@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AVR2B_HUMAN: (2020-09-05 )
MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI
Atome Classification :
(129 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210-..----......220-----.......230...---...-.240.......250.-..-....260.......270.....-----.----.280........290.......300.......310.......320.......330.......340....------...350--.--..--.--....360.......370...---.-.--.-.380.-......390.......400.--...--...410.......420.......430.......440....-..-.450.......460.......470.......480.......490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTA
P
W
V
A
L
A
L
L
W
G
S
LCAGSGRGEAE
T
R
E
C
I
Y
YNAN
W
E
L
E
RT
N
Q
S
G
L
E
R
CEGEQD
K
R
L
H
C
Y
A
SWRNSSG
T
I
E
L
V
KKGCWLDDFNCY
D
R
Q
E
CVATEENP
Q
V
Y
F
C
CCEGNF
C
N
E
R
F
THLPEAGGPEVTYEPPPT
A
P
T
L
L
T
V
L
A
Y
S
LLPI
G
G
L
S
L
I
V
L
L
A
F
W
M
Y
R
HRKPPYGHVDIHEDPGPPPPSPLVGLK
P
L
Q
L
L
E
I
KARGRF
G
C
V
W
K
A
Q
L
MN--
D
F
----
V
A
V
K
I
F
PLQ-----
D
K
Q
S
W
Q
S
E
R
E
I
FS---TPG-M
K
H
E
N
L
L
Q
F
I
A
A
EKR-GS-N
L
E
V
E
L
W
L
I
T
A
FHDKGS
L
T
D
Y
L-----K----GNI-I
T
W
N
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
HEDVPWCRGEGHKPSIAHRDFKSK
N
V
L
L
K
S
D
L
T
A
V
L
A
DF
G
L
A
V
R
F------EPGKP---P--GD--T--HGQVGTRRYM
A
P
E
V
L
E
G
A
IN---F-Q--R-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
KAA--DG
P
--
V
D
E
YML
P
F
E
E
E
IGQHP
S
L
E
E
L
Q
E
V
V
V
H
KKMR
P
T
I
K
D
H
WLK-HP-
G
L
A
Q
L
C
V
T
I
E
E
CWDH
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
SVNGT
T
S
D
C
L
V
S
L
V
T
S
V
TNVDLPPKESSI
1
PsiBlast_PDB
98.25
98%
-107
- C2 -
-
2QLU
1
AVR2B_HUMAN
A:
[15-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
L
Q
L
L
E
I
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
M
N
--
D
F
----
V
A
V
K
I
F
P
L
Q
-----
D
K
Q
S
W
Q
S
E
R
E
I
F
S
---
T
P
G
-
M
K
H
E
N
L
L
Q
F
I
A
A
E
K
R
-
G
S
-
N
L
E
V
E
L
W
L
I
T
A
F
H
D
K
G
S
L
T
D
Y
L
-----
K
----
G
N
I
-
I
T
W
N
E
L
C
H
V
A
E
T
M
S
R
G
L
S
Y
L
H
E
D
V
P
W
C
R
G
E
G
H
K
P
S
I
A
H
R
D
F
K
S
K
N
V
L
L
K
S
D
L
T
A
V
L
A
D
F
G
L
A
V
R
F
------
E
P
G
K
P
---
P
--
G
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
V
S
R
C
K
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
E
L
Q
E
V
V
V
H
K
K
M
R
P
T
I
K
D
H
W
L
K
-
H
P
-
G
L
A
Q
L
C
V
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
E
E
R
V
S
L
I
R
R
S
----------------------------
329
HHSearch
91.01
76%
-106
- C2 -
-
4ASX
5
AVR2A_HUMAN
A:
[18-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
-
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
--
G
---
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
4
PsiBlast_PDB
89.90
77%
-106
- C2 -
-
4ASX
4
AVR2A_HUMAN
A:
[25-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
--
G
---
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
330
HHSearch
89.75
76%
-100
- C2 -
-
3SOC
7
AVR2A_HUMAN
A:
[18-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
-
L
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
--
G
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
21
Blastp_CBE
89.26
78%
-100
- C2 -
-
4ASX
6
AVR2A_HUMAN
B:
[25-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
--
G
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
22
Blastp_CBE
89.25
78%
-106
- C2 -
-
3SOC
5
AVR2A_HUMAN
B:
[25-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
------
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
3
PsiBlast_PDB
88.58
77%
-100
- C2 -
-
3SOC
7
AVR2A_HUMAN
A:
[25-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
--
G
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
T
---------------------------
23
Blastp_CBE
88.41
78%
-105
- C2 -
-
3Q4T
10
AVR2A_HUMAN
B:
[25-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
------
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
L
----------------------------
2
PsiBlast_PDB
88.33
77%
-99
- C2 -
-
3Q4T
13
AVR2A_HUMAN
A:
[25-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
N
--
E
Y
----
V
A
V
K
I
F
P
I
Q
-----
D
K
Q
S
W
Q
N
E
Y
E
V
Y
S
---
L
P
G
-
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
-
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
-----
K
----
A
N
V
-
V
S
W
N
E
L
C
H
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
K
-
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
---
A
--
G
D
--
T
--
H
G
Q
V
G
T
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
---
F
-
Q
--
R
-
D
A
F
L
R
-
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
--
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
-
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
-----------------------------
331
HHSearch
75.93
39%
-68
- C2 -
-
5E8X
2
TGFR1_HUMAN
A:
[6-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
F
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
------
D
S
A
T
D
---
T
ID
I
A
--
P
--
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
H-
F
-
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
--
G
I
H
--
E
-
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
--------------------------
13
PsiBlast_PDB
74.27
40%
-69
- C2 -
-
5E8X
2
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
F
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
332
HHSearch
73.79
39%
-61
- C2 -
-
4X2J
1
TGFR1_HUMAN
A:
[5-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
ID
I
A
--
P
--
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
H-
F
-
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
--
G
I
H
---
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
---------------------------
38
Blastp_CBE
73.77
40%
-62
- C2 -
-
4X2F
1
TGFR1_HUMAN
A:
[5-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
84
Blastp_CBE
73.57
38%
-69
- C2 -
-
6T6D
2
?
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
------
L
D
--
V
---
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
39
Blastp_CBE
73.52
40%
-59
- C2 -
-
4X0M
1
TGFR1_HUMAN
A:
[5-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
37
Blastp_CBE
73.28
40%
-61
- C2 -
-
4X2G
2
TGFR1_HUMAN
A:
[5-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
116
Blastp_CBE
73.15
38%
-62
- C2 -
-
6ACR
1
ACVR1_HUMAN
A:
[10-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
--
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
36
Blastp_CBE
72.80
40%
-61
- C2 -
-
4X2J
1
TGFR1_HUMAN
A:
[5-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
35
Blastp_CBE
72.80
40%
-61
- C2 -
-
4X2K
1
TGFR1_HUMAN
A:
[5-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
111
Blastp_CBE
72.72
38%
-56
- C2 -
-
3MTF
12
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
92
Blastp_CBE
72.61
38%
-63
- C2 -
-
6GI6
11
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
117
Blastp_CBE
72.48
38%
-64
- C2 -
-
4DYM
5
ACVR1_HUMAN
A:
[10-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
86
Blastp_CBE
72.47
38%
-72
- C2 -
-
6SZM
8
?
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
-----------------
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
33
Blastp_CBE
72.35
40%
-58
- C2 -
-
5FRI
3
TGFR1_HUMAN
A:
[6-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
108
Blastp_CBE
72.17
38%
-59
- C2 -
-
3Q4U
7
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
14
PsiBlast_PDB
72.11
40%
-61
- C2 -
-
5E90
1
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
F
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
338
HHSearch
72.04
37%
-75
- C2 -
-
6SRH
11
ACVR1_HUMAN
A:
[7-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
------------------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
--
C
F
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
--
G
I
V
---
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
16
PsiBlast_PDB
71.91
39%
-61
- C2 -
-
2WOT
2
TGFR1_HUMAN
A:
[6-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
109
Blastp_CBE
71.86
38%
-55
- C2 -
-
3OOM
16
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
48
Blastp_CBE
71.77
40%
-60
- C2 -
-
5E8W
3
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
335
HHSearch
71.69
39%
-65
- C2 -
-
5USQ
1
TGFR1_HUMAN
A:
[4-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
ID
I
A
--
P
--
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
--
G
I
H
--
E
-
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
-----------------------------
82
Blastp_CBE
71.68
38%
-70
- C2 -
-
6T6D
2
?
C:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--------
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
------------------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
342
HHSearch
71.62
38%
-74
- C2 -
-
3MDY
1
BMR1B_HUMAN
A:
[36-333]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
K
----
V
A
V
K
V
F
F
T
T
-----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
---
T
V
L
-
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
-
G
T
-
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
-----
K
----
S
T
T
-
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
---
S
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
------
I
--------------
P
--
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
---
R
-
N
--
H
F
Q
S
Y
I
M
-
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
--
G
I
V
---
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
-
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
---------------------------
91
Blastp_CBE
71.56
38%
-58
- C2 -
-
6GIN
4
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
32
Blastp_CBE
71.54
40%
-64
- C2 -
-
5USQ
1
TGFR1_HUMAN
A:
[4-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
43
Blastp_CBE
71.49
40%
-66
- C2 -
-
1VJY
1
TGFR1_HUMAN
A:
[3-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
----
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
45
Blastp_CBE
71.47
40%
-57
- C2 -
-
5QIL
1
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
17
PsiBlast_PDB
71.44
39%
-62
- C2 -
-
2WOU
2
TGFR1_HUMAN
A:
[6-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
44
Blastp_CBE
71.23
40%
-62
- C2 -
-
6B8Y
1
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
114
Blastp_CBE
71.20
38%
-74
- C2 -
-
3H9R
4
ACVR1_HUMAN
A:
[37-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
--------------------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
103
Blastp_CBE
71.16
38%
-58
- C2 -
-
4BGG
1
ACVR1_HUMAN
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
40
Blastp_CBE
71.15
40%
-59
- C2 -
-
1RW8
1
TGFR1_HUMAN
A:
[4-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
19
PsiBlast_PDB
71.14
39%
-61
- C2 -
-
5QIM
2
TGFR1_HUMAN
A:
[6-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
104
Blastp_CBE
71.13
38%
-56
- C2 -
-
4BGG
2
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
83
Blastp_CBE
71.11
38%
-58
- C2 -
-
6T6D
1
?
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
98
Blastp_CBE
71.03
38%
-52
- C2 -
-
5OXG
1
ACVR1_HUMAN
C:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
87
Blastp_CBE
71.01
38%
-58
- C2 -
-
6SRH
7
ACVR1_HUMAN
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
107
Blastp_CBE
70.96
38%
-59
- C2 -
-
3Q4U
3
ACVR1_HUMAN
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
88
Blastp_CBE
70.94
38%
-70
- C2 -
-
6SRH
11
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
------------------
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
75
Blastp_CBE
70.90
39%
-72
- C2 -
-
3MDY
1
BMR1B_HUMAN
A:
[37-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
K
----
V
A
V
K
V
F
F
T
T
-----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
---
T
V
L
-
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
-
G
T
-
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
-----
K
----
S
T
T
-
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
S
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I-------------
P
---------
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
RNH
F
-
Q
-----
S
Y
I
M
-
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
-
V
S
--
G
G
I
--
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
-
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
----------------------------
334
HHSearch
70.87
37%
-55
- C2 -
-
5OXG
1
ACVR1_HUMAN
C:
[7-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
---
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
LD
V
G
--
N
--
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
--
C
F
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
--
G
I
---
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
100
Blastp_CBE
70.81
38%
-54
- C2 -
-
5OXG
2
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
47
Blastp_CBE
70.81
40%
-59
- C2 -
-
5E8Z
1
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
20
PsiBlast_PDB
70.76
39%
-64
- C2 -
-
3TZM
1
TGFR1_HUMAN
A:
[9-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
106
Blastp_CBE
70.74
38%
-54
- C2 -
-
3Q4U
6
ACVR1_HUMAN
C:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
113
Blastp_CBE
70.72
38%
-60
- C2 -
-
4C02
11
ACVR1_HUMAN
A:
[37-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
V-----
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
78
Blastp_CBE
70.67
38%
-58
- C2 -
-
6TN8
8
?
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
112
Blastp_CBE
70.66
38%
-55
- C2 -
-
6I1S
8
ACVR1_HUMAN (first)
A:
[37-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
VG
N
--
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
46
Blastp_CBE
70.54
40%
-59
- C2 -
-
5QIK
3
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
49
Blastp_CBE
70.53
40%
-57
- C2 -
-
5E8T
3
TGFR1_HUMAN
A:
[7-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
79
Blastp_CBE
70.43
38%
-58
- C2 -
-
6T8N
4
?
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
------
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
76
Blastp_CBE
70.31
38%
-53
- C2 -
-
6EIX
10
ACVR1_HUMAN
A:
[37-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
VG
N
--
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
D
N
S
L
D
--------------------------
80
Blastp_CBE
70.26
38%
-60
- C2 -
-
6T8N
3
?
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
99
Blastp_CBE
70.15
38%
-52
- C2 -
-
5OXG
1
ACVR1_HUMAN
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
89
Blastp_CBE
70.11
38%
-55
- C2 -
-
6GIP
3
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
97
Blastp_CBE
70.06
38%
-54
- C2 -
-
5OXG
2
ACVR1_HUMAN
D:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-----
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
81
Blastp_CBE
69.91
38%
-69
- C2 -
-
6T6D
1
?
D:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
------------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
94
Blastp_CBE
69.90
38%
-56
- C2 -
-
5OY6
1
ACVR1_HUMAN
C:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
-------
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
95
Blastp_CBE
69.73
38%
-58
- C2 -
-
5OY6
1
ACVR1_HUMAN
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
-------
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
85
Blastp_CBE
69.63
38%
-56
- C2 -
-
6SZM
4
?
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
96
Blastp_CBE
69.52
38%
-56
- C2 -
-
5OY6
3
ACVR1_HUMAN
A:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
-------
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
101
Blastp_CBE
69.42
38%
-57
- C2 -
-
4BGG
1
ACVR1_HUMAN
D:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
--------
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
93
Blastp_CBE
69.16
38%
-55
- C2 -
-
5OY6
1
ACVR1_HUMAN
D:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
-------
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
11
PsiBlast_PDB
69.10
40%
-31
- C2 -
-
3G2F
4
BMPR2_HUMAN
A:
[9-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
P
----
V
A
V
K
V
F
S
F
A
-----
N
R
Q
N
F
I
N
E
K
N
I
Y
R
---
V
P
L
-
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
-
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
-----
S
----
L
H
T
-
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
--
R
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
TGNRLV
R
P
------------------
E
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
---
L
-
R
DR
E
-
S
A
L
K
Q
-
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
FP
G
E
S
--
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
-
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
L
A
E
E
R
M
A
---------------------------------
348
HHSearch
69.06
41%
-17
- C2 -
-
3G2F
4
BMPR2_HUMAN
A:
[9-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
P
----
V
A
V
K
V
F
S
F
A
-----
N
R
Q
N
F
I
N
E
K
N
I
Y
R
---
V
P
L
-
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
-
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
-----
S
----
L
H
T
-
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
R
--
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
------
T
G
N
R
L
VRP------------
E
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
---
L
-
R
DC
E
-
S
A
L
K
Q
-
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
--
F
P
G
ES
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
-
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
C
A
E
E
R
M
A
E
L
M
M
I
W
E
R
N
K
S
----------------------
115
Blastp_CBE
69.03
38%
-56
- C2 -
-
6ACR
1
ACVR1_HUMAN
B:
[10-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
---
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
42
Blastp_CBE
68.92
40%
-63
- C2 -
-
3GXL
1
TGFR1_HUMAN
A:
[3-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
-----
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
-------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
-----
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
--
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
90
Blastp_CBE
68.90
38%
-54
- C2 -
-
6GIN
2
ACVR1_HUMAN
B:
[8-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
---
Q
--
L
D
--
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
R
M
V
S
--
N
G
I
--
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-------------------------------
102
Blastp_CBE
68.67
38%
-51
- C2 -
-
4BGG
1
ACVR1_HUMAN
C:
[8-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
--
E
N
----
V
A
V
K
I
F
S
S
R
-----
D
E
K
S
W
F
R
E
T
E
L
Y
N
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
-
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
-----
Q
----
L
T
T
-
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
----
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
------
S
Q
S
T
N
----------
V
GN
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
---
V
-
D
C-
F
-
D
S
Y
K
R
-
V
D
I
W
A
F
G
L
V
L
W
E
-
V
A
R
------------
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
-
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
--------------------------------
15
PsiBlast_PDB
68.59
39%
-54
- C2 -
-
1PY5
1
TGFR1_HUMAN
A:
[29-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
AP
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
74
Blastp_CBE
68.57
39%
-71
- C2 -
-
3MDY
1
BMR1B_HUMAN
C:
[37-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
--
E
K
----
V
A
V
K
V
F
F
T
T
-----
E
E
A
S
W
F
R
E
T
E
I
Y
Q
---
T
V
L
-
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
-
G
T
-
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
-----
K
----
S
T
T
-
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
S
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I--------
I
P
---
P
---------
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
RNH
F
-
Q
-----
S
Y
I
M
-
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
-
V
S
--
G
G
I
--
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
-
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
----------------------------
41
Blastp_CBE
68.21
40%
-50
- C2 -
-
3HMM
1
TGFR1_HUMAN
A:
[3-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
--
E
E
----
V
A
V
K
I
F
S
S
R
-----
E
E
R
S
W
F
R
E
A
E
I
Y
Q
---
T
V
M
-
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
-
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
-----
N
----
R
Y
T
-
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
------
D
S
A
T
D
---
T
--
I
D
--
I
A-----
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
---
M
-
K
--
H
F
E
S
F
K
R
-
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
-
S
I
--
G
G
I
--
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
-
C
E
-
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
---------------------------------
343
HHSearch
67.89
45%
-2
- C2 -
-
5E8Y
1
TGFR2_HUMAN
A:
[7-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
QF
E
T
----
V
A
V
K
I
F
P
Y
E
-----
E
Y
A
S
W
K
T
E
K
D
I
F
S
---
D
I
N
-
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
-
K
T
-
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
-----
T
----
R
H
V
-
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
--
G
R
P
K
M
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
------
D
P
T
L
S
---
V
DD
L
A
--
N
--
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
E
N
--
V
-
E
S
F
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
--
G
E
V
--
K
D
-
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
-
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------------------------
8
PsiBlast_PDB
66.07
45%
-1
- C2 -
-
5E92
1
TGFR2_HUMAN
A:
[8-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-----FET-
V
A
V
K
I
F
P
Y
E
-----
E
Y
A
S
W
K
T
E
K
D
I
F
S
---
D
I
N
-
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
-
K
T
-
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
-----
T
----
R
H
V
-
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
-
G
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
------
D
P
T
L
S
---
V
--
D
D
LA
N
--
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
-
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
---------------------------------
345
HHSearch
65.78
45%
-1
- C2 -
-
5QIN
2
TGFR2_HUMAN
A:
[8-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-QF
E
T
----
V
A
V
K
I
F
P
Y
E
-----
E
Y
A
S
W
K
T
E
K
D
I
F
S
---
D
I
N
-
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
-
K
T
-
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
-----
T
----
R
H
V
-
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
--
C
G
R
P
K
M
P
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
------
D
P
T
L
S
---
V
DD
L
A
--
N
----
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
E
N
--
V
-
E
S
F
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
--
G
E
V
--
K
D
-
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
-
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
E
L
-------------------------------
6
PsiBlast_PDB
65.74
45%
11
- C2 -
-
5E8Y
1
TGFR2_HUMAN
A:
[8-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
Q
----QFET
V
A
V
K
I
F
P
Y
E
-----
E
Y
A
S
W
K
T
E
K
D
I
F
S
---
D
I
N
-
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
-
K
T
-
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
-----
T
----
R
H
V
-
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
-
G
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
------
D
P
T
L
S
---
V
--
D
D
LA
N
--
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
-
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
---------------------------------
7
PsiBlast_PDB
65.35
45%
5
- C2 -
-
5E91
1
TGFR2_HUMAN
A:
[8-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-----ET--
V
A
V
K
I
F
P
Y
E
-----
E
Y
A
S
W
K
T
E
K
D
I
F
S
---
D
I
N
-
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
-
K
T
-
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
-----
T
----
R
H
V
-
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
-
G
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
------
D
P
T
L
S
---
V
--
D
D
LA
N
--
S
G
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
-
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
---------------------------------
9
PsiBlast_PDB
63.86
45%
8
- C2 -
-
5QIN
2
TGFR2_HUMAN
A:
[8-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
P
I
E
L
D
T
L
V
G
K
G
R
F
A
E
V
Y
K
A
K
L
K
-----QFET
V
A
V
K
I
F
P
Y
E
-----
E
Y
A
S
W
K
T
E
K
D
I
F
S
---
D
I
N
-
L
K
H
E
N
I
L
Q
F
L
T
A
E
E
R
-
K
T
-
E
L
G
K
Q
Y
W
L
I
T
A
F
H
A
K
G
N
L
Q
E
Y
L
-----
T
----
R
H
V
-
I
S
W
E
D
L
R
K
L
G
S
S
L
A
R
G
I
A
H
L
H
S
D
H
T
P
C
-
G
R
P
K
M
P
-
I
V
H
R
D
L
K
S
S
N
I
L
V
K
N
D
L
T
C
C
L
C
D
F
G
L
S
L
R
L
------
D
P
T
L
S
---
V
--
D
D
LA
N
----
Q
V
G
T
A
R
Y
M
A
P
E
V
L
A
S
A
M
N
---
L
-
E
--
N
V
E
S
F
K
Q
-
T
D
V
Y
S
M
A
L
V
L
W
E
M
T
S
R
C
N
A
V
---
G
E
--
V
K
D
Y
E
P
P
F
G
S
K
V
R
E
H
P
C
V
A
S
M
A
D
N
V
L
A
D
A
G
R
P
E
I
P
S
F
W
L
N
-
H
Q
-
G
I
Q
M
V
C
E
T
L
T
E
C
W
D
H
D
P
E
A
R
L
T
A
Q
C
V
A
E
R
F
S
---------------------------------
31
Blastp_CBE
62.10
40%
-25
- C2 -
-
3G2F
2
BMPR2_HUMAN
B:
[10-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
E
--
R
P
----
V
A
V
K
V
F
S
F
A
-----
N
R
Q
N
F
I
N
E
K
N
I
Y
R
---
V
P
L
-
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
-
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
K
A
Y
L
-----
S
----
L
H
T
-
S
D
W
V
S
S
C
R
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
--
R
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
TGNRL----------------------
V
G
T
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
---
L
-
R
--
D
-
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
FP
G
E
S
--
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
-
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
A
E
E
R
M
A
E
L
M
-------------------------------
231
Blastp_CBE
40.12
31%
-42
- C2 -
-
2OIC
1
IRAK4_HUMAN
D:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
----------
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
39.90
31%
-46
- C2 -
-
2OIC
1
IRAK4_HUMAN
C:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
--------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
----------------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
39.85
31%
-45
- C2 -
-
2OIC
1
IRAK4_HUMAN
B:
[34-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
----------
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
--------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
38.87
31%
-40
- C2 -
-
2OIC
1
IRAK4_HUMAN
A:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
-----------
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
--------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
38.38
32%
-33
- C2 -
-
2NRY
1
IRAK4_HUMAN
D:
[42-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
---------
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
------
S
E
---------
T
V
--
M
--
S
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
38.22
31%
-35
- C2 -
-
2OID
1
IRAK4_HUMAN
B:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
-----------
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
--------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
37.08
34%
-10
- C2 -
-
5LPY
1
A:
[28-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
-
I
L
K
--
D
G
----
S
A
V
A
I
K
K
L
I
------
H
V
S
G
Q
G
D
R
E
F
M
A
EME
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
-
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HDPKK
A
----
G
V
K
-
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
------
M
S
A
M
D
---
H
--
L
V
--
T
----
L
A
G
T
P
G
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
--------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
37.02
34%
-23
- C2 -
-
5LPZ
1
A:
[28-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
-
I
L
K
--
D
G
----
S
A
V
A
I
K
K
L
I
------
H
V
S
G
Q
G
D
R
E
F
M
A
EME
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
-
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HDPKK
A
----
G
V
K
-
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
---
C
-----
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
------
M
S
A
M
D
---
H
--
L
V
--
T
----
L
A
G
T
P
G
Y
V
P
P
E
Y
Y
Q
---
S
---
F
-
R
-----
C
S
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
--------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
36.84
31%
-24
- C2 -
-
4Y73
1
IRAK4_HUMAN
B:
[37-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
M
VDITT
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
---------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
36.81
31%
-30
- C2 -
-
2OID
1
IRAK4_HUMAN
D:
[35-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
---------------
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
36.54
33%
-23
- C2 -
-
6EG9
1
IRAK4_HUMAN
B:
[47-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
-ITT--
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
---------------------------------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
36.50
33%
-5
- C2 -
-
6O8U
2
IRAK4_HUMAN
A:
[37-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
---TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
-----------------
Q
T
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
36.43
34%
-7
- C2 -
-
5LPB
1
A:
[28-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
-
I
L
K
--
D
G
----
S
A
V
A
I
K
K
L
I
------
H
V
S
G
Q
G
D
R
E
F
M
A
EME
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
-
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HDP-------
G
V
K
-
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
------
M
S
A
M
D
---
H
--
L
V
--
T
----
L
A
G
T
P
G
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
--------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
36.04
31%
-31
- C2 -
-
2OID
1
IRAK4_HUMAN
A:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
------------------
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
------------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
36.04
32%
-8
- C2 -
-
6EGF
1
IRAK4_HUMAN
B:
[37-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
M
VDITT
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
R
A
S
------
E
K
---------------------
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
35.41
34%
3
- C2 -
-
4OH4
1
B:
[53-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
-
I
L
K
--
D
G
----
S
A
V
A
I
K
K
L
I
------
H
-----
D
R
E
F
M
A
EME
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
-
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H----------
V
K
-
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
------
M
S
A
M
D
---
H
--
L
V
--
T
----
L
A
G
T
P
G
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
--------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
35.35
32%
-13
- C2 -
-
2NRY
1
IRAK4_HUMAN
B:
[42-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
-ITT--
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
------
S
-------
Q
--
T
V
--
M
--
S
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
35.29
31%
-26
- C2 -
-
4ZTL
1
IRAK4_HUMAN
A:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
---------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
35.05
31%
2
- C2 -
-
6MOM
1
?
A:
[38-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
35.03
32%
-6
- C2 -
-
2NRY
1
IRAK4_HUMAN
A:
[42-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
-ITT--
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
-
R
A
------
S
-------
Q
--
T
V
--
M
--
S
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
34.91
33%
-21
- C2 -
-
6EG9
1
IRAK4_HUMAN
A:
[47-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
-ITT--
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
--------------------------------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
34.37
31%
-12
- C2 -
-
4ZTM
1
IRAK4_HUMAN
D:
[35-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
34.33
31%
2
- C2 -
-
6MOM
1
?
C:
[38-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--DITT-
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
34.24
33%
-10
- C2 -
-
6EGA
1
IRAK4_HUMAN
A:
[45-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
---TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
---
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
---------------------------------
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
34.16
31%
-10
- C2 -
-
5KX7
1
IRAK4_HUMAN
B:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
-TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
34.15
31%
-11
- C2 -
-
5KX8
1
IRAK4_HUMAN
C:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
-TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
34.08
31%
-8
- C2 -
-
6MOM
2
?
D:
[38-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
M
VDITT
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
33.90
31%
-1
- C2 -
-
4Y73
1
IRAK4_HUMAN
A:
[37-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
M
VDITT
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
33.89
31%
-9
- C2 -
-
5KX8
1
IRAK4_HUMAN
D:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
33.67
32%
-10
- C2 -
-
5W84
1
IRAK4_HUMAN
A:
[40-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
---ITT-----
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
33.67
31%
-21
- C2 -
-
5KX8
1
IRAK4_HUMAN
B:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
------------
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
---------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
33.64
31%
-10
- C2 -
-
4XS2
1
IRAK4_HUMAN
D:
[34-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
33.08
31%
-5
- C2 -
-
6N8G
1
IRAK4_HUMAN
B:
[32-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
33.01
31%
-13
- C2 -
-
5KX8
1
IRAK4_HUMAN
A:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
32.99
34%
9
- C2 -
-
4OH4
1
BRI1_ARATH
A:
[53-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
D
V
Y
K
A
-
I
L
K
--
D
G
----
S
A
V
A
I
K
K
L
I
------
H
V
S
G
Q
G
D
R
E
F
M
A
EME
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
K
V
-
G
D
-----
E
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
HD----------
K
-
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
C
--------
S
P
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
R
V
S
D
F
G
M
A
-
R
L
------
M
S
A
M
D
---
H
--
L
V
--
T
----
L
A
G
T
P
G
Y
V
P
P
E
Y
---------
Y
-
Q
--
F
-
R
C
S
T
K
-
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
T
--
D
S
P
--------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
32.93
31%
-22
- C2 -
-
4ZTL
1
IRAK4_HUMAN
B:
[34-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
----------------
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
---------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
32.66
31%
0
- C2 -
-
6MOM
2
?
B:
[38-231]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
A
-ITT--
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
32.03
31%
-7
- C2 -
-
4XS2
1
IRAK4_HUMAN
A:
[36-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
L
A
--TT---
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
------
A
Q
--
V
--
M
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
31.70
32%
-8
- C2 -
-
5W84
1
IRAK4_HUMAN
B:
[40-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
-----------------
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
------------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLD-
G
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
30.81
31%
2
- C2 -
-
6N8G
1
IRAK4_HUMAN
D:
[32-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
F
G
V
V
Y
K
G
Y
V
N
N
--
T
T
----
V
A
V
K
K
-----------
L
K
Q
Q
F
D
Q
E
I
K
V
---
M
A
K
-
C
Q
H
E
N
L
V
E
L
L
G
F
S
S
D
-
G
D
-----
D
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
-----
S
CLDG
T
P
P
-
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
E
N
--------
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
K
I
S
D
F
G
L
A
---------
R
A
S
E
K
---
F
--
A
Q
------
R
I
V
G
T
T
A
Y
M
A
P
E
A
L
R
G
E
I
T
-------------
P
K
-
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
G
L
P
A
V
--
D
----------------------------------------------------------------------------------------------------------------