9
1
IRAK4_HUMAN
A:
[45-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAA---
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
-------------------------------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
42.04
35%
-37
- C4 -
-
6EG9
1
IRAK4_HUMAN
B:
[45-240]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAA---
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
--------------------------------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
41.76
32%
-51
- C4 -
-
5C9C
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
--------------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
41.74
35%
-11
- C4 -
-
6MOM
2
?
B:
[36-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAA---
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
---
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
41.65
36%
-22
- C4 -
-
2NRY
1
IRAK4_HUMAN
B:
[40-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAA---
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
S
--------------
Q
T
--
V
--
M
S
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
41.42
31%
-96
- C4 -
-
5NXD
2
B:
[49-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
----
D
-
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
----
R
----
S
M
D
P
-
F
P
W
--
Q
--
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
-----------
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
----------------------------
P
Y
W
M
A
P
E
M
L
N
G
K
S
Y
---
D
-
E
---------
T
-
V
D
I
F
S
F
G
I
V
L
C
E
I
I
G
Q
V
Y
A
-------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
41.29
33%
-52
- C4 -
-
4XV2
1
BRAF_HUMAN
A:
[35-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
PTP--
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--------------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
41.23
35%
-8
- C4 -
-
6MOM
1
?
C:
[36-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAD---
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
F
--
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
41.18
35%
-15
- C4 -
-
5W84
1
IRAK4_HUMAN
A:
[38-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KL-----
I
T
T
--------
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
F
--
A
Q
------
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
40.96
35%
-24
- C4 -
-
2OID
1
IRAK4_HUMAN
A:
[34-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
K----------------------------
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
---
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
40.92
33%
-57
- C4 -
-
5HIE
1
BRAF_HUMAN
C:
[47-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
T
P
-----
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
40.89
33%
-28
- C4 -
-
4RZV
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
40.85
35%
-7
- C4 -
-
6MOM
1
?
A:
[36-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLA-----
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
F
--
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
40.79
32%
-29
- C4 -
-
3PSB
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
---------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
40.81
32%
-31
- C4 -
-
1UWH
1
BRAF_HUMAN
A:
[19-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
40.79
32%
-26
- C4 -
-
3PSB
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
40.68
32%
-36
- C4 -
-
3II5
1
BRAF_HUMAN
A:
[46-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-----------------------
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
40.63
33%
-65
- C4 -
-
5HI2
1
A:
[31-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
T
P
-----
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
--------------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
40.58
33%
-24
- C4 -
-
5LPZ
1
A:
[28-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
I
L
K
D
G-
S
A
V
A
I
K
K------
L
I
H
V
-----
S
G
Q
-----
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HDPK
K
----
A
-
G
V
K
L
N
W
--
S
--
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
M
S
A
------
M
D
H
L
--
V
T
--
L
--
A
G
T
-
P
G
---
Y
V
P
P
E
Y
Y
Q
---
S
---
F
-
R
-----
C
S
-
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
-------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
40.57
32%
-35
- C4 -
-
4EHE
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
-----------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
40.56
32%
-31
- C4 -
-
3PPK
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
---------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
40.50
32%
-31
- C4 -
-
1UWH
1
B:
[19-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
40.37
32%
-28
- C4 -
-
4KSP
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
40.36
32%
-39
- C4 -
-
6N0Q
1
?
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
40.19
33%
-46
- C4 -
-
5HID
3
B:
[31-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
T
P
-----
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
40.14
32%
-37
- C4 -
-
5VAL
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
40.03
32%
-31
- C4 -
-
5VAM
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-----
R
------
W
----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
40.02
32%
-28
- C4 -
-
4MBJ
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
-------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
40.01
32%
-22
- C4 -
-
4H58
1
BRAF_HUMAN
A:
[19-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
-------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
40.00
33%
-32
- C4 -
-
5JSM
3
BRAF_HUMAN
C:
[23-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
----------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
39.96
31%
-91
- C4 -
-
5NXD
2
LIMK2_HUMAN
A:
[49-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
----
D
-
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
----
R
----
S
M
D
P
-
F
P
W
--
Q
--
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
-----------
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
----------------------------
P
Y
W
M
A
P
E
M
L
N
G
K
S
Y
---
D
-
E
---------
T
-
V
D
I
F
S
F
G
I
V
L
C
E
I
I
G
Q
V
Y
A
-------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
39.94
32%
-30
- C4 -
-
4G9C
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
39.89
32%
-32
- C4 -
-
6B8U
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
39.85
31%
-71
- C4 -
-
4TPT
1
B:
[47-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
----
D
-
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
----
R
----
S
M
D
P
-
F
P
W
--
Q
--
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
-----------
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
---------------------
Y
T
V
-
V
G
N
P
Y
W
M
A
P
E
M
L
N
G
K
S
Y
---
D
-
E
---------
T
-
V
D
I
F
S
F
G
I
V
L
C
E
I
I
G
Q
V
Y
A
-------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
39.83
32%
-22
- C4 -
-
4E26
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
----------------
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
39.80
33%
-44
- C4 -
-
5JT2
2
BRAF_HUMAN
C:
[23-214]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
PTP--
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
K
S
R
-------------------------
S
I
L
W
M
A
P
E
V
I
R
--------------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
39.78
32%
-31
- C4 -
-
4PP7
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
-------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
39.76
32%
-22
- C4 -
-
3PRI
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
39.78
33%
-9
- C4 -
-
5LPB
1
A:
[28-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
I
L
K
D
G-
S
A
V
A
I
K
K------
L
I
H
V
-----
S
G
Q
-----
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HDP--------
G
V
K
L
N
W
--
S
--
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
M
S
A
------
M
D
H
L
--
V
T
--
L
--
A
G
T
-
P
G
---
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
-
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
-------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
39.77
32%
-25
- C4 -
-
4MNF
1
BRAF_HUMAN
A:
[59-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
----------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
39.76
32%
-24
- C4 -
-
3TV6
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
39.75
33%
-30
- C4 -
-
4WO5
1
BRAF_HUMAN
A:
[43-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
--
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
--------
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
39.74
33%
-14
- C4 -
-
4OH4
1
BRI1_ARATH
A:
[53-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
I
L
K
D
G-
S
A
V
A
I
K
K------
L
I
H
V
-----
S
G
Q
-----
G
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HD-----------K
L
N
W
--
S
--
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
M
S
A
------
M
D
H
L
--
V
T
--
L
--
A
G
T
-
P
G
---
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
-
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
-------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
39.67
32%
-41
- C4 -
-
3Q96
1
BRAF_HUMAN
A:
[21-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
--------------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
39.66
33%
-22
- C4 -
-
4OH4
1
B:
[53-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
I
L
K
D
G-
S
A
V
A
I
K
K------
L
I
H
---------------
D
R
E
F
M
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H-----------
V
K
L
N
W
--
S
--
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
M
S
A
------
M
D
H
L
--
V
T
--
L
--
A
G
T
-
P
G
---
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
-
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
-------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
39.66
33%
-53
- C4 -
-
5HID
3
BRAF_HUMAN
A:
[31-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
T
P
-----
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-------------------------
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
39.64
32%
-21
- C4 -
-
3PRF
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
---------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
39.59
32%
-23
- C4 -
-
3PPK
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
39.56
32%
-24
- C4 -
-
3PRI
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
39.55
32%
-22
- C4 -
-
4EHE
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
39.52
32%
-18
- C4 -
-
2FB8
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
39.52
32%
-18
- C4 -
-
2FB8
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
--------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
39.47
32%
-25
- C4 -
-
1UWJ
1
BRAF_HUMAN
A:
[19-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
K
-------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
39.43
32%
-28
- C4 -
-
6N0Q
1
?
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
------
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
39.42
32%
-25
- C4 -
-
3II5
1
B:
[46-231]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
39.36
33%
-33
- C4 -
-
5CSX
2
A:
[25-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
-----------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
39.35
32%
-23
- C4 -
-
4KSP
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
39.32
32%
-31
- C4 -
-
5FD2
1
BRAF_HUMAN
A:
[40-225]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
39.32
33%
-27
- C4 -
-
4CQE
1
BRAF_HUMAN
A:
[19-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
--------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
39.27
32%
-25
- C4 -
-
4MNF
1
B:
[59-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
----------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
39.24
33%
-32
- C4 -
-
4JVG
1
BRAF_HUMAN
B:
[27-212]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
-----------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
39.23
33%
-29
- C4 -
-
4RZW
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
---------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
39.20
33%
-39
- C4 -
-
5ITA
1
BRAF_HUMAN
A:
[40-225]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
--------------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
39.18
32%
-27
- C4 -
-
4KSQ
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
39.14
32%
-31
- C4 -
-
6B8U
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
---APTP-
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
---------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
39.12
32%
-24
- C4 -
-
3TV6
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
---------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
39.12
32%
-26
- C4 -
-
4PP7
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
39.07
32%
-31
- C4 -
-
5C9C
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
-APTP-
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
-----------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
39.02
32%
-31
- C4 -
-
4G9R
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
K
-------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
39.01
32%
-26
- C4 -
-
4E4X
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
-------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
38.98
32%
-30
- C4 -
-
3TV4
1
BRAF_HUMAN
A:
[45-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
-----------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
38.98
33%
-36
- C4 -
-
5JSM
3
D:
[23-211]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
PTP--
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
K
S
------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
38.96
32%
-19
- C4 -
-
3PPJ
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
38.94
32%
-21
- C4 -
-
3TV4
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
38.90
32%
-20
- C4 -
-
4KSQ
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
38.90
33%
-28
- C4 -
-
3OG7
1
BRAF_HUMAN
A:
[35-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
----
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
------------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
38.90
35%
11
- C4 -
-
2OIC
1
IRAK4_HUMAN
D:
[34-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KL---------------
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
F
--
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
38.89
32%
-21
- C4 -
-
4MBJ
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
38.88
35%
0
- C4 -
-
5KX8
1
IRAK4_HUMAN
C:
[34-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAA----
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
---
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
38.87
33%
-18
- C4 -
-
4WO5
1
B:
[43-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
38.84
32%
-30
- C4 -
-
3IDP
1
BRAF_HUMAN
A:
[39-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
----------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
--------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
38.83
32%
-29
- C4 -
-
4G9C
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
-----------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
38.78
33%
-25
- C4 -
-
4YHT
2
BRAF_HUMAN
A:
[18-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
T
-
N
E
-
T
K
F
EM
T
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
--------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
38.77
32%
-25
- C4 -
-
4G9R
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
K
--------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
38.74
32%
-27
- C4 -
-
4EHG
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
38.70
33%
-21
- C4 -
-
4XV2
1
B:
[35-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
---
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
------------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
38.65
36%
-3
- C4 -
-
6F3I
1
IRAK4_HUMAN
A:
[51-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
----
T
T
V
A
V
K
KL---------------
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
S
---------------
T
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
38.59
33%
-23
- C4 -
-
5JSM
5
BRAF_HUMAN
A:
[23-208]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
K
-------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
38.57
32%
-27
- C4 -
-
4FC0
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
38.53
32%
-30
- C4 -
-
5VAL
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
---------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
------
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
38.52
32%
-22
- C4 -
-
1UWJ
1
B:
[19-204]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
K
--------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
38.48
33%
-23
- C4 -
-
6NSQ
1
B:
[27-212]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--------------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
38.45
32%
-24
- C4 -
-
4DBN
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
38.42
33%
-28
- C4 -
-
5CSW
1
B:
[25-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
--------------------------------
S
I
L
W
M
A
P
E
V
I
R
--------------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
38.39
32%
-22
- C4 -
-
3SKC
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
38.35
33%
-36
- C4 -
-
6CAD
1
B:
[25-212]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
--
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
--------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
-----------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
38.25
32%
-18
- C4 -
-
3PRF
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
---------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
38.24
33%
-25
- C4 -
-
4YHT
2
B:
[18-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
T
-
N
E
-
T
K
F
EM
T
--
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
-------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
38.20
32%
-18
- C4 -
-
5CT7
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
38.20
33%
-23
- C4 -
-
3C4C
1
BRAF_HUMAN
A:
[23-208]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
38.15
32%
-22
- C4 -
-
3SKC
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
38.15
33%
-24
- C4 -
-
4R5Y
1
BRAF_HUMAN
A:
[35-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
---------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
38.08
33%
-30
- C4 -
-
4FK3
1
BRAF_HUMAN
A:
[35-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
38.05
33%
-21
- C4 -
-
4RZW
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
--------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
------------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
38.04
33%
-24
- C4 -
-
3C4C
1
B:
[23-208]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
--------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
38.03
31%
-62
- C4 -
-
4TPT
1
LIMK2_HUMAN
A:
[47-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
V
M
R
S
L
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
----
D
-
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
F
L
----
R
----
S
M
D
P
-
F
P
W
--
Q
--
Q
K
V
R
F
A
K
G
I
A
S
G
M
A
Y
L
H
S
-----------
M
C
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
T
V
V
V
A
D
F
G
L
S
R
L
I
V
--------------
K
K
--
R
--
Y
T
V
-
V
G
N
P
Y
W
M
A
P
E
M
L
N
G
K
S
Y
---
D
-
E
---------
T
-
V
D
I
F
S
F
G
I
V
L
C
E
I
I
G
Q
V
Y
A
-------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
37.98
32%
-24
- C4 -
-
4EHG
1
BRAF_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
---------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
37.98
33%
-24
- C4 -
-
5JT2
2
BRAF_HUMAN
A:
[23-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
K
S
R
------
W
------------------
S
I
L
W
M
A
P
E
V
I
---------------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
37.97
36%
6
- C4 -
-
6O8U
2
IRAK4_HUMAN
A:
[35-230]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KL------
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
S
--------------
Q
T
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
37.91
32%
-21
- C4 -
-
3Q96
1
B:
[21-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
37.92
35%
-14
- C4 -
-
5W84
1
IRAK4_HUMAN
B:
[38-233]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
---------------------------
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
F
--
A
Q
------
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
37.91
32%
-10
- C4 -
-
3OMV
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
I
L
K
V
-----
V
D
P
TPEQF
Q
A
F
R
N
E
V
A
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
D
------
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
----
H
----
V
-
Q
E
-
T
K
F
--
Q
MF
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
P
-
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
D
N
----------
N
P
F
S
F
Q
-
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
37.85
32%
-18
- C4 -
-
4E4X
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
37.85
32%
-27
- C4 -
-
6N0P
1
B:
[18-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-----------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
------
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
37.85
35%
4
- C4 -
-
2OID
1
IRAK4_HUMAN
D:
[34-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
-
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KL-------------------------
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
F
--
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
37.74
33%
-20
- C4 -
-
4XV9
1
A:
[35-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
---------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
37.73
32%
-13
- C4 -
-
5VAM
1
BRAF_HUMAN
A:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
--------
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
37.72
33%
-19
- C4 -
-
4JVG
1
D:
[27-212]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
--------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
37.62
32%
-15
- C4 -
-
4FC0
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
37.60
32%
-22
- C4 -
-
5CT7
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
---------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
37.59
36%
27
- C4 -
-
2NRY
1
IRAK4_HUMAN
D:
[40-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KL--------------
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
S
E
--------------
T
--
V
--
M
S
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
37.57
33%
-31
- C4 -
-
4R5Y
1
B:
[35-220]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
---------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
-----------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
37.49
33%
-11
- C4 -
-
6NSQ
1
BRAF_HUMAN
A:
[27-212]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
-
S
--
H
Q
--
F
--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
37.49
35%
12
- C4 -
-
2OIC
1
IRAK4_HUMAN
C:
[34-229]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KL--------
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
-------------
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
37.43
33%
-20
- C4 -
-
4JVG
1
BRAF_HUMAN
A:
[27-212]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
--------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
37.43
33%
-2
- C4 -
-
6U2H
1
D:
[21-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
G
S
---------
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
37.34
33%
-21
- C4 -
-
4JVG
1
BRAF_HUMAN
C:
[27-212]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-------------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
37.18
32%
-16
- C4 -
-
3IDP
1
B:
[39-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
37.03
35%
9
- C4 -
-
6EGF
1
IRAK4_HUMAN
B:
[35-230]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAAMVD
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
S
E
K
-------------------------
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
36.98
33%
-20
- C4 -
-
5JRQ
3
BRAF_HUMAN
A:
[23-208]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
K
S
R
-------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
36.97
32%
-12
- C4 -
-
4E26
1
B:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
-----------
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
36.96
33%
-25
- C4 -
-
5JSM
5
BRAF_HUMAN
B:
[23-208]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
K
S
R
-------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
---------
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
36.95
33%
-18
- C4 -
-
5JT2
2
BRAF_HUMAN
B:
[23-208]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
-TP---
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
-----------------------------
S
I
L
W
M
A
P
E
V
I
R
--
M
------
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
36.94
33%
-12
- C4 -
-
5CSW
1
BRAF_HUMAN
A:
[25-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
---------------------------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
S
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
36.54
35%
14
- C4 -
-
6MOM
2
?
D:
[36-231]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
V
A
V
K
KLAAMVD
I
T
T
E
-----
E
L
K
-----
Q
Q
F
D
Q
E
I
K
V
--
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
----
S
CLDG
T
-
P
P
-
L
S
W
--
H
--
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
I
---
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
----
R
A
------
S
E
K
F
--
A
Q
--
V
--
M
R
I
-
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
--------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
---------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
36.53
32%
-11
- C4 -
-
6N0P
1
BRAF_HUMAN
A:
[18-203]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
S
-----------
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
36.37
32%
-12
- C4 -
-
4DBN
1
B:
[24-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
V
TAPTP
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
I
-
I
E
-
T
K
F
--
E
MI
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
K
S
R
------
W
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
--
M
Q
---
D
-
K
--
N
-
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
36.34
33%
-26
- C4 -
-
6CAD
1
BRAF_HUMAN
A:
[26-213]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
M
L
N
-APTP-
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
-
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
----
A
-
S
E
-
T
K
F
EM
K
--
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
-----------
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-------------------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
--
M
-----------
P
Y
S
-
F
Q
-
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
36.25
32%
-6
- C4 -
-
3OMV
1
RAF1_HUMAN
A:
[47-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
F
G
T
V
Y
K
G
K
W
H
G
--
D
-
V
A
V
K
-------
I
L
K
V
-----
V
D
P
TPEQF
Q
A
F
R
N
E
V
A
V
--
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
D
------
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
----
H
----
V
-
Q
E
-
T
K
F
--
Q
MF
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
-----------
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------------
P
-
T
G
S
V
L
W
M
A
P
E
V
I
R
M
Q
D
N
----------
N
P
F
S
F
Q
-
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-----------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
32.84
32%
-6
- C4 -
-
4Q5J
1
BRI1_ARATH
A:
[53-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
I
L
K
D
G-
S
A
V
A
I
K
-------
K
L
-
I
-----
H
V
S
--------
D
R
E
F
A
E
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
G
------
D
E
R
L
L
V
Y
E
F
K
Y
G
S
L
E
D
V
L
HDP-------------
W
--
S
--
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
-
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
A
R
-
L
------------
S
A
--
D
H
--
L
--
V
T
L
-
A
G
T
P
G
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
-
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
DF
G
D
N
N
L
V
G
W
---
V
K
Q
H
A
K
L
R
I
S
D
V
F
D
P
E
L
K
E
D
P
A
L
E
I
E
L
L
Q
H
L
-
K
V
A
V
A
C
----------------------------------------------------------
-
* C *
-
-
:
------------------------------------------------------------------