@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BUB1B_HUMAN: (2020-09-05 )
MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSHLNKALWKVGKLTSPGALLFQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730....-...740.......750.......760.......770.......780.....-..790.......800----------........810...-.---..-----.820----........830..---...---..840.-----.....-------------.850----........860.......870.......880.......890.......900.......910.......920...---...----..----.930.......940.------......950--.........960.......970..--...-..980.-.----.--..-...990.......1000..-....1010......1020......1030......1040......1050
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAAVKKEGGA
L
S
E
A
MSLEGDEWELSKE
N
V
Q
P
L
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Q
E
S
A
CN
N
T
L
Q
Q
Q
KR
A
F
E
Y
E
I
R
F
Y
TGND
P
L
D
V
W
D
R
Y
I
S
W
T
EQNYPQGGKES
N
M
S
T
L
L
E
R
A
V
E
A
LQGEKRYYSD
P
R
F
L
N
L
W
L
K
L
G
R
L
CNE
P
L
D
M
Y
S
Y
L
H
NQGI
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
L
ALE
K
E
E
E
E
E
V
F
E
SSVP
Q
R
S
T
L
A
E
L
K
SKGKKTARA
P
I
I
RVGGALKAPSQNRGLQNPF
P
Q
Q
MQNN
S
R
I
T
V
F
DENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTA
S
L
I
A
VPAVLPSF
T
P
Y
V
E
E
TARQPVMTPCKIEP
S
I
N
H
I
L
STRKPGKEEG
D
P
L
Q
R
V
Q
S
H
Q
Q
A
S
E
E
K
K
E
K
M
M
Y
C
K
E
K
I
Y
AGVGEF
S
F
E
E
I
R
A
E
V
F
R
K
K
L
K
E
Q
R
E
A
E
L
L
T
S
A
E
K
R
A
E
M
Q
K
Q
I
E
E
M
E
K
K
L
K
E
I
Q
T
T
Q
Q
ERTGD
Q
Q
EETMPTKE
T
T
K
L
Q
IASESQKIP
G
M
TLSS
S
V
C
Q
V
N
CCAR
E
T
S
L
A
E
N
I
W
Q
EQPHSKGPSV
P
F
S
I
F
D
E
F
L
L
S
EKKNKSPPAD
P
P
R
V
L
A
QRR
P
L
A
V
L
KTSESITSNEDV
S
P
D
V
C
D
E
FTGIEPLSED
A
I
I
TGF
R
N
V
T
ICPN
P
E
D
T
C
D
F
A
R
A
A
R
F
V
S
T
P
F
H
E
I
M
S
L
KDLPS
D
P
E
RLLPEEDLDVKTSEDQ
Q
T
A
C
G
T
I
Y
S
QTLS
I
K
K
L
S
P
I
I
E
D
S
R
EATHSSGFSGSSASVASTS
S
I
K
C
LQIP
E
K
LELTNETSENPTQS
P
W
C
S
Q
Y
R
R
Q
L
L
K
S
L
P
E
-LSASA
E
L
C
IEDRPMPKL
E
I
E
K
EIELGNE
D
Y
C
I
K
R
E
Y
L
I
CE
D
Y
K
L
F
W
V
APRN-SA
E
L
T
V
I
K
VSSQPV-----------
P
W
D
F
Y
I
N
L
K
L
K
E
R
L
-
N
---
E
D
-----
F
D
-
H
----
F
C
S
C
Y
QYQD
G
C
I
V
---
W
H
Q
---
Y
I
N
C
F
T
-----
L
Q
D
L
L
-------------
Q
H
S
-----
E
Y
I
T
H
E
I
T
V
L
I
I
Y
N
L
L
T
I
V
E
M
L
H
K
A
E
IVHGDLSPR
C
L
I
L
R
NRIHDPYDCNKNN
Q
A
L
K
I
V
D
F
S
Y
S
V
D
L
R
V
--
Q
L
D
---
V
F
T
----LS----G
F
R
T
V
Q
ILEGQ
K
I
L
A------NCSS
P
Y
Q
----
V
D
L
F
G
I
A
D
L
A
H
L
L
L
F
K
E
H
L
Q
V
FWD--G
S
F
-
W
K
L
-
S
Q
-
N
----
I
--
S
E-LKD
G
E
L
W
N
K
F
F
V
R
ILNAN
D
-
E
A
T
V
S
V
L
G
E
L
A
A
E
MNG
V
F
D
T
T
F
Q
S
H
L
N
K
A
L
W
K
VGKLTSPG
A
L
LFQ
2
PsiBlast_PDB
96.19
100%
0
- C- -
-
5LCW
-
BUB1B_HUMAN
S:
[19-329]
------------------
G
D
E
W
E
L
S
K
E
N
V
Q
P
L
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Q
E
S
A
C
N
N
T
L
Q
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
L
A
-------------
V
P
Q
R
S
T
L
A
E
L
K
S
K
G
K
K
T
A
R
---------------
N
R
G
L
Q
N
P
F
P
Q
Q
M
Q
N
N
S
R
I
T
V
F
D
E
N
A
D
E
A
S
T
A
E
L
S
K
P
T
V
Q
P
W
I
A
P
P
M
P
R
A
K
E
N
E
L
Q
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Fugue
78.95
94%
-38
- C11 -
-
5LCW
-
BUB1B_HUMAN
S:
[19-342]
------------------
G
D
E
W
E
L
S
K
E
N
V
Q
P
L
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Q
E
S
A
C
N
N
T
L
Q
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
L
A
V
-------------
P
Q
R
S
T
L
A
E
L
K
S
K
G
K
K
T
A
R
---------------
N
R
G
L
Q
N
P
F
P
Q
Q
M
Q
N
N
S
R
I
T
V
F
D
E
N
A
D
E
A
S
T
A
E
L
S
K
P
T
V
Q
P
W
I
A
P
P
M
P
R
A
K
E
N
E
L
Q
A
S
I
F
D
E
A
Q
R
R
P
L
A
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
78.79
97%
-37
- C11 -
-
5LCW
-
BUB1B_HUMAN
S:
[19-342]
------------------
G
D
E
W
E
L
S
K
E
N
V
Q
P
L
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Q
E
S
A
C
N
N
T
L
Q
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
L
A
-------------
V
P
Q
R
S
T
L
A
E
L
K
S
K
G
K
K
T
A
R
---------------
N
R
G
L
Q
N
P
F
P
Q
Q
M
Q
N
N
S
R
I
T
V
F
D
E
N
A
D
E
A
S
T
A
E
L
S
K
P
T
V
Q
P
W
I
A
P
P
M
P
R
A
K
E
N
E
L
Q
A
S
I
F
D
E
F
L
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
61.80
23%
-27
- C8 -
-
5DMZ
1
B:
[15-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
-
G
E
G
A
F
A
Q
V
Y
E
A
T
Q
----
Q
K
F
V
L
K
V
Q
K
P
A
N
-----------
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
-
K
PSM
Q
H
-----
M
F
M
K
----
F
Y
S
A
H
L
F
Q
N
G
S
V
L
---
V
G
E
---
L
Y
S
Y
G
T
-----
L
L
N
A
I
-------------
N
L
Y
KNTPE
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
--
F
P
K
GTI
F
T
A
----
K
C
----
E
T
S
G
F
Q
C
---
V
E
M
L
S
------
N
K
P
W
N
Y
Q
----
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
T
Y
M
K
V
K
N
E
--
G
G
E
-
C
K
P
-
E
G
-
L
----
F
--
R
R
-
L
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
P
D
C
H
H
L
P
S
L
-
D
L
L
R
Q
K
L
K
K
V
F
Q
Q
H
Y
T
N
K
I
R
------------------
132
HHSearch
60.97
23%
-17
- C8 -
-
6F7B
1
A:
[11-343]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
-
G
E
G
A
F
A
Q
V
Y
E
A
T
Q
-K
N
K
Q
K
F
V
L
K
V
Q
K
P
A
N
-----------
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
-
K
PSM
Q
H
-----
M
F
M
K
----
F
Y
S
A
H
L
F
Q
N
G
S
V
L
---
V
G
E
---
L
Y
S
Y
G
T
-----
L
L
N
A
I
-------------
N
L
Y
KNTPE
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
--
F
P
K
GTI
F
T
A
----
K
C
----
E
T
S
G
F
Q
C
---
V
E
M
L
S
------
N
K
P
W
N
Y
Q
----
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
T
Y
M
K
V
K
N
E
----
E
-
C
K
P
-
E
G
-
L
----
F
--
R
R
-
L
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
P
D
-
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
F
Q
Q
H
Y
T
N
K
I
R
------------------
4
PsiBlast_PDB
56.52
100%
-107
- C11 -
-
2WVI
2
BUB1B_HUMAN
A:
[1-164]
--------------------------------------------------------
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
----
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
L
A
L
E
K
E
E
E
E
E
V
F
E
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
55.24
95%
-111
- C11 -
-
3SI5
-
BUB1B_HUMAN
A:
[10-161]
-----------------------------------------------------
T
G
S
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
54.59
98%
-106
* C11 *
-
3SI5
-
BUB1B_HUMAN
B:
[11-159]
------------------------------------------------------
G
S
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
53.91
100%
-107
- C11 -
-
2WVI
2
BUB1B_HUMAN
A:
[2-155]
---------------------------------------------------------
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
----
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
L
A
L
E
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.41
26%
-33
- C10 -
-
5DMZ
1
BUB1_HUMAN
A:
[99-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
V
Q
K
P
A
N
-----------
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
-
K
---
P
S
-----
M
Q
-
H
MFMK
F
Y
S
A
H
L
F
Q
N
G
S
V
L
VGE
L
Y
S
---
Y
G
T
L
L
N
-----
A
I
N
L
Y
-------------
K
N
T
PE---
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
FP
K
G
T
---
I
F
T
AKCE
T
S
----
G
F
Q
C
V
E
M
L
------
S
------
N
K
P
W
N
Y
Q
----
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
T
Y
M
K
V
K
N
E
--
G
G
E
-
C
K
P
-
E
G
-
L
----
F
--
R
R
-
L
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
P
D
-
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
F
Q
---
Q
H
Y
T
N
K
-----------------
152
Fugue
50.10
12%
-16
- C8 -
-
3DZO
-
?
A:
[13-382]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
G
F
R
G
T
D
P
G
D
V
V
I
E
E
L
F
N
R
----
I
P
Q
A
N
V
R
T
T
S
E
Y
A
A
D
S
L
V
S
T
S
L
W
N
T
G
Q
P
F
R
V
-
E
S
--------
E
L
G
E
R
P
R
T
L
V
R
G
T
V
L
G
Q
E
D
P
Y
A
Y
L
E
A
T
D
Q
E
T
G
E
S
F
E
V
H
V
P
Y
-
F
T
E
R
A
I
K
Q
M
K
E
E
V
L
-----------
R
L
R
L
L
R
G
I
K
N
Q
K
Q
A
-
K
---
V
H
LRFIF
P
F
-
D
----
L
V
K
D
P
Q
V
L
S
R
F
F
L
---
Y
P
R
---
M
Q
S
N
L
Q
TFGEV
L
L
S
H
S
-------------
S
T
H
-----
K
S
L
V
H
H
A
R
L
Q
L
T
L
Q
V
I
R
L
L
A
S
L
H
H
Y
G
L
V
H
T
Y
L
R
P
V
D
I
V
L
D
Q
R
G
G
-----------
V
F
L
T
G
F
E
H
L
V
R
D
G
A
--
S
A
V
---
S
P
I
----
G
R
----
G
F
A
P
P
E
T
T
A
E
R
M
L
P
F
------
G
Q
H
H
P
T
L
MTFA
F
D
T
W
T
L
G
L
A
I
Y
W
I
W
C
A
D
--
L
P
N
T
D
--
D
A
A
-
L
G
G
-
S
E
-
W
----
I
FR
S
C
-
K
N
I
P
Q
P
V
R
A
L
L
E
G
F
L
R
Y
P
K
-
E
D
R
L
L
--
P
L
Q
A
M
E
T
P
E
Y
E
Q
L
R
T
E
L
S
A
A
L
P
L
Y
Q
-------------
9
PsiBlast_PDB
49.97
27%
-39
- C10 -
-
4R8Q
1
A:
[99-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
V
Q
K
P
A
N
-----------
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
-
K
---
P
S
-----
M
Q
-
H
MFMK
F
Y
S
A
H
L
F
Q
N
G
S
V
L
VGE
L
Y
S
---
Y
G
T
L
L
N
-----
A
I
N
L
Y
-------------
K
N
T
PE---
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
-------
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
FP
K
G
T
---
I
F
T
AKCE
T
S
----
G
F
Q
C
V
E
M
L
------
S
------
N
K
P
W
N
Y
Q
----
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
T
Y
M
K
V
K
N
E
--
G
G
E
-
C
K
P
-
E
G
-
L
----
F
--
R
R
-
L
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
P
D
-
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
F
Q
---
Q
H
Y
T
N
K
-----------------
10
PsiBlast_PDB
49.95
26%
-34
- C10 -
-
4QPM
1
BUB1_HUMAN
A:
[90-336]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
V
Q
K
P
A
N
-----------
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
-
K
---
P
S
-----
M
Q
-
H
MFMK
F
Y
S
A
H
L
F
Q
N
G
S
V
L
VGE
L
Y
S
---
Y
G
T
L
L
N
-----
A
I
N
L
Y
-------------
K
N
T
PE---
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
-------
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
FP
K
G
T
---
I
F
T
----
A
K
CETS
G
F
Q
C
V
E
M
L
------
S
------
N
K
P
W
N
Y
Q
----
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
T
Y
M
K
V
K
N
E
--
G
G
E
-
C
K
P
-
E
G
-
L
----
F
--
R
R
-
L
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
P
D
-
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
F
Q
---
Q
H
Y
T
N
K
-----------------
12
PsiBlast_PDB
49.33
26%
-19
- C10 -
-
6F7B
1
A:
[95-341]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
V
Q
K
P
A
N
-----------
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
-
K
---
P
S
-----
M
Q
-
H
MFMK
F
Y
S
A
H
L
F
Q
N
G
S
V
L
VGE
L
Y
S
---
Y
G
T
L
L
N
-----
A
I
N
L
Y
-------------
K
N
T
PE---
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
FP
K
G
T
---
I
F
T
AKCE
T
S
----
G
F
Q
C
V
E
M
L
------
S
------
N
K
P
W
N
Y
Q
----
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
T
Y
M
K
V
K
N
E
----
E
-
C
K
P
-
E
G
-
L
----
F
--
R
R
-
L
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
P
D
-
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
F
Q
---
Q
H
Y
T
N
K
-----------------
1
PsiBlast_PDB
46.00
99%
-
- C11 -
-
5KHU
-
BUB1B_HUMAN
Q:
[18-308]
-----------------
E
G
D
E
W
E
L
S
K
E
N
V
Q
P
L
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Q
E
S
A
C
N
N
T
L
Q
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
------------------
R
S
T
L
A
E
L
-----------------------------------------
I
T
V
F
D
E
-------------
T
V
Q
P
W
I
A
P
P
M
P
R
A
K
E
N
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
45.37
96%
-
- C11 -
-
5KHU
-
BUB1B_HUMAN
Q:
[18-308]
-----------------
E
G
D
E
W
E
L
S
K
E
N
V
Q
P
L
R
Q
G
R
I
M
S
T
L
Q
G
A
L
A
Q
E
S
A
C
N
N
T
L
Q
Q
Q
K
R
A
F
E
Y
E
I
R
F
Y
T
G
N
D
P
L
D
V
W
D
R
Y
I
S
W
T
E
Q
N
Y
P
Q
G
G
K
E
S
N
M
S
T
L
L
E
R
A
V
E
A
L
Q
G
E
K
R
Y
Y
S
D
P
R
F
L
N
L
W
L
K
L
G
R
L
C
N
E
P
L
D
M
Y
S
Y
L
H
N
Q
G
I
G
V
S
L
A
Q
F
Y
I
S
W
A
E
E
Y
E
A
R
E
N
F
R
K
A
D
A
I
F
Q
E
G
I
Q
Q
K
A
E
P
L
E
R
L
Q
S
Q
H
R
Q
F
Q
A
R
V
S
R
Q
T
L
------------------
R
S
T
L
A
E
L
-----------------------------------------
I
T
V
F
D
E
-------------
T
V
Q
P
W
I
A
P
P
M
P
R
A
K
E
N
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
HHSearch
42.96
17%
10
- C8 -
-
2Y7J
1
PHKG2_HUMAN
A:
[93-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
-
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
ERLSPEQLEEV
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
---
H
P
-----
H
I
I
T
----
L
I
D
S
Y
E
S
S
S
F
M
F
L
---
V
F
D
---
L
M
R
K
G
E
-----
L
F
D
Y
L
-------------
T
E
K
-----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-----------
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
--
G
E
K
---
L
R
E
----
L
C
----
G
T
P
G
Y
L
A
P
---
E
I
L
K
CSMDET
H
P
G
Y
G
K
E
----
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
--
Q
I
L
M
L
R
M
I
M
E
G
Q
YQFS
S
--
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
-
E
A
R
L
T
A
-
E
Q
A
L
Q
---------------------------------
6
PsiBlast_PDB
42.58
38%
-149
- C11 -
-
4A1G
-
BUB1_HUMAN
A:
[11-149]
-----------------------------------------------------------
Q
M
L
E
A
H
M
Q
S
Y
K
G
N
D
P
L
G
E
W
E
R
Y
I
Q
W
V
E
E
N
F
P
E
--
N
K
E
Y
L
I
T
L
L
E
H
L
M
K
E
F
L
D
K
K
K
Y
H
N
D
P
R
F
I
S
Y
C
L
K
F
A
E
Y
N
S
D
L
H
Q
F
F
E
F
L
Y
N
H
G
I
G
T
L
S
S
P
L
Y
I
A
W
A
G
H
L
E
A
Q
G
E
L
Q
H
A
S
A
V
L
Q
R
G
I
Q
N
Q
A
E
P
R
E
F
L
Q
Q
Q
Y
R
L
F
Q
T
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
42.43
38%
-131
- C11 -
-
2LAH
-
BUB1_HUMAN
A:
[12-159]
----------------------------------------------------
D
T
P
E
N
V
L
Q
M
L
E
A
H
M
Q
S
Y
K
G
N
D
P
L
G
E
W
E
R
Y
I
Q
W
V
E
E
N
F
P
E
N
--
K
E
Y
L
I
T
L
L
E
H
L
M
K
E
F
L
D
K
K
K
Y
H
N
D
P
R
F
I
S
Y
C
L
K
F
A
E
Y
N
S
D
L
H
Q
F
F
E
F
L
Y
N
H
G
I
G
T
L
S
S
P
L
Y
I
A
W
A
G
H
L
E
A
Q
G
E
L
Q
H
A
S
A
V
L
Q
R
G
I
Q
N
Q
A
E
P
R
E
F
L
Q
Q
Q
Y
R
L
F
Q
T
R
L
T
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
42.30
23%
-44
- C10 -
-
6JKM
2
?
A:
[93-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
Y
I
C
L
E
I
H
S
R
L
-
T
---
S
E
--------
Q
----
M
I
P
S
Y
A
H
I
D
Y
A
L
V
---
G
N
N
SSV
Y
I
S
E
F
S
-----
D
Y
G
S
L
IGVCNKVKSVTNR
N
M
D
-----
E
Y
V
V
M
H
L
S
C
----
Q
M
L
D
I
V
D
H
L
H
A
M
G
I
I
H
A
D
I
K
P
D
N
F
L
L
M
K
----
P
I
C
A
D
P
N
E
V
S
L
Q
L
I
D
F
G
V
S
I
D
M
K
L
--
F
P
D
---
N
Q
T
----
F
N
----
Y
V
H
H
D
D
L
F
K
C
I
E
M
R
T
------
G
R
P
W
T
Y
Q
----
L
D
L
Y
G
L
V
S
V
M
H
V
L
L
F
G
R
Y
M
E
V
V
Q
R
SP
S
T
I
-
W
M
P
-
K
T
-
N
----
V
--
P
R
-
Y
F
Q
R
T
M
W
E
N
I
F
R
T
L
L
N
I
R
D
-
C
R
T
M
P
N
L
Q
Q
L
R
T
Q
L
-------------------------------