@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CD11A_HUMAN: (2020-09-05 )
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Atome Classification :
(477 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440...-....450.......460.......470......---.480.......490------..----.----.----..-.--500.......510......---.520....------.-..530.......540.......550.......560.---.......570.......580--.....----....590.......600.......610.......620-.......630........640.......650....-------...--660.-.-...---..670.......680-----.-.......690......-.700.......710----...-...-..720.......730.......740.......750.......760.......770.......780.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGDEKDSW
K
V
K
T
L
D
E
I
L
Q
E
K
K
R
R
K
E
Q
E
E
K
A
E
I
K
R
LKNSDDRDSKRDSLEE
G
E
L
R
D
H
C
M
E
I
T
IRNSPYRREDSMEDRGEEDD
S
L
AIK
P
P
Q
Q
M
S
R
K
E
K
V
H
HR
K
D
E
K
R
K
E
K
W
K
H
A
R
V
K
E
R
E
H
E
R
R
K
R
H
R
E
E
Q
D
K
A
R
R
E
W
E
R
Q
K
R
R
E
M
A
R
E
H
S
R
R
E
R
D
R
L
E
Q
L
E
R
K
R
E
R
E
R
K
M
R
E
Q
Q
K
E
Q
R
E
Q
K
E
R
E
R
R
A
E
E
R
R
K
E
R
E
A
R
R
E
V
S
A
H
H
R
T
M
R
E
D
Y
S
D
K
VKASHWSRSPPRP
P
R
E
RFELGDGRKPGEARPAPAQ
K
P
A
Q
L
K
E
E
K
M
E
E
R
D
L
L
S
D
L
Q
D
IS
D
S
ERKTSSAESSSAESGSGSE
E
E
E
E
E
E
E
E
E
EEEGSTSEESE
E
E
E
E
E
E
E
E
E
E
EETGSNS
E
E
A
S
E
Q
S
A
E
E
V
S
E
E
E
MSE
D
E
E
RENEN
H
L
L
V
VPESRFDRDSGE
S
E
E
A
E
E
E
VGEGTPQSSALTEGDYVPDSP
A
L
L
P
I
E
L
K
Q
E
L
P
K
Y
L
P
A
L
Q
G
C
R
S
V
E
E
F
Q
C
L
N
R
IEEGT
Y
G
V
V
Y
RAKD-KKT
D
E
I
V
A
L
K
R
L
K
M
E
K
EKEGFPI
T
S
L
R
E
I
N
T
I
L
---KAQHP
N
I
V
T
V
R
E
I
V------VG----S----N----M
D
-
K
--
I
Y
I
V
M
N
Y
V
E
H
D
L
K
S
L
M
E
T
M
---KQPFLP
G
E
------
V
-
K
T
L
M
I
Q
L
L
R
G
V
K
H
L
HDN
W
I
L
H
RDLKTS
N
L
L
LSH-A
G
---
I
L
K
VGD
F
G
L
A
R
EYGSPLK----AYT
P
V
----
V
V
T
Q
WYRA
P
E
L
LLGA
K
E
YS
T
A
V
D
M
W
S
V
G
C
I
F
G
E
L
L
TQ-KPLFPGN
S
E
-
I
D
Q
I
N
K
V
F
K
E
LGT
P
S
EKIWPGYSEL-------
P
V
V
--
K
KMT-F-SEH---
P
Y
N
N
L
R
K
R
F
G
A
L
LS------D-Q
G
F
D
L
M
N
K
F
L
T
YFPGR-RISAEDGL
K
H
E
Y
F-----RET-PLP-IDPSMFPTWPAK
S
E
Q
Q
R
V
KRGTSPRPPEGGLGYSQLGD
D
D
L
K
ETG
F
H
L
T
TTNQGASAAGPGFSLKF
450
Blastp_CBE
93.61
44%
0
- C- -
-
4ERW
17
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
X
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
150
Blastp_CBE
88.73
44%
-63
- C1 -
-
2C5Y
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
140
Blastp_CBE
88.55
44%
-49
- C1 -
-
2EXM
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
171
Blastp_CBE
88.42
44%
-60
- C1 -
-
1Y8Y
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
147
Blastp_CBE
88.06
44%
-59
- C1 -
-
2C6I
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
94
Blastp_CBE
88.05
44%
-53
- C1 -
-
3F5X
2
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
284
Blastp_CBE
87.92
44%
-56
- C1 -
-
3QZG
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
217
Blastp_CBE
87.73
44%
-59
- C1 -
-
1B38
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
186
Blastp_CBE
87.70
44%
-55
- C1 -
-
1PXI
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
225
Blastp_CBE
87.64
44%
-54
- C1 -
-
6Q4C
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
30
Blastp_CBE
87.66
44%
-57
- C1 -
-
2BKZ
1
CDK2_HUMAN
C:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
19
PsiBlast_PDB
87.64
44%
-55
- C1 -
-
2BKZ
1
CDK2_HUMAN
A:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
269
Blastp_CBE
87.59
44%
-54
- C1 -
-
3R83
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
47
Blastp_CBE
87.58
44%
-52
- C1 -
-
5ANE
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
129
Blastp_CBE
87.53
44%
-50
- C1 -
-
2UUE
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
222
Blastp_CBE
87.50
44%
-54
- C1 -
-
6Q4H
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
142
Blastp_CBE
87.49
44%
-54
- C1 -
-
2CLX
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
102
Blastp_CBE
87.39
44%
-54
- C1 -
-
2XMY
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
---
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
126
Blastp_CBE
87.38
44%
-53
- C1 -
-
2V0D
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
275
Blastp_CBE
87.28
44%
-54
- C1 -
-
3R73
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
155
Blastp_CBE
87.27
44%
-47
- C1 -
-
2C5O
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
239
Blastp_CBE
87.25
44%
-56
- C1 -
-
3S00
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
56
Blastp_CBE
87.23
44%
-56
- C1 -
-
4FKU
3
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
197
Blastp_CBE
87.21
44%
-54
- C1 -
-
1HCK
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
101
Blastp_CBE
87.20
44%
-52
- C1 -
-
2XNB
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
143
Blastp_CBE
87.13
44%
-55
- C1 -
-
2C6O
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
24
Blastp_CBE
87.11
44%
-49
- C1 -
-
2WPA
1
CDK2_HUMAN
A:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
164
Blastp_CBE
87.10
44%
-54
- C1 -
-
2B54
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
216
Blastp_CBE
87.09
44%
-60
- C1 -
-
1B39
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
448
Blastp_CBE
87.07
44%
-54
- C1 -
-
6Q3F
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
127
Blastp_CBE
86.99
44%
-61
- C1 -
-
2UZO
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
279
Blastp_CBE
86.94
44%
-55
- C1 -
-
3R1Y
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
98
Blastp_CBE
86.96
44%
-51
- C1 -
-
3EJ1
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
53
Blastp_CBE
86.94
44%
-46
- C1 -
-
4FX3
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
20
PsiBlast_PDB
86.94
44%
-49
- C1 -
-
2WIH
1
CDK2_HUMAN
A:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
63
Blastp_CBE
86.93
44%
-56
- C1 -
-
4FKL
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
283
Blastp_CBE
86.89
44%
-54
- C1 -
-
3QZH
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
137
Blastp_CBE
86.80
44%
-52
- C1 -
-
2I40
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
261
Blastp_CBE
86.76
44%
-55
- C1 -
-
3R9H
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
265
Blastp_CBE
86.75
44%
-54
- C1 -
-
3R8U
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
248
Blastp_CBE
86.74
44%
-57
- C1 -
-
3RM7
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
257
Blastp_CBE
86.73
44%
-57
- C1 -
-
3RAI
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
148
Blastp_CBE
86.72
44%
-56
- C1 -
-
2C69
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
206
Blastp_CBE
86.71
44%
-51
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
144
Blastp_CBE
86.68
44%
-53
- C1 -
-
2C6M
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
447
Blastp_CBE
86.59
44%
-51
- C1 -
-
6Q4F
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
245
Blastp_CBE
86.63
44%
-55
- C1 -
-
3ROY
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
157
Blastp_CBE
86.62
44%
-47
- C1 -
-
2C5N
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
299
Blastp_CBE
86.61
44%
-54
- C1 -
-
3QTQ
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
156
Blastp_CBE
86.59
44%
-48
- C1 -
-
2C5O
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
169
Blastp_CBE
86.58
44%
-51
- C1 -
-
1YKR
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
158
Blastp_CBE
86.57
44%
-49
- C1 -
-
2C5N
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
99
Blastp_CBE
86.56
44%
-54
- C1 -
-
3EJ1
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
305
Blastp_CBE
86.55
44%
-55
- C1 -
-
3QQH
4
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
277
Blastp_CBE
86.54
44%
-56
- C1 -
-
3R6X
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
310
Blastp_CBE
86.47
44%
-57
- C1 -
-
3PY0
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
211
Blastp_CBE
86.50
44%
-55
- C1 -
-
1E1X
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
38
Blastp_CBE
86.51
44%
-58
- C1 -
-
5IEX
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
23
Blastp_CBE
86.50
44%
-54
- C1 -
-
2WPA
1
CDK2_HUMAN
C:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
282
Blastp_CBE
86.45
44%
-55
- C1 -
-
3QZI
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
276
Blastp_CBE
86.48
44%
-52
- C1 -
-
3R71
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
238
Blastp_CBE
86.47
44%
-58
- C1 -
-
3S0O
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
--
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
100
Blastp_CBE
86.46
44%
-52
- C1 -
-
3EID
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
36
Blastp_CBE
86.45
44%
-50
- C1 -
-
5JQ5
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
445
Blastp_CBE
86.36
44%
-54
- C1 -
-
1W8C
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
82
Blastp_CBE
86.40
44%
-51
- C1 -
-
3TI1
9
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
264
Blastp_CBE
86.35
44%
-54
- C1 -
-
3R8V
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
105
Blastp_CBE
86.37
44%
-47
- C1 -
-
2WEV
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
289
Blastp_CBE
86.36
44%
-54
- C1 -
-
3QX2
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
76
Blastp_CBE
86.35
44%
-59
- C1 -
-
3WBL
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
-
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
14
PsiBlast_PDB
86.35
44%
-42
- C1 -
-
2IW8
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
280
Blastp_CBE
86.32
44%
-54
- C1 -
-
3R1S
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
44
Blastp_CBE
86.31
44%
-51
- C1 -
-
5ANJ
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
-------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
295
Blastp_CBE
86.26
44%
-48
- C1 -
-
3QTW
6
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
221
Blastp_CBE
86.25
44%
-55
- C1 -
-
6Q4J
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
--
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
205
Blastp_CBE
86.26
44%
-51
- C1 -
-
1FVV
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
149
Blastp_CBE
86.25
44%
-52
- C1 -
-
2C68
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
21
Blastp_CBE
86.24
44%
-49
- C1 -
-
2WXV
1
CDK2_HUMAN
C:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
317
Blastp_CBE
86.18
44%
-55
- C1 -
-
6Q4G
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
133
Blastp_CBE
86.17
44%
-52
- C1 -
-
2R3H
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
106
Blastp_CBE
86.16
44%
-47
- C1 -
-
2WEV
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
146
Blastp_CBE
86.15
44%
-53
- C1 -
-
2C6K
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
103
Blastp_CBE
86.13
44%
-44
- C1 -
-
2X1N
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
303
Blastp_CBE
86.08
44%
-49
- C1 -
-
3QQK
6
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
312
Blastp_CBE
86.12
44%
-56
- C1 -
-
3PXY
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
565
HHSearch
86.11
44%
-104
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
--
N
Y
G
E
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
---
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------
H
T
--------------
K
K
-
R
--
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
---
E
G
G
L
E
S
V
T
------
A
-
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
-------
P
K
Y
--
D
P
N
F
-
T
-
V
Y
E
---
P
L
--
P
W
E
S
F
L
K
G
L
D
------
E
-
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
-
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----
K
E
------------------------------------------------------------------------
37
Blastp_CBE
86.10
44%
-57
- C1 -
-
5IEY
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
266
Blastp_CBE
86.06
44%
-50
- C1 -
-
3R8P
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
281
Blastp_CBE
86.08
44%
-56
- C1 -
-
3R1Q
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
183
Blastp_CBE
86.06
44%
-60
- C1 -
-
1PXL
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
154
Blastp_CBE
86.06
44%
-52
- C1 -
-
2C5V
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
294
Blastp_CBE
86.07
44%
-51
- C1 -
-
3QTX
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
22
Blastp_CBE
86.06
44%
-48
- C1 -
-
2WXV
1
CDK2_HUMAN
A:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
278
Blastp_CBE
86.00
44%
-52
- C1 -
-
3R28
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
135
Blastp_CBE
85.99
44%
-56
- C1 -
-
2R3F
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
274
Blastp_CBE
85.96
44%
-58
- C1 -
-
3R7E
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
77
Blastp_CBE
85.99
44%
-52
- C1 -
-
3UNK
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
271
Blastp_CBE
85.95
44%
-50
- C1 -
-
3R7V
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
86
Blastp_CBE
85.98
44%
-52
- C1 -
-
3NS9
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
168
Blastp_CBE
85.96
44%
-51
- C1 -
-
2A0C
1
CDK2_HUMAN
X:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
130
Blastp_CBE
85.95
44%
-50
- C1 -
-
2UUE
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
242
Blastp_CBE
85.94
44%
-50
- C1 -
-
3RPV
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
285
Blastp_CBE
85.89
44%
-51
- C1 -
-
3QZF
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
307
Blastp_CBE
85.90
44%
-53
- C1 -
-
3QQF
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
28
Blastp_CBE
85.89
44%
-49
- C1 -
-
2C4G
1
CDK2_HUMAN
C:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
451
Blastp_CBE
85.87
44%
-52
- C1 -
-
4RJ3
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
L
I
R
L
D
T
-------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
252
Blastp_CBE
85.83
44%
-51
- C1 -
-
3RK7
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
249
Blastp_CBE
85.82
44%
-50
- C1 -
-
3RM6
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
-
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
302
Blastp_CBE
85.77
44%
-47
- C1 -
-
3QQL
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
69
Blastp_CBE
85.81
44%
-52
- C1 -
-
4EK5
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
253
Blastp_CBE
85.77
44%
-48
- C1 -
-
3RK5
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
27
Blastp_CBE
85.77
44%
-51
- C1 -
-
2WIH
1
CDK2_HUMAN
C:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
270
Blastp_CBE
85.73
44%
-49
- C1 -
-
3R7Y
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
54
Blastp_CBE
85.72
44%
-61
- C1 -
-
4FKW
2
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
78
Blastp_CBE
85.71
44%
-60
- C1 -
-
3UNJ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
17
PsiBlast_PDB
85.71
44%
-50
- C1 -
-
2C4G
1
CDK2_HUMAN
A:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
311
Blastp_CBE
85.67
44%
-42
- C1 -
-
3PXZ
3
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
198
Blastp_CBE
85.62
44%
-57
- C1 -
-
1H0W
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
----------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
444
Blastp_CBE
85.55
44%
-58
- C1 -
-
2R3I
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
291
Blastp_CBE
85.61
44%
-55
- C1 -
-
3QWJ
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
51
Blastp_CBE
85.60
44%
-50
- C1 -
-
4KD1
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
25
Blastp_CBE
85.59
44%
-56
- C1 -
-
2WIP
1
CDK2_HUMAN
C:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
4
PsiBlast_PDB
85.59
44%
-90
- C1 -
-
3NIZ
1
?
A:
[20-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
-
S
Q
-
G
R
I
V
A
L
K
R
I
R
------
G
I
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
H
H
P
N
I
V
S
L
I
D
V
I
------
H
S
----
E
----
R
----
C
-----
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
N
---
K
T
G
L
Q
D
S
Q
------
I
-
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
-
D
G
---
A
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
-------
H
E
----
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
T
G
-
K
P
L
F
P
G
V
T
D
-
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
-------
P
L
W
--
K
Q
R
T
-
F
-
Q
V
F
EKK
P
W
S
S
I
I
P
G
F
----
C
------
Q
-
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
-
R
I
S
A
R
D
A
M
N
H
P
Y
F
-----
K
D
------
L
D
P
Q
I
-------------------------------------------------------------
244
Blastp_CBE
85.58
44%
-52
- C1 -
-
3RPO
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
262
Blastp_CBE
85.55
44%
-50
- C1 -
-
3R9D
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
81
Blastp_CBE
85.57
44%
-51
- C1 -
-
3TIY
12
CDK2_HUMAN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
296
Blastp_CBE
85.51
44%
-52
- C1 -
-
3QTU
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
233
Blastp_CBE
85.55
44%
-44
- C1 -
-
4GCJ
5
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
52
Blastp_CBE
85.54
44%
-46
- C1 -
-
4FX3
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
62
Blastp_CBE
85.53
44%
-53
- C1 -
-
4FKO
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
292
Blastp_CBE
85.48
44%
-50
- C1 -
-
3QU0
5
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
95
Blastp_CBE
85.52
44%
-50
- C1 -
-
3F5X
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
-
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
180
Blastp_CBE
85.50
44%
-52
- C1 -
-
1PXO
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
194
Blastp_CBE
85.51
44%
-61
- C1 -
-
1KE5
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
39
Blastp_CBE
85.50
44%
-58
- C1 -
-
5IEV
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
437
Blastp_CBE
85.43
44%
-54
- C1 -
-
2R3P
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
254
Blastp_CBE
85.49
44%
-51
- C1 -
-
3RJC
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
179
Blastp_CBE
85.48
44%
-50
- C1 -
-
1PXP
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
153
Blastp_CBE
85.46
44%
-46
- C1 -
-
2C5V
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
80
Blastp_CBE
85.46
44%
-52
- C1 -
-
3TIZ
9
CDK2_HUMAN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
145
Blastp_CBE
85.43
44%
-54
- C1 -
-
2C6L
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
306
Blastp_CBE
85.37
44%
-52
- C1 -
-
3QQG
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
308
Blastp_CBE
85.36
44%
-53
- C1 -
-
3QL8
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
60
Blastp_CBE
85.41
44%
-57
- C1 -
-
4FKQ
2
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
26
Blastp_CBE
85.39
44%
-53
- C1 -
-
2WIP
1
CDK2_HUMAN
A:
[6-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
-----
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
185
Blastp_CBE
85.38
44%
-53
- C1 -
-
1PXJ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
104
Blastp_CBE
85.37
44%
-47
- C1 -
-
2X1N
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
214
Blastp_CBE
85.36
44%
-57
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
193
Blastp_CBE
85.34
44%
-62
- C1 -
-
1KE6
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
290
Blastp_CBE
85.29
44%
-53
- C1 -
-
3QWK
5
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
50
Blastp_CBE
85.31
44%
-57
- C1 -
-
4LYN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
287
Blastp_CBE
85.30
44%
-48
- C1 -
-
3QXO
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
251
Blastp_CBE
85.29
44%
-50
- C1 -
-
3RK9
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
300
Blastp_CBE
85.23
44%
-49
- C1 -
-
3QRU
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
449
Blastp_CBE
85.20
44%
-51
- C1 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
301
Blastp_CBE
85.24
44%
-47
- C1 -
-
3QRT
3
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
212
Blastp_CBE
85.23
44%
-54
- C1 -
-
1E1V
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
286
Blastp_CBE
85.17
44%
-54
- C1 -
-
3QXP
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
138
Blastp_CBE
85.20
44%
-52
- C1 -
-
2I40
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
-------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
182
Blastp_CBE
85.17
44%
-52
- C1 -
-
1PXM
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
132
Blastp_CBE
85.17
44%
-56
- C1 -
-
2R3R
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
263
Blastp_CBE
85.14
44%
-54
- C1 -
-
3R8Z
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
--------
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
250
Blastp_CBE
85.15
44%
-53
- C1 -
-
3RKB
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
3
PsiBlast_PDB
85.14
44%
-53
- C1 -
-
5OO3
1
CDK2_HUMAN
A:
[7-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
115
Blastp_CBE
85.10
44%
-48
- C1 -
-
2VTR
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
438
Blastp_CBE
85.07
44%
-54
- C1 -
-
2R3O
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
304
Blastp_CBE
85.00
44%
-55
- C1 -
-
3QQJ
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
268
Blastp_CBE
85.01
44%
-51
- C1 -
-
3R8L
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
181
Blastp_CBE
85.01
44%
-51
- C1 -
-
1PXN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
79
Blastp_CBE
85.00
44%
-56
- C1 -
-
3ULI
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
-----------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
478
Blastp_CBE
84.97
44%
-54
- C1 -
-
5MHQ
1
?
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
190
Blastp_CBE
84.95
44%
-64
- C1 -
-
1KE9
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
246
Blastp_CBE
84.92
44%
-51
- C1 -
-
3RNI
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
152
Blastp_CBE
84.93
44%
-49
- C1 -
-
2C5X
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
128
Blastp_CBE
84.92
44%
-58
- C1 -
-
2UZN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
208
Blastp_CBE
84.91
44%
-53
- C1 -
-
1FIN
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
84
Blastp_CBE
84.89
44%
-58
- C1 -
-
3SW4
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
199
Blastp_CBE
84.87
44%
-55
- C1 -
-
1H0V
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
---
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
173
Blastp_CBE
84.85
44%
-64
- C1 -
-
1W0X
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
91
Blastp_CBE
84.84
44%
-58
- C1 -
-
3IGG
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
288
Blastp_CBE
84.80
44%
-54
- C1 -
-
3QX4
3
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
209
Blastp_CBE
84.80
44%
-47
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
223
Blastp_CBE
84.76
44%
-56
- C1 -
-
6Q4E
3
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
184
Blastp_CBE
84.76
44%
-57
- C1 -
-
1PXK
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
97
Blastp_CBE
84.75
44%
-52
- C1 -
-
3EOC
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
96
Blastp_CBE
84.67
44%
-54
- C1 -
-
3EOC
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
187
Blastp_CBE
84.59
44%
-52
- C1 -
-
1PF8
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
88
Blastp_CBE
84.58
44%
-47
- C1 -
-
3LFQ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
192
Blastp_CBE
84.56
44%
-58
- C1 -
-
1KE7
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
258
Blastp_CBE
84.57
44%
-55
- C1 -
-
3RAH
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
123
Blastp_CBE
84.56
44%
-63
- C1 -
-
2VTI
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
66
Blastp_CBE
84.56
44%
-50
- C1 -
-
4FKG
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
151
Blastp_CBE
84.55
44%
-50
- C1 -
-
2C5X
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
219
Blastp_CBE
84.53
44%
-52
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
215
Blastp_CBE
84.51
44%
-63
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
170
Blastp_CBE
84.49
44%
-54
- C1 -
-
1Y91
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---------
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
134
Blastp_CBE
84.45
44%
-53
- C1 -
-
2R3G
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
74
Blastp_CBE
84.45
44%
-60
- C1 -
-
4BGH
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
436
Blastp_CBE
84.41
44%
-52
- C1 -
-
2R3Q
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
234
Blastp_CBE
84.40
44%
-38
- C1 -
-
4EZ7
7
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
108
Blastp_CBE
84.38
44%
-58
- C1 -
-
2W17
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
-
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
-----
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
------------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
131
Blastp_CBE
84.35
44%
-61
- C1 -
-
2R64
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
309
Blastp_CBE
84.33
44%
-40
- C1 -
-
3PY1
4
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
224
Blastp_CBE
84.28
44%
-54
- C1 -
-
6Q4D
6
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
-
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
45
Blastp_CBE
84.26
44%
-55
- C1 -
-
5ANI
1
CDK2_HUMAN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
1
PsiBlast_PDB
84.26
44%
-50
- C1 -
-
5OSM
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
C
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
A
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
118
Blastp_CBE
84.25
44%
-56
- C1 -
-
2VTO
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
90
Blastp_CBE
84.25
44%
-48
- C1 -
-
3LE6
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
-----------------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
229
Blastp_CBE
84.21
44%
-54
- C1 -
-
6Q48
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
93
Blastp_CBE
84.15
44%
-54
- C1 -
-
3FZ1
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
314
Blastp_CBE
84.12
44%
-41
- C1 -
-
3PXQ
4
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
507
Blastp_CBE
84.09
41%
-78
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
---
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
S
----
D
----
K
-------
K
--
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
------
V
-
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
----
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-------
P
D
Y
--
K
P
---
Y
-
P
M
Y
---
P
A
T
T
S
L
V
N
V
V
P
K
L
N
------
A
-
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
-
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-----
S
D
------------------------------------------------------------------------
409
Blastp_CBE
84.07
44%
-50
- C1 -
-
6Q4I
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
L
---
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
6
PsiBlast_PDB
84.00
44%
-57
- C1 -
-
1GII
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
201
Blastp_CBE
83.96
44%
-49
- C1 -
-
1H07
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
----
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
59
Blastp_CBE
83.91
44%
-53
- C1 -
-
4FKR
2
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
191
Blastp_CBE
83.89
44%
-57
- C1 -
-
1KE8
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
167
Blastp_CBE
83.90
44%
-58
- C1 -
-
2A4L
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
273
Blastp_CBE
83.86
44%
-54
- C1 -
-
3R7I
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
114
Blastp_CBE
83.89
44%
-57
- C1 -
-
2VTS
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
236
Blastp_CBE
83.88
44%
-50
- C1 -
-
3SQQ
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
------
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
112
Blastp_CBE
83.87
44%
-49
- C1 -
-
2VU3
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
----
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
57
Blastp_CBE
83.86
44%
-54
- C1 -
-
4FKT
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
49
Blastp_CBE
83.81
44%
-45
- C1 -
-
5A14
2
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
--
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
85
Blastp_CBE
83.79
44%
-60
- C1 -
-
3S2P
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
243
Blastp_CBE
83.70
44%
-55
- C1 -
-
3RPR
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
111
Blastp_CBE
83.65
44%
-56
- C1 -
-
2VV9
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
260
Blastp_CBE
83.64
44%
-52
- C1 -
-
3R9N
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
15
PsiBlast_PDB
83.59
44%
-54
- C1 -
-
5K4J
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
293
Blastp_CBE
83.54
44%
-52
- C1 -
-
3QTZ
3
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
125
Blastp_CBE
83.57
44%
-58
- C1 -
-
2VTA
3
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
207
Blastp_CBE
83.54
44%
-55
- C1 -
-
1FVT
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
511
Blastp_CBE
83.48
41%
-84
- C1 -
-
1UNG
1
CDK5_HUMAN
A:
[1-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
---
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
S
----
D
----
K
-------
K
--
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
------
V
-
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
----
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-------
P
D
Y
--
K
P
---
Y
-
P
M
Y
---
P
A
T
T
S
L
V
N
V
V
P
K
L
N
------
A
-
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
-
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-----
S
D
------------------------------------------------------------------------
267
Blastp_CBE
83.47
44%
-56
- C1 -
-
3R8M
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
166
Blastp_CBE
83.46
44%
-53
- C1 -
-
2B52
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
61
Blastp_CBE
83.41
44%
-55
- C1 -
-
4FKP
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
159
Blastp_CBE
83.36
44%
-56
- C1 -
-
2BTS
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
89
Blastp_CBE
83.32
44%
-49
- C1 -
-
3LFN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
-------------
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
55
Blastp_CBE
83.31
44%
-52
- C1 -
-
4FKV
2
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
---------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
65
Blastp_CBE
83.30
44%
-51
- C1 -
-
4FKI
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
---
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
297
Blastp_CBE
83.24
44%
-54
- C1 -
-
3QTS
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
161
Blastp_CBE
83.22
44%
-57
- C1 -
-
2BHH
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
109
Blastp_CBE
83.22
44%
-53
- C1 -
-
2W06
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
441
Blastp_CBE
83.21
44%
-56
- C1 -
-
2R3L
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
-----------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
67
Blastp_CBE
83.20
44%
-57
- C1 -
-
4EK8
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
58
Blastp_CBE
83.07
44%
-56
- C1 -
-
4FKS
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
73
Blastp_CBE
83.01
44%
-57
- C1 -
-
4BZD
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
231
Blastp_CBE
82.98
44%
-52
- C1 -
-
6GUK
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
272
Blastp_CBE
82.99
44%
-54
- C1 -
-
3R7U
2
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
200
Blastp_CBE
82.98
44%
-54
- C1 -
-
1H08
2
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-----------
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
35
Blastp_CBE
82.94
44%
-56
- C1 -
-
5JQ8
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
64
Blastp_CBE
82.93
44%
-53
- C1 -
-
4FKJ
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
92
Blastp_CBE
82.89
44%
-56
- C1 -
-
3IG7
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
124
Blastp_CBE
82.84
44%
-57
- C1 -
-
2VTH
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
176
Blastp_CBE
82.80
44%
-60
- C1 -
-
1URW
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
83
Blastp_CBE
82.76
44%
-57
- C1 -
-
3SW7
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
492
Blastp_CBE
82.73
42%
-73
- C1 -
-
1V0P
1
CDC2H_PLAFK
A:
[1-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
---
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------------
H
----
T
----
K
K
-
R
--
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
---
E
G
G
L
E
S
V
T
------
A
-
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
G
-----------------
I
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
-------
P
K
Y
DP
N
F
T
V
-
Y
-
E
P
L
---
P
W
E
S
F
L
K
G
----
L
D
------
E
-
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
-
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----
K
E
------------------------------------------------------------------------
117
Blastp_CBE
82.70
44%
-54
- C1 -
-
2VTP
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
40
Blastp_CBE
82.62
44%
-50
- C1 -
-
5FP6
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
163
Blastp_CBE
82.61
44%
-51
- C1 -
-
2B55
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
110
Blastp_CBE
82.59
44%
-57
- C1 -
-
2W05
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
-----------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
440
Blastp_CBE
82.53
44%
-54
- C1 -
-
2R3M
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
---------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
107
Blastp_CBE
82.50
44%
-49
- C1 -
-
2W1H
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
247
Blastp_CBE
82.43
44%
-53
- C1 -
-
3RMF
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
68
Blastp_CBE
82.35
44%
-52
- C1 -
-
4EK6
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
241
Blastp_CBE
82.34
44%
-55
- C1 -
-
3RPY
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
203
Blastp_CBE
82.30
44%
-54
- C1 -
-
1GIH
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
72
Blastp_CBE
82.26
44%
-54
- C1 -
-
4D1X
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
-------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
298
Blastp_CBE
82.22
44%
-52
- C1 -
-
3QTR
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
48
Blastp_CBE
82.18
44%
-61
- C1 -
-
5AND
1
CDK2_HUMAN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
-------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
237
Blastp_CBE
82.15
44%
-55
- C1 -
-
3S1H
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
435
Blastp_CBE
82.09
44%
-51
- C1 -
-
4NJ3
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
----------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
116
Blastp_CBE
82.08
44%
-49
- C1 -
-
2VTQ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
175
Blastp_CBE
82.07
44%
-56
- C1 -
-
1V1K
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
10
PsiBlast_PDB
81.98
44%
-51
- C1 -
-
3EZV
1
CDK2_HUMAN
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
213
Blastp_CBE
81.90
44%
-57
- C1 -
-
1DM2
5
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
---------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
562
HHSearch
81.88
40%
-78
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[2-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
---
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
S
--------------
D
K
-
K
--
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
------
V
-
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
---
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
----
C
Y
S
A
E
----
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-------
P
D
Y
--
K
P
Y
P
----
M
Y
---
P
A
T
T
S
L
V
N
V
V
P
K
L
N
------
A
-
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
-
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-----
S
D
F
-
C
---------------------------------------------------------------------
139
Blastp_CBE
81.84
44%
-49
- C1 -
-
2FVD
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------------
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
--
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
113
Blastp_CBE
81.79
44%
-50
- C1 -
-
2VTT
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
-----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
256
Blastp_CBE
81.78
44%
-56
- C1 -
-
3RAK
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
259
Blastp_CBE
81.76
44%
-51
- C1 -
-
3R9O
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
43
Blastp_CBE
81.75
44%
-60
- C1 -
-
5ANK
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
---------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
--------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
119
Blastp_CBE
81.59
44%
-51
- C1 -
-
2VTN
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
240
Blastp_CBE
81.55
44%
-49
- C1 -
-
3RZB
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
----------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
177
Blastp_CBE
81.54
44%
-54
- C1 -
-
1R78
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
442
Blastp_CBE
81.53
44%
-55
- C1 -
-
2R3K
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
443
Blastp_CBE
81.50
44%
-56
- C1 -
-
2R3J
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
---------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
160
Blastp_CBE
81.46
44%
-53
- C1 -
-
2BTR
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
----------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
202
Blastp_CBE
81.45
44%
-54
- C1 -
-
1H00
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
--------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
255
Blastp_CBE
81.39
44%
-53
- C1 -
-
3RAL
1
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
---------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
32
Blastp_CBE
81.30
44%
-58
- C1 -
-
1OIT
1
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
-
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
S
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
-------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
5
PsiBlast_PDB
80.84
44%
-56
- C1 -
-
6INL
1
?
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
-----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
218
Blastp_CBE
80.80
44%
-49
- C1 -
-
1AQ1
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
-----------------
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
75
Blastp_CBE
80.75
44%
-50
- C1 -
-
4ACM
3
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
-----------------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
--------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
232
Blastp_CBE
80.73
44%
-45
- C1 -
-
6GUH
3
CDK2_HUMAN
A:
[9-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
--------
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
9
PsiBlast_PDB
80.42
44%
-47
- C1 -
-
3EZR
2
CDK2_HUMAN
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
--------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
204
Blastp_CBE
80.35
44%
-53
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
497
Blastp_CBE
80.09
41%
-75
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
---
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
S
---------
K
-------
K
--
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
------
V
-
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
---
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
--------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-------
P
D
Y
--
K
P
---
Y
-
P
M
Y
---
P
A
T
T
S
L
V
N
V
V
P
K
L
N
------
A
-
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
-
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-----
S
D
F
-----------------------------------------------------------------------
141
Blastp_CBE
80.07
44%
-51
- C1 -
-
2DUV
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-------------
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
---------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
7
PsiBlast_PDB
79.77
44%
-47
- C1 -
-
1GIJ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
-----------
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
H
V
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
512
Blastp_CBE
79.42
43%
-38
- C1 -
-
3GC0
1
?
A:
[32-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
D
R
Y
R
R
I
T
K
L
G
E
G
T
Y
G
E
V
Y
K
A
I
D
-
T
V
T
N
E
T
V
A
I
K
R
I
R
L
E
H
-------
T
A
I
R
E
V
S
L
L
K
---
E
L
Q
H
R
N
I
I
E
L
K
S
V
I
------------
H
----
H
----
N
H
-
R
--
L
H
L
I
F
E
Y
A
E
N
D
L
K
K
Y
M
D
-----
K
N
P
D
V
S
M
R
------
V
I
K
S
F
L
Y
Q
L
I
N
G
V
N
F
C
H
S
R
R
C
L
H
R
D
L
K
P
Q
N
L
L
L
S
V
---ETP
V
L
K
I
G
D
F
G
L
A
R
A
F
-------------
E
----
I
I
T
L
W
Y
R
P
P
E
I
L
L
G
S
R
H
Y
S
T
S
V
D
I
W
S
I
A
C
I
W
A
E
M
L
M
K
-
T
P
L
F
P
G
D
S
E
-
I
D
Q
L
F
K
I
F
E
V
L
G
L
P
D
D
T
T
W
P
G
V
T
A
L
-------
P
D
W
--
K
Q
-
S
-
F
-
P
K
F
---
R
G
K
T
L
K
R
V
L
G
A
L
L
D
------
D
-
E
G
L
D
L
L
T
A
M
L
E
M
D
P
V
K
-
R
I
S
A
K
N
A
L
E
H
P
Y
F
-------------------------------------------------------------------------------
498
Blastp_CBE
78.96
41%
-71
- C1 -
-
4AU8
2
CDK5_HUMAN
A:
[4-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
---------
V
P
S
S
A
L
R
E
I
C
L
L
K
---
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
------------------
K
--
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
------
V
-
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
---
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
R
------
S
A
E
----
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
-
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-------
P
D
Y
--
K
P
---
Y
-
P
M
Y
---
P
A
T
T
S
L
V
N
V
V
P
K
L
N
------
A
-
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
-
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-----
S
D
F
-----------------------------------------------------------------------
489
Blastp_CBE
78.88
42%
-62
- C1 -
-
1V0O
1
CDC2H_PLAFK
B:
[3-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
----------
T
I
R
E
I
S
I
L
K
---
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------------
H
----
T
----
K
K
-
R
--
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
---
E
G
G
L
E
S
V
T
------
A
-
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
-------
P
K
Y
DP
N
F
T
V
-
Y
-
E
P
L
---
P
W
E
S
F
L
K
G
----
L
D
------
E
-
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
-
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----
K
E
------------------------------------------------------------------------
490
Blastp_CBE
78.84
42%
-65
- C1 -
-
1V0O
1
CDC2H_PLAFK
A:
[3-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
--------
S
T
T
I
R
E
I
S
I
L
K
---
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------------
H
----
T
----
K
K
-
R
--
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
---
E
G
G
L
E
S
V
T
------
A
-
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
G
I
P
V
R
----
K
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
-------
P
K
Y
DP
N
F
T
V
-
Y
-
E
P
L
---
P
W
E
S
F
L
K
G
----
L
D
------
E
-
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
-
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----
K
E
------------------------------------------------------------------------
41
Blastp_CBE
78.48
44%
-52
- C1 -
-
5FP5
3
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
--------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
563
HHSearch
78.36
40%
-76
- C1 -
-
4AU8
2
CDK5_HUMAN
B:
[6-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
-
R
E
T
H
E
I
V
A
L
K
R
V
R
L
----
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
---
E
L
K
H
K
N
I
V
R
L
H
D
V
L
------
H
S
---------------
K
-
K
--
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
C
---
N
G
D
L
D
P
E
I
------
V
-
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
N
G
---
E
L
K
L
A
D
F
G
L
A
R
A
F
G
I
P
V
--------------
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
-
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-------
P
D
Y
--
K
P
Y
P
-
M
---
Y
---
P
A
T
T
S
L
V
N
V
V
P
K
L
N
------
A
-
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
-
R
I
S
A
E
E
A
L
Q
H
P
Y
F
-----
S
D
F
-----------------------------------------------------------------------
189
Blastp_CBE
78.16
44%
-56
- C1 -
-
1OIQ
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
--------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
188
Blastp_CBE
77.98
44%
-51
- C1 -
-
1P2A
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----------
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
178
Blastp_CBE
77.43
44%
-62
- C1 -
-
1PYE
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
---------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
------------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
42
Blastp_CBE
77.43
44%
-52
- C1 -
-
5D1J
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
--------------
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
-------------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
71
Blastp_CBE
76.91
44%
-51
- C1 -
-
4D1Z
2
CDK2_HUMAN
A:
[3-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
Q
K
V
E
K
I
G
----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
-----------------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
-------------------------
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
46
Blastp_CBE
76.82
44%
-55
- C1 -
-
5ANG
1
CDK2_HUMAN
A:
[2-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
--------------------
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
----------------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
529
Blastp_CBE
75.86
42%
-67
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
-
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
-
E
G
A
P
C
T
A
I
R
E
V
S
L
L
K
---
D
L
K
H
A
N
I
V
T
L
H
D
I
I
------------
H
----
T
----
E
K
-
S
--
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
C
---
G
N
I
I
N
M
H
N
------
V
-
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
-
R
G
---
E
L
K
L
A
D
F
G
L
A
R
A
--------------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
T
G
-
R
P
L
F
P
G
S
T
V
-
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
------------
I
L
--
S
N
E
E
-
F
-
K
T
-----
Y
N
Y
P
K
Y
R
A
E
A
L
L
S
HAPRLD
S
-
D
G
A
D
L
L
T
K
L
L
Q
-
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
LSLGE
R
I
H
-
K
L
P
-
D
T
T
S
I
F
------------------------------------------------------------
400
Blastp_CBE
75.27
44%
-22
- C1 -
-
1E9H
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
416
Blastp_CBE
75.16
44%
-15
- C1 -
-
4CFX
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
491
Blastp_CBE
75.08
42%
-75
- C1 -
-
1V0P
1
CDC2H_PLAFK
B:
[2-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
-
N
-
Y
G
E
T
F
A
L
K
-----------
P
S
T
T
I
R
E
I
S
I
L
K
---
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
------------
H
----
T
----------
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
V
C
---
E
G
G
L
E
S
V
T
------
A
-
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
-
E
G
---
E
L
K
I
A
D
F
G
L
A
R
A
F
---------------------
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
-
T
P
L
F
P
G
V
S
E
-
A
D
Q
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
-------
P
K
Y
DP
N
F
T
V
-
Y
-
E
P
L
---
P
W
E
S
F
L
K
G
----
L
D
------
E
-
S
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
-
R
I
T
A
K
Q
A
L
E
H
A
Y
F
-----
K
E
------------------------------------------------------------------------
429
Blastp_CBE
74.94
44%
-17
- C1 -
-
1H1P
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
336
Blastp_CBE
74.92
44%
-21
- C1 -
-
1OI9
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
432
Blastp_CBE
74.85
44%
-24
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
425
Blastp_CBE
74.80
44%
-15
- C1 -
-
1H1R
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
350
Blastp_CBE
74.64
44%
-18
- C1 -
-
3DDQ
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
341
Blastp_CBE
74.43
44%
-19
- C1 -
-
4EOR
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
424
Blastp_CBE
74.41
44%
-20
- C1 -
-
1H1S
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
337
Blastp_CBE
74.38
44%
-19
- C1 -
-
1OI9
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
354
Blastp_CBE
74.29
44%
-19
- C1 -
-
2G9X
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
399
Blastp_CBE
74.25
44%
-10
- C1 -
-
1E9H
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
433
Blastp_CBE
74.22
44%
-15
- C1 -
-
4EON
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
427
Blastp_CBE
74.21
44%
-21
- C1 -
-
1H1Q
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
362
Blastp_CBE
74.19
44%
-21
- C1 -
-
1P5E
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
330
Blastp_CBE
74.14
44%
-17
- C1 -
-
4CFN
1
CDK2_HUMAN
C:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
423
Blastp_CBE
74.05
44%
-21
- C1 -
-
1H1S
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
457
Blastp_CBE
74.11
44%
-22
- C1 -
-
2UZL
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
383
Blastp_CBE
74.05
44%
-21
- C1 -
-
3BHT
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
459
Blastp_CBE
74.01
44%
-19
- C1 -
-
2UZE
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
467
Blastp_CBE
73.96
44%
-19
- C1 -
-
2C6T
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
394
Blastp_CBE
73.94
44%
-17
- C1 -
-
4EOI
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
345
Blastp_CBE
73.88
44%
-19
- C1 -
-
5LMK
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
458
Blastp_CBE
73.83
44%
-19
- C1 -
-
2UZE
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
414
Blastp_CBE
73.82
44%
-17
- C1 -
-
5CYI
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
418
Blastp_CBE
73.71
44%
-15
- C1 -
-
4CFW
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
342
Blastp_CBE
73.59
44%
-20
- C1 -
-
4EOS
1
CDK2_HUMAN
C:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
379
Blastp_CBE
73.61
44%
-18
- C1 -
-
3BHV
2
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
462
Blastp_CBE
73.60
44%
-21
- C1 -
-
2UZB
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
329
Blastp_CBE
73.59
44%
-19
- C1 -
-
6GUB
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
487
Blastp_CBE
73.56
41%
-10
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
------
M
Q
----
D
----
S
-------
R
--
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
---
P
----
P
G
Q
YMDSSL
V
-
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
-------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
QDYKNTF
P
K
W
--
K
P
G
S
-
L
-
A
S
H
---
V
K
N
---------
L
D
------
E
-
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
-
R
I
S
G
K
M
A
L
N
H
P
Y
F
-----
N
D
------------------------------------------------------------------------
439
Blastp_CBE
73.52
44%
-59
- C1 -
-
2R3N
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
472
Blastp_CBE
73.42
44%
-11
- C1 -
-
4I3Z
3
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
388
Blastp_CBE
73.49
44%
-20
- C1 -
-
4BCQ
1
CDK2_HUMAN
C:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
372
Blastp_CBE
73.41
44%
-26
- C1 -
-
4BCK
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
456
Blastp_CBE
73.46
44%
-18
- C1 -
-
2UZL
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
387
Blastp_CBE
73.40
44%
-21
- C1 -
-
4EOQ
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
412
Blastp_CBE
73.39
44%
-14
- C1 -
-
5NEV
1
?
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
488
Blastp_CBE
73.37
41%
-6
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
------
M
Q
----
D
----
S
-------
R
--
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
---
P
----
P
G
Q
YMDSSL
V
-
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
----
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
QDYKNTF
P
K
W
--
K
P
G
S
-
L
-
A
S
H
---
V
K
N
---------
L
D
------
E
-
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
-
R
I
S
G
K
M
A
L
N
H
P
Y
F
-----
N
D
------------------------------------------------------------------------
413
Blastp_CBE
73.44
44%
-16
- C1 -
-
5NEV
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
355
Blastp_CBE
73.43
44%
-21
- C1 -
-
2CCI
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
360
Blastp_CBE
73.42
44%
-15
- C1 -
-
1QMZ
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
356
Blastp_CBE
73.41
44%
-17
- C1 -
-
2CCI
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
359
Blastp_CBE
73.40
44%
-16
- C1 -
-
1QMZ
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
352
Blastp_CBE
73.39
44%
-14
- C1 -
-
3DDP
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
473
Blastp_CBE
73.38
44%
-12
- C1 -
-
4I3Z
4
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
486
Blastp_CBE
73.37
41%
-6
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
------
M
Q
----
D
----
S
-------
R
--
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
---
P
----
P
G
Q
YMDSSL
V
-
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
----
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
QDYKNTF
P
K
W
--
K
P
G
S
-
L
-
A
S
H
---
V
K
N
---------
L
D
------
E
-
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
-
R
I
S
G
K
M
A
L
N
H
P
Y
F
-----
N
D
------------------------------------------------------------------------
407
Blastp_CBE
73.33
44%
-16
- C1 -
-
4EOK
1
CDK2_HUMAN
C:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
381
Blastp_CBE
73.27
44%
-19
- C1 -
-
3BHU
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
339
Blastp_CBE
73.26
44%
-18
- C1 -
-
1OGU
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
390
Blastp_CBE
73.24
44%
-20
- C1 -
-
4BCM
1
CDK2_HUMAN
C:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
374
Blastp_CBE
73.15
44%
-17
- C1 -
-
3TNW
1
CDK2_HUMAN
C:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
361
Blastp_CBE
73.17
44%
-16
- C1 -
-
1P5E
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
323
Blastp_CBE
73.16
44%
-12
- C1 -
-
6GUF
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
326
Blastp_CBE
73.15
44%
-22
- C1 -
-
6GUC
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
319
Blastp_CBE
73.14
44%
-18
- C1 -
-
2IW9
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
392
Blastp_CBE
73.13
44%
-15
- C1 -
-
4EOP
1
CDK2_HUMAN
C:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
482
Blastp_CBE
73.05
41%
-5
- C1 -
-
6GU3
1
CDK1_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
------
M
Q
----
D
----
S
-------
R
--
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
---
P
----
P
G
Q
YMDSSL
V
-
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
H
E
----
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
QDYKNTF
P
K
W
--
K
P
G
S
-
L
-
A
S
H
---
V
K
N
---------
L
D
------
E
-
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
-
R
I
S
G
K
M
A
L
N
H
P
Y
F
-----
N
D
------------------------------------------------------------------------
411
Blastp_CBE
73.06
44%
-20
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
402
Blastp_CBE
73.06
44%
-15
- C1 -
-
4CFV
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
375
Blastp_CBE
73.12
44%
-21
- C1 -
-
3TNW
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
428
Blastp_CBE
73.05
44%
-19
- C1 -
-
1H1Q
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
348
Blastp_CBE
73.06
44%
-17
- C1 -
-
3DOG
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
357
Blastp_CBE
73.05
44%
-14
- C1 -
-
2CCH
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
332
Blastp_CBE
73.04
44%
-19
- C1 -
-
1OIY
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
476
Blastp_CBE
73.00
44%
-14
- C1 -
-
3QHR
2
CDK2_HUMAN
C:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
391
Blastp_CBE
72.93
44%
-16
- C1 -
-
4BCM
1
CDK2_HUMAN
A:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
370
Blastp_CBE
72.92
44%
-16
- C1 -
-
4BCN
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
358
Blastp_CBE
72.92
44%
-15
- C1 -
-
2CCH
3
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
335
Blastp_CBE
72.96
44%
-18
- C1 -
-
1OIU
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
321
Blastp_CBE
72.93
44%
-19
- C1 -
-
2IW6
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
333
Blastp_CBE
72.92
44%
-21
- C1 -
-
1OIY
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
377
Blastp_CBE
72.90
44%
-20
- C1 -
-
3MY5
3
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
322
Blastp_CBE
72.89
44%
-18
- C1 -
-
6GUE
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
N
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
461
Blastp_CBE
72.88
44%
-17
- C1 -
-
2UZD
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
327
Blastp_CBE
72.85
44%
-22
- C1 -
-
6GUC
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
-----
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
397
Blastp_CBE
72.84
44%
-17
- C1 -
-
1PKD
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
404
Blastp_CBE
72.71
44%
-16
- C1 -
-
4CFU
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
398
Blastp_CBE
72.74
44%
-18
- C1 -
-
1PKD
1
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
384
Blastp_CBE
72.72
44%
-13
- C1 -
-
4EOO
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
367
Blastp_CBE
72.71
44%
-14
- C1 -
-
4BCP
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
426
Blastp_CBE
72.68
44%
-17
- C1 -
-
1H1R
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
477
Blastp_CBE
72.67
44%
-16
- C1 -
-
3QHR
6
CDK2_HUMAN
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
421
Blastp_CBE
72.51
44%
-14
- C1 -
-
4CFM
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
389
Blastp_CBE
72.56
44%
-24
- C1 -
-
4BCQ
1
CDK2_HUMAN
A:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
-----
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
320
Blastp_CBE
72.55
44%
-21
- C1 -
-
2IW6
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
351
Blastp_CBE
72.51
44%
-20
- C1 -
-
3DDP
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
463
Blastp_CBE
72.43
44%
-16
- C1 -
-
2UZB
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
371
Blastp_CBE
72.49
44%
-15
- C1 -
-
4BCN
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
470
Blastp_CBE
72.46
44%
-16
- C1 -
-
1JST
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
480
Blastp_CBE
72.44
41%
-13
- C1 -
-
6GU6
1
CDK1_HUMAN
A:
[6-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
------
M
Q
----
D
----
S
-------
R
--
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
---
P
----
P
G
Q
YMDSSL
V
-
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
-------
T
H
E
----
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
QDYKNTF
P
K
W
--
K
P
G
S
-
L
-
A
S
H
---
V
K
N
---------
L
D
------
E
-
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
-
R
I
S
G
K
M
A
L
N
H
P
Y
F
-----
N
D
------------------------------------------------------------------------
434
Blastp_CBE
72.43
44%
-18
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
405
Blastp_CBE
72.40
44%
-15
- C1 -
-
4EOL
1
CDK2_HUMAN
C:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
373
Blastp_CBE
72.34
44%
-20
- C1 -
-
4BCK
2
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
483
Blastp_CBE
72.33
41%
-11
- C1 -
-
6GU2
1
CDK1_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
-
K
T
T
G
Q
V
V
A
M
K
K
I
R
L
E
S
E
E
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
R
H
P
N
I
V
S
L
Q
D
V
L
------
M
Q
----
D
----
S
-------
R
--
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
I
---
P
----
P
G
Q
YMDSSL
V
-
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
-
K
G
---
T
I
K
L
A
D
F
G
L
A
R
A
F
G
I
P
I
R
----
V
Y
T
-------
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
T
K
-
K
P
L
F
H
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
QDYKNTF
P
K
W
--
K
P
G
S
-
L
-
A
S
H
---
V
K
N
---------
L
D
------
E
-
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
-
R
I
S
G
K
M
A
L
N
H
P
Y
F
-----
N
D
------------------------------------------------------------------------
475
Blastp_CBE
72.24
44%
-13
- C1 -
-
3QHW
2
CDK2_HUMAN
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
343
Blastp_CBE
72.27
44%
-20
- C1 -
-
4EOS
1
CDK2_HUMAN
A:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
---
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
385
Blastp_CBE
72.24
44%
-21
- C1 -
-
4EOO
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
369
Blastp_CBE
72.23
44%
-13
- C1 -
-
4BCO
1
CDK2_HUMAN
A:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
328
Blastp_CBE
72.17
44%
-17
- C1 -
-
6GUB
1
?
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
--------
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
419
Blastp_CBE
72.15
44%
-17
- C1 -
-
4CFW
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
415
Blastp_CBE
72.12
44%
-20
- C1 -
-
5CYI
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
469
Blastp_CBE
71.97
44%
-19
- C1 -
-
1JST
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
455
Blastp_CBE
72.03
44%
-16
- C1 -
-
4II5
2
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
454
Blastp_CBE
71.95
44%
-16
- C1 -
-
4II5
3
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
408
Blastp_CBE
71.97
44%
-17
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
324
Blastp_CBE
71.95
44%
-15
- C1 -
-
6GUF
1
CDK2_HUMAN
A:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
364
Blastp_CBE
71.94
44%
-14
- C1 -
-
1GY3
1
CDK2_HUMAN
A:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
474
Blastp_CBE
71.93
44%
-14
- C1 -
-
3QHW
3
CDK2_HUMAN
C:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
466
Blastp_CBE
71.83
44%
-16
- C1 -
-
2C6T
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
395
Blastp_CBE
71.77
44%
-15
- C1 -
-
4EOI
2
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
D
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
363
Blastp_CBE
71.77
44%
-16
- C1 -
-
1GY3
2
CDK2_HUMAN
C:
[2-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
344
Blastp_CBE
71.76
44%
-15
- C1 -
-
6GVA
3
CDK2_HUMAN
A:
[2-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
--------------------------------------------------------------------
346
Blastp_CBE
71.65
44%
-16
- C1 -
-
5L2W
2
CDK2_HUMAN
A:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
393
Blastp_CBE
71.59
44%
-16
- C1 -
-
4EOP
1
CDK2_HUMAN
A:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
331
Blastp_CBE
71.56
44%
-15
- C1 -
-
4CFN
1
CDK2_HUMAN
A:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
417
Blastp_CBE
71.52
44%
-12
- C1 -
-
4CFX
1
CDK2_HUMAN
A:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
460
Blastp_CBE
71.47
44%
-17
- C1 -
-
2UZD
1
CDK2_HUMAN
C:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
504
Blastp_CBE
71.39
40%
-27
- C1 -
-
4NST
3
C:
[8-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T----------------------
D
-
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
-
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
S
K
M
A
P
P
D
L
P
H
W
---------------------------------------------------------
516
Blastp_CBE
71.17
40%
-21
- C1 -
-
6B3E
1
CDK12_HUMAN
A:
[4-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T----------------------
D
-
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
S
K
M
A
P
P
D
L
P
H
W
---------------------------------------------------------
353
Blastp_CBE
71.09
44%
-28
- C1 -
-
2G9X
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
---------------------------------------
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
338
Blastp_CBE
71.07
44%
-31
- C1 -
-
1OGU
1
CDK2_HUMAN
C:
[2-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
382
Blastp_CBE
71.02
44%
-34
- C1 -
-
3BHT
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
325
Blastp_CBE
70.94
44%
-16
- C1 -
-
6GUE
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
-----
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
------
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
378
Blastp_CBE
70.90
44%
-30
- C1 -
-
3BHV
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
380
Blastp_CBE
70.89
44%
-32
- C1 -
-
3BHU
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
515
Blastp_CBE
70.86
40%
-24
- C1 -
-
6B3E
3
C:
[4-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
T----------------------
D
-
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
S
K
M
A
P
P
D
L
P
H
W
---------------------------------------------------------
316
Blastp_CBE
70.64
45%
-32
- C1 -
-
2IW8
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
H
V
D
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------------
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
403
Blastp_CBE
70.60
44%
-29
- C1 -
-
4CFU
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
410
Blastp_CBE
70.59
44%
-31
- C1 -
-
4EOJ
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
--------------------------------
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
396
Blastp_CBE
70.53
44%
-34
- C1 -
-
5LMK
1
?
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------------
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
471
Blastp_CBE
70.50
44%
-13
- C1 -
-
1FQ1
1
CDK2_HUMAN
B:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
420
Blastp_CBE
70.37
44%
-31
- C1 -
-
4CFM
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
---------------------------------------------
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
318
Blastp_CBE
70.32
44%
-32
- C1 -
-
2IW9
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
T
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
-------------------------------------------
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
347
Blastp_CBE
70.30
44%
-30
- C1 -
-
3DOG
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------------
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
406
Blastp_CBE
70.26
44%
-15
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[3-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
S
----
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
368
Blastp_CBE
69.88
44%
-24
- C1 -
-
4BCO
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
------------------------------------------
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
334
Blastp_CBE
69.80
44%
-32
- C1 -
-
1OIU
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------------
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
340
Blastp_CBE
69.66
44%
-32
- C1 -
-
4EOR
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
---------------------------------------
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
376
Blastp_CBE
69.61
44%
-32
- C1 -
-
3MY5
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
---------------------------------------------
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
349
Blastp_CBE
69.39
44%
-28
- C1 -
-
3DDQ
1
CDK2_HUMAN
C:
[1-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
----------------------------------------------
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
505
Blastp_CBE
69.27
40%
-2
- C1 -
-
4NST
3
CDK12_HUMAN
A:
[8-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
TDKQD---------------------GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
S
K
M
A
P
P
D
L
P
H
W
---------------------------------------------------------
386
Blastp_CBE
69.22
44%
-33
- C1 -
-
4EOQ
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
514
Blastp_CBE
69.04
40%
-2
- C1 -
-
5EFQ
2
CDK13_HUMAN
A:
[6-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
TDKE----------------------GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
N
E
N
H
------
I
-
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
R
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
Q
E
-
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
K
L
R
E
E
F
-
V
F
I
P
------
A
-
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
-
R
C
T
A
E
Q
A
L
Q
C
E
F
L
-----
R
D
V
E
P
S
K
-
M
P
P
P
D
L
P
L
W
---------------------------------------------------------
551
HHSearch
69.01
34%
-17
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[53-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
---
H
F
K
H
D
N
I
I
A
I
K
D
I
L
------
R
P
----
T
VPYG
E
----
F
K
-
S
--
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
----
Q
P
L
T
L
E
H
------
V
-
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
---
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
----
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
-
R
Q
L
F
P
G
K
N
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
-------
R
V
R
--
A
Y
I
Q
S
L
P
P
R
Q
---
P
V
-
P
W
-
E
T
V
Y
P
G
A
D
------
R
-
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
-
R
I
S
A
A
A
A
L
R
H
P
F
L
-----
A
K
Y
-
H
D
P
-------------------------------------------------------------------
554
HHSearch
69.00
34%
-12
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[5-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
-
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
---
H
F
K
H
D
N
I
I
A
I
K
D
I
L
------
R
P
TVPY
G
----
E
----
F
K
-
S
--
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
----
Q
P
L
T
L
E
H
------
V
-
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
-
N
C
---
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
----
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
-
R
Q
L
F
P
G
K
N
Y
-
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
-------
R
V
R
--
A
Y
I
Q
S
L
P
P
R
Q
---
P
V
-
P
W
-
E
T
V
Y
P
G
A
D
------
R
-
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
-
R
I
S
A
A
A
A
L
R
H
P
F
L
-----
A
K
Y
-
H
D
P
-
D
-----------------------------------------------------------------
366
Blastp_CBE
68.82
44%
-26
- C1 -
-
4BCP
1
CDK2_HUMAN
C:
[2-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
-----------------------------------------
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
501
Blastp_CBE
68.66
40%
-3
- C1 -
-
4CXA
1
CDK12_HUMAN
A:
[8-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
TDKQ--
L
D
----
F
----
K
----
K
D
-
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
-----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
S
K
M
A
P
P
D
L
P
H
W
---------------------------------------------------------
513
Blastp_CBE
68.57
40%
-3
- C1 -
-
5EFQ
2
C:
[6-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
R
D
-
K
D
T
G
E
M
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
T
H
Q
S
I
I
N
M
K
E
I
V
TDKE----------------------GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
N
E
N
H
------
I
-
K
S
F
M
R
Q
L
M
E
G
L
D
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
R
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
S
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
Q
E
-
L
A
Q
L
E
L
I
S
R
I
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
K
L
R
E
E
F
-
V
F
I
P
------
A
-
A
A
L
D
L
F
D
Y
M
L
A
L
D
P
S
K
-
R
C
T
A
E
Q
A
L
Q
C
E
F
L
-----
R
D
V
E
P
S
K
-
M
P
P
P
D
L
P
L
W
---------------------------------------------------------
560
HHSearch
68.46
31%
-20
- C1 -
-
1J1B
1
GSK3B_HUMAN
A:
[53-344]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
R
------
F
K
N
R
E
L
Q
I
M
R
---
K
L
D
H
C
N
I
V
R
L
R
Y
F
F
------
Y
S
----
S
----
G
EKKD
E
V
-
Y
--
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
SRA
K
Q
T
L
P
V
I
Y
------
V
-
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
---
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
V
S
Y
----
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
-
Q
P
I
F
P
G
D
S
G
-
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
---------
N
Y
--
T
E
F
K
-
F
-
P
Q
I
---
K
A
H
P
W
T
K
V
F
R
P
R
T
P
------
P
-
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
-
R
L
T
P
L
E
A
C
A
H
S
F
F
-----
D
E
L
-
R
---------------------------------------------------------------------
431
Blastp_CBE
68.39
44%
-28
- C1 -
-
4EOM
1
CDK2_HUMAN
C:
[4-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
401
Blastp_CBE
67.99
44%
-31
- C1 -
-
4CFV
1
CDK2_HUMAN
C:
[5-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
E
N
F
Q
K
V
E
K
I
G
E
--
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
H
E
V
----
V
-
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
---------------------------------------------
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
500
Blastp_CBE
67.97
40%
9
- C1 -
-
5ACB
1
CDK12_HUMAN
C:
[8-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
TDKQDA
L
D
----
F
----
K
----
K
D
-
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
S
K
M
A
P
P
D
L
P
H
W
---------------------------------------------------------
499
Blastp_CBE
66.45
40%
3
- C1 -
-
5ACB
1
D:
[8-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
TDKQ--------
F
----
K
----
K
D
-
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
---
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
S
K
M
A
P
P
D
L
P
H
W
---------------------------------------------------------
533
Blastp_CBE
66.07
38%
-13
- C1 -
-
4BCJ
1
CDK9_HUMAN
A:
[14-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Q
G
T
F
G
E
V
F
K
A
R
H
-
R
K
T
G
Q
K
V
A
L
K
K
V
L
M
E
N
E
K
E
G
F
P
I
T
A
L
R
E
I
K
I
L
Q
---
L
L
K
H
E
N
V
V
N
L
I
E
I
C
RTK-------------------
K
G
-
S
--
I
Y
L
V
F
D
F
C
E
H
D
L
A
G
L
L
S
N
V
---
L
V
K
F
T
L
S
E
------
I
-
K
R
V
M
Q
M
L
L
N
G
L
Y
Y
I
H
R
N
K
I
L
H
R
D
M
K
A
A
N
V
L
I
T
R
-
D
G
---
V
L
K
L
A
D
F
G
L
A
R
A
F
-
S
L
A
--------
P
N
RYNR
V
V
T
L
W
Y
R
P
P
E
L
L
L
G
E
R
D
Y
G
P
P
I
D
L
W
G
A
G
C
I
M
A
E
M
W
T
R
-
S
P
I
M
Q
G
N
T
E
-
Q
H
Q
L
A
L
I
S
Q
L
C
G
S
I
T
P
E
V
W
P
N
V
D
N
Y
-------
E
L
Y
--
E
K
L
E
-
L
-
V
K
G
---
Q
K
R
K
V
K
D
R
L
K
A
Y
V
R
------
D
P
Y
A
L
D
L
I
D
K
L
L
V
L
D
P
A
Q
-
R
I
D
S
D
D
A
L
N
H
D
F
F
-----
W
S
D
-
P
M
P
-
S
D
----------------------------------------------------------------
503
Blastp_CBE
65.79
40%
2
- C1 -
-
6CKX
1
CDK12_HUMAN
A:
[10-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
TD-----------------------
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
--------------------------------------------------------------------
522
Blastp_CBE
64.76
40%
-0
- C1 -
-
5L2T
1
CDK6_HUMAN
A:
[11-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
Y
E
C
V
A
E
I
G
E
G
A
Y
G
K
V
F
K
A
R
D
L
K
N
G
G
R
F
V
A
L
K
R
V
R
V
---------
S
T
I
R
E
V
A
V
L
R
HLE
T
F
E
H
P
N
V
V
R
L
F
D
V
C
------------------------T
K
--
L
T
L
V
F
E
H
V
D
Q
D
L
T
T
Y
L
D
K
V
---
P
E
P
G
V
P
T
E
T-----
I
-
K
D
M
M
F
Q
L
L
R
G
L
D
F
L
H
S
H
R
V
V
H
R
D
L
K
P
Q
N
I
L
V
T
S
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
----------------------
V
T
L
W
Y
R
A
P
E
V
L
L
Q
S
-
S
Y
A
T
P
V
D
L
W
S
V
G
C
I
F
A
E
M
F
R
R
-
K
P
L
F
R
G
S
S
D
-
V
D
Q
L
G
K
I
L
D
V
I
G
L
P
G
E
E
D
W
P
R
D
V
A
L
-------
P
R
Q
--
A
F
H
S
-
K
-
S
A
Q
---
P
I
----
E
K
F
V
T
D
I
D
------
E
-
L
G
K
D
L
L
L
K
C
L
T
F
N
P
A
K
-
R
I
S
A
Y
S
A
L
S
H
P
Y
F
-----
Q
-------------------------------------------------------------------------
502
Blastp_CBE
64.73
40%
2
- C1 -
-
6CKX
1
C:
[10-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
C
V
D
K
F
D
I
I
G
I
I
G
E
G
T
Y
G
Q
V
Y
K
A
K
D
-
K
D
T
G
E
L
V
A
L
K
K
V
R
L
D
N
E
K
E
G
F
P
I
T
A
I
R
E
I
K
I
L
R
---
Q
L
I
H
R
S
V
V
N
M
K
E
I
V
TD-----------------------
K
GA
F
Y
L
V
F
E
Y
M
D
H
D
L
M
G
L
L
E
S
G
---
L
V
H
F
S
E
D
H
------
I
-
K
S
F
M
K
Q
L
M
E
G
L
E
Y
C
H
K
K
N
F
L
H
R
D
I
K
C
S
N
I
L
L
N
N
-
S
G
---
Q
I
K
L
A
D
F
G
L
A
R
L
Y
N
S
E
E
S
----
R
P
Y
N
K
----
V
I
T
L
W
Y
R
P
P
E
L
L
L
G
E
E
R
Y
T
P
A
I
D
V
W
S
C
G
C
I
L
G
E
L
F
T
K
-
K
P
I
F
Q
A
N
L
E
-
L
A
Q
L
E
L
I
S
R
L
C
G
S
P
C
P
A
V
W
P
D
V
I
K
L
-------
P
Y
F
--
N
T
M
K
-
P
-
K
K
Q
---
Y
R
R
R
L
R
E
E
F
-
S
F
I
P
------
S
-
A
A
L
D
L
L
D
H
M
L
T
L
D
P
S
K
-
R
C
T
A
E
Q
T
L
Q
S
D
F
L
-----
K
D
V
-
E
L
--------------------------------------------------------------------
453
Blastp_CBE
52.38
44%
-2
- C1 -
-
1H01
3
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
452
Blastp_CBE
52.13
44%
-0
- C1 -
-
1OIR
1
CDK2_HUMAN
A:
[1-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
-
K
L
T
G
E
V
V
A
L
K
-
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
---
E
L
N
H
P
N
I
V
K
L
L
D
V
I
------
H
T
----
E
----
N
-------
K
--
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
---
A
L
T
G
I
P
L
P
L-----
I
-
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
-
E
G
---
A
I
K
L
A
D
F
G
L
A
R
A
F
G
V
P
V
R
----
T
Y
T
H
E
----
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
-
R
A
L
F
P
G
D
S
E
-
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
-------
P
D
Y
--
K
P
-
S
-
F
-
P
K
W
---
A
R
Q
D
F
S
K
V
V
P
P
-
L
D
------
E
-
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
-
R
I
S
A
K
A
A
L
A
H
P
F
F
-----
Q
D
V
-
T
K
P
-
V
-----------------------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------