@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BAZ1B_HUMAN: (2020-09-05 )
MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPAWYEKLVLEMVHHNTASLEKLVDTAWLEIMTKYAVGEECDFEVGKEKMLKVKIVKIHPLEKVDEEATEKKSDGACDSPSSDKENSSQIAQDHQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEIVRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNPKLWCHVHLKKSLSGSPLKVKNSKNSKSPEEHLEEMMKMMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKTPKTKMKQMTLLDMAKGTQKMTRAPRNSGGTPRTSSKPHKHLPPAALHLIAYYKENKDREDKRSALSCVISKTARLLSSEDRARLPEELRSLVQKRYELLEHKKRWASMSEEQRKEYLKKKREELKKKLKEKAKERREKEMLERLEKQKRYEDQELTGKNLPAFRLVDTPEGLPNTLFGDVAMVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRSDVQEESEGSDTDDNKDSAAFEDNEVQDEFLEKLETSEFFELTSEEKLQILTALCHRILMTYSVQDHMETRQQMSAELWKERLAVLKEENDKKRAEKQKRKEMEAKNKENGKVENGLGKTDRKKEIVKFEPQVDTEAEDMISAVKSRRLLAIQAKKEREIQEREMKVKLERQAEEERIRKHKAAAEKAFQEGIAKAKLVMRRTPIGTDRNHNRYWLFSDEVPGLFIEKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGTATEVAVETTTPKQGQNLWFLCDSQKELDELLNCLHPQGIRESQLKERLEKRYQDIIHSIHLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYVEETSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKRRKLQSEDSAKTEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESDEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPVDDAEVDELVLQTKRSSRRQSLELQKCEEILHKIVKYRFSWPFREPVTRDEAEDYYDVITHPMDFQTVQNKCSCGSYRSVQEFLTDMKQVFTNAEVYNCRGSHVLSCMVKTEQCLVALLHKHLPGHPYVRRKRKKFPDRLAEDEGDSEPEAVGQSRGRRQKK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190..-....1200......1210......1220.......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390..---.--.---..1400......1410......-1420----.-........1430......1440......1450......1460......1470......1480
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAPLLGRKPFPLVKPLPGEEP
L
F
TIPH
T
Q
E
A
F
R
T
R
E
E
Y
E
A
R
L
E
R
Y
S
E
R
I
W
T
CKSTGSSQL
T
H
K
E
A
W
E
E
E
Q
E
V
A
E
L
L
K
E
E
F
P
A
W
Y
E
K
L
V
L
E
M
V
HH
N
T
A
S
L
E
K
L
V
D
T
A
W
L
E
I
M
T
K
YAVGEECDFEVGK
E
K
M
L
K
V
K
I
V
K
I
H
P
L
E
KV
D
E
E
A
TEKKSDGACDSPSSDKE
N
S
S
Q
I
A
Q
D
H
Q
K
K
E
T
VVKEDEGR
R
E
S
I
N
D
R
ARRS
P
R
KLP
T
S
L
KKGERKWAPPKFLPH
K
Y
D
V
K
LQNEDKIISNVPA
D
S
LIRTERPP
N
K
E
I
V
R
Y
F
I
R
HNALRAGTGENA
P
W
V
V
E
D
E
L
V
K
K
YSL
P
S
K
F
S
D
FLLDP
Y
K
Y
M
T
LNPSTKRKNTGSPDRKPSKKSKTDNSSLSSPLNP
K
L
W
C
H
V
H
L
K
K
SLSGS
P
L
K
VKNSKNSK
S
P
E
E
H
L
E
E
M
M
K
MMSPNKLHTNFHIPKKGPPAKKPGKHSDKPLKAKGRSKGILNGQKSTGNSKSPKKGLKT
P
K
T
K
M
K
Q
M
T
L
L
D
M
AKG
T
Q
K
M
TRAPRNSGGTPRTSSKPHKHL
P
P
A
A
L
H
L
I
A
Y
Y
KENK
D
R
E
D
K
R
S
A
L
S
C
V
I
S
K
T
A
R
L
LS
S
E
D
R
A
R
L
P
E
E
L
R
S
L
V
Q
K
R
Y
E
L
L
E
H
K
K
R
W
ASM
S
E
E
Q
R
K
E
Y
L
K
K
K
R
E
E
L
K
K
K
L
K
E
K
A
K
E
R
R
E
K
E
M
L
E
R
L
E
K
Q
KRYEDQELTGKNL
P
A
F
R
L
VDTPEGL
P
N
T
L
F
G
D
V
A
M
V
V
E
F
L
S
C
YSGLLLPDAQYP
I
T
A
V
S
L
M
E
A
L
SADKG
G
F
L
Y
L
N
R
V
L
V
I
L
L
Q
T
L
L
Q
D
E
I
A
E
D
Y
G
E
LGM
K
L
SEIP
L
T
L
H
S
V
S
E
L
V
R
L
C
L
R
RSDVQEESEGSDTDDNKDSAAFED
N
E
V
Q
D
E
F
L
E
K
LE
T
S
E
F
F
E
LT
S
E
E
K
L
Q
I
L
T
A
L
C
H
R
I
L
M
T
Y
S
V
Q
D
H
M
E
T
R
Q
Q
M
S
A
E
L
W
K
E
R
L
A
V
LKEEN
D
K
K
R
A
E
K
Q
K
R
K
E
M
EAKNKENGKVENGLGK
T
D
R
KK
E
I
V
K
FEPQVD
T
E
A
E
D
M
I
S
A
V
K
SR
R
L
L
A
I
Q
A
K
K
E
R
E
I
Q
E
R
E
M
K
V
K
L
E
R
Q
A
E
E
E
R
I
R
K
H
K
A
A
A
E
K
A
F
Q
E
G
I
A
K
A
K
L
V
M
RRTPIGTDRNH
N
R
Y
W
L
FSDEVP
G
L
F
I
EKGWVHDSIDYRFNHHCKDHTVSGDEDYCPRSKKANLGKNASMNTQHGT
A
T
E
V
A
V
ETTTPKQG
Q
N
L
W
F
L
CD
S
Q
K
E
L
D
E
L
L
N
CLHPQGI
R
E
S
Q
L
K
E
R
L
E
K
R
Y
Q
D
I
I
H
S
I
HLARKPNLGLKSCDG
N
Q
E
L
L
N
F
L
R
S
D
L
I
E
V
A
T
R
L
Q
KGGLGYVEETSEF
E
A
R
V
I
S
L
E
K
L
K
D
F
G
E
C
V
I
A
L
Q
A
S
V
I
K
K
F
L
Q
G
F
MA
P
K
Q
K
R
R
K
LQSEDSAK
T
E
E
V
D
E
E
K
K
M
V
E
E
A
K
V
A
S
A
L
E
K
W
K
T
A
I
R
E
A
Q
T
F
S
R
M
H
V
L
L
G
M
L
D
A
C
I
KWDMSAEN
A
R
C
K
V
C
R
KKGE-DD
K
L
I
L
CDECNK
A
F
H
L
F
CL
R
P
A
L
YEV-PDGEWQCPACQPATARRNSRGRNYTEESASEDSEDDESD
E
E
E
E
E
E
E
E
E
E
E
EEDYEVAG
L
R
LRPRKTIRGKHSVIPPAARSGRRPGKKPHSTRRSQPKAPPV
D
D
A
E
V
D
E
L
V
L
Q
T
K
R
SS
R
R
QSL
E
L
Q
K
C
E
E
I
L
H
K
I
V
K
Y
RFSWPFREPVT
R
D
E
A
E
D
Y
Y
D
VITHPM
D
F
Q
T
V
Q
NKCSC---G--
S
---
Y
R
S
V
Q
E
F
L
T
D
M
K
Q
VFTNA
E
V
YN-C-------R-G
S
H
V
L
S
C
M
V
K
T
E
Q
C
L
V
A
L
L
H
KHLPG
H
P
Y
V
R
R
K
R
K
KF
P
D
R
LAEDEGDSE
P
E
A
V
G
Q
SRGRRQKK
592
HHSearch
85.23
31%
-81
- C6 -
-
6IEU
2
A:
[5-191]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
F
C
A
V
C
L
N
G
G
E
----
L
L
C
C
D
R
C
P
K
V
F
H
L
S
C
H
V
P
A
L
T
S
F
-
P
G
G
E
W
V
C
T
L
C
R
S
L
------------------------------------------------------------------------------------
S
P
------------------
G
L
S
M
Y
D
Q
K
K
C
E
K
L
V
L
S
L
C
C
N
N
L
S
L
P
F
H
E
P
V
S
P
-
L
A
R
H
Y
Y
Q
I
I
K
R
P
M
D
L
S
T
I
R
R
K
L
Q
K
KDP
A
--
H
---
Y
T
T
P
E
E
V
V
S
D
V
R
L
M
F
W
N
C
A
K
F
N
-
Y
-------
P
-
D
S
E
V
A
E
A
G
R
S
L
E
N
F
F
E
G
W
L
K
E
I
Y
P
E
K
R
F
A
Q
--------------------------------
593
HHSearch
85.06
28%
-54
- C6 -
-
5MR8
-
A:
[6-191]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
E
D
W
C
A
V
C
Q
N
G
G
D
----
L
L
C
C
E
K
C
P
K
V
F
H
L
T
C
H
V
P
T
L
L
S
F
-
P
S
G
D
W
I
C
T
F
C
R
D
I
G
K
P
E
V
----
E
Y
-----------
D
--------
C
D
-------------
N
L
Q
--
H
S
----------------
K
K
G
------
K
T
----
A
Q
------------------
G
L
S
P
V
D
Q
R
K
C
E
R
L
L
L
Y
L
Y
C
H
E
L
S
I
E
F
Q
E
P
V
P
A
-
S
I
P
N
Y
Y
K
I
I
K
K
P
M
D
L
S
T
V
K
K
K
L
Q
K
KHS
Q
--
H
---
Y
Q
I
P
D
D
F
V
A
D
V
R
L
I
F
K
N
C
E
R
F
N
-
E
-------
A
-
D
S
E
V
A
Q
A
G
K
A
V
A
L
Y
F
E
D
K
L
T
E
I
Y
S
D
R
T
F
A
---------------------------------
596
HHSearch
83.30
29%
-67
- C6 -
-
4YAT
1
B:
[3-184]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
W
C
A
V
C
Q
N
G
G
E
----
L
L
C
C
E
K
C
P
K
V
F
H
L
S
C
H
V
P
T
L
T
N
F
-
P
S
G
E
W
I
C
T
F
C
R
D
L
S
K
P
E
V
----------
E
-----
Y
D
--------
C
D
-------------------------------------------------
K
K
T
E
G
---------------
L
V
K
L
T
P
I
D
K
R
K
C
E
R
L
L
L
F
L
Y
C
H
E
M
S
L
A
F
Q
D
P
V
P
L
-
T
V
P
D
Y
Y
K
I
I
K
N
P
M
D
L
S
T
I
K
K
R
L
Q
E
----S-
M
---
Y
S
K
P
E
D
F
V
A
D
F
R
L
I
F
Q
N
C
A
E
F
N
-
E
-------
P
-
D
S
E
V
A
N
A
G
I
K
L
E
N
Y
F
E
E
L
L
K
N
L
Y
P
--------------------------------------
600
HHSearch
81.24
30%
-32
- C6 -
-
3O36
-
TIF1A_HUMAN
A:
[4-184]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
W
C
A
V
C
Q
N
G
G
E
----
L
L
C
C
E
K
C
P
K
V
F
H
L
S
C
H
V
P
T
L
T
N
F
-
P
S
G
E
W
I
C
T
F
C
R
D
L
S
K
P
E
V
----------
E
-----
Y
D
--------
C
-----
D
-
A
P
---
S
H
N
S
---
E
---------------------
K
--------
K
K
T
E
G
---------------
L
V
K
L
T
P
I
D
K
R
K
C
E
R
L
L
L
F
L
Y
C
H
E
M
S
L
A
F
Q
D
P
V
P
L
-
T
V
P
D
Y
Y
K
I
I
K
N
P
M
D
L
S
T
I
K
K
R
L
Q
E
---
D
YS
M
---
Y
S
K
P
E
D
F
V
A
D
F
R
L
I
F
Q
N
C
A
E
F
N
-
E
-------
P
-
D
S
E
V
A
N
A
G
I
K
L
E
N
Y
F
E
E
L
L
K
N
L
Y
P
--------------------------------------
601
HHSearch
78.69
26%
-65
- C6 -
-
3U5N
-
TRI33_HUMAN
A:
[5-206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
E
D
W
C
A
V
C
Q
N
G
G
D
----
L
L
C
C
E
K
C
P
K
V
F
H
L
T
C
H
V
P
T
L
L
S
F
-
P
S
G
D
W
I
C
T
F
C
R
D
I
G
K
P
E
V
E
-------------------
Y
----
D
-------------
C
D
--------------------------------------------------------
A
Q
G
L
S
P
V
D
Q
R
K
C
E
R
L
L
L
Y
L
Y
C
H
E
L
S
I
E
F
Q
E
P
V
P
A
-
S
I
P
N
Y
Y
K
I
I
K
K
P
M
D
L
S
T
V
K
K
K
L
Q
K
KHS
Q
--
H
---
Y
Q
I
P
D
D
F
V
A
D
V
R
L
I
F
K
N
C
E
R
F
N
-
E
MMKVVQK
A
-
D
S
E
V
A
Q
A
G
K
A
V
A
L
Y
F
E
D
K
L
T
E
I
Y
S
D
R
T
F
----------------------------------
605
HHSearch
73.05
28%
48
- C6 -
-
2RI7
2
A:
[7-173]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
L
Y
C
-
I
C
K
T
P
E
D
E
S
K
F
Y
I
G
C
D
R
C
Q
N
W
Y
H
G
R
C
V
G
I
L
Q
S
E
A
E
L
I
D
E
Y
V
C
P
Q
C
Q
S
T
E
D
A
M
T
V
------------------------------------------------------------------------------
L
T
P
------------------
L
T
E
K
D
Y
E
G
L
K
R
V
L
R
S
L
Q
A
H
K
M
A
W
P
F
L
E
P
V
D
P
N
D
A
P
D
Y
Y
G
V
I
K
E
P
M
D
L
A
T
M
E
E
R
V
Q
R
---
R
--
Y
---
Y
E
K
L
T
E
F
V
A
D
M
T
K
I
F
D
N
C
R
Y
Y
N
-
P
-------
S
-
D
S
P
F
Y
Q
C
A
E
V
L
E
S
F
F
V
Q
K
L
K
G
F
K
---------------------------------------
595
HHSearch
73.05
29%
-23
- C6 -
-
4YBM
4
B:
[3-184]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
D
W
C
A
V
C
Q
N
G
G
E
----
L
L
C
C
E
K
C
P
K
V
F
H
L
S
C
H
V
P
T
L
T
N
F
-
P
S
G
E
W
I
C
T
F
C
R
D
L
S
K
P
E
V
----------
E
-----
Y
D
--------
C
D
------
A
P
--------------------------------------------------------------
V
K
L
T
P
I
D
K
R
K
C
E
R
L
L
L
F
L
Y
C
H
E
M
S
L
A
F
Q
D
P
V
P
L
-
T
V
P
D
Y
Y
K
I
I
K
N
P
M
D
L
S
T
I
K
K
R
L
Q
E
---
D
YS
M
---
Y
S
K
P
E
D
F
V
A
D
F
R
L
I
F
Q
N
C
A
E
F
N
-
E
-------
P
-
D
S
E
V
A
N
A
G
I
K
L
E
N
Y
F
E
E
L
L
K
N
L
Y
P
--------------------------------------
604
HHSearch
70.58
25%
-128
- C6 -
-
4COS
1
PKCB1_HUMAN
A:
[6-173]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
D
F
Y
C
W
V
C
H
R
E
G
Q
----
V
L
C
C
E
L
C
P
R
V
Y
H
A
K
C
L
R
--
L
T
S
E
-
P
E
G
D
W
F
C
P
E
C
E
K
I
T
V
A
E
C
I
-------------------------
E
T
Q
------
S
----------
K
-------------------------------
A
M
T
------------------
M
L
T
I
E
Q
L
S
Y
L
L
K
F
A
I
Q
K
M
K
Q
P
G
T
D
A
F
Q
K
P
V
P
L
E
Q
H
P
D
Y
A
E
Y
I
F
H
P
M
D
L
C
T
L
E
K
N
A
K
K
---
K
--
M
---
Y
G
C
T
E
A
F
L
A
D
A
K
W
I
L
H
N
C
I
I
Y
N
-
G
-------
G
-
N
H
K
L
T
Q
I
A
K
V
V
I
K
I
C
E
H
E
M
N
E
I
----------------------------------------
602
HHSearch
67.94
20%
-131
- C6 -
-
6G8R
-
B:
[4-177]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
D
E
C
E
V
C
R
D
G
G
E
----
L
F
C
C
D
T
C
S
R
V
F
H
E
D
C
H
I
P
P
V
E
-
A
-
E
R
T
P
W
N
C
I
F
C
R
M
K
E
S
P
------------------------------------------------
C
Q
-----------------
E
------
S
---
E
V
L
E
R
------------------
Q
M
C
P
E
E
Q
L
K
C
E
F
L
L
L
K
V
Y
C
C
S
E
S
S
F
F
A
K
I
P
Y
Y
Y
Y
I
R
-----
L
K
E
P
M
W
L
D
K
I
K
K
R
L
N
E
---
H
--
G
---
Y
P
Q
V
E
G
F
V
Q
D
M
R
L
I
F
Q
N
H
R
A
S
Y
-------------
D
F
G
Q
M
G
F
R
L
E
A
E
F
E
K
N
F
K
E
V
F
A
I
Q
E
-----------------------------------
594
HHSearch
67.25
22%
-64
- C6 -
-
2RO1
-
A:
[2-186]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
I
C
R
V
C
Q
K
P
G
D
----
L
V
M
C
N
Q
C
E
F
C
F
H
L
D
C
H
L
P
A
L
Q
D
V
-
P
G
E
E
W
S
C
S
L
C
H
V
L
P
D
L
K
E
E
D
G
--------------------------------
S
-----
L
S
L
---------------------
D
G
A
D
--
S
T
G
V
----------------------
V
A
K
L
S
P
A
N
Q
R
K
C
E
R
V
L
L
A
L
F
C
H
E
P
C
R
P
L
H
Q
L
A
T
D
S
T
F
--
S
L
D
Q
P
G
G
T
L
D
L
T
L
I
R
A
R
L
Q
E
---
K
--
L
SPP
Y
S
S
P
Q
E
F
A
Q
D
V
G
R
M
F
K
Q
F
N
K
L
T
---------
E
-
D
K
A
D
V
Q
S
I
I
G
L
Q
R
F
F
E
T
R
M
N
E
A
F
G
D
T
K
F
S
A
V
L
------------------------------
597
HHSearch
63.92
21%
-117
- C6 -
-
5PXL
3
SP100_HUMAN
A:
[3-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
C
E
V
C
N
K
W
G
R
----
L
F
C
C
D
T
C
P
R
S
F
H
E
H
C
H
I
P
S
V
E
A
--
N
K
N
P
W
S
C
I
F
C
R
I
K
T
I
Q
E
R
C
P
E
S
------------------------------
Q
----
S
G
H
---------------------------
Q
E
S
E
V
L
----------------------
M
R
Q
M
L
P
E
E
Q
L
K
C
E
F
L
L
L
K
V
Y
C
D
S
K
S
C
F
F
A
S
E
P
Y
--
Y
N
R
E
G
S
Q
G
P
Q
K
P
M
W
L
N
K
V
K
T
S
L
N
E
---
Q
--
M
---
Y
T
R
V
E
G
F
V
Q
D
M
R
L
I
F
H
N
H
K
E
F
Y
-
R
-------
E
-
D
K
-
F
T
R
L
G
I
Q
V
Q
D
I
F
E
K
N
F
R
N
I
F
A
I
Q
E
-----------------------------------
598
HHSearch
63.14
21%
-116
- C6 -
-
5PYI
3
SP100_HUMAN
A:
[3-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
C
E
V
C
N
K
W
G
R
----
L
F
C
C
D
T
C
P
R
S
F
H
E
H
C
H
I
P
S
V
E
A
--
N
K
N
P
W
S
C
I
F
C
R
I
K
T
I
Q
E
R
C
P
E
S
------------------------------
Q
----
S
G
H
---------------------------
Q
E
S
E
V
L
----------------------
M
R
Q
M
L
P
E
E
Q
L
K
C
E
F
L
L
L
K
V
Y
C
D
S
K
S
C
F
F
A
S
E
P
Y
--
Y
N
R
E
G
S
Q
G
P
Q
K
P
M
W
L
N
K
V
K
T
S
L
N
E
---
Q
--
M
---
Y
T
R
V
E
G
F
V
Q
D
M
R
L
I
F
H
N
H
K
E
F
Y
-
R
-------
E
-
D
K
-
F
T
R
L
G
I
Q
V
Q
D
I
F
E
K
N
F
R
N
I
F
A
I
Q
E
-----------------------------------
603
HHSearch
62.65
32%
-175
- C6 -
-
6AZE
-
H31_HUMAN
A:
[69-166]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
L
K
R
V
L
R
S
L
Q
A
H
K
M
A
W
P
F
L
E
P
V
D
P
N
D
A
P
D
Y
Y
G
V
I
K
E
P
M
D
L
A
T
M
E
E
R
V
Q
R
---
R
--
Y
---
Y
E
K
L
T
E
F
V
A
D
M
T
K
I
F
D
N
C
R
Y
Y
N
-
P
-------
S
-
D
S
P
F
Y
Q
C
A
E
V
L
E
S
F
F
V
Q
K
L
K
G
F
----------------------------------------
610
HHSearch
60.32
30%
-104
- C6 -
-
3Q2E
-
A:
[10-116]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
W
K
K
Q
C
K
E
L
V
N
L
I
F
Q
C
E
D
S
E
P
F
R
Q
P
V
D
L
V
E
Y
P
D
Y
R
D
I
I
D
T
P
M
D
F
G
T
V
R
E
T
L
D
A
---
G
--
N
---
Y
D
S
P
L
E
F
C
K
D
I
R
L
I
F
S
N
A
K
A
Y
T
-
P
-------
N
K
R
S
K
I
Y
S
M
T
L
R
L
S
A
L
F
E
E
K
M
K
K
I
S
S
D
F
K
-----------------------------------
608
HHSearch
60.14
25%
-167
- C6 -
-
5UIY
1
BAZ1A_HUMAN
A:
[11-114]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
L
S
A
F
E
Q
L
V
V
E
L
V
R
H
D
D
S
W
P
F
L
K
L
V
S
K
I
Q
V
P
D
Y
Y
D
I
I
K
K
P
I
A
L
N
I
I
R
E
K
V
N
K
---
C
--
E
---
Y
K
L
A
S
E
F
I
D
D
I
E
L
M
F
S
N
C
F
E
Y
N
-
P
-------
R
-
N
T
S
E
A
K
A
G
T
R
L
Q
A
F
F
H
I
Q
A
Q
K
L
G
L
H
-------------------------------------
599
HHSearch
59.47
21%
-126
- C6 -
-
6G5P
3
B:
[3-177]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
I
C
E
V
C
N
K
W
G
R
----
L
F
C
C
D
T
C
P
R
S
F
H
E
H
C
H
I
P
S
V
E
A
--
N
K
N
P
W
S
C
I
F
C
R
I
K
T
I
Q
E
R
C
P
E
S
------------------------------
Q
----
S
G
H
---------------------------
Q
E
S
E
V
L
----------------------
M
R
Q
M
L
P
E
E
Q
L
K
C
E
F
L
L
L
K
V
Y
C
D
S
K
S
C
F
F
A
S
E
P
Y
--
Y
N
R
----
G
P
Q
K
P
M
W
L
N
K
V
K
T
S
L
N
E
---
Q
--
M
---
Y
T
R
V
E
G
F
V
Q
D
M
R
L
I
F
H
N
H
K
E
F
Y
-
R
-------
E
-
D
K
-
F
T
R
L
G
I
Q
V
Q
D
I
F
E
K
N
F
R
N
I
F
A
I
Q
E
-----------------------------------
431
Blastp_CBE
59.34
35%
-124
- C6 -
-
5ENF
3
A:
[14-109]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
C
E
E
L
L
N
L
I
F
Q
C
E
D
S
E
P
F
R
Q
P
V
D
L
L
E
Y
P
D
Y
R
D
I
I
D
T
P
M
D
F
A
T
V
R
E
T
L
E
A
---
G
--
N
---
Y
E
S
P
M
E
L
C
K
D
V
R
L
I
F
S
N
S
K
A
Y
T
P
S
-------
K
-
R
S
R
I
Y
S
M
S
L
R
----
L
S
A
F
F
E
E
H
I
---------------------------------------
434
Blastp_CBE
59.14
35%
-124
- C6 -
-
5ENB
3
A:
[14-109]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
C
E
E
L
L
N
L
I
F
Q
C
E
D
S
E
P
F
R
Q
P
V
D
L
L
E
Y
P
D
Y
R
D
I
I
D
T
P
M
D
F
A
T
V
R
E
T
L
E
A
---
G
--
N
---
Y
E
S
P
M
E
L
C
K
D
V
R
L
I
F
S
N
S
K
A
Y
T
P
S
-------
K
-
R
S
R
I
Y
S
M
S
L
R
----
L
S
A
F
F
E
E
H
I
---------------------------------------
432
Blastp_CBE
58.92
35%
-127
- C6 -
-
5ENE
1
A:
[14-109]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
C
E
E
L
L
N
L
I
F
Q
C
E
D
S
E
P
F
R
Q
P
V
D
L
L
E
Y
P
D
Y
R
D
I
I
D
T
P
M
D
F
A
T
V
R
E
T
L
E
A
---
G
--
N
---
Y
E
S
P
M
E
L
C
K
D
V
R
L
I
F
S
N
S
K
A
Y
T
P
S
-------
K
-
R
S
R
I
Y
S
M
S
L
R
----
L
S
A
F
F
E
E
H
I
---------------------------------------
428
Blastp_CBE
58.72
35%
-128
- C6 -
-
5ENJ
1
A:
[14-109]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
C
E
E
L
L
N
L
I
F
Q
C
E
D
S
E
P
F
R
Q
P
V
D
L
L
E
Y
P
D
Y
R
D
I
I
D
T
P
M
D
F
A
T
V
R
E
T
L
E
A
---
G
--
N
---
Y
E
S
P
M
E
L
C
K
D
V
R
L
I
F
S
N
S
K
A
Y
T
P
S
-------
K
-
R
S
R
I
Y
S
M
S
L
R
----
L
S
A
F
F
E
E
H
I
---------------------------------------