@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BUB1_HUMAN: (2020-09-05 )
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGNNMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKEKLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPPVVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSGAEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTLPDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGLPQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDFTSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEKSPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750..--.....760.......770.--------......780.......790.......800...------....810.......820--.....---..830.......840-----..-.....850.......860--........870.......880.-......890.......900.......910--.......920.......930.......940.......950.......------960.......970......---.980----........990.......1000--------.....--...1010.--.......---1020--.......1030.....-----.1040......1050....-----..1060......1070......1080..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MD
T
P
E
N
V
L
Q
M
L
E
A
H
M
Q
SYKGNDP
L
G
E
W
E
R
Y
I
Q
W
V
E
ENFPE
N
K
E
Y
L
I
T
L
L
E
H
L
M
K
E
F
L
D
K
K
KYHND
P
R
F
I
S
Y
C
L
K
F
A
EY
N
S
D
L
H
Q
F
F
E
F
L
Y
NHGIGTLSS
P
L
Y
I
A
WAGHLEAQG
E
L
Q
H
A
S
A
V
L
Q
R
G
I
QN
Q
A
E
P
R
E
F
L
Q
Q
Q
Y
R
L
F
Q
T
R
LTETHLPAQARTSEP
L
H
N
V
Q
V
L
N
Q
M
I
TSKSNPGNN
M
A
C
I
SKNQG
S
E
L
S
G
V
I
S
S
ACDKESNME
R
R
V
I
T
I
SKSE
Y
S
V
H
S
S
L
A
SKV
D
V
E
Q
V
V
M
Y
C
K
E
K
L
IRGESEF
S
F
E
E
L
R
A
Q
K
Y
N
Q
R
R
K
H
E
Q
W
V
N
E
D
R
H
Y
M
K
R
KEA
N
A
F
E
E
Q
L
L
K
Q
K
M
D
E
L
H
K
K
L
H
Q
V
V
E
TSHEDLPASQERSEV
N
P
A
RMGPSVGS
Q
Q
ELRAPCL
P
V
TYQQTPVNMEKNPREAPPVVP
P
L
A
N
A
I
S
A
A
LVSPATSQSIAPPVP
L
K
A
Q
TVT
D
S
M
F
A
V
ASKDAGCVNKSTHEFKPQSG
A
E
I
K
E
GCETHKVANTSSFHTTPNTSL
G
M
V
QATPSKVQPSPTV
H
T
K
E
A
L
G
F
I
M
N
M
FQAPTLPDISD
D
K
D
E
W
Q
SLDQNE
D
A
F
E
A
Q
F
Q
K
N
VRSSGA
W
G
V
N
K
I
I
S
S
L
S
S
A
F
H
V
FEDGNKENYGLPQPKNKPTGA
R
T
F
G
E
R
S
V
S
RLPSKPKEEVP
H
A
E
E
FLDDS
T
V
W
G
I
RCNKTLAPSPKSPGD
F
T
S
A
A
Q
L
ASTPFHKLPV
E
S
V
H
I
LED
K
E
N
V
V
A
K
Q
C
T
Q
A
T
L
D
S
C
EEN
M
V
VPSRDGKFSPIQEK
S
P
K
Q
A
L
S
S
H
M
Y
S
A
S
L
L
RLSQPAAG
G
V
L
T
C
EAELG
V
E
A
C
RLTDTDAAIAEDP
P
D
A
I
A
G
L
Q
A
E
W
M
Q
M
SSLGTVDAPNFIVGNPW
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
SYPN
T
F
E
W
Q
CKLPA--------IKPKTEFQLGS
K
L
V
Y
V
H
H
L
LGE
G
A
F
A
Q
V
Y
E
AT------QGDLNDAKNK
Q
K
F
V
L
K
V--QKPA
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
FQNG---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
YKN-
T
P
E
K
VMPQ
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
VHD
C
E
--
I
I
HGDIKPD
N
F
I
LGNGFLEQDDE
D
D
L
S
A
G
L
A
L
IDLGQSID
M
K
LFPKG------
T
I
F
T
A
KCETS
G
F
Q
C
V
E
M
L
S---NKP-----W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--KNEG--GE--C
K
P
E
G
L
F
---
R
R-L--PH
L
D
M
W
N
E
F
F
H
V
M
LNI-----PDCHHLP
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
KRSRK
131
HHSearch
90.32
100%
-144
- C5 -
-
6F7B
1
A:
[9-359]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
------
K
N
K
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
----
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
R
S
--
2
PsiBlast_PDB
90.12
99%
-144
- C5 -
-
6F7B
1
A:
[9-359]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
N
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
------
K
N
K
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
----
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
R
S
--
132
HHSearch
88.14
100%
-139
- C5 -
-
5DMZ
1
B:
[15-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
---------
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
G
--
G
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
R
S
--
21
Blastp_CBE
87.82
99%
-139
- C5 -
-
5DMZ
1
B:
[15-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
---------
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
G
--
G
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
R
S
--
3
PsiBlast_PDB
87.80
99%
-142
- C5 -
-
5DMZ
1
BUB1_HUMAN
A:
[15-363]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
---------
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
Q
D
D
E
D
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
G
--
G
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
R
S
--
1
PsiBlast_PDB
86.32
100%
-156
- C5 -
-
4R8Q
1
A:
[16-363]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
V
G
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
---------
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
-------
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
G
--
G
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
R
S
--
22
Blastp_CBE
85.78
98%
-159
- C5 -
-
4QPM
1
B:
[10-352]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
---------
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
-----
D
L
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
G
--
G
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
----
4
PsiBlast_PDB
85.22
97%
-155
- C5 -
-
4QPM
1
BUB1_HUMAN
A:
[10-354]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
P
W
D
D
K
L
I
F
K
L
L
S
G
L
--
S
K
P
V
S
S
Y
P
N
T
F
E
W
Q
C
K
L
P
A
--------
I
K
P
K
T
E
F
Q
L
G
S
K
L
V
Y
V
H
H
L
L
G
E
G
A
F
A
Q
V
Y
E
A
T
------
Q
--------
K
Q
K
F
V
L
K
V
--
Q
K
P
A
N
---
P
W
E
F
Y
I
G
T
Q
L
M
E
R
L
K
-----
P
S
-
M
Q
H
M
F
M
K
F
Y
S
A
H
L
F
Q
N
G
---
S
V
L
V
G
E
L
Y
S
Y
G
T
L
L
N
A
I
N
L
Y
K
N
-
T
P
E
K
V
M
P
Q
G
L
V
I
S
F
A
M
R
M
L
Y
M
I
E
Q
V
H
D
C
E
--
I
I
H
G
D
I
K
P
D
N
F
I
L
G
N
G
F
L
E
-------
S
A
G
L
A
L
I
D
L
G
Q
S
I
D
M
K
L
F
P
K
G
------
T
I
F
T
A
K
C
E
T
S
G
F
Q
C
V
E
M
L
S
---
N
K
P
-----
W
N
Y
Q
I
D
Y
F
G
V
A
A
T
V
Y
C
M
L
F
G
----------
T
Y
M
K
V
--
K
N
E
G
--
G
E
--
C
K
P
E
G
L
F
---
R
R
-
L
--
P
H
L
D
M
W
N
E
F
F
H
V
M
L
N
I
-----
P
D
C
H
H
L
P
S
L
D
L
L
R
Q
K
L
K
K
V
-----
F
Q
Q
H
Y
T
N
K
I
R
A
L
R
N
R
L
I
V
L
L
L
E
C
K
R
S
--
8
PsiBlast_PDB
55.58
32%
-16
- C5 -
-
6JKM
2
?
A:
[7-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
N
P
F
N
V
E
L
I
S
S
L
L
E
S
I
DF
S
M
Y
I
E
K
L
P
H
-----
C
Q
L
V
G
HVKR----
L
H
P
N
T
H
L
E
V
H
N
E
K
F
E
V
S
K
M
I
G
K
G
A
Y
G
S
V
Y
V
G
K
------
H
-----
L
K
S
G
K
K
V
A
L
K
Q
--
E
R
P
T
N
---
Y
W
E
F
Y
I
C
L
E
I
H
S
R
L
T
SEQMI
P
S
-
Y
A
H
I
----
D
Y
A
L
V
G
N
N
S
---
S
V
Y
I
S
E
F
S
D
Y
G
S
L
I
G
V
C
N
K
V
K
S
-
V
T
N
R
N
M
D
E
Y
V
V
M
H
L
S
C
Q
M
L
D
I
V
D
H
L
H
A
M
G
--
I
I
H
A
D
I
K
P
D
N
F
L
L
M
K
P
I
C
A
D
P
N
E
----
V
S
L
Q
L
I
D
F
G
V
S
I
D
M
K
L
F
P
D
N
------
Q
T
F
N
Y
V
H
H
D
D
L
F
K
C
I
E
M
R
T
---
G
R
P
-----
W
T
Y
Q
L
D
L
Y
G
L
V
S
V
M
H
V
L
L
F
G
----------
R
Y
M
E
V
VQ
R
S
P
S
--
T
I
--
W
M
P
K
T
N
V
---
P
R
-
Y
--
F
Q
R
T
M
W
E
N
I
F
R
T
L
L
N
I
-----
R
D
C
R
T
M
P
N
L
Q
Q
L
R
T
Q
L
K
-----------------------------------
7
PsiBlast_PDB
55.27
32%
-14
- C5 -
-
6JKK
2
?
A:
[7-318]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
---
N
P
F
N
V
E
L
I
S
S
L
L
E
S
I
DF
S
M
Y
I
E
K
L
P
H
-----
C
Q
L
V
G
HVKR----
L
H
P
N
T
H
L
E
V
H
N
E
K
F
E
V
S
K
M
I
G
K
G
A
Y
G
S
V
Y
V
G
K
------
H
-----
L
K
S
G
K
K
V
A
L
K
Q
--
E
R
P
T
N
---
Y
W
E
F
Y
I
C
L
E
I
H
S
R
L
T
SEQMI
P
S
-
Y
A
H
I
----
D
Y
A
L
V
G
N
N
S
---
S
V
Y
I
S
E
F
S
D
Y
G
S
L
I
G
V
C
N
K
V
K
S
-
V
T
N
R
N
M
D
E
Y
V
V
M
H
L
S
C
Q
M
L
D
I
V
D
H
L
H
A
M
G
--
I
I
H
A
D
I
K
P
D
N
F
L
L
M
K
P
I
C
A
D
P
N
E
----
V
S
L
Q
L
I
D
F
G
V
S
I
D
M
K
L
F
P
D
N
------
Q
T
F
N
Y
V
H
H
D
D
L
F
K
C
I
E
M
R
T
---
G
R
P
-----
W
T
Y
Q
L
D
L
Y
G
L
V
S
V
M
H
V
L
L
F
G
----------
R
Y
M
E
V
VQ
R
S
P
S
--
T
I
--
W
M
P
K
T
N
V
---
P
R
-
Y
--
F
Q
R
T
M
W
E
N
I
F
R
T
L
L
N
I
-----
R
D
C
R
T
M
P
N
L
Q
Q
L
R
T
Q
L
K
-----------------------------------
141
HHSearch
53.22
34%
-81
- C5 -
-
6JKK
2
?
A:
[48-324]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
E
V
H
N
E
K
F
E
V
S
K
M
I
G
K
G
A
Y
G
S
V
Y
V
G
K
------
H
L
K
S
-----
G
K
K
V
A
L
K
Q
--
E
R
P
T
N
---
Y
W
E
F
Y
I
C
L
E
I
H
S
R
L
T
-----
S
E
Q
M
I
P
S
Y
A
H
I
D
Y
A
L
V
G
N
N
S
---
S
V
Y
I
S
E
F
S
D
Y
G
S
L
I
G
V
C
N
K
V
K
S
-
V
T
N
R
N
M
D
E
Y
V
V
M
H
L
S
C
Q
M
L
D
I
V
D
H
L
H
A
M
G
--
I
I
H
A
D
I
K
P
D
N
F
L
L
M
K
P
I
----
C
A
D
P
N
E
V
S
L
Q
L
I
D
F
G
V
S
I
D
M
K
L
F
P
D
N
------
Q
T
F
N
Y
V
H
H
D
D
L
F
K
C
I
E
M
R
T
---
G
R
P
-----
W
T
Y
Q
L
D
L
Y
G
L
V
S
V
M
H
V
L
L
F
G
----------
R
Y
M
E
V
--
V
Q
R
S
PS
T
I
--
W
M
P
K
T
N
V
---
P
R
-
Y
--
F
Q
R
T
M
W
E
N
I
F
R
T
L
L
N
I
-----
R
D
C
R
T
M
P
N
L
Q
Q
L
R
T
Q
L
K
C
A
-----
L
A
E
K
------------------------
5
PsiBlast_PDB
46.12
100%
-158
- C7 -
-
2LAH
-
BUB1_HUMAN
A:
[11-160]
M
D
T
P
E
N
V
L
Q
M
L
E
A
H
M
Q
S
Y
K
G
N
D
P
L
G
E
W
E
R
Y
I
Q
W
V
E
E
N
F
P
E
N
K
E
Y
L
I
T
L
L
E
H
L
M
K
E
F
L
D
K
K
K
Y
H
N
D
P
R
F
I
S
Y
C
L
K
F
A
E
Y
N
S
D
L
H
Q
F
F
E
F
L
Y
N
H
G
I
G
T
L
S
S
P
L
Y
I
A
W
A
G
H
L
E
A
Q
G
E
L
Q
H
A
S
A
V
L
Q
R
G
I
Q
N
Q
A
E
P
R
E
F
L
Q
Q
Q
Y
R
L
F
Q
T
R
L
T
E
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
45.82
100%
-159
- C7 -
-
2LAH
-
BUB1_HUMAN
A:
[11-159]
M
D
T
P
E
N
V
L
Q
M
L
E
A
H
M
Q
S
Y
K
G
N
D
P
L
G
E
W
E
R
Y
I
Q
W
V
E
E
N
F
P
E
N
K
E
Y
L
I
T
L
L
E
H
L
M
K
E
F
L
D
K
K
K
Y
H
N
D
P
R
F
I
S
Y
C
L
K
F
A
E
Y
N
S
D
L
H
Q
F
F
E
F
L
Y
N
H
G
I
G
T
L
S
S
P
L
Y
I
A
W
A
G
H
L
E
A
Q
G
E
L
Q
H
A
S
A
V
L
Q
R
G
I
Q
N
Q
A
E
P
R
E
F
L
Q
Q
Q
Y
R
L
F
Q
T
R
L
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
45.54
100%
-161
- C7 -
-
4A1G
-
BUB1_HUMAN
A:
[4-149]
-
D
T
P
E
N
V
L
Q
M
L
E
A
H
M
Q
S
Y
K
G
N
D
P
L
G
E
W
E
R
Y
I
Q
W
V
E
E
N
F
P
E
N
K
E
Y
L
I
T
L
L
E
H
L
M
K
E
F
L
D
K
K
K
Y
H
N
D
P
R
F
I
S
Y
C
L
K
F
A
E
Y
N
S
D
L
H
Q
F
F
E
F
L
Y
N
H
G
I
G
T
L
S
S
P
L
Y
I
A
W
A
G
H
L
E
A
Q
G
E
L
Q
H
A
S
A
V
L
Q
R
G
I
Q
N
Q
A
E
P
R
E
F
L
Q
Q
Q
Y
R
L
F
Q
T
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
45.05
100%
-151
- C7 -
-
4A1G
-
BUB1_HUMAN
D:
[3-150]
M
D
T
P
E
N
V
L
Q
M
L
E
A
H
M
Q
S
Y
K
G
N
D
P
L
G
E
W
E
R
Y
I
Q
W
V
E
E
N
F
P
E
N
K
E
Y
L
I
T
L
L
E
H
L
M
K
E
F
L
D
K
K
K
Y
H
N
D
P
R
F
I
S
Y
C
L
K
F
A
E
Y
N
S
D
L
H
Q
F
F
E
F
L
Y
N
H
G
I
G
T
L
S
S
P
L
Y
I
A
W
A
G
H
L
E
A
Q
G
E
L
Q
H
A
S
A
V
L
Q
R
G
I
Q
N
Q
A
E
P
R
E
F
L
Q
Q
Q
Y
R
L
F
Q
T
R
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Fugue
43.86
16%
-88
- C5 -
-
4DN5
7
M3K14_HUMAN
A:
[8-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
E
E
Y
L
V
H
A
L
Q
G
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
R
S
R
--
E
P
S
P
K
T
E
D
N
E
G
V
L
L
T
E
K
L
K
---------
P
V
D
Y
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
------
D
K
Q
----
T
G
F
Q
C
A
V
K
K
V
--
R
L
E
V
F
---
R
------
A
E
E
L
M
A
C
A
-----
G
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
---
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
G
------
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
----------
G
S
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
I
P
G
----------------
T
E
T
H
M
A
P
E
V
V
L
---
G
R
S
-----
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
----------
C
-----------------
H
P
W
T
Q
F
---
F
R
-
G
--
P
L
C
L
K
I
A
S
E
P
P
P
V
R
E
I
-----
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
-------
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
G
G
L
K
S
145
HHSearch
41.70
20%
-85
- C5 -
-
6MYN
1
M3K14_MOUSE
B:
[72-332]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
------
D
K
Q
T
-----
G
F
Q
C
A
V
K
K
--
V
R
L
E
V
---
F
--
R
V
E
E
L
V
A
C
A
G
L
S
---------
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
W
---
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
------
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
----------
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
Q
P
D
G
L
G
KSL---
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
---
G
K
P
-----
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
----------
C
H
P
W
T
--
Q
Y
F
R
--
G
P
LC
L
K
I
A
S
E
P
PPI
R
E
-
I
PP
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
-----
E
P
V
-
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
-----
L
Q
E
V
------------------------
147
HHSearch
39.44
18%
-54
- C5 -
-
5TE0
10
AAK1_HUMAN
A:
[14-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
------
T
S
N
------
G
M
K
C
A
L
K
R
--
M
F
V
N
N
EHD
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
-----
G
---
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V
-VWE
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
----
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
TP
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
-----------
R
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
EGVNAV
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
LYS
G
K
I
-----
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
----------
T
L
P
F
G
--
E
S
Q
V
--
A
I
--
C
D
G
N
F
T
I
---
P
D
N
S
--
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
-----
D
P
D
-
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
-----
L
---------------------------
119
Fugue
37.37
9%
-5
- C5 -
-
3DZO
-
?
A:
[13-382]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
G
F
R
G
T
D
P
G
-
D
V
V
I
E
E
L
F
N
R
I
--
P
Q
A
N
V
R
T
T
S
E
Y
A
A
D
S
L
V
S
T
SLWNTGQP
F
R
V
E
S
E
L
G
E
R
P
R
T
L
V
R
G
T
V
L
G
Q
E
D
P
Y
A
Y
L
E
A
T
DQETGE
S
F
E
V
H
V
P
Y
F
T
E
R
A
I
K
Q
M
--
K
E
E
V
L
---
R
L
R
L
L
R
G
I
K
N
Q
K
Q
A
K
-----
V
H
-
L
R
F
I
F
P
F
D
L
V
K
D
P
Q
V
L
S
---
R
F
F
L
Y
P
R
M
Q
S
N
L
Q
T
F
G
E
V
L
L
S
H
S
S
T
H
K
S
L
V
H
H
A
R
L
Q
L
T
L
Q
V
I
R
L
L
A
S
L
H
H
Y
G
--
L
V
H
T
Y
L
R
P
V
D
I
V
L
-----------
D
Q
R
G
G
V
F
L
T
G
F
E
H
L
V
R
D
G
A
S
A
V
S
------
P
I
G
R
G
F
A
-
P
P
E
T
T
A
E
R
M
L
P
---
F
G
Q
HHPTL
M
T
F
A
F
D
T
W
T
L
G
L
A
I
Y
W
I
W
C
A
----------
D
L
P
N
T
--
D
D
A
A
--
L
G
--
G
S
E
W
I
F
R
---
S
C
-
K
--
N
I
P
Q
P
V
R
A
L
L
E
G
F
L
R
Y
-----
P
K
E
D
R
L
L
P
L
Q
A
M
E
T
P
E
Y
E
Q
-----
L
R
T
E
L
S
A
A
L
P
L
Y
Q
---------------
116
Fugue
36.84
16%
-33
- C5 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
------
E
-----
T
S
S
K
K
T
Y
M
A
K
F
VK
V
K
G
T
D
---
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
---------
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
---
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
-----
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
---------
Q
T
R
R
S
S
T
I
K
I
I
E
F
G
Q
A
---
R
Q
L
K
P
G
------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
---
H
D
V
-----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
INPFLAETNQ
Q
I
I
E
N
--
I
M
N
A
--
E
Y
--
T
F
D
E
E
A
F
---
K
E
-
I
--
S
--
I
E
A
M
D
F
V
D
R
L
L
V
K
ERKSR
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
STKVI
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C