@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CDC7_HUMAN: (2020-09-05 )
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Atome Classification :
(20 SA)
----------------------.........10........20........30........40.....-------...50........60........70........80........------90.-----....-----...100.......110.......120.....--.----..130.-------......140....----.------.-----.150.......160.......170.......180...--....190.......200.......210.......220......----------.230.......240........250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380......------.390.........400.......-410..-------------------------.....420.......430.......440.......450.......460.......470.......480.......490.-......500.......510..---.....520.......530.......540......------.550.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQN
F
K
LA
G
V
K
K
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
IEDKIGEGTF
S
S
V
Y
L
A
T
A
Q
L
QVGPE
E
K
I
A
L
------
K
H
L-----IPTS-----H
P
I
R
I
A
A
E
L
Q
C
L
T
VAGGQDN
V
M
G
V
K
-
Y
C
FRK--N----D
H
V
V
I
A-------MPYLE
H
E
S
F
L
D
I
L
----
N
------S-----L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
FG
I
V
HRDVKPS
N
F
L
Y
--
N
R
RL
K
K
Y
A
L
V
D
FGLAQGTH
D
T
K
I
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
CSQNK
S
----------
H
I
ITGNKIPLSG-PV
P
K
E
L
D
QQSTTKASVKRPYTN
A
Q
I
Q
I
KQGKDGKEGSV
G
L
S
V
Q
R
S
VFGERN
F
N
I
HSSISHE
S
P
A
V
K
L
M
K
QS
K
T
V
D
V
L
S
R
K
L
A
T
K
K
K
A
I
S
T
K
V
M
N
S
A
V
M
R
K
T
ASSCPA
S
L
T
C
D
CYA
T
D
K
V
C
S
I
C
L
S
R
R
Q
QVAPRAGTPGFRA
P
E
V
L
T
KC------PN--Q
T
T
A
I
D
M
W
S
A
G
V
I
F
L
S
L
LS-GRYPF-------------------------YKASD
D
L
T
A
L
A
Q
I
M
T
IRGS
R
E
T
I
Q
A
A
K
T
F
G
K
S
ILCSKEV
P
A
Q
D
L
R
K
L
C
E
R
L
RGMDSSTPK
L
T
S
DIQGHASHQPAISEKT-DHK
A
S
C
L
V
QTPPGQYSGNSFK---KGDSN
S
C
E
H
C
F
D
E
YNTNLEGWNEV
P
D
E
A
Y
D
L
L
D
K
------
L
LDLNPASRI
T
A
E
E
A
L
L
H
P
F
F
K
DMSL
22
Blastp_CBE
84.88
99%
-132
- C3 -
-
4F9A
1
CDC7_HUMAN
C:
[2-249]
----------------------------------------------------------
L
A
G
V
K
K
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
H
D
T
K
I
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
C
S
Q
N
K
C
----------
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.81
98%
-131
- C3 -
-
4F9A
1
CDC7_HUMAN
A:
[4-249]
------------------------------------------------------------
G
V
K
K
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
H
D
T
K
I
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
C
S
Q
N
K
C
----------
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
82.82
99%
-123
- C3 -
-
4F9B
1
CDC7_HUMAN
C:
[2-249]
----------------------------------------------------------
L
A
G
V
K
K
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
H
D
T
K
I
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
C
S
Q
N
K
C
----------
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.51
98%
-129
- C3 -
-
4F99
1
CDC7_HUMAN
A:
[6-250]
--------------------------------------------------------------
K
K
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
H
D
T
K
I
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
C
S
Q
N
K
C
----------
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.19
98%
-120
- C3 -
-
4F9B
1
CDC7_HUMAN
A:
[4-249]
------------------------------------------------------------
G
V
K
K
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
H
D
T
K
I
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
C
S
Q
N
K
C
----------
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.01
98%
-123
- C3 -
-
4F9C
1
CDC7_HUMAN
A:
[6-250]
--------------------------------------------------------------
K
K
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
H
D
T
K
I
E
L
L
K
F
V
Q
S
E
A
Q
Q
E
R
C
S
Q
N
K
C
----------
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
HHSearch
74.09
100%
-145
- C3 -
-
4F9B
1
CDC7_HUMAN
A:
[9-206]
-----------------------------------------------------------------
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
HHSearch
73.47
100%
-142
- C3 -
-
4F9C
1
CDC7_HUMAN
A:
[8-216]
----------------------------------------------------------------
D
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
HHSearch
73.32
100%
-148
- C3 -
-
4F9B
1
CDC7_HUMAN
C:
[9-210]
-----------------------------------------------------------------
I
E
K
-------
L
Y
E
A
V
P
Q
L
S
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
S
V
Y
L
A
T
A
Q
L
Q
V
G
P
E
E
K
I
A
L
------
K
H
L
-----
I
P
T
S
-----
H
P
I
R
I
A
A
E
L
Q
C
L
T
V
A
G
G
Q
D
N
V
M
G
V
K
-
Y
C
F
R
K
--
N
----
D
H
V
V
I
A
-------
M
P
Y
L
E
H
E
S
F
L
D
I
L
----
N
------
S
-----
L
S
F
Q
E
V
R
E
Y
M
L
N
L
F
K
A
L
K
R
I
H
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Y
--
N
R
R
L
K
K
Y
A
L
V
D
F
G
L
A
Q
G
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Fugue
64.63
21%
-49
- C4 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
-----------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
G
S
F
----
Q
G
R
P
V
A
V
------
K
R
M
-----
L
-
I
D
-----
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
-
C
S
E
T
T
--
D
----
R
F
L
Y
I
A
-------
L
E
L
C
N
-
L
N
L
Q
D
L
V
----
E
------
S
-------
K
Y
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
--
S
T
S
S
R
F
T
A
----
D
Q
Q
T
G
A
E
N
L
R
I
L
I
S
D
F
---------------------------------------------------------------------------------------------------------------------
G
L
C
K
K
L
D
------------------------------------------------
S
T
S
G
W
R
A
P
E
L
L
E
E
S
NNLQTK
R
R
--
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
GDKYSRESNIIRGIFSLDEMKCLHD
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
P
T
A
M
K
V
L
R
H
P
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
--
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
-
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
K
L
M
DLL
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
RFPNLL
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
---
526
Fugue
58.44
22%
29
- C4 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
SGEVRLRQLEQFILDGPAQTNG
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
----
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
-------
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
---
N
A
D
K
V
F
A
M
------
K
I
L
NKWEM
L
K
R
A
-----
E
T
A
C
F
R
E
E
R
D
V
L
-
V
N
G
D
S
K
W
I
T
T
L
H
-
Y
A
F
Q
D
--
D
----
N
N
L
Y
L
V
-------
M
D
Y
Y
V
G
G
D
L
L
T
L
L
SKFE
D
------
R
-----
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
--
D
M
N
-
G
H
I
R
L
A
D
F
G
-------------------------------------------------------------------------------------------------------------------
S
C
L
K
L
M
E
D
G
T
---
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
-------------------------------------
G
G
K
G
R
Y
G
P
-------------------
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
-
G
E
T
P
F
-------------------------
Y
--
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
Q
F
P
T
Q
V
T
---------
D
V
S
-
E
N
A
K
D
L
I
R
R
L
--
I
C
S
R
E
H
R
L
G
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
---
N
F
D
V
D
S
G
H
H
------
L
P
F
V
G
F
T
Y
T
----------------------
S
S
C
V
L
S
D
R
S
C
L
R
--------
508
HHSearch
49.05
29%
-139
- C3 -
-
6O6Q
1
?
A:
[40-184]
-----------------------------------------------------------------------------------
Q
E
N
Y
E
I
L
R
K
L
G
R
G
K
Y
S
E
V
F
L
G
I
D
L
---
E
K
R
E
K
V
V
I
------
K
V
L
-----
K
P
V
K
------
R
K
K
I
K
R
E
I
S
I
L
K
N
L
V
D
G
P
N
I
I
A
M
L
-
D
V
V
R
E
--------
T
P
G
L
I
-------
F
E
H
I
N
N
I
D
F
R
S
L
Y
----
P
------
T
-----
F
T
D
Y
D
I
R
F
Y
M
Y
E
L
L
K
A
L
D
Y
S
H
S
M
G
I
M
H
R
D
V
K
P
H
N
V
M
I
--
D
H
D
K
K
L
L
R
L
I
D
W
G
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
45.68
30%
-36
- C3 -
-
3SV0
-
?
A:
[3-159]
--------------------------------------------------------------------------------
P
R
V
G
N
K
F
R
L
G
R
K
I
G
S
G
S
F
G
E
I
Y
L
G
T
-
N
I
Q
T
N
E
E
V
A
I
K
L
------
E
N
------
V
K
T
K
-----
H
P
-
Q
L
L
Y
E
S
K
I
Y
R
I
L
Q
G
G
T
G
I
P
N
V
R
-
W
F
G
V
E
--
G
----
D
Y
N
V
L
V
-------
M
D
L
L
-
G
P
S
L
E
D
L
F
----
N
FCSR--
K
-----
L
S
L
K
T
V
L
M
L
A
D
Q
M
I
N
R
V
E
F
V
H
S
K
S
F
L
H
R
D
I
K
P
D
N
F
L
M
GL
G
R
R
A
N
Q
V
Y
I
I
D
F
G
L
A
K
K
Y
R
D
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
HHSearch
44.92
28%
-48
- C3 -
-
5ONI
2
CSK21_HUMAN
B:
[36-181]
-----------------------------------------------------------------------------------
Q
D
D
Y
Q
L
V
R
K
L
G
R
G
K
Y
S
E
V
F
E
A
I
N
I
---
T
N
N
E
K
V
V
V
------
K
I
L
-----
K
P
V
K
------
K
K
K
I
K
R
E
I
K
I
L
E
N
L
R
G
G
P
N
I
I
T
L
A
-
D
I
V
K
D
PV
S
----
R
T
P
A
L
V
-------
F
E
H
V
N
N
T
D
F
K
Q
L
Y
----
Q
------
T
-----
L
T
D
Y
D
I
R
F
Y
M
Y
E
I
L
K
A
L
D
Y
C
H
S
M
G
I
M
H
R
D
V
K
P
H
N
V
M
I
--
D
H
E
H
R
K
L
R
L
I
D
W
G
L
A
E
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
HHSearch
44.84
27%
-51
- C3 -
-
5XVU
3
?
C:
[30-174]
-----------------------------------------------------------------------------------
P
N
R
Y
E
I
M
K
K
I
G
R
G
K
Y
S
E
V
F
N
G
Y
D
T
---
E
C
N
R
P
C
A
I
------
K
V
L
-----
K
P
V
K
------
K
K
K
I
K
R
E
I
K
I
L
Q
N
L
N
G
G
P
N
I
I
K
L
L
-
D
I
V
K
D
PV
T
----
K
T
P
S
L
I
-------
F
E
Y
I
N
N
I
D
F
K
T
L
Y
----
P
------
K
-----
F
T
D
K
D
I
R
Y
Y
I
Y
Q
I
L
K
A
L
D
Y
C
H
S
Q
G
I
M
H
R
D
V
K
P
H
N
I
M
I
--
D
H
E
N
R
Q
I
R
L
I
S
W
G
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Fugue
43.61
15%
14
- C2 -
-
5CKW
1
?
B:
[6-410]
-------------------------
T
M
K
L
L
R
F
H
E
L
K
S
L
P
G
M
D
----
E
K
A
L
E
L
L
I
K
V
L
G
N
K
G
I
R
K
L
I
K
S
ADGKPIS
R
E
I
M
I
H
E
F
G
I
D
C
Q
I
L
F
I
T
T
E
A
S
L
K
P
I
I
V
P
T
E
N
K
I
S
Y
C
E
Q
F
K
V
Y
ALDDGK
T
Y
F
-----
L
K
S
V
KIDAE
S
L
T
E
F
T
N
E
K
D
T
L
S
K
L
G
---
R
L
V
G
T
F
-
F
N
E
Q
T
--
Q
----
V
H
Y
I
L
T
TFIKGID
L
S
R
Y
K
N
A
L
P
L
N
V
-----
N
------
L
-----
K
H
F
W
E
V
L
G
I
M
I
S
V
C
H
Q
V
K
Q
F
H
E
L
G
L
I
H
R
D
L
K
P
G
N
I
M
L
--
D
A
D
-
M
Q
C
H
L
V
D
F
G
S
S
S
S
D
K
E
P
K
P
A
S
W
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
A
S
Y
L
A
P
E
L
N
A
Q
E
------
D
F
IA
F
S
Q
V
S
D
L
F
A
L
A
Y
S
L
D
E
L
F
----
N
P
F
-------------------------
R
Q
V
K
F
A
K
V
D
I
G
I
K
N
-----
K
H
L
V
L
L
H
A
E
I
E
A
C
I
T
G
L
M
S
N
E
T
S
V
R
T
L
Y
F
S
R
I
L
Q
L
Q
R
V
P
E
S
F
K
S
R
P
E
A
F
T
Y
L
I
M
L
L
T
Q
W
K
-
S
C
Y
E
A
-------------------
P
E
M
N
K
E
L
D
E
I
I
A
E
I
K
V
A
Y
E
N
H
E
Q
D
A
V
K
I
I
T
L
L
E
Q
------
L
S
--
K
A
D
G
L
L
N
S
H
K
A
L
L
S
V
L
I
K
S
L
A
N
505
HHSearch
43.61
29%
-93
- C3 -
-
4NM3
3
GSK3B_HUMAN
A:
[53-205]
-----------------------------------------------------------------------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
---
D
S
G
E
L
V
A
I
------
K
K
V
-----
L
Q
D
K
-------
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
H
C
N
I
V
R
L
R
-
Y
F
F
Y
S
--
S
KKDE
V
Y
L
N
L
V
-------
L
D
Y
V
P
E
T
V
Y
R
V
A
R
----
H
YSRAKQ
T
-----
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
--
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
HHSearch
43.23
29%
-43
- C3 -
-
6HMQ
6
CSK22_HUMAN
A:
[51-195]
-----------------------------------------------------------------------------------
Q
D
D
Y
Q
L
V
R
K
L
G
R
G
K
Y
S
E
V
F
E
A
I
N
I
---
T
N
N
E
R
V
V
V
------
K
I
L
-----
K
P
V
K
------
K
K
K
I
K
R
E
V
K
I
L
E
N
L
R
G
G
T
N
I
I
K
L
I
-
D
T
V
K
D
PV
S
----
K
T
P
A
L
V
-------
F
E
Y
I
N
N
T
D
F
K
Q
L
Y
----
Q
------
I
-----
L
T
D
F
D
I
R
F
Y
M
Y
E
L
L
K
A
L
D
Y
C
H
S
K
G
I
M
H
R
D
V
K
P
H
N
V
M
I
--
D
H
Q
Q
K
K
L
R
L
I
D
W
G
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Fugue
43.08
20%
-12
* C4 *
-
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
-----
N
K
V
A
V
------
K
C
I
-----
K
--
N
-----
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
----
E
----
E
G
L
Y
I
V
-------
T
E
Y
M
A
K
G
S
L
V
D
Y
L
----
R
------
S
RGRSV
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
--
S
E
D
-
N
V
A
K
V
S
D
F
G
---------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
DVWSFGILLW
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
---
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
HHSearch
42.96
28%
-41
- C3 -
-
5OMY
1
CSK21_HUMAN
A:
[36-180]
-----------------------------------------------------------------------------------
Q
D
D
Y
Q
L
V
R
K
L
G
R
G
K
Y
S
E
V
F
E
A
I
N
I
---
T
N
N
E
K
V
V
V
------
K
I
L
-----
K
P
V
K
------
K
K
K
I
K
R
E
I
K
I
L
E
N
L
R
G
G
P
N
I
I
T
L
A
-
D
I
V
K
D
PV
S
----
R
T
P
A
L
V
-------
F
E
H
V
N
N
T
D
F
K
Q
L
Y
----
Q
------
T
-----
L
T
D
Y
D
I
R
F
Y
M
Y
E
I
L
K
A
L
D
Y
C
H
S
M
G
I
M
H
R
D
V
K
P
H
N
V
M
I
--
D
H
E
H
R
K
L
R
L
I
D
W
G
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------