@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BRAF_HUMAN: (2020-09-05 )
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Atome Classification :
(176 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470..-------..--..--.------480.......490.......500.......510..-.....520-.-..-.....530.......540.--..-..-.-.550.......560.......--570-........580.......590......-.600........610.---...--...620.....----..630.......640.......650........660.......670.--......680.......690.......700.......710.......720........730.......740.......750.......760....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAALSGGGGGGAEP
G
Q
A
LFNGDMEPEAGAGAGAAASSAADPAI
P
E
E
V
W
N
I
K
Q
M
I
K
L
T
Q
E
H
I
E
A
L
L
D
K
FGGEHNP
P
S
I
Y
L
E
A
Y
E
E
Y
T
S
K
L
D
A
L
Q
Q
R
E
Q
Q
L
L
E
SLGNGT
D
F
SVSSSAS
M
D
T
VTSSSSSS
L
S
VLP
S
S
L
S
VFQNP
T
D
V
ARSNPKSPQK
P
I
V
R
V
FLPNKQ
R
T
V
VPARCG
V
T
V
R
D
S
L
K
K
A
L
M
MRGL
I
P
E
C
C
A
V
Y
RIQDGEKKPIGWDTDISWLTG
E
E
L
H
V
E
V
L
ENVPL
T
T
H
N
F
V
R
K
T
F
F
T
L
A
F
C
D
F
C
R
K
L
L
FQGFRCQTCG
Y
K
F
H
Q
RCSTEV
P
L
M
C
V
N
Y
D
Q
L
D
L
L
F
V
S
K
F
F
E
HHPI
P
Q
E
E
A
S
L
A
E
T
A
LTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPA
D
E
D
H
R
N
Q
FGQRDRSSSAP
N
V
H
I
N
T
IEPV
N
I
D
D
L
I
R
DQGFRGDGGSTTGLSATPPASLPGSL
T
N
V
K
A
L
QKSPGP
Q
R
ERKSSSSS
E
D
R
N
R
M
K
T
LGRRDSSDDWEIPDG
Q
I
T
V
G
Q
R
IGSGSFG
T
V
YK
G
-------
K
W--HG--
D
------
V
A
V
K
M
L
NVTAP
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
RKT
R
H
V
N
I
L
-
L
F
MGYST--K-P
Q
-
L
A
I
V
T
QWCEGSS
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
AQG
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
DLKSN
N
I
F
L
HED
L
T
V
K
IGDF
G
L
A
-
T
V
-
K
S
RWSGSH
Q
F
E
Q
L---SG
S
--
I
L
W
MA
P
E
V
IRM----QDKNPYSF
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
MT-GQLPYSNINNR
D
Q
I
I
F
M
VGRGY--LSP
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
KKRDERP
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
I
H
RSASEPSLNRAGFQTE
D
F
S
L
Y
ACASPKTPIQAGGYGAFPVH
4
PsiBlast_PDB
93.63
99%
-108
- C3 -
-
6NYB
1
?
A:
[260-765]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
H
N
F
V
R
K
T
F
F
T
L
A
F
C
D
F
C
R
K
L
L
F
Q
G
F
R
C
Q
T
C
G
Y
K
F
H
Q
R
C
S
T
E
V
P
L
M
C
V
------------------------------------------------------------------------------
R
D
R
S
S
S
A
P
N
V
H
------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
I
H
R
S
A
S
E
P
S
L
N
R
A
G
F
----------------------------
556
HHSearch
93.42
98%
-108
- C3 -
-
6NYB
1
?
A:
[260-765]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
H
N
F
V
R
K
T
F
F
T
L
A
F
C
D
F
C
R
K
L
L
F
Q
G
F
R
C
Q
T
C
G
Y
K
F
H
Q
R
C
S
T
E
V
P
L
M
C
V
------------------------------------------------------------------------------
R
D
R
S
S
S
A
P
N
V
H
------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
I
H
R
S
A
S
E
P
S
L
N
R
A
G
F
----------------------------
1
PsiBlast_PDB
85.90
99%
-125
- C3 -
-
6Q0K
-
?
A:
[476-764]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
----
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
I
H
R
S
A
S
E
P
S
L
N
R
A
G
-----------------------------
3
PsiBlast_PDB
84.82
99%
-118
- C3 -
-
6Q0T
-
?
A:
[476-759]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
----
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
I
H
R
S
A
S
E
P
S
----------------------------------
30
Blastp_CBE
84.55
100%
-126
- C3 -
-
4EHE
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
2
PsiBlast_PDB
84.24
99%
-120
- C3 -
-
6Q0J
-
?
A:
[476-760]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
----
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
I
H
R
S
A
S
E
P
S
L
---------------------------------
557
HHSearch
84.07
98%
-120
- C3 -
-
6Q0J
-
?
A:
[476-760]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
----
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
I
H
R
S
A
S
E
P
S
L
---------------------------------
35
Blastp_CBE
83.12
100%
-127
- C3 -
-
3TV6
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
91
Blastp_CBE
83.00
95%
-118
- C3 -
-
6U2H
1
D:
[3-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
---
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
P
K
I
H
R
S
A
-
E
P
S
L
N
--------------------------------
20
PsiBlast_PDB
82.82
100%
-128
- C3 -
-
4E26
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
------
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
71
Blastp_CBE
82.72
99%
-119
- C3 -
-
6PP9
1
?
A:
[7-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
36
Blastp_CBE
82.69
100%
-127
- C3 -
-
3TV4
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
7
PsiBlast_PDB
82.64
100%
-124
- C3 -
-
4MNE
1
BRAF_HUMAN
B:
[30-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
----
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
83
Blastp_CBE
82.58
100%
-140
- C3 -
-
2FB8
1
BRAF_HUMAN
A:
[7-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-----------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
561
HHSearch
82.44
95%
-118
- C3 -
-
6U2H
1
D:
[3-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
---
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
P
K
I
H
R
S
A
S
E
------------------------------------
77
Blastp_CBE
82.32
100%
-121
- C3 -
-
5VAM
1
BRAF_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
----
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
55
Blastp_CBE
82.27
100%
-129
- C3 -
-
4MBJ
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
37
Blastp_CBE
82.27
100%
-121
- C3 -
-
3SKC
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
89
Blastp_CBE
82.09
100%
-136
- C3 -
-
6N0P
1
B:
[1-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
--------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
560
HHSearch
82.07
100%
-130
- C3 -
-
4H58
-
C:
[2-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
65
Blastp_CBE
82.04
100%
-132
- C3 -
-
4FC0
1
B:
[6-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
-------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
92
Blastp_CBE
81.98
95%
-126
- C3 -
-
6U2H
1
BRAF_HUMAN
C:
[3-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
--------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
P
K
I
H
R
S
A
-
E
P
S
L
N
--------------------------------
29
Blastp_CBE
81.98
100%
-133
- C3 -
-
4G9C
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
-----------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
56
Blastp_CBE
81.96
100%
-137
- C3 -
-
4MBJ
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
-------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
84
Blastp_CBE
81.95
100%
-137
- C3 -
-
4H58
1
BRAF_HUMAN
A:
[1-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
---------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
81
Blastp_CBE
81.93
100%
-135
- C3 -
-
5CT7
1
BRAF_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
---------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
63
Blastp_CBE
81.89
100%
-132
- C3 -
-
4KSP
1
B:
[6-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
33
Blastp_CBE
81.87
100%
-138
- C3 -
-
4E4X
1
BRAF_HUMAN
A:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
-------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
25
Blastp_CBE
81.86
100%
-124
- C3 -
-
6U2G
1
MP2K1_HUMAN
B:
[32-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
--------
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
34
Blastp_CBE
81.82
100%
-133
- C3 -
-
4E26
1
B:
[29-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
--------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
97
Blastp_CBE
81.78
95%
-117
- C3 -
-
6NSQ
1
BRAF_HUMAN
A:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
-
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
21
Blastp_CBE
81.78
99%
-134
- C3 -
-
4MNF
1
B:
[42-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
28
Blastp_CBE
81.72
100%
-134
- C3 -
-
4G9C
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
67
Blastp_CBE
81.69
100%
-117
- C3 -
-
4DBN
1
B:
[6-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
-------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
27
Blastp_CBE
81.69
100%
-128
- C3 -
-
4PP7
1
BRAF_HUMAN
A:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
-------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
10
PsiBlast_PDB
81.68
100%
-129
- C3 -
-
3PSB
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
32
Blastp_CBE
81.67
100%
-127
- C3 -
-
4E4X
1
B:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
61
Blastp_CBE
81.58
100%
-132
- C3 -
-
4KSQ
1
B:
[7-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
26
Blastp_CBE
81.52
100%
-125
- C3 -
-
4PP7
1
B:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
43
Blastp_CBE
81.49
100%
-128
- C3 -
-
3PPJ
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
80
Blastp_CBE
81.46
100%
-134
- C3 -
-
5CT7
1
B:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
------------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
64
Blastp_CBE
81.46
100%
-134
- C3 -
-
4KSP
1
BRAF_HUMAN
A:
[6-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
15
PsiBlast_PDB
81.44
100%
-132
- C3 -
-
3Q4C
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
---------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
69
Blastp_CBE
81.38
100%
-130
- C3 -
-
3Q96
1
B:
[4-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
-------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
57
Blastp_CBE
81.37
98%
-138
- C3 -
-
5HIE
1
D:
[30-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
48
Blastp_CBE
81.33
99%
-136
- C3 -
-
5C9C
1
BRAF_HUMAN
A:
[30-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
--------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
59
Blastp_CBE
81.22
98%
-143
- C3 -
-
5HIE
1
BRAF_HUMAN
B:
[30-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
-------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
62
Blastp_CBE
81.18
100%
-134
- C3 -
-
4KSQ
1
BRAF_HUMAN
A:
[6-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
562
HHSearch
81.17
100%
-135
- C3 -
-
6N0P
1
B:
[2-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
--------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
------------------------------------------------
46
Blastp_CBE
81.11
100%
-129
- C3 -
-
5FD2
1
BRAF_HUMAN
A:
[22-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
18
PsiBlast_PDB
81.10
100%
-132
- C3 -
-
3TV4
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
--
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
-------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
12
PsiBlast_PDB
81.10
100%
-136
- C3 -
-
3PPK
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
53
Blastp_CBE
81.00
99%
-131
- C3 -
-
3IDP
1
B:
[22-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
75
Blastp_CBE
80.96
100%
-133
- C3 -
-
6B8U
1
BRAF_HUMAN
A:
[7-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
---------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
16
PsiBlast_PDB
80.95
100%
-130
- C3 -
-
3PSD
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
38
Blastp_CBE
80.90
100%
-128
- C3 -
-
3PSD
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
13
PsiBlast_PDB
80.89
100%
-139
- C3 -
-
3PRF
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
11
PsiBlast_PDB
80.89
100%
-126
- C3 -
-
3PPJ
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
58
Blastp_CBE
80.85
98%
-136
- C3 -
-
5HIE
1
BRAF_HUMAN
C:
[30-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
73
Blastp_CBE
80.81
100%
-132
- C3 -
-
6N0Q
1
?
A:
[4-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
44
Blastp_CBE
80.74
100%
-130
- C3 -
-
3D4Q
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
76
Blastp_CBE
80.73
100%
-134
- C3 -
-
5VAM
1
B:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
------
R
W
------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
41
Blastp_CBE
80.69
100%
-132
- C3 -
-
3PRF
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
6
PsiBlast_PDB
80.68
99%
-128
- C3 -
-
4MNF
1
BRAF_HUMAN
A:
[42-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
82
Blastp_CBE
80.66
100%
-130
- C3 -
-
2FB8
1
B:
[7-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-----------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
24
Blastp_CBE
80.63
100%
-133
- C3 -
-
3II5
1
B:
[29-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
---------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
19
PsiBlast_PDB
80.59
100%
-131
- C3 -
-
3TV6
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
-----------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
137
Blastp_CBE
80.57
93%
-123
- C3 -
-
5HID
3
B:
[14-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
79
Blastp_CBE
80.55
100%
-128
- C3 -
-
5VAL
1
BRAF_HUMAN
A:
[4-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
------------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
52
Blastp_CBE
80.51
99%
-129
- C3 -
-
4EHG
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
95
Blastp_CBE
80.47
95%
-129
- C3 -
-
4XV9
1
A:
[17-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
----------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
563
HHSearch
80.41
100%
-135
- C3 -
-
6N0Q
1
?
B:
[6-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
109
Blastp_CBE
80.42
95%
-124
- C3 -
-
4RZV
1
B:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
72
Blastp_CBE
80.41
100%
-135
- C3 -
-
6N0Q
1
?
B:
[6-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
68
Blastp_CBE
80.38
100%
-126
- C3 -
-
4DBN
1
BRAF_HUMAN
A:
[6-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
54
Blastp_CBE
80.36
99%
-132
- C3 -
-
3IDP
1
BRAF_HUMAN
A:
[22-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
-------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
90
Blastp_CBE
80.31
100%
-123
- C3 -
-
6N0P
1
BRAF_HUMAN
A:
[1-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
-----
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
39
Blastp_CBE
80.19
100%
-127
- C3 -
-
3PSB
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
86
Blastp_CBE
80.18
99%
-130
- C3 -
-
1UWH
1
BRAF_HUMAN
A:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
A
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
85
Blastp_CBE
80.17
99%
-132
- C3 -
-
1UWH
1
B:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
A
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
60
Blastp_CBE
80.15
98%
-138
- C3 -
-
5HIE
1
BRAF_HUMAN
A:
[30-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
--------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
42
Blastp_CBE
80.14
100%
-128
- C3 -
-
3PPK
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
47
Blastp_CBE
80.09
99%
-134
- C3 -
-
5C9C
1
B:
[30-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-----------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
93
Blastp_CBE
80.07
98%
-130
- C3 -
-
4YHT
3
B:
[1-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
T
--
N
E
-
T
K
-
F
-
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
---------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
T
L
A
R
S
-----------------------------------------------
70
Blastp_CBE
80.07
100%
-136
- C3 -
-
3Q96
1
BRAF_HUMAN
A:
[4-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
-----------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
31
Blastp_CBE
80.07
100%
-130
- C3 -
-
4EHE
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
-------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
74
Blastp_CBE
79.99
100%
-133
- C3 -
-
6B8U
1
B:
[5-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
----
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
------------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
66
Blastp_CBE
79.99
100%
-133
- C3 -
-
4FC0
1
BRAF_HUMAN
A:
[6-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
--------------------------------------------
9
PsiBlast_PDB
79.95
100%
-129
- C3 -
-
3D4Q
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
51
Blastp_CBE
79.75
99%
-132
- C3 -
-
4EHG
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
17
PsiBlast_PDB
79.65
100%
-132
- C3 -
-
3SKC
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
------------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
565
HHSearch
79.61
94%
-143
- C3 -
-
5ITA
1
B:
[22-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
-----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
-
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
110
Blastp_CBE
79.62
95%
-137
- C3 -
-
4RZV
1
BRAF_HUMAN
A:
[7-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
123
Blastp_CBE
79.61
94%
-143
- C3 -
-
5ITA
1
B:
[22-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
-----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
-
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
8
PsiBlast_PDB
79.50
100%
-128
- C3 -
-
3II5
1
BRAF_HUMAN
A:
[28-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
------------
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
94
Blastp_CBE
79.48
98%
-128
- C3 -
-
4YHT
2
BRAF_HUMAN
A:
[1-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
T
--
N
E
-
T
K
-
F
-
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
----------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
T
L
A
R
------------------------------------------------
114
Blastp_CBE
79.41
95%
-127
- C3 -
-
4WO5
1
BRAF_HUMAN
A:
[25-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
--
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
W
S
----
F
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
78
Blastp_CBE
79.40
100%
-132
- C3 -
-
5VAL
1
B:
[6-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
50
Blastp_CBE
79.22
99%
-123
- C3 -
-
4G9R
1
BRAF_HUMAN
A:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
---------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
102
Blastp_CBE
79.16
95%
-130
- C3 -
-
5CSW
1
BRAF_HUMAN
A:
[8-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
------------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
40
Blastp_CBE
78.74
100%
-124
- C3 -
-
3PRI
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
49
Blastp_CBE
78.65
99%
-120
- C3 -
-
4G9R
1
B:
[29-302]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
----------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
---------------------------------------------
100
Blastp_CBE
78.41
95%
-124
- C3 -
-
5CSX
2
A:
[7-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
R
-------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
119
Blastp_CBE
78.21
94%
-133
- C3 -
-
4XV2
1
B:
[17-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
----
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
14
PsiBlast_PDB
78.22
100%
-123
- C3 -
-
3PRI
1
BRAF_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
101
Blastp_CBE
78.21
95%
-128
- C3 -
-
5CSW
1
B:
[6-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
-----------------------
S
--
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
138
Blastp_CBE
78.14
93%
-129
- C3 -
-
5HID
3
BRAF_HUMAN
A:
[14-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
--------------
E
Q
L
---
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
87
Blastp_CBE
78.14
99%
-118
- C3 -
-
1UWJ
1
B:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
----------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
113
Blastp_CBE
78.05
95%
-125
- C3 -
-
4WO5
1
B:
[27-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
-------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
115
Blastp_CBE
77.79
94%
-131
- C3 -
-
4R5Y
1
B:
[18-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
--------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
105
Blastp_CBE
77.72
95%
-130
- C3 -
-
4JVG
1
BRAF_HUMAN
B:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
--------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
88
Blastp_CBE
77.51
99%
-118
- C3 -
-
1UWJ
1
BRAF_HUMAN
A:
[1-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
---------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-
L
P
K
-------------------------------------------
99
Blastp_CBE
77.50
95%
-134
- C3 -
-
6CAD
1
BRAF_HUMAN
A:
[10-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
-
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
--------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
-
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
108
Blastp_CBE
77.46
95%
-129
- C3 -
-
4RZW
1
BRAF_HUMAN
A:
[6-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
96
Blastp_CBE
77.44
95%
-128
- C3 -
-
6NSQ
1
B:
[8-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
139
Blastp_CBE
77.31
93%
-131
- C3 -
-
5HI2
1
A:
[14-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
-----------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
107
Blastp_CBE
77.29
95%
-137
- C3 -
-
4RZW
1
B:
[6-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
------------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
135
Blastp_CBE
77.25
95%
-134
- C3 -
-
4CQE
1
B:
[3-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
116
Blastp_CBE
77.25
94%
-127
- C3 -
-
4R5Y
1
BRAF_HUMAN
A:
[18-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
------------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
136
Blastp_CBE
77.22
95%
-124
- C3 -
-
4CQE
1
BRAF_HUMAN
A:
[4-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
103
Blastp_CBE
77.21
95%
-123
- C3 -
-
4JVG
1
D:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
----------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
124
Blastp_CBE
77.17
94%
-132
- C3 -
-
5ITA
1
BRAF_HUMAN
A:
[22-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
-----------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
-------------------------------------------------
130
Blastp_CBE
77.09
95%
-132
- C3 -
-
5JSM
3
BRAF_HUMAN
C:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
-
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
132
Blastp_CBE
77.06
95%
-123
- C3 -
-
5JSM
6
BRAF_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
---------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
129
Blastp_CBE
77.00
95%
-128
- C3 -
-
5JSM
4
D:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
S
--------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
---
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
112
Blastp_CBE
76.89
95%
-114
- C3 -
-
3C4C
1
BRAF_HUMAN
A:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
106
Blastp_CBE
76.89
95%
-128
- C3 -
-
4JVG
1
BRAF_HUMAN
A:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
V
-
K
S
----------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
131
Blastp_CBE
76.71
95%
-132
- C3 -
-
5JSM
5
BRAF_HUMAN
B:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
S
R
---------------
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
104
Blastp_CBE
76.70
95%
-124
- C3 -
-
4JVG
1
BRAF_HUMAN
C:
[9-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
----------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
120
Blastp_CBE
76.38
94%
-125
- C3 -
-
4XV2
1
BRAF_HUMAN
A:
[18-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
141
Blastp_CBE
76.35
78%
-135
- C3 -
-
3OMV
1
RAF1_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
M
T
--
K
-
D
N
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
--
Q
E
-
T
K
-
F
-
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
P
---
T
G
S
--
V
L
W
M
A
P
E
V
I
R
M
----
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
-
L
P
K
-------------------------------------------
127
Blastp_CBE
76.20
95%
-128
- C3 -
-
5JT2
2
BRAF_HUMAN
B:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
--------------------
S
--
I
L
W
M
A
P
E
V
I
R
M
------
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
------------------------------------------------
122
Blastp_CBE
76.13
94%
-135
- C3 -
-
3OG7
1
BRAF_HUMAN
A:
[18-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
A
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
-----
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
-----------------------
G
S
--
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
------------------------------------------------
111
Blastp_CBE
76.09
95%
-129
- C3 -
-
3C4C
1
B:
[5-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
-----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
128
Blastp_CBE
76.02
95%
-133
- C3 -
-
5JT2
2
BRAF_HUMAN
A:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
S
R
W
--------------
S
--
I
L
W
M
A
P
E
V
I
----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
--
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
------------------------------------------------
118
Blastp_CBE
75.95
94%
-128
- C3 -
-
4XV3
1
BRAF_HUMAN
A:
[17-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
--------------------------------------------------
140
Blastp_CBE
75.88
78%
-135
- C3 -
-
3OMV
1
B:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
M
T
--
K
-
D
N
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
--
Q
E
-
T
K
-
F
-
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
L
A
-
T
V
-------------
P
---
T
G
S
--
V
L
W
M
A
P
E
V
I
R
M
----
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
A
S
P
D
L
S
K
L
Y
K
N
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
-
L
P
K
-------------------------------------------
117
Blastp_CBE
75.71
94%
-119
- C3 -
-
4FK3
1
BRAF_HUMAN
A:
[17-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
-------------------------------------------------
134
Blastp_CBE
75.69
95%
-122
- C3 -
-
5JRQ
3
BRAF_HUMAN
A:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
S
R
---------------
S
--
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
------------------------------------------------
98
Blastp_CBE
75.64
95%
-138
- C3 -
-
6CAD
1
B:
[10-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
--
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
--
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
-----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
--------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-
L
---------------------------------------------
126
Blastp_CBE
75.31
95%
-134
- C3 -
-
5JT2
2
BRAF_HUMAN
C:
[5-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-
K
S
R
---------------
S
--
I
L
W
M
A
P
E
V
I
R
---------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
-
I
N
N
---
I
I
E
M
V
G
R
G
----
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
------------------------------------------------
121
Blastp_CBE
74.96
94%
-132
- C3 -
-
4XV1
1
BRAF_HUMAN
A:
[18-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
-
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
---
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
--
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
---------------------------------------------------
45
Blastp_CBE
74.75
100%
-136
- C3 -
-
5FD2
1
B:
[23-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
----------
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
-----------
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
--
I
E
-
T
K
-
F
-
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
V
K
I
G
D
F
G
----------------------
S
G
S
--
I
L
W
M
A
P
E
V
I
R
M
----
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------
133
Blastp_CBE
73.74
95%
-125
- C3 -
-
5JRQ
2
B:
[5-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
--
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
----------------------
I
L
W
M
A
P
E
V
I
R
M
-------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
-------
I
I
E
M
V
G
R
G
S
--
L
S
P
D
L
S
K
V
R
S
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------
125
Blastp_CBE
71.34
95%
-122
- C3 -
-
5JT2
2
D:
[5-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
-------
K
W
--
H
G
--
D
------
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
-
L
F
M
G
Y
S
T
--
K
-
P
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
--
S
E
-
T
K
-
F
-
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
--
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
V
K
I
G
D
F
G
L
A
-
T
E
-------------------
S
--
I
L
W
M
A
P
E
V
I
R
--------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
-------------------
S
P
D
L
S
K
V
R
-
N
C
P
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
-------------------------------------------------
444
Blastp_CBE
55.02
33%
-37
- C3 -
-
5D7V
3
PTK6_HUMAN
D:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
--
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
407
Blastp_CBE
54.85
31%
-27
- C3 -
-
6FNJ
2
B:
[14-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
-------
R
L
--
K
A
--
P
GKKESC
V
A
I
K
T
L
K
-
G
G
Y
T
E
R
Q
R
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
-
R
L
E
G
V
V
T
--
N
-
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
--
N
D
-
G
Q
-
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
--
M
S
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------------IP
I
R
W
T
A
P
E
A
I
A
F
----
R
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
M
S
N
Q
D
-
V
I
N
A
I
E
Q
D
Y
--
R
L
P
P
----
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
-
P
A
S
L
K
I
V
A
--------------------------------------
517
Blastp_CBE
54.71
31%
-9
- C3 -
-
5IA0
7
C:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
MLKTG--
K
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
--
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
449
Blastp_CBE
54.55
33%
-37
- C3 -
-
5H2U
4
PTK6_HUMAN
D:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
---
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
452
Blastp_CBE
54.25
33%
-40
- C3 -
-
5H2U
4
PTK6_HUMAN
A:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
---
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
445
Blastp_CBE
54.21
33%
-41
- C3 -
-
5D7V
3
PTK6_HUMAN
C:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
--
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
446
Blastp_CBE
54.00
33%
-38
- C3 -
-
5D7V
3
PTK6_HUMAN
B:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
--
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
150
Blastp_CBE
53.98
37%
-30
- C3 -
-
3P86
1
CTR1_ARATH
A:
[32-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
-------
E
W
--
H
G
S-
D
------
V
A
V
K
I
L
M
E
Q
D
F
H
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
-
L
F
M
G
A
V
T
--
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
SG
A
R
-
E
Q
-
L
-
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
--
R
N
PP
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
------------------------
G
T
--
P
E
W
M
A
P
E
V
L
R
-------
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
-
Q
V
V
A
A
V
--
G
F
--
K
C
K
R
L
E
I
P
R
N
L
N
P
Q
-
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
------------------------------------------------
143
Blastp_CBE
53.98
37%
-34
- C3 -
-
5KKR
1
B:
[27-301]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
---
F
G
Q
V
Y
H
G
-------
R
W
--
H
G
--
E
------
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
-
L
F
M
G
A
C
M
--
S
P
P
H
-
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
--
A
K
-
I
V
-
L
-
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
--
K
G
--
I
L
H
K
D
L
K
S
K
N
V
F
-
Y
D
N
G
K
V
V
I
T
D
F
G
L
F
-
S
I
-
S
G
V
L
Q
-----
D
K
L
RIQ
N
G
W
--
L
C
H
L
A
P
E
I
I
R
Q
LSPD-
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
-
R
E
W
P
F
K
T
-
Q
P
A
E
A
I
I
W
Q
M
G
T
G
---
M
K
P
N
L
S
Q
I
--
G
M
G
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
----
K
-
L
P
--------------------------------------------
447
Blastp_CBE
53.88
33%
-36
- C3 -
-
5D7V
3
PTK6_HUMAN
A:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
D
--
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
411
Blastp_CBE
53.80
33%
-24
- C3 -
-
2XYU
7
A:
[4-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
RLKVPG-
K
R
--
E
I
--
C
------
V
A
I
K
T
L
K
-
A
G
Y
T
D
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
-
H
L
E
G
V
V
T
--
K
-
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
R
K
--
N
D
-
G
R
-
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
--
M
S
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
I
P
--
I
R
W
T
A
P
E
A
I
A
Y
----
R
---
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
-
V
I
K
A
I
E
E
G
Y
R-
L
P
P
P
M
-----
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
I
R
N
-
P
N
S
L
K
R
T
---------------------------------------
451
Blastp_CBE
53.68
33%
-39
- C3 -
-
5H2U
4
PTK6_HUMAN
B:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
---
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
480
Blastp_CBE
53.24
31%
-17
- C3 -
-
6HEY
1
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
MLKTS------
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
--------------------
K
I
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
441
Blastp_CBE
53.22
32%
-10
- C3 -
-
5L6O
2
A:
[20-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
K
I
E
E
V
I
G
A
---
G
E
V
C
R
G
-------
R
L
--
K
Q
--
P
GRREVF
V
A
I
K
T
L
K
V
-
G
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
-
R
L
E
G
V
V
T
--
K
-
S
R
P
V
M
I
L
T
E
F
M
E
N
C
A
L
D
S
F
L
R
L
--
N
D
-
G
Q
-
F
-
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
----
L
-
E
D
D
P
S
D
P
T
Y
T
S
S
L
---
G
G
K
IP
I
R
W
T
A
P
E
A
I
A
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
S
N
Q
D
-
V
I
N
A
V
E
Q
D
Y
R-
L
P
P
P
M
-----
D
C
P
T
A
L
H
Q
L
M
L
D
C
W
V
R
D
R
N
L
R
P
K
F
S
Q
I
V
N
T
L
D
K
L
I
R
N
-
P
A
S
L
K
V
I
---------------------------------------
524
Blastp_CBE
53.06
31%
-12
- C3 -
-
5I9V
1
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
MLKTSSG
K
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
-
R
V
L----------------
K
I
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
372
Blastp_CBE
53.06
33%
-19
- C3 -
-
4LUD
2
HCK_HUMAN
B:
[181-440]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-------
T
Y
NK
H
T
--
K
------
V
A
V
K
T
M
K
---
P
G
--
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
-
K
L
H
A
V
V
T
--
K
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
--
D
E
G
S
K
-
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
--
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
-
R
V
-
I
------------------P-
I
K
W
T
A
P
E
A
I
N
F
-------
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
E
V
I
R
A
L
E
R
G
Y
--
R
M
P
R
----
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
----------------------------------------------------
450
Blastp_CBE
52.95
33%
-40
- C3 -
-
5H2U
4
PTK6_HUMAN
C:
[2-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
P
R
E
E
F
T
L
C
R
K
L
G
S
G
Y
F
G
E
V
F
E
G
-------
L
W
--
K
D
--
R
------
V
Q
V
A
I
K
V
I
S
R
D
N
L
L
H
Q
Q
M
L
Q
S
E
I
Q
A
M
K
K
L
R
H
K
H
I
L
A
L
Y
A
V
V
S
V
--
G
-
D
P
-
V
Y
I
I
T
E
L
M
A
K
G
S
L
L
E
L
L
R
---
S
D
-
E
K
V
L
-
P
V
S
E
L
L
D
I
A
W
Q
V
A
E
G
M
C
Y
L
E
S
--
Q
N
--
Y
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
T
L
C
K
V
G
D
F
G
L
A
R
L
I
-
K
E
D
V
Y
L
S
H
D
H
------
N
I
P
--
Y
K
W
T
A
P
E
A
L
-------
S
R
G
H
Y
S
T
K
S
D
V
W
S
F
G
I
L
L
H
E
M
F
S
R
G
Q
V
P
Y
P
G
M
S
N
H
E
A
F
L
-
R
V
D
A
G
Y
--
R
M
P
----
C
P
L
E
C
P
P
S
V
H
K
L
M
L
T
C
W
C
R
D
P
E
Q
R
P
T
F
K
A
L
---------------------------------------------------------
483
Blastp_CBE
52.93
31%
-28
- C3 -
-
6HEV
1
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
ML-----
K
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
---------------------
I
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
477
Blastp_CBE
52.91
31%
-19
- C3 -
-
6Q7D
1
?
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
MLKT----
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
----------------------
I
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
474
Blastp_CBE
52.79
31%
-18
- C3 -
-
6Q7G
1
?
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
MLKT----
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
490
Blastp_CBE
52.41
31%
-25
- C3 -
-
6FNG
7
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
ML-----
K
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
---------------------
K
I
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
486
Blastp_CBE
52.38
31%
-26
- C3 -
-
6HES
2
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
ML-----
K
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
476
Blastp_CBE
51.97
31%
-19
- C3 -
-
6Q7E
1
?
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
MLKT-------
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
484
Blastp_CBE
51.79
31%
-19
- C3 -
-
6HEU
1
A:
[13-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
MLKT----
K
--
E
V
--
P
------
V
A
I
K
T
L
K
-
A
G
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
-
R
L
E
G
V
I
S
--
K
-
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
--
K
D
-
G
E
-
F
-
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
--
M
N
--
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
S
----------------------
P
--
I
R
W
T
A
P
E
A
I
S
Y
----
R
K
---
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
N
H
-
E
V
M
K
A
I
N
D
G
F
--
R
L
P
----
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
-----------------------------------------------
370
Blastp_CBE
51.08
33%
-20
- C3 -
-
4LUE
3
HCK_HUMAN
B:
[181-440]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-------
T
Y
NK
H
T
--
K
------
V
A
V
K
T
M
K
---
P
--------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
-
K
L
H
A
V
V
T
--
K
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
--
D
E
G
S
K
-
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
--
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
-
R
V
-
I
------------------P-
I
K
W
T
A
P
E
A
I
N
----------
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
E
V
I
R
A
L
E
R
G
Y
--
R
M
P
R
----
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
----------------------------------------------------
371
Blastp_CBE
50.23
33%
-15
- C3 -
-
4LUE
3
HCK_HUMAN
A:
[181-440]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
-------
T
Y
NK
H
T
--
K
------
V
A
V
K
T
M
K
---
P
G
S
------
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
-
K
L
H
A
V
V
T
--
K
-
E
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
--
D
E
G
S
K
-
Q
-
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
--
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
-
R
V
-
I
------------------P-
I
K
W
T
A
P
E
A
I
N
F
-------
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
N
-
P
E
V
I
R
A
L
E
R
G
Y
--
R
M
P
R
----
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
----------------------------------------------------
286
Blastp_CBE
50.20
33%
-25
- C3 -
-
3F3U
1
SRC_CHICK
B:
[10-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
A
W
E
I
P
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
-------
T
W
--
N
G
--
T
TR----
V
A
I
K
T
L
K
P
G
--
S
P
E
---
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
-
Q
L
Y
A
V
V
S
--
E
-
E
P
-
I
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
K
G
--
E
M
-
G
K
-
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
--
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------FP
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
-
V
L
D
Q
V
E
R
G
Y
--
R
M
P
----
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
----------------------------------------------------
570
HHSearch
49.90
30%
-44
- C3 -
-
4YFI
1
TNI3K_HUMAN
C:
[56-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
H
L
Q
L
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
Y
K
G
-------
R
C
--
R
N
K-
I
------
V
A
I
K
R
Y
R
------
S
D
V
D
M
F
C
R
E
V
S
I
L
C
Q
L
N
H
P
C
V
I
-
Q
F
V
G
A
C
L
ND
P
-
S
Q
-
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
H
E
--
Q
K
-
R
I
-
L
-
D
L
Q
S
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
LT
Q
P
--
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
H
A
V
V
A
D
F
G
E
S
-
R
F
-
L
Q
S
--------------
G
N
--
L
R
W
M
A
P
E
V
F
T
Q
------
C
T
R
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
-
G
E
I
P
F
A
H
L
K
P
A
A
A
D
M
D
M
A
Y
H
H
I
---
R
P
---
P
I
G
Y
S
I
P
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
E
C
L
C
N
-----------------------------------------------
147
Blastp_CBE
48.06
37%
-13
- C3 -
-
3PPZ
1
CTR1_ARATH
A:
[30-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
M
D
I
P
W
C
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
-------
E
W
--
H
G
S-
D
------
V
A
V
K
I
L
M
E
----
A
E
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
-
L
F
M
G
A
V
T
--
Q
P
P
N
-
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
SG
A
R
-
E
Q
-
L
-
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
--
R
N
PP
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
V
K
V
C
D
F
G
L
S
-
R
L
-
K
A
S
F
-----
L
S
K
A
---
A
G
T
--
P
E
W
M
A
P
E
V
L
R
-------
D
E
P
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
-
Q
V
V
A
A
V
--
G
F
--
K
C
K
R
L
E
I
P
R
N
L
N
P
Q
-
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
S
A
V
---------------------------------------------
264
Blastp_CBE
47.65
33%
-21
- C3 -
-
1QPC
2
?
A:
[5-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
E
W
E
V
P
R
E
T
L
K
L
V
E
R
L
G
A
G
Q
F
G
E
V
W
M
G
-------
Y
Y
--
N
G
HT
K
------
V
A
V
K
S
L
K
Q
G
S
M
S
P
D
---
A
F
L
A
E
A
N
L
M
K
Q
L
Q
H
Q
R
L
V
-
R
L
Y
A
V
V
T
--
Q
-
E
P
-
I
Y
I
I
T
E
Y
M
E
N
G
S
L
V
D
F
L
K
T
--
P
S
G
I
K
-
L
-
T
I
N
K
L
L
D
M
A
A
Q
I
A
E
G
M
A
F
I
E
E
--
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-
R
L
-
I
E
--
D
N
E
T
A
R
E
G
A
---
K
F
P
--
I
K
W
T
A
P
E
A
I
-------
N
Y
G
T
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
I
V
T
H
G
R
I
P
Y
P
G
M
T
N
-
P
E
V
I
Q
N
L
E
R
G
Y
RM
V
R
P
D
------
N
C
P
E
E
L
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
L
R
S
V
L
E
----------------------------------------------------
172
Blastp_CBE
44.42
34%
-3
- C3 -
-
2DQ7
1
X:
[1-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
V
W
E
I
P
R
E
S
L
Q
L
I
K
R
L
G
N
G
Q
F
G
E
V
W
M
G
-------
T
W
--
N
G
--
N
TK----
V
A
I
K
T
L
K
P
G
T
M
S
P
E
---
S
F
L
E
E
A
Q
I
M
K
K
L
K
H
D
K
L
V
-
Q
L
Y
A
V
V
S
--
E
-
E
P
-
I
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
D
--
G
E
-
G
R
A
L
-
K
L
P
N
L
V
D
M
A
A
Q
V
A
A
G
M
A
Y
I
E
R
--
M
N
--
Y
I
H
R
D
L
R
S
A
N
I
L
V
G
N
G
L
I
C
K
I
A
D
F
G
L
A
-
R
L
-
I
E
D
N
E
T
A
R
Q
G
A
K
F
-----
P
--
I
K
W
T
A
P
E
A
A
L
Y
-------
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
V
T
K
G
R
V
P
Y
P
G
M
N
N
R
-
E
V
L
E
Q
V
E
R
G
Y
--
R
M
P
----
C
P
Q
D
C
P
I
S
L
H
E
L
M
I
H
C
W
K
K
D
P
E
E
R
P
T
F
E
Y
L
Q
S
F
L
E
----------------------------------------------------