@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BMPR2_HUMAN: (2020-09-05 )
MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSNLKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNCL
Atome Classification :
(129 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.------......230---..-......-240.......250.......260.......270.......280.......290....------..--.300.----......310.......320-........330.......340.......350.......360.......370....---....---380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTSSLQRPWRVPWL
P
W
T
I
L
L
V
STAAASQ
N
Q
E
R
L
CAFK
D
P
Y
Q
Q
DLGIGESRISHEN
G
T
I
L
CSKG
S
T
C
Y
G
L
WEKSKG
D
I
N
L
V
K
Q
G
C
W
SHIG
D
P
Q
E
C
H
YE
E
C
V
VTTTPPSIQNG
T
Y
R
F
C
CCSTDLCNVNFTENFPPPDTTPLSPPHSFNRD
E
T
I
I
I
A
L
A
S
V
S
V
L
A
V
L
I
V
A
L
C
F
G
Y
R
MLTG
D
R
K
QG
L
H
S
M
N
M
M
E
A
AASEPSLD
L
D
N
L
K
L
L
E
L
IGRGRYG
A
V
YKGSLD------ER
P
V
A
V
K
V
----
F
S-FA
N
R
QN-FINEK
N
I
Y
RVPLMEHD
N
I
A
R
F
I
VGD
E
R
VTADG
R
M
E
Y
L
L
V
M
E
YYPNG
S
L
C
K
Y
L
SLH
T
S
------
D
W
--
V
S
S
C
R
----
L
A
H
S
V
T
R
G
L
A
Y
L
HTELP-R-GDHYKPAISHRDLNSR
N
V
L
V
KND
G
T
C
V
I
SDFG
L
S
M
R
LTGNRLVRPGEED-N
A
A
I
S
---EV
G
T
---
I
R
YM
A
P
E
V
L
E
GAV
N
L
R
D
C
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
DLFPGESVP
E
Y
Q
M
A
F
QTEVGNHP
T
F
E
D
M
Q
V
L
V
S
R
EKQRPKF
P
E
A
WKEN
S
L
A
V
R
S
L
K
E
T
I
E
D
C
WDQ
D
A
E
A
R
L
T
A
Q
C
A
E
E
R
M
A
E
L
M
M
I
W
ERNKSVSPTV
N
P
M
S
T
A
M
Q
NERNLSHNRRVPKIGPYPDYSSSS
Y
I
E
D
S
IH
H
T
D
S
I
V
K
N
I
S
SEHSMSSTP
L
T
IGEKNRNSI
N
Y
E
R
Q
Q
A
QARIPSPET
S
V
T
S
LSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLH
T
T
N
V
A
QSIGPT
P
V
C
L
Q
L
T
E
E
DLETNKL
D
P
K
E
V
D
K
N
L
KESS
D
E
N
L
M
E
H
S
L
K
QFSGPDPLSST
S
S
S
L
L
Y
P
L
I
K
L
A
V
EATGQQDFTQTANG
Q
A
C
LIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEP
R
L
KFGSKHK
S
N
L
K
Q
V
E
T
G
V
A
KMNTINAAEP
H
V
V
T
V
T
MNGVAGRNHSVNSHAA
T
T
QYAN
G
T
V
LSGQTT
N
I
V
T
H
R
A
Q
E
M
L
Q
N
QFIGED
T
R
L
NINSSPD
E
H
E
P
L
L
R
R
E
Q
QAGH
D
E
G
V
L
D
R
L
V
D
R
R
ERPLEGGRTNSNNNNSNPC
S
E
Q
D
V
L
A
QGVPSTAADPGPSKPRRAQRPNSLDLS
A
T
NVLDGS
S
I
QIGESTQDGKSG
S
G
E
K
I
K
K
R
VKTPYSLKRWRPS
T
W
V
I
S
TE
S
L
D
C
E
VNNNGSN
R
A
V
HSKS
S
T
A
V
Y
L
AEGG
T
A
T
T
M
V
SKDIGMNCL
212
HHSearch
99.31
100%
-110
- C4 -
-
3G2F
4
BMPR2_HUMAN
A:
[9-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
------
E
R
P
V
A
V
K
V
----
F
S
-
F
A
N
R
Q
N
-
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
T
S
------
D
W
--
V
S
S
C
R
----
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
-
R
-
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
N
R
L
V
R
P
-------------
E
V
G
T
---
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
C
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
C
A
E
E
R
M
A
E
L
M
M
I
W
E
R
N
K
S
V
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
98.48
98%
-108
- C4 -
-
3G2F
4
BMPR2_HUMAN
A:
[9-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
------
E
R
P
V
A
V
K
V
----
F
S
-
F
A
N
R
Q
N
-
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
T
S
------
D
W
--
V
S
S
C
R
----
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
-
R
-
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
N
R
L
V
R
P
-------------
E
V
G
T
---
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
R
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
L
A
E
E
R
M
A
E
L
M
M
I
W
E
R
N
K
S
V
S
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
79.97
98%
-56
- C4 -
-
3G2F
2
BMPR2_HUMAN
B:
[10-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
D
N
L
K
L
L
E
L
I
G
R
G
R
Y
G
A
V
Y
K
G
S
L
D
------
E
R
P
V
A
V
K
V
----
F
S
-
F
A
N
R
Q
N
-
F
I
N
E
K
N
I
Y
R
V
P
L
M
E
H
D
N
I
A
R
F
I
V
G
D
E
R
V
T
A
D
G
R
M
E
Y
L
L
V
M
E
Y
Y
P
N
G
S
L
C
K
Y
L
S
L
H
T
S
------
D
W
--
V
S
S
C
R
----
L
A
H
S
V
T
R
G
L
A
Y
L
H
T
E
L
P
-
R
-
G
D
H
Y
K
P
A
I
S
H
R
D
L
N
S
R
N
V
L
V
K
N
D
G
T
C
V
I
S
D
F
G
L
S
M
R
L
T
G
N
R
L
-----------------
V
G
T
---
I
R
Y
M
A
P
E
V
L
E
G
A
V
N
L
R
D
-
E
S
A
L
K
Q
V
D
M
Y
A
L
G
L
I
Y
W
E
I
F
M
R
C
T
D
L
F
P
G
E
S
V
P
E
Y
Q
M
A
F
Q
T
E
V
G
N
H
P
T
F
E
D
M
Q
V
L
V
S
R
E
K
Q
R
P
K
F
P
E
A
W
K
E
N
S
L
A
V
R
S
L
K
E
T
I
E
D
C
W
D
Q
D
A
E
A
R
L
T
A
Q
-
A
E
E
R
M
A
E
L
M
M
I
W
E
R
N
K
S
V
S
P
T
A
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
77.89
38%
-100
- C4 -
-
5FRI
3
TGFR1_HUMAN
A:
[10-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
77.88
38%
-101
- C4 -
-
5QIK
3
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
77.71
38%
-104
- C4 -
-
6B8Y
1
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
77.68
37%
-111
* C4 *
-
5E8X
2
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
77.52
38%
-103
- C4 -
-
4X2F
1
TGFR1_HUMAN
A:
[9-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
77.46
38%
-99
- C4 -
-
5QIL
1
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
77.43
38%
-101
- C4 -
-
5E8W
3
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
77.22
37%
-101
- C4 -
-
5E8U
3
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
77.21
38%
-101
- C4 -
-
5E8Z
1
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
76.77
38%
-101
- C4 -
-
3HMM
1
TGFR1_HUMAN
A:
[7-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
--------
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
76.55
38%
-99
- C4 -
-
5E8T
3
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
76.52
38%
-103
- C4 -
-
4X2G
2
TGFR1_HUMAN
A:
[9-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
HHSearch
76.49
36%
-107
- C4 -
-
5E8X
2
TGFR1_HUMAN
A:
[6-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
-
N
G
T
W
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
-
G
--
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
T
D
T
----
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
-
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
H
---
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
-
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
76.23
38%
-101
- C4 -
-
4X2J
1
TGFR1_HUMAN
A:
[9-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
76.23
38%
-101
- C4 -
-
4X2K
1
TGFR1_HUMAN
A:
[9-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
76.20
38%
-101
- C4 -
-
1RW8
1
TGFR1_HUMAN
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
76.10
38%
-102
- C4 -
-
4X0M
1
TGFR1_HUMAN
A:
[9-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
76.06
38%
-102
- C4 -
-
5USQ
1
TGFR1_HUMAN
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
75.77
38%
-100
- C4 -
-
1VJY
1
TGFR1_HUMAN
A:
[7-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
-------
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
75.31
37%
-101
- C4 -
-
5E90
1
TGFR1_HUMAN
A:
[8-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
V
L
Q
E
S
V
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
F
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
T
D
F
H
E
H
G
N
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
C
D
F
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
HHSearch
75.27
37%
-101
- C4 -
-
4X2J
1
TGFR1_HUMAN
A:
[5-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
-
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
-
G
--
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
----
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
-
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
---
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
-
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
75.21
38%
-104
- C4 -
-
3MDY
1
BMR1B_HUMAN
C:
[38-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
------
G
E
K
V
A
V
K
V
----
F
F
-
T
T
E
E
A
S
-
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
-
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
------
D
A
--
K
S
M
L
K
----
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
--
F
-
S
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
------------
I
P
P
N
T
---
R
V
G
T
---
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
-
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
---
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.02
38%
-104
- C4 -
-
3MDY
1
BMR1B_HUMAN
A:
[38-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
------
G
E
K
V
A
V
K
V
----
F
F
-
T
T
E
E
A
S
-
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
-
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
------
D
A
--
K
S
M
L
K
----
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
--
F
-
S
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
--------------
P
N
T
---
R
V
G
T
---
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
-
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
---
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
-
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
HHSearch
74.58
37%
-104
- C4 -
-
3MDY
1
BMR1B_HUMAN
A:
[36-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
------
G
E
K
V
A
V
K
V
----
F
F
-
T
T
E
E
A
S
-
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
-
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
------
D
A
--
K
S
M
L
K
----
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
-
S
--
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
--------------
P
N
T
---
R
V
G
T
---
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
-
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
G
---
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
-
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
73.94
39%
-96
- C4 -
-
6ACR
1
ACVR1_HUMAN
A:
[10-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
--
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
HHSearch
73.62
37%
-103
- C4 -
-
5USQ
1
TGFR1_HUMAN
A:
[4-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
-
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
-
G
--
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
----
I
D
-
I
A
P
N
H
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
-
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
---
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
-
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
73.54
39%
-98
- C4 -
-
3Q4U
3
ACVR1_HUMAN
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
72.73
39%
-95
- C4 -
-
6GI6
11
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
HHSearch
72.70
38%
-105
- C4 -
-
6SRH
11
ACVR1_HUMAN
A:
[7-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
-
G
--
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----------------
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
-
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
---
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
-
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
72.54
39%
-98
- C4 -
-
6SRH
6
ACVR1_HUMAN
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
72.34
39%
-99
- C4 -
-
6T6D
2
?
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
-
L
D
-
V
---
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
72.00
39%
-104
- C4 -
-
6SZM
8
?
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
---------------
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.94
38%
-93
- C4 -
-
3MTF
12
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
HHSearch
71.89
38%
-95
- C4 -
-
5OXG
1
ACVR1_HUMAN
C:
[7-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
-
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
-
G
--
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
----
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
-
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
---
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
-
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
71.79
39%
-103
- C4 -
-
6SRH
11
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
----------------
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.74
39%
-91
- C4 -
-
6EIX
9
ACVR1_HUMAN
A:
[39-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
71.68
39%
-92
- C4 -
-
5OY6
1
ACVR1_HUMAN
D:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.63
38%
-93
- C4 -
-
3OOM
16
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
71.57
39%
-92
- C4 -
-
4BGG
1
ACVR1_HUMAN
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
----
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
71.55
39%
-92
- C4 -
-
6GIN
4
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
71.36
39%
-96
- C4 -
-
4DYM
5
ACVR1_HUMAN
A:
[10-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
71.35
38%
-97
- C4 -
-
3GXL
1
TGFR1_HUMAN
A:
[7-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
---------
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
----
T
D
T
I
D
---------
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
------
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
---
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
71.34
39%
-94
- C4 -
-
6GIN
2
ACVR1_HUMAN
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
71.18
39%
-91
- C4 -
-
5OY6
3
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
71.16
39%
-91
- C4 -
-
6GIP
3
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
71.15
39%
-90
- C4 -
-
4BGG
2
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.04
39%
-106
- C4 -
-
3H9R
4
ACVR1_HUMAN
A:
[39-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
---------------------
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
71.03
39%
-95
- C4 -
-
6SZM
4
?
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
71.01
39%
-91
- C4 -
-
5OXG
1
ACVR1_HUMAN
C:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
70.96
39%
-95
- C4 -
-
6T6D
1
?
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
70.95
39%
-95
- C4 -
-
6ACR
1
ACVR1_HUMAN
B:
[10-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
----
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.91
38%
-93
- C4 -
-
3Q4U
7
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
70.79
39%
-100
- C4 -
-
6T6D
1
?
D:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
-------------------
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
70.78
39%
-91
- C4 -
-
5OXG
1
ACVR1_HUMAN
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
70.57
39%
-91
- C4 -
-
6T8N
3
?
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.51
39%
-95
- C4 -
-
6I1S
8
ACVR1_HUMAN (first)
A:
[39-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
70.50
39%
-90
- C4 -
-
3Q4U
6
ACVR1_HUMAN
C:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
70.29
39%
-91
- C4 -
-
6T8N
4
?
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
----
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
70.18
38%
-55
- C4 -
-
3TZM
1
TGFR1_HUMAN
A:
[13-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
-------
H
D
S
A
T
D
-
T
I
D
I
A
P--
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
70.15
39%
-96
- C4 -
-
5OY6
1
ACVR1_HUMAN
B:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
--------
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
70.04
38%
-62
- C4 -
-
2WOU
2
TGFR1_HUMAN
A:
[10-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
-------
H
D
S
A
T
D
-
T
I
D
I
A
PNH
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
69.86
39%
-91
- C4 -
-
4BGG
1
ACVR1_HUMAN
D:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
------
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
----
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
69.72
39%
-99
- C4 -
-
4BGG
1
ACVR1_HUMAN
C:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
-------
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
----
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
-----------
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
69.72
39%
-92
- C4 -
-
5OXG
2
ACVR1_HUMAN
A:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
69.67
38%
-61
- C4 -
-
1PY5
1
TGFR1_HUMAN
A:
[33-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
-------
H
D
S
A
T
D
-
T
I
D
I
A
PNH
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
69.54
38%
-61
- C4 -
-
2WOT
2
TGFR1_HUMAN
A:
[10-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
-------
H
D
S
A
T
D
-
T
I
D
I
A
PNH
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
69.37
38%
-60
- C4 -
-
5QIM
2
TGFR1_HUMAN
A:
[10-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
------
G
E
E
V
A
V
K
I
----
F
S
-
S
R
E
E
R
S
-
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
-
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
------
T
V
--
E
G
M
I
K
----
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
---
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
-------
H
D
S
A
T
D
-
T
I
D
I
A
PNH
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
-
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
---
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
-
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
69.31
39%
-91
- C4 -
-
5OXG
1
ACVR1_HUMAN
D:
[9-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
------
G
E
N
V
A
V
K
I
----
F
S
-
S
R
D
E
K
S
-
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
-
M
T
---
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
------
D
T
--
V
S
C
L
R
----
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
--
F
-
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
----
T
N
Q
L
D
-
V
G
N
N
P
---
R
V
G
T
---
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
-
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
---
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
-
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
HHSearch
69.29
43%
-49
- C4 -
-
4ASX
5
AVR2A_HUMAN
A:
[20-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
Q
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
------
N
E
Y
V
A
V
K
I
----
F
P
-
I
Q
D
K
Q
S
-
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
------
S
W
--
N
E
L
C
H
----
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
-
G
L
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
-------
G
-
T
H
G
---
Q
V
G
T
---
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
--
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
69.12
43%
-44
- C4 -
-
3SOC
5
AVR2A_HUMAN
B:
[26-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
------
N
E
Y
V
A
V
K
I
----
F
P
-
I
Q
D
K
Q
S
-
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
------
S
W
--
N
E
L
C
H
----
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
-
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
A
---
T
H
G
---
Q
V
G
T
---
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
--
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.18
42%
-41
- C4 -
-
4ASX
4
AVR2A_HUMAN
A:
[26-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
------
N
E
Y
V
A
V
K
I
----
F
P
-
I
Q
D
K
Q
S
-
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
------
S
W
--
N
E
L
C
H
----
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
-
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
A
-
G
-
T
H
G
---
Q
V
G
T
---
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
--
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
68.11
43%
-42
- C4 -
-
3Q4T
9
AVR2A_HUMAN
B:
[26-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
------
N
E
Y
V
A
V
K
I
----
F
P
-
I
Q
D
K
Q
S
-
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
------
S
W
--
N
E
L
C
H
----
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
-
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
A
---
T
H
G
---
Q
V
G
T
---
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
--
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
67.32
43%
-35
- C4 -
-
4ASX
6
AVR2A_HUMAN
B:
[26-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
------
N
E
Y
V
A
V
K
I
----
F
P
-
I
Q
D
K
Q
S
-
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
------
S
W
--
N
E
L
C
H
----
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
-
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
A
-
G
D
T
H
G
---
Q
V
G
T
---
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
--
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
HHSearch
67.02
42%
-44
- C4 -
-
3SOC
7
AVR2A_HUMAN
A:
[19-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
F
Q
S
M
P
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
------
N
E
Y
V
A
V
K
I
----
F
P
-
I
Q
D
K
Q
S
-
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
-
S
V
D
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
------
S
W
--
N
E
L
C
H
----
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
-
G
L
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
E
A
G
K
S
A
-------
G
D
T
H
G
---
Q
V
G
T
---
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
A
D
G
P
V
--
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
-
K
H
A
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
65.00
42%
-35
- C4 -
-
3SOC
7
AVR2A_HUMAN
A:
[26-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
L
L
E
V
K
A
R
G
R
F
G
C
V
W
K
A
Q
L
L
------
N
E
Y
V
A
V
K
I
----
F
P
-
I
Q
D
K
Q
S
-
W
Q
N
E
Y
E
V
Y
S
L
P
G
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
G
T
S
V
D
-
V
D
L
W
L
I
T
A
F
H
E
K
G
S
L
S
D
F
L
K
A
N
V
V
------
S
W
--
N
E
L
C
H
----
I
A
E
T
M
A
R
G
L
A
Y
L
H
E
D
I
P
G
L
-
K
D
G
H
K
P
A
I
S
H
R
D
I
K
S
K
N
V
L
L
K
N
N
L
T
A
C
I
A
D
F
G
L
A
L
K
F
------
E
A
G
K
S
A
-
G
D
T
H
G
---
Q
V
G
T
---
R
R
Y
M
A
P
E
V
L
E
G
A
I
N
F
Q
--
R
D
A
F
L
R
I
D
M
Y
A
M
G
L
V
L
W
E
L
A
S
R
C
T
A
--
A
D
G
P
V
D
E
Y
M
L
P
F
E
E
E
I
G
Q
H
P
S
L
E
D
M
Q
E
V
V
V
H
K
K
K
R
P
V
L
R
D
Y
W
Q
K
H
A
-
G
M
A
M
L
C
E
T
I
E
E
C
W
D
H
D
A
E
A
R
L
S
A
G
C
V
G
E
R
I
T
Q
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
37.73
31%
-45
- C4 -
-
3KUL
2
EPHA8_HUMAN
A:
[46-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
A
S
R
I
H
I
E
K
I
I
G
S
G
D
S
G
E
V
C
Y
G
R
L
R
VPGQR-
D
V
P
V
A
I
K
A
LKAG
Y
T
-
E
R
Q
R
R
D
-
F
L
S
E
A
S
I
--
M
G
Q
F
D
H
P
N
I
I
R
L
----
E
G
V
V
T
R
G
R
L
A
-
M
I
V
T
E
Y
M
E
N
G
S
L
D
T
F
L
R
T
H
D
G
------
Q
F
TI
M
Q
L
V
G
----
M
L
R
G
V
G
A
G
M
R
Y
L
-
S
D
L
----------
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
---------
E
----
A
A
Y
T
---
T
T
--IP-
I
R
W
T
A
P
E
----
A
I
A
F
R
T
F
S
S
A
---
S
D
V
W
S
F
G
V
V
M
W
E
V
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
36.83
31%
-71
- C4 -
-
5HI2
1
A:
[28-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-------
H
G
D
V
A
V
K
M
----
L
T
-
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
--
R
H
V
N
I
L
L
F
M
------
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
--
Y
H
H
L
H
A
S
------
E
T
--
K
F
E
M
K
KLID
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
----------------------------
S
---
I
L
W
M
A
P
E
V
----
I
R
M
---
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
36.33
34%
-36
- C4 -
-
3PPZ
1
CTR1_ARATH
A:
[38-232]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
W
H
------
G
S
D
V
A
V
K
I
----
L
M
E-
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
--
R
L
R
H
P
N
I
V
L
F
M
G
A
---
V
T
Q
P
P
N
L
S
--
I
V
T
E
Y
L
S
R
G
S
L
--
Y
R
L
L
H
K
S
GAREQL
D
E
--
R
R
R
L
S
----
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
---------
N
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
-
R
L
K
A
S
F
L
S
K
A
A
--------------
G
T
---
P
E
W
M
A
P
E
V
------
L
R
D
-
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
35.71
31%
-55
- C4 -
-
5HID
3
BRAF_HUMAN
A:
[28-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-------
H
G
D
V
A
V
K
M
----
L
T
-
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
--
R
H
V
N
I
L
L
F
M
------
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
--
Y
H
H
L
H
A
S
------
E
T
--
K
F
E
M
K
KLID
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-----------------
E
Q
L
S
-----
G
S
---
I
L
W
M
A
P
E
V
----
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
35.59
31%
-48
- C4 -
-
5HID
3
B:
[28-210]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
-------
H
G
D
V
A
V
K
M
----
L
T
-
P
Q
Q
L
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
--
R
H
V
N
I
L
L
F
M
------
G
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
--
Y
H
H
L
H
A
S
------
E
T
--
K
F
E
M
K
KLID
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
-----------
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
T
--
V
K
S
R
W
--
S
G
S
H
Q
-
F
E
Q
L
S
-----
G
S
---
I
L
W
M
A
P
E
V
----
I
R
M
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
34.60
31%
-36
- C4 -
-
5NJZ
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TKK---
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
34.53
31%
-32
- C4 -
-
1MQB
1
EPHA2_HUMAN
A:
[50-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TKK---
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
33.95
31%
-27
- C4 -
-
6FNH
4
C:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TGKK--
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
33.52
31%
-29
- C4 -
-
1MQB
1
B:
[50-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
----------------KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
33.40
31%
-22
- C4 -
-
5IA0
8
EPHA2_HUMAN
B:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TSK---
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
----------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
32.63
31%
-10
- C4 -
-
5I9V
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TSSGKK
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
----------------KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
32.63
31%
-33
- C4 -
-
6FNG
6
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
32.52
31%
-29
- C4 -
-
6Q7D
1
?
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
32.40
31%
-20
- C4 -
-
5IA3
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
------------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
32.25
31%
-23
- C4 -
-
5IA0
5
EPHA2_HUMAN
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
------------------------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
32.13
31%
-28
- C4 -
-
6HET
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
32.03
31%
-16
- C4 -
-
5IA1
2
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-K-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
32.00
31%
-28
- C4 -
-
5NKI
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
------------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
31.97
31%
-29
- C4 -
-
5I9W
2
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-K-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
31.83
31%
-16
- C4 -
-
5NK0
1
A:
[23-217]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TSSGKK
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
31.63
31%
-28
- C4 -
-
6HEX
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
31.36
31%
3
- C4 -
-
6FNH
5
EPHA2_HUMAN
B:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TSK---
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
----------KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
31.31
31%
-23
- C4 -
-
6HEY
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TS----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
31.08
31%
-21
- C4 -
-
6Q7G
1
?
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
30.97
31%
-22
- C4 -
-
5IA0
5
C:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TGKK--
E
V
P
V
A
I
K
T
LKA--
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
30.84
31%
3
- C4 -
-
6FNH
10
EPHA2_HUMAN
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TSGKK-
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
-------------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
30.83
31%
-13
- C4 -
-
5I9Y
4
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TKK---
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
--------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
30.76
31%
-23
- C4 -
-
6Q7E
1
?
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
30.42
31%
-3
- C4 -
-
5NKA
2
A:
[23-218]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TSSGKK
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
30.31
31%
-10
- C4 -
-
6FNF
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
30.15
31%
-20
- C4 -
-
6HEW
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------------------------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
30.00
31%
-19
- C4 -
-
6Q7F
1
?
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
------------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
29.80
31%
-8
- C4 -
-
5NK2
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
-------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
29.70
31%
-24
- C4 -
-
6Q7C
1
?
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
--
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------------------------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
29.66
31%
1
- C4 -
-
5IA2
2
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
T
---
T
S
G
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
29.66
31%
-12
- C4 -
-
6HEU
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
29.65
31%
-13
- C4 -
-
5I9Z
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
--
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
----------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
29.60
31%
-7
- C4 -
-
5NK1
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
-------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
29.56
31%
-4
- C4 -
-
5NK8
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
----
G
E
V
Y
K
G
M
L
K
TSSGKK
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
------------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
29.56
31%
-17
- C4 -
-
6Q7B
1
?
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------------------------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
29.45
31%
-15
- C4 -
-
6HES
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------P--
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
29.39
31%
-15
- C4 -
-
6HEV
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------------IP-
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
28.92
31%
2
- C4 -
-
5I9X
4
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
T-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
-------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
28.89
31%
-8
- C4 -
-
5NK7
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
-------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
28.87
31%
3
- C4 -
-
5NK3
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
K
TK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
T
------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
28.84
31%
3
- C4 -
-
5NK9
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
T
---
T
--
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
28.66
31%
-3
- C4 -
-
5NKC
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
--------KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
28.50
31%
2
- C4 -
-
5NK6
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
------
G
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
28.43
31%
-0
- C4 -
-
5NKD
2
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-K-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
-------
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
28.39
31%
0
- C4 -
-
5NK4
1
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-K-----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
T
---
T
S
G
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
27.65
31%
2
- C4 -
-
5NKB
2
A:
[23-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-KK----
E
V
P
V
A
I
K
T
LKAG
Y
T
-
E
K
Q
R
V
D
-
F
L
G
E
A
G
I
--
M
G
Q
F
S
H
H
N
I
I
R
L
----
E
G
V
I
S
K
Y
K
-
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
K
D
G
------
E
F
---
S
V
L
Q
----
L
V
-
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
-
N
-
M
N
Y
V
-----
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------
R
V
L
E
D
D
P
E
A
T
Y
T
---
T
--
G
KIP
I
R
W
T
A
P
E
----
A
I
S
Y
R
K
F
T
S
A
---
S
D
V
W
S
F
G
I
V
M
W
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------